Takanashi Mikio 高梨幹生

… Alternative Names

高梨幹生タカナシミキオ

TAKANASHI Mikio 高梨幹生

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Researcher Number	70610799
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help	2022: 東京大学, 医学部附属病院, 助教 2017 – 2020: 東京大学, 医学部附属病院, 助教 2016: 東京大学, 医学部附属病院, 特任助教 2015: 東京大学, 医学部附属病院, 助教 2013 – 2014: 東京大学, 医学部附属病院, 特任助教 2012 – 2013: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Metabolomics / Basic Section 59040:Nutrition science and health science-related / Basic Section 54040:Metabolism and endocrinology-related Except Principal Investigator Gastroenterology / Metabolomics
Keywords	Principal Investigator インスリン / リポ蛋白リパーゼ / ホルモン感受性リパーゼ / リパーゼ / 糖尿病 / 脂質異常症 / 高カイロミクロン血症 / 中鎖脂肪酸 / レプチン / 致死的代謝異常 … More / SREBP1c / アポリポ蛋白A5 / 高中性脂肪血症 / カイロミクロン / MCTオイル / 脂質 / ストレプトゾトシン … More Except Principal Investigator リパーゼ / 非アルコール性脂肪性肝炎 / コレステロール / 肝臓学 / 肝癌 / 脂肪性肝炎 / 脂質代謝 / 分子標的 / 炎症 / 脂肪毒性 / 脂肪肝 / インスリン分泌刺激物質 / 脂肪分解 / インスリン / メタボローム解析 / 脂肪細胞 / インスリン分泌 / 脂質 / 糖尿病 Less

中鎖脂肪酸による高カイロミクロン血症抑制機序の解明および新規治療ターゲットの探索Principal Investigator
- Principal Investigator
  
  高梨幹生
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  The University of Tokyo
Elucidation of novel relationships between lipase and diabetesPrincipal Investigator
- Principal Investigator
  
  Takanashi Mikio
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  The University of Tokyo
Elucidation of novel molecular mechanisms and therapeutic targets of hypertriglyceridemiaPrincipal Investigator
- Principal Investigator
  
  Takanashi Mikio
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
The physiological roles of intracellular lipases in the pathogenesis of nonalcoholic fatty liver diseases
- Principal Investigator
  
  OKAZAKI Sachiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
The role and molecular mechanisms of free-cholesterol toxicity in steatohepatitis
- Principal Investigator
  
  OKAZAKI Sachiko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Molecular identity and mechanisms of lipolysis-stimulated insulin secretion
- Principal Investigator
  
  OKAZAKI Hiroaki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
Molecular mechanisms of diabetic lipemia in streptozotocin-treated micePrincipal Investigator
- Principal Investigator
  
  TAKANASHI Mikio
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo

All 2020 2019 2016 2015 2014 2013

All Journal Article Presentation

[Journal Article] Critical Role of SREBP-1c Large-VLDL Pathway in Environment-Induced Hypertriglyceridemia of Apo AV Deficiency2019
- Author(s)
  Takanashi M, Kimura T, Li C, Tanaka M, Matsuhashi A, Yoshida H, Noda A, Xu P, Takase S, Okazaki S, Iizuka Y, Kumagai H, Ikeda Y, Gotoda T, Takahashi M, Yagyu H, Ishibashi S, Yamauchi T, Kadowaki T, Liang G, Okazaki H.
- Journal Title
  
  Arteriosclerosis, Thrombosis, and Vascular Biology
  
  Volume: 39 Issue: 3 Pages: 373-386
- DOI
  10.1161/atvbaha.118.311931
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08585, KAKENHI-PROJECT-17K09858, KAKENHI-PROJECT-18K08504, KAKENHI-PROJECT-18H04053, KAKENHI-PROJECT-17K09867, KAKENHI-PROJECT-26000012
[Presentation] インスリン欠乏による致死的代謝異常におけるホルモン感受性リパーゼの重要な役割2020
- Author(s)
  高梨幹生、石セイセン、李騁騁、田中督記、木村武史、高瀬暁、岡崎佐智子、飯塚陽子、門脇孝、山内敏正、岡崎啓明
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K08504
[Presentation] ホルモン感受性リパーゼ欠損がインスリン欠乏時の生存に及ぼす影響2020
- Author(s)
  高梨幹生、石セイセン、李騁騁、田中督記、木村武史、高瀬暁、岡崎佐智子、飯塚陽子、門脇孝、山内敏正、岡崎啓明
- Organizer
  第52回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K08504
[Presentation] 糖尿病性高中性脂肪血症とホルモン感受性リパーゼ2019
- Author(s)
  高梨幹生
- Organizer
  第179回　東京脂質談話会
- Data Source
  KAKENHI-PROJECT-18K08504
[Presentation] Amelioration of streptozotocin-induced diabetic hypertriglyceridemia in the absence of hormone-sensitive lipase2016
- Author(s)
  Mikio Takanashi, Satoru Takase, Yoshino Taira, Takeshi Kimura, Sachiko Okazaki, Pengfei Xu, Chengcheng Li, Futoshi Shionoiri, Yoko IIzuka, Jun-ichi Osuga, Shun Ishibashi, Takashi Kadowaki, Hiroaki Okazaki
- Organizer
  American Heart Association Scientific Sessions 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19506
[Presentation] インスリン欠乏性高中性脂肪血症の成因におけるホルモン感受性リパーゼの重要な役割2015
- Author(s)
  高梨幹生
- Organizer
  第47回日本動脈硬化学会総会・学術集会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-15K19506
[Presentation] インスリン欠乏性高中性脂肪血症に与えるホルモン感受性リパーゼの重要な役割2015
- Author(s)
  高梨幹生
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  グランプラスセント・ヴァレンタイン（山口県下関市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K19506
[Presentation] Molecular regulation of diabetic hyperlipidemia2014
- Author(s)
  Hiroaki Okazaki, Mikio Takanashi, Guosheng Liang
- Organizer
  The 4th International Symposium on Chylomicrons in Disease
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-24790915
[Presentation] インスリン欠乏時の高中性脂肪血症の成因とホルモン感受性リパーゼの役割2013
- Author(s)
  高梨幹生
- Organizer
  第45回　日本動脈硬化学会　総会・学術集会
- Place of Presentation
  京王プラザホテル（東京）
- Data Source
  KAKENHI-PROJECT-24790915
[Presentation] インスリン欠乏時の高中性脂肪血症におけるホルモン感受性リパーゼの役割2013
- Author(s)
  高梨幹生, 他
- Organizer
  第56回日本糖尿病学会学術集会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24790915
[Presentation] インスリン欠乏時の高中性脂肪血症におけるホルモン感受性リパーゼの役割2013
- Author(s)
  高梨幹生
- Organizer
  第56回　日本糖尿病学会　年次学術集会
- Place of Presentation
  ホテル日航熊本
- Data Source
  KAKENHI-PROJECT-24790915
[Presentation] インスリン欠乏時の高中性脂肪血症の成因とホルモン感受性リパーゼの役割2013
- Author(s)
  高梨幹生, 他
- Organizer
  第45回日本動脈硬化学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790915

1. OKAZAKI Hiroaki (80610211)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. OKAZAKI Sachiko (30648720)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. TAKASE Satoru (80508094)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KUBOTA Midori (20383804)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TAKAMOTO Iseki (60431871)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAKAHASHI Masafumi (40296108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 熊谷英敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 池田祐一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takanashi Mikio 高梨 幹生

高梨 幹生 タカナシ ミキオ

TAKANASHI Mikio 高梨 幹生

Research Projects

Research Products

Co-Researchers

中鎖脂肪酸による高カイロミクロン血症抑制機序の解明および新規治療ターゲットの探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of novel relationships between lipase and diabetesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of novel molecular mechanisms and therapeutic targets of hypertriglyceridemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The physiological roles of intracellular lipases in the pathogenesis of nonalcoholic fatty liver diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role and molecular mechanisms of free-cholesterol toxicity in steatohepatitis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular identity and mechanisms of lipolysis-stimulated insulin secretion

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of diabetic lipemia in streptozotocin-treated micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Critical Role of SREBP-1c Large-VLDL Pathway in Environment-Induced Hypertriglyceridemia of Apo AV Deficiency2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] インスリン欠乏による致死的代謝異常におけるホルモン感受性リパーゼの重要な役割2020

Author(s)

Organizer

Data Source

[Presentation] ホルモン感受性リパーゼ欠損がインスリン欠乏時の生存に及ぼす影響2020

Author(s)

Organizer

Data Source

[Presentation] 糖尿病性高中性脂肪血症とホルモン感受性リパーゼ2019

Author(s)

Organizer

Data Source

[Presentation] Amelioration of streptozotocin-induced diabetic hypertriglyceridemia in the absence of hormone-sensitive lipase2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] インスリン欠乏性高中性脂肪血症の成因におけるホルモン感受性リパーゼの重要な役割2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] インスリン欠乏性高中性脂肪血症に与えるホルモン感受性リパーゼの重要な役割2015

Author(s)

Organizer

Takanashi Mikio 高梨幹生

高梨幹生タカナシミキオ

TAKANASHI Mikio 高梨幹生