Takayama Kentaro 高山健太郎

Researcher Number	70611482
Other IDs
Affiliation (Current)	2025: 京都薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 京都薬科大学, 薬学部, 准教授 2019 – 2020: 京都薬科大学, 薬学部, 准教授 2017 – 2018: 東京薬科大学, 薬学部, 講師 2013 – 2016: 東京薬科大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Drug development chemistry Except Principal Investigator Basic Section 48030:Pharmacology-related / Basic Section 56050:Otorhinolaryngology-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Drug development chemistry
Keywords	Principal Investigator ペプチド / アクチビン / マイオスタチン / 短鎖化ペプチド / 光反応性アミノ酸 / 2型炎症 / アンタゴニスト / 抗肥満 / 抗炎症 / ニューロメジンU … More / ペプチドモジュレータ / 生体分子 / 選択的阻害 / マイオスタチン阻害ペプチド / 構造活性相関 / マイオスタチン阻害 / フォリスタチン / calu-6 / Calu-6 / 細胞増殖抑制 / リードスルー … More Except Principal Investigator 構造活性相関研究 / ペプチド / 構造修飾 / 腹腔内免疫 / 急性炎症 / 腸内環境 / 中分子ペプチド / 横紋筋融解症後急性腎障害 / ラクトフェリン / 白血球細胞外トラップ / ILC-2 / 自然免疫 / 中分子ペプチド化合物 / ニューロメジン / 治療薬 / 好酸球性副鼻腔炎 / ストレス / うつ病 / アストロサイト / ATPシグナリング / 腸内細菌 / 抗がん剤 / ストレス感受性 / うつ様所見 / αヘリックス / ペプチド誘導体 / 構造活性相関 / 受容体選択性 / 阻害剤 / アゴニスト / マイオスタチン / ニューロメジンU Less

マイオスタチンとアクチビンのデュアル阻害に基づく先端的な骨格筋増強ペプチドの創出Principal Investigator
- Principal Investigator
  
  高山健太郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Kyoto Pharmaceutical University
抗がん剤のうつ病誘発リスクに関する基礎的および薬剤疫学的検証
- Principal Investigator
  
  長澤一樹
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Kyoto Pharmaceutical University
好酸球性副鼻腔炎に対するニューロメジンの機能解析と治療薬への応用
- Principal Investigator
  
  若林健一郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Keio University
Development of Novel Therapeutic Agents for Crush Syndrome by Targeting Leukocyte Extracellular Traps
- Principal Investigator
  
  平橋淳一
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Keio University
Development of peptidic NMUR1 antagonist and the application to suppression of type 2 inflammationPrincipal Investigator
- Principal Investigator
  
  Takayama Kentaro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Kyoto Pharmaceutical University
Structure activity relationship study of a follistatin-derived myostatin inhibitory peptide for enhancement of skeletal muscle massPrincipal Investigator
- Principal Investigator
  
  Takayama Kentaro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyoto Pharmaceutical University
  Tokyo University of Pharmacy and Life Science
Studies on molecular functions of mid-size peptides derived from living system and their basic research for practical drug discovery
- Principal Investigator
  
  Yoshio Hayashi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Development of anti-cancer agents based on readthrough of nonsense mutation on TP53 genePrincipal Investigator
- Principal Investigator
  
  Takayama Kentaro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science

All 2024 2023 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation Patent

[Journal Article] Sub-chronic and mild social defeat stress exposure to C57BL/6J mice increases visceral fat mass and causes accumulation of cholesterol and bile acids in the liver2024
- Author(s)
  Katsuya Morito, Mayu Yamagata, Futaba Naka, Kayo Kobayashi, Hikari Ueda, Hirotoshi Morimoto, Takeshi Yasukawa, Kentaro Takayama, Yoshinobu Uozumi, Kazuki Nagasawa
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 702 Pages: 149631-149631
- DOI
  10.1016/j.bbrc.2024.149631
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06590
[Journal Article] Discovery of a follistatin-derived myostatin inhibitory peptide2020
- Author(s)
  Saitoh Mariko、Takayama Kentaro、Hitachi Keisuke、Taguchi Akihiro、Taniguchi Atsuhiko、Tsuchida Kunihiro、Hayashi Yoshio
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 30 Issue: 3 Pages: 126892-126892
- DOI
  10.1016/j.bmcl.2019.126892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07001, KAKENHI-PROJECT-19H03427, KAKENHI-PROJECT-17K08646, KAKENHI-PROJECT-17K15484
[Journal Article] Design and synthesis of potent myostatin inhibitory cyclic peptides2019
- Author(s)
  Rentier Cedric、Takayama Kentaro、Saitoh Mariko、Nakamura Akari、Ikeyama Hiroaki、Taguchi Akihiro、Taniguchi Atsuhiko、Hayashi Yoshio
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Issue: 7 Pages: 1437-1443
- DOI
  10.1016/j.bmc.2019.02.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04658, KAKENHI-PROJECT-19K07001
[Journal Article] Structural basis for the effective myostatin inhibition of the mouse myostatin prodomain-derived minimum peptide2017
- Author(s)
  Tomo Asari, Kentaro Takayama, Akari Nakamura, Takahiro Shimada, Akihiro Taguchi and Yoshio Hayashi
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume: 8 Issue: 1 Pages: 113-117
- DOI
  10.1021/acsmedchemlett.6b00420
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04658
[Journal Article] Discovery of a Human Neuromedin U Receptor 1-Selective Hexapeptide Agonist with Enhanced Serum Stability2017
- Author(s)
  Takayama Kentaro、Mori Kenji、Tanaka Akiko、Nomura Erina、Sohma Yuko、Mori Miwa、Taguchi Akihiro、Taniguchi Atsuhiko、Sakane Toshiyasu、Yamamoto Akira、Minamino Naoto、Miyazato Mikiya、Kangawa Kenji、Hayashi Yoshio
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 60 Issue: 12 Pages: 5228-5234
- DOI
  10.1021/acs.jmedchem.7b00694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04658, KAKENHI-PROJECT-15K09445
[Journal Article] Development of Potent Myostatin Inhibitory Peptides through Hydrophobic Residue-Directed Structural Modification2017
- Author(s)
  Takayama Kentaro、Rentier Cedric、Asari Tomo、Nakamura Akari、Saga Yusuke、Shimada Takahiro、Nirasawa Kei、Sasaki Eri、Muguruma Kyohei、Taguchi Akihiro、Taniguchi Atsuhiko、Negishi Yoichi、Hayashi Yoshio
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 8 Issue: 7 Pages: 751-756
- DOI
  10.1021/acsmedchemlett.7b00168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K13260, KAKENHI-PROJECT-15H04658, KAKENHI-PROJECT-16F16413
[Journal Article] Neuromedin U suppresses glucose-stimulated insulin secretion in pancreatic β cells.2017
- Author(s)
  Zhang W, Sakoda H, Miura A, Shimizu K, Mori K, Miyazato M, Takayama K, Hayashi Y, Nakazato M.: Neuromedin U
- Journal Title
  
  Biochem Biophys Res Commun,
  
  Volume: 493 Issue: 1 Pages: 677-683
- DOI
  10.1016/j.bbrc.2017.08.132
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09761, KAKENHI-PROJECT-17K16051, KAKENHI-PROJECT-15H04658, KAKENHI-PROJECT-16H05333, KAKENHI-PROJECT-15K09445
[Journal Article] Identification of a degrading enzyme in human serum that hydrolyzes a C-terminal core sequence of neuromedin U2016
- Author(s)
  Kentaro Takayama, Akihiro Taguchi, Fumika Yakushiji, and Yoshio Hayashi
- Journal Title
  
  Biopolymers
  
  Volume: - Issue: 4 Pages: 440-445
- DOI
  10.1002/bip.22770
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04658
[Journal Article] Effect of N-terminal acylation on the activity of myostatin inhibitory peptides2016
- Author(s)
  Kentaro Takayama, Akari Nakamura, Cédric Rentier, Yusaku Mino, Tomo Asari, Yusuke Saga, Akihiro Taguchi, Fumika Yakushiji and Yoshio Hayashi
- Journal Title
  
  ChemMedChem
  
  Volume: 11 Issue: 8 Pages: 845-849
- DOI
  10.1002/cmdc.201500533
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04658
[Journal Article] The Inhibitory Core of the Myostatin Prodomain: Its Interaction with Both Type I and II Membrane Receptors, and Potential to Treat Muscle Atrophy.2015
- Author(s)
  Ohsawa Y, Takayama K, Nishimatsu S, Okada T, Fujino M, Fukai Y, Murakami T, Hagiwara H, Itoh F, Tsuchida K, Hayashi Y, Sunada Y.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 7 Pages: e0133713-e0133713
- DOI
  10.1371/journal.pone.0133713
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09330, KAKENHI-PROJECT-26461285, KAKENHI-PROJECT-15H04658
[Patent] Peptide or pharmaceutically acceptable salts or prodrugs and applications thereof2018
- Inventor(s)
  林　良雄、高山　健太郎、宮里　幹也、寒川　賢治、森　健二
- Industrial Property Rights Holder
  学校法人東京薬科大学、国立研究開発法人国立循環器病研究センター
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-15H04658
[Patent] Peptide or pharmaceutically acceptable salts or prodrugs thereof2018
- Inventor(s)
  林　良雄、高山　健太郎、宮里　幹也、寒川　賢治、森　健二ら7名
- Industrial Property Rights Holder
  学校法人東京薬科大学、国立研究開発法人国立循環器病研究センター他
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-15H04658
[Patent] ペプチドもしくはその薬学的に許容される塩、またはそれらのプロドラッグ2018
- Inventor(s)
  林　良雄、高山　健太郎、齋藤　まりこ、土田　邦博、常陸　圭介
- Industrial Property Rights Holder
  学校法人東京薬科大学、学校法人藤田学園
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-190981
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K15484
[Patent] ペプチド、その薬学的に許容される塩、またはそれらのプロドラッグ、およびそれらの用途2017
- Inventor(s)
  林良雄、高山健太郎、宮里幹也、寒川賢治、森健二
- Industrial Property Rights Holder
  林良雄、高山健太郎、宮里幹也、寒川賢治、森健二
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-008302
- Filing Date
  2017-01-20
- Data Source
  KAKENHI-PROJECT-15H04658
[Patent] Peptide or pharmaceutically acceptable salts or prodrugs thereof2017
- Inventor(s)
  林　良雄、高山　健太郎、根岸　洋一
- Industrial Property Rights Holder
  学校法人東京薬科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-15H04658
[Patent] ペプチドもしくはその薬学的に許容される塩、またはそれらのプロドラッグ2017
- Inventor(s)
  林良雄、高山健太郎、宮里幹也、寒川賢治、森健二、山本昌、坂根稔康
- Industrial Property Rights Holder
  林良雄、高山健太郎、宮里幹也、寒川賢治、森健二、山本昌、坂根稔康
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-008301
- Filing Date
  2017-01-20
- Data Source
  KAKENHI-PROJECT-15H04658
[Patent] ペプチドもしくはその薬学的に許容される塩、またはそれらのプロドラッグ2016
- Inventor(s)
  林良雄、高山健太郎、根岸洋一
- Industrial Property Rights Holder
  林良雄、高山健太郎、根岸洋一
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-158123
- Filing Date
  2016-08-10
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Doxorubicin decreases sweet taste sensitivity in mice2023
- Author(s)
  Keisuke Mogi, Misaki Azuma, Shiori Iwaki, Chisaki Yoshioka, Katsuya Morito, Kentaro Takayama, Kazuki Nagasawa
- Organizer
  第33回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-22K06590
[Presentation] Identification of the minimum bioactive-peptide structure derived from endogenous myostatin inhibitory molecules2020
- Author(s)
  Kentaro Takayama
- Organizer
  7th International Postgraduate Conference on Pharmaceutical Sciences (iPoPS2020)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15484
[Presentation] Structural requirements of mouse myostatin prodomain-derived small peptide for effective myostatin inhibition2018
- Author(s)
  K. Takayama, T. Asari, M. Saitoh, Y. Roppongi, A. Nakamura, A. T. Shimada, Taguchi, A. Taniguchi, Y. Negishi and Y. Hayashi
- Organizer
  8th Peptide Engineering Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] 網羅的構造活性相関研究によるマウス由来マイオスタチン阻害ペプチドの高活性化2018
- Author(s)
  高山　健太郎，淺利　知，齋藤　まりこ，六本木　佳美，中村　明里，嶋田　嵩大，池山　弘晃，田口　晃弘，谷口　敦彦，根岸　洋一，林　良雄
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] ヒト２型ニューロメジンU受容体選択的アゴニストの創製と抗肥満効果2018
- Author(s)
  高山　健太郎，森　健二，田中　晶子，石兼　真，田口　晃弘，谷口　敦彦，坂根　稔康，山本　昌，南野　直人，宮里　幹也，寒川　賢治，林　良雄
- Organizer
  第91回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Structural requirements for the effective myostatin inhibition of myostatin prodomain-derived peptide derivatives2018
- Author(s)
  K. Takayama, T. Asari, M. Saitoh, Y. Roppongi, A. Nakamura, A. Taguchi, A. Taniguchi and Y. Hayashi
- Organizer
  256th American Chemical Society National Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Structure Activity Relationship Study for Obtaining Human Neuromedin U Receptor Selective Hexapeptide Agonists2018
- Author(s)
  K. Takayama, K. Mori, E. Nomura, Y. Sohma, A. Tanaka, A. Taguchi, A. Taniguchi, T. Sakane, A. Yamamoto, N. Minamino, M. Miyazato, K. Kangawa, and Y. Hayashi
- Organizer
  XXII International Conference on Organic Synthesis; 22-ICOS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Structural derivatization for the effective myostatin inhibition of myostatin prodomain-derived peptide derivatives2018
- Author(s)
  K. Takayama, T. Asari, M. Saitoh, Y. Roppongi, A. Nakamura, A. Taguchi, A. Taniguchi, Y. Negishi and Y. Hayashi
- Organizer
  11th Japanese-French Workshop “New insights in personalized medicine for neuromuscular diseases: From Basic to Applied Myology”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] マイオスタチン阻害ペプチドの小型化と構造活性相関研究2018
- Author(s)
  高山　健太郎、淺利　知、齋藤　まりこ、六本木　佳美、中村　明里、佐賀　裕介、嶋田　嵩大、池山　弘晃、田口　晃弘、谷口　敦彦、根岸　洋一、林　良雄
- Organizer
  日本筋学会第4回学術集会
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] 小型化マイオスタチン阻害ペプチドの発見と高活性誘導体の創製2018
- Author(s)
  六本木　佳美、高山　健太郎、齊藤　まりこ、中村　明里、嶋田　嵩大、田口　晃弘、谷口　敦彦、根岸　洋一、林　良雄
- Organizer
  創薬懇話会2017 in 志賀島
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] 小型化マイオスタチン阻害ペプチドの発見と高活性化2018
- Author(s)
  齊藤　まりこ、高山　健太郎、C. Rentier、中村　明里、嶋田　嵩大、六本木　佳美、田口　晃弘、谷口　敦彦、根岸　洋一、林良雄
- Organizer
  日本薬学会第 138 年会
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Discovery of Selective Hexapeptidic Agonists to Human NMUR1 and NMUR22018
- Author(s)
  K. Takayama, K. Mori, A. Tanaka, Y. Sohma, E. Nomura, A. Taguchi, A. Taniguchi, T. Sakane, A. Yamamoto, N. Minamino, M. Miyazato, K. Kangawa, Y. Hayashi
- Organizer
  54th International Conference on Medicinal Chemistry (RICT2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Discovery of Selective Hexapeptide Agonists Toward Human NMUR1 and NMUR22017
- Author(s)
  K. Takayama, K. Mori, K. Taketa, Y. Sohma, E. Nomura, A. Tanaka, A. Taguchi, A. Taniguchi, T. Sakane, A. Yamamoto, N. Minamino, M. Miyazato, K. Kangawa, and Y. Hayashi
- Organizer
  The EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC’17)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] ヒトNMU受容体の各サブタイプに選択的なヘキサペプチドアゴニストの創製2017
- Author(s)
  高山　健太郎，森　健二，武田　康嗣，相馬　悠子，野村　恵梨奈，田口　晃弘，谷口　敦彦，南野　直人，宮里　幹也，寒川　賢治，林　良雄
- Organizer
  日本ケミカルバイオロジー学会第１２回年会
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Transnasal delivery of the peptide to the brain2017
- Author(s)
  A. Tanaka, C. Maeda, M. Amano, K. Takayama, Y. Hayashi, D. Inoue, T. Furubayashi, K. Kusamori, H. Katsumi, T. Sakane, A. Yamamoto
- Organizer
  6th Pharmaceutical Sciences World Congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] ヒト１型ニューロメジンU受容体に対する選択的ペプチドアゴニストの創製2017
- Author(s)
  野村　恵梨奈、高山　健太郎、森　健二、相馬　悠子、田口　晃弘、谷口　敦彦、南野　直人、宮里　幹也、寒川　賢治、林　良雄
- Organizer
  日本薬学会第 137 年会
- Place of Presentation
  宮城県仙台市、仙台国際センターおよび東北大学川内キャンパス
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] マイオスタチン阻害ペプチドの活性強化を目指した構造活性相関研究2017
- Author(s)
  高山　健太郎、C. Rentier、淺利　知、中村　明里、佐賀　裕介、嶋田　嵩大、齋藤　まりこ、六本木　佳美、田口　晃弘、谷口　敦彦、根岸　洋一、林　良雄
- Organizer
  日本筋学会第3回学術集会
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Discovery of Selective Hexapeptide Agonists to Human NMUR1 and NMUR22017
- Author(s)
  K. Takayama, K. Mori, A. Tanaka, A. Taguchi, A. Taniguchi, T. Sakane, A. Yamamoto, N. Minamino, M. Miyazato, K. Kangawa, and Y. Hayashi
- Organizer
  12th Annual Peptide Therapeutics Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] マイオスタチン阻害ペプチドの活性強化を目指した網羅的構造活性相関研究2017
- Author(s)
  高山　健太郎、池山　弘晃、C. Rentier、中村　明里、佐賀　裕介、嶋田　嵩大、齋藤　まりこ、田口　晃弘、谷口　敦彦、根岸　洋一、林　良雄
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Mouse Myostatin Prodomain-derived Inhibitory Peptides for Treatment of Muscle Atrophic Disorders2017
- Author(s)
  C. Rentier, M. Saitoh, A. Nakamura, T. Shimada, S. Sashida, K. Takayama, Y. Negishi and Y. Hayashi
- Organizer
  25th American Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] マイオスタチン阻害ペプチドの活性強化を指向した構造活性相関研究2017
- Author(s)
  六本木　佳美、高山　健太郎、C. Rentier、中村　明里、佐賀　裕介、嶋田　嵩大、齋藤　まりこ、田口　晃弘、谷口　敦彦、根岸　洋一、林　良雄
- Organizer
  日本ケミカルバイオロジー学会第１２回年会
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] ヒトニューロメジンU受容体の各サブタイプに選択的なペプチドアゴニストの創製2017
- Author(s)
  高山　健太郎，森　健二，武田　康嗣，相馬　悠子，野村　恵梨奈，田口　晃弘，谷口　敦彦，南野　直人，宮里　幹也，寒川　賢治，林　良雄
- Organizer
  第14回GPCR研究会
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] ヒトニューロメジンU受容体の各サブタイプに選択的なヘキサペプチドアゴニストの創製2017
- Author(s)
  高山　健太郎，森　健二，武田　康嗣，相馬　悠子，野村　恵梨奈，田口　晃弘，谷口　敦彦，南野　直人，宮里　幹也，寒川　賢治，林　良雄
- Organizer
  第90回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] DISCOVERY OF SELECTIVE HEXAPEPTIDE AGONISTS TOWARD HUMAN NMUR12017
- Author(s)
  K. Takayama, K. Mori, E. Nomura, Y. Sohma, A. Tanaka, A. Taguchi, A. Taniguchi, T. Sakane, A. Yamamoto, N. Minamino, M. Miyazato, K. Kangawa, and Y. Hayashi
- Organizer
  第 54 回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Discovery of human NMUR2 selective hexapeptidic agonists2016
- Author(s)
  Koji Taketa, Kentaro Takayama, Kenji Mori, Yuko Sohma, Akihiro Taguchi, Naoto Minamino, Mikiya Miyazato, Kenji Kangawa, Yoshio Hayashi
- Organizer
  252nd American Chemical Society National Meeting & Exposition
- Place of Presentation
  Philadelphia Convention Center, Philadelphia, PA, USA
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] ヒトNMUR2選択的に作用するヘキサペプチドアゴニストの創製2016
- Author(s)
  武田　康嗣、高山　健太郎、相馬　悠子、森　健二、田口　晃弘、南野　直人、宮里　幹也、寒川　賢治、林　良雄
- Organizer
  創薬懇話会2016 in 蓼科
- Place of Presentation
  長野県茅野市、エクシブ蓼科
- Year and Date
  2016-06-30
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Structural basis for the effective myostatin inhibitory activity of the minimum peptide originated from mouse myostatin prodomain2016
- Author(s)
  Kentaro Takayama, Tomo Asari, Akari Nakamura, Yusuke Saga, Takahiro Shimada, Akihiro Taguchi, and Yoshio Hayashi
- Organizer
  2016 ASCB Annual Meeting
- Place of Presentation
  Moscone Center, San Francisco, CA, USA
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] マウス由来最小マイオスタチン機能阻害ペプチドN末端部の構造活性相関2016
- Author(s)
  高山　健太郎、中村　明里、レンティール　セドリック、佐賀　裕介、嶋田　嵩大、田口　晃弘、根岸　洋一、林　良雄
- Organizer
  第二回日本筋学会学術集会
- Place of Presentation
  東京都小平市、国立研究開発法人国立精神・神経医療研究センター
- Year and Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] マイオスタチン阻害ペプチドのN末端Trp残基に着目した構造活性相関研究2016
- Author(s)
  中村　明里、高山　健太郎、佐賀　裕介、嶋田　嵩大、田口　晃弘、林　良雄
- Organizer
  創薬懇話会2016 in 蓼科
- Place of Presentation
  長野県茅野市、エクシブ蓼科
- Year and Date
  2016-06-30
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] 鼻腔内投与による生理活性ペプチドCPN-116の脳内送達2016
- Author(s)
  竹村　有希、田中　晶子、武田　康嗣、高山　健太郎、井上　大輔、古林　呂之、草森　浩輔、勝見　英正、坂根　稔康、林　良雄、山本　昌
- Organizer
  第32会DDS学会学術集会
- Place of Presentation
  静岡県静岡市、静岡県コンベンションセンター
- Year and Date
  2016-06-30
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Optimization of myostatin inhibiting peptides incorporating multiple modifications for the improvement of inhibitory activity2016
- Author(s)
  Cedric Rentier, Akari Nakamura, Kentaro Takayama, Yusuke Saga, Takahiro Shimada, Sanae Sashida, Akihiro Taguchi, Yoichi Negishi, Yoshio Hayashi
- Organizer
  第 53 回ペプチド討論会
- Place of Presentation
  京都府京都市、京都テルサ
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] マイオスタチン阻害ペプチドのN末端トリプトファン残基に着目した構造活性相関研究2016
- Author(s)
  佐賀　裕介，高山　健太郎，三野　友作，中村　明里，淺利　知，田口　晃弘，薬師寺　文華，林　良雄
- Organizer
  日本薬学会第 136 年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Structural basis for the effective myostatin inhibitory activity of the minimum peptide derived from mouse myostatin prodomain2016
- Author(s)
  Kentaro Takayama, Tomo Asari, Akari Nakamura, Yusuke Saga, Takahiro Shimada, Akihiro Taguchi, Yoshio Hayashi
- Organizer
  第 53 回ペプチド討論会
- Place of Presentation
  京都府京都市、京都テルサ
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] マウス由来最小マイオスタチン阻害ペプチドを基盤とする網羅的構造活性相関研究2016
- Author(s)
  高山　健太郎、淺利　知、中村　明里、佐賀　裕介、嶋田　嵩大、田口　晃弘、林　良雄
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  茨城県つくば市、つくば国際会議場
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] マウス由来マイオスタチン機能阻害ペプチドの発見と構造活性相関2016
- Author(s)
  高山　健太郎、中村　明里、レンティール　セドリック、佐賀　裕介、嶋田　嵩大、田口　晃弘、林　良雄
- Organizer
  日本ケミカルバイオロジー学会第１１回年会
- Place of Presentation
  京都府京都市、京都テルサ
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] マイオスタチン阻害ペプチドの二次構造に着目した構造活性相関研究2016
- Author(s)
  嶋田　嵩大、高山　健太郎、三野　友作、中村　明里、淺利　知、佐賀　裕介、齊藤　まりこ、六本木　佳美、田口　晃弘、林　良雄
- Organizer
  第 60 回日本薬学会関東支部大会
- Place of Presentation
  東京都文京区、東京大学大学院薬学系研究科山上会館
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Discovery of hexapeptide agonists toward human NMUR1 and NMUR2 and their metabolism in serum2016
- Author(s)
  Kentaro Takayama, Kenji Mori, Koji Taketa, Yuko Sohma, Akihiro Taguchi, Fumika Yakushiji, Naoto Minamino, Mikiya Miyazato, Kenji Kangawa, Yoshio Hayashi
- Organizer
  The 8th Takeda Science Foundation Symposium on PharmaSciences
- Place of Presentation
  Osaka, Japan
- Year and Date
  2016-01-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Transnasal delivery of peptide agonist specific to neuromedin U receptor 2 to the brain for the treatment of obesity2016
- Author(s)
  A. Tanaka, Y. Takemura, D. Inoue, T. Furubayashi, K. Taketa, K. Takayama, Y. Hayashi, K. Kusamori, H. Katsumi, T. Sakane, A. Yamamoto
- Organizer
  2016 Annual Meeting and Exposition of Controlled Release Society
- Place of Presentation
  Washington State Convention Center, Seattle, WA, USA
- Year and Date
  2016-07-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Discovery of mouse-derived human myostatin-inhibitory peptides and its N-terminal acylation2016
- Author(s)
  Kentaro Takayama, Akari Nakamura, Yusaku Mino, Tomo Asari, Yusuke Saga, Akihiro Taguchi, and Yoshio Hayashi
- Organizer
  The XXIV EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2016)
- Place of Presentation
  Manchester Central Convention Complex, Manchester, UK
- Year and Date
  2016-08-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Structure-activity relationship study of N-terminal Trp residue in prodomain-derived myostatin inhibitory peptide2015
- Author(s)
  Akari Nakamura, Kentaro Takayama, Yusaku Mino, Tomo Asari, Yusuke Saga, Akihiro Taguchi, Fumika Yakushiji, Yoshio Hayashi
- Organizer
  The 7th International Peptide Sympodium
- Place of Presentation
  Matrix Biopolis, Singapore
- Year and Date
  2015-12-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] 高リードスルー活性を有する新規ネガマイシン誘導体の合成と癌細胞増殖抑制への応用2015
- Author(s)
  濵田　圭佑、高山　健太郎、田口　晃弘、会田　俊、生澤　俊太郎、村上　沙織、薬師寺　文華、臼井　健郎、林　良雄
- Organizer
  第17回日本RNA学会
- Place of Presentation
  札幌
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-25860092
[Presentation] Discovery of hexapeptide agonists to human neuromedin U receptors 1 and 22015
- Author(s)
  Kentaro Takayama, Koji Taketa, Yuko Sohma, Akihiro Taguchi, Fumika Yakushiji, Yoshio Hayashi
- Organizer
  10th AFMC International Medicinal Chemistry Symposium (AIMECS15)
- Place of Presentation
  Jeju, South Korea
- Year and Date
  2015-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] ニューロメジンU受容体1型及び2型に対する選択的ヘキサペプチドアゴニストの創製2015
- Author(s)
  高山　健太郎、森　健二、武田　康嗣、相馬　悠子、田口　晃弘、薬師寺　文華、南野　直人、宮里　幹也、寒川　賢治、林　良雄
- Organizer
  第 12 回 GPCR 研究会
- Place of Presentation
  東京
- Year and Date
  2015-05-15
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] ヒトNMU受容体を強力に活性化するヘキサペプチドアゴニストの創製と血清中代謝解析2015
- Author(s)
  相馬　悠子、高山　健太郎、森　健二、武田　康嗣、田口　晃弘，薬師寺　文華，南野　直人，宮里　幹也，寒川　賢治，林　良雄
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  平塚、神奈川
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] マイオスタチン阻害ペプチドのN末端アシル化と構造活性相関2015
- Author(s)
  中村　明里，高山　健太郎，三野　友作，淺利　知，佐賀　裕介，田口　晃弘，薬師寺　文華，林　良雄
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  千葉
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Medicinal Chemistry of Peptidic Compounds for the Treatment of Muscular Diseases2015
- Author(s)
  Kentaro Takayama, Akihiro Taguchi, Keisuke Hamada, Fumika Yakushiji, Yoshio Hayashi
- Organizer
  24th American Peptide Symposium
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-06-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Discovery of hexapeptide agonists to human NMUR1 and NMUR22015
- Author(s)
  Kentaro Takayama, Kenji Mori, Koji Taketa, Yuko Sohma, Akihiro Taguchi, Fumika Yakushiji, Naoto Minamino, Mikiya Miyazato, Kenji Kangawa, Yoshio Hayashi
- Organizer
  Frontiers in Medicinal Chemistry 2015
- Place of Presentation
  Antwerp, Belgium
- Year and Date
  2015-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] ヒト１型ニューロメジンU 受容体に対する高活性ヘキサペプチドアゴニストの創製と血清中代謝解析2015
- Author(s)
  高山　健太郎、森　健二、相馬　悠子、武田　康嗣、田口　晃弘、薬師寺　文華、南野　直人、宮里　幹也、寒川　賢治、林　良雄
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  千葉
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Development of (+)-negamycin-derived ester-type prodrugs promoting premature termination codon-readthrough and its application for supressing cancer cell growth
- Author(s)
  Kentaro Takayama, Akihiro Taguchi, Keisuke Hamada, Masaya Kotake, Masataka Shiozuka, Fumika Yakushiji, Ryoichi Matsuda, Takeo Usui, Yoshio Hayashi
- Organizer
  The 2014 ASCB/IFCB Meeting
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2014-12-06 – 2014-12-10
- Data Source
  KAKENHI-PROJECT-25860092

1. Yoshio Hayashi (10322562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 51 results
2. 長澤一樹 (30228001)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 森戸克弥 (10878333)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 村木優一 (50571452)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 若林健一郎 (40348743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 神崎晶 (50286556)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 平橋淳一 (70296573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HAMADA Keisuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. KANGAWA Kenji

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
10. MIYAZATO Mikiya

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
11. MORI Kenji

# of Collaborated Projects: 1 results

# of Collaborated Products: 21 results
12. MINAMINO Naoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
13. YAMAMOTO Akira

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
14. SAKANE Toshiyasu

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
15. TANAKA Akiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
16. NEGISHI Yoichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
17. 谷口敦彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 大沢裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 村上龍文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 砂田芳秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 西松伸一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 藤野雅広

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 迫田秀之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takayama Kentaro 高山 健太郎

Research Projects

Research Products

Co-Researchers

マイオスタチンとアクチビンのデュアル阻害に基づく先端的な骨格筋増強ペプチドの創出Principal Investigator

Principal Investigator

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Review Section

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抗がん剤のうつ病誘発リスクに関する基礎的および薬剤疫学的検証

Principal Investigator

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Review Section

Research Institution

好酸球性副鼻腔炎に対するニューロメジンの機能解析と治療薬への応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Novel Therapeutic Agents for Crush Syndrome by Targeting Leukocyte Extracellular Traps

Principal Investigator

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Review Section

Research Institution

Development of peptidic NMUR1 antagonist and the application to suppression of type 2 inflammationPrincipal Investigator

Principal Investigator

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Research Category

Review Section

Research Institution

Structure activity relationship study of a follistatin-derived myostatin inhibitory peptide for enhancement of skeletal muscle massPrincipal Investigator

Principal Investigator

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Research Institution

Studies on molecular functions of mid-size peptides derived from living system and their basic research for practical drug discovery

Principal Investigator

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Research Institution

Development of anti-cancer agents based on readthrough of nonsense mutation on TP53 genePrincipal Investigator

Principal Investigator

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Research Category

Research Field

Research Institution

[Journal Article] Sub-chronic and mild social defeat stress exposure to C57BL/6J mice increases visceral fat mass and causes accumulation of cholesterol and bile acids in the liver2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discovery of a follistatin-derived myostatin inhibitory peptide2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Design and synthesis of potent myostatin inhibitory cyclic peptides2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural basis for the effective myostatin inhibition of the mouse myostatin prodomain-derived minimum peptide2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discovery of a Human Neuromedin U Receptor 1-Selective Hexapeptide Agonist with Enhanced Serum Stability2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of Potent Myostatin Inhibitory Peptides through Hydrophobic Residue-Directed Structural Modification2017

Author(s)

Journal Title

Takayama Kentaro 高山健太郎