Ishihara Tomohiko 石原智彦

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ISHIHARA Tomohiko 石原智彦

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Researcher Number	70612232
Other IDs
Affiliation (Current)	2025: 新潟大学, 脳研究所, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 新潟大学, 脳研究所, 特任准教授 2021 – 2022: 新潟大学, 医歯学総合病院, 講師 2019: 新潟大学, 医歯学総合病院, 講師 2011 – 2018: 新潟大学, 脳研究所, 助教 2012: 新潟大学, 脳研究所神経内科, 助教
Review Section/Research Field	Principal Investigator Neurology / Basic Section 51030:Pathophysiologic neuroscience-related Except Principal Investigator Neurology
Keywords	Principal Investigator ALS / 筋萎縮性側索硬化症 / TDP-43 / スプライシング / 人工知能 / エクソーム解析 / 病理多型 / テキストマイニング / biomarker / alternative splicing … More / バイオマーカー / 選択的スプライシング / iPS細胞 / stasimon / 介在ニューロン / GEM body / snRNAs / SMN / GEM / GEM小体 / U snRNAs / 内在性コントロール / U12 / ｓｎRNA / 逆転写定量PCR / U12 snRNA / snRNA … More Except Principal Investigator 筋萎縮性側索硬化症 / ALS / アンチセンスオリゴ / TDP-43 / 神経病態 Less

AIと剖検組織を用いたALSの新規原因遺伝子同定Principal Investigator
- Principal Investigator
  
  石原智彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Niigata University
Exploring genetic factors that define TDP-43 pathological polymorphisms in ALS.Principal Investigator
- Principal Investigator
  
  Ishihara Tomohiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Niigata University
The disease mechanism and biomarker of ALS, the view from TDP-43 alternative splicingPrincipal Investigator
- Principal Investigator
  
  Ishihara Tomohiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Therapeutic strategy for ALS with nucleic acid technology focusing on the vulnerability of TDP-43 autoregulation
- Principal Investigator
  
  Sugai Akihiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Elucidation of a mechanism of ALS system selectivity focusing on TDP-43 function in interneurons.Principal Investigator
- Principal Investigator
  
  Ishihara Tomohiko
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Autoreguation of TDP-43 in ALS
- Principal Investigator
  
  Nishizawa Masatoyo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
The pathogenesis of GEM bodies reduction in ALS affected tissues.Principal Investigator
- Principal Investigator
  
  ISHIHARA Tomohiko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Alteration of snRNAs in amyotrophic lateral sclerosisPrincipal Investigator
- Principal Investigator
  
  ISHIHARA Tomohiko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Neurology
- Research Institution
  Niigata University

All 2024 2023 2022 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] Neurodegenerative Disorders as Systemic Diseases2015
- Author(s)
  Ishihara, Tomohiko，Nishizawa Masatoyo，Onodera, Osamu
- Total Pages
  20
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-15K19479
[Book] 新領域別症候群27 神経症候群II2014
- Author(s)
  酒井直子，石原智彦，小野寺理，西澤正豊
- Total Pages
  5
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-25860703
[Journal Article] Slow disease progression and characteristic TDP-43 inclusions in a patient with familial amyotrophic lateral sclerosis carrying a TARDBP G357S variant2024
- Author(s)
  Sainouchi, M. Oginezawa, S. Tada, M. Ishihara, T. Onodera, O. Kakita, A.
- Journal Title
  
  Neuropathol Appl Neurobiol
  
  Volume: 50 Issue: 1
- DOI
  10.1111/nan.12966
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07272, KAKENHI-PROJECT-23H00434, KAKENHI-PROJECT-23K24256
[Journal Article] Accuracy of a machine learning method based on structural and locational information from AlphaFold2 for predicting the pathogenicity of TARDBP and FUS gene variants in ALS2023
- Author(s)
  Hatano Yuya、Ishihara Tomohiko、Onodera Osamu
- Journal Title
  
  BMC Bioinformatics
  
  Volume: 24 Issue: 1
- DOI
  10.1186/s12859-023-05338-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14771, KAKENHI-PROJECT-21K07272
[Journal Article] Endogenous human retrovirus-K is not increased in the affected tissues of Japanese ALS patients2022
- Author(s)
  Ishihara Tomohiko、Koyama Akihide、Hatano Yuya、Takeuchi Ryoko、Koike Yuka、Kato Taisuke、Tada Mari、Kakita Akiyoshi、Onodera Osamu
- Journal Title
  
  Neuroscience Research
  
  Volume: 178 Pages: 78-82
- DOI
  10.1016/j.neures.2022.01.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07972, KAKENHI-PROJECT-21K07272
[Journal Article] Molecular mechanism of amyotrophic lateral sclerosis (ALS) from the viewpoint of the formation and degeneration of transactive response DNA-binding protein 43 kDa (TDP-43) inclusions2020
- Author(s)
  Kasahara Sou、Ishihara Tomohiko、Koike Yuka、Sugai Akihiro、Onodera Osamu
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 60 Issue: 2 Pages: 109-116
- DOI
  10.5692/clinicalneurol.cn-001362
- NAID
  130007802650
- ISSN
  0009-918X, 1882-0654
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09751, KAKENHI-PROJECT-19H01043
[Journal Article] Non-genetically modified models exhibit TARDBP mRNA increase due to perturbed TDP-43 autoregulation2019
- Author(s)
  Sugai Akihiro、Kato Taisuke、Koyama Akihide、Koike Yuka、Konno Takuya、Ishihara Tomohiko、Onodera Osamu
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 130 Pages: 104534-104534
- DOI
  10.1016/j.nbd.2019.104534
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09750, KAKENHI-PROJECT-17K09751, KAKENHI-PROJECT-19H01043
[Journal Article] 増大特集 ALS2019 TDP-43封入体から解くALSの分子病態2019
- Author(s)
  坪口晋太朗、石原智彦、須貝章弘、横関明男、小野寺理
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 71 Issue: 11 Pages: 1183-1189
- DOI
  10.11477/mf.1416201428
- ISSN
  1344-8129, 1881-6096
- Year and Date
  2019-11-01
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09750, KAKENHI-PROJECT-17K09751
[Journal Article] Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions.2019
- Author(s)
  Mori F, Tada M, Kon T, Miki Y, Tanji K, Kurotaki H, Tomiyama M, Ishihara T, Onodera O, Kakita A, Wakabayashi K.
- Journal Title
  
  Acta Neuropatholgica Communications
  
  Volume: 7 Issue: 1 Pages: 165-165
- DOI
  10.1186/s40478-019-0824-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07972, KAKENHI-PROJECT-18H02533, KAKENHI-PROJECT-17K07088, KAKENHI-PROJECT-17K09751
[Journal Article] Robustness and Vulnerability of the Autoregulatory System That Maintains Nuclear TDP-43 Levels: A Trade-off Hypothesis for ALS Pathology Based on in Silico Data2018
- Author(s)
  Sugai Akihiro、Kato Taisuke、Koyama Akihide、Koike Yuka、Kasahara Sou、Konno Takuya、Ishihara Tomohiko、Onodera Osamu
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 12 Pages: 0-0
- DOI
  10.3389/fnins.2018.00028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09750, KAKENHI-PROJECT-17K09751, KAKENHI-PLANNED-26117006
[Journal Article] The Japanese early-stage trial of high-dose methylcobalamin for amyotrophic lateral sclerosis (JETALS): Protocol for a randomized controlled trial2018
- Author(s)
  Oki Ryosuke、Izumi Yuishin、Nodera Hiroyuki、Ishihara Tomohiko，Kaji Ryuji、JETALS et al.
- Journal Title
  
  JMIR Research Protocols
  
  Volume: 7 Issue: 12 Pages: e12046-e12046
- DOI
  10.2196/12046
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09750, KAKENHI-PROJECT-17K09778, KAKENHI-PROJECT-17K09811, KAKENHI-PROJECT-17K16110, KAKENHI-PROJECT-16H05279
[Journal Article] Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43.2016
- Author(s)
  Koyama A, Sugai A, Kato T, Ishihara T, Shiga A, Toyoshima Y, Koyama M, Konno T, Hirokawa S, Yokoseki A, Nishizawa M, Kakita A, Takahashi H, Onodera O.
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 44 Issue: 12 Pages: 5820-5836
- DOI
  10.1093/nar/gkw499
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26250017, KAKENHI-PROJECT-15H06225, KAKENHI-PROJECT-15K19479, KAKENHI-PLANNED-26117006
[Journal Article] Clinical course and serial brain MRI findings in a patient with Lissauer form of general paresis2015
- Author(s)
  Ishihara, T，Nishizawa, M
- Journal Title
  
  Rinsho shinkeigaku = Clinical neurology
  
  Volume: 55 Issue: 4 Pages: 238-242
- DOI
  10.5692/clinicalneurol.55.238
- NAID
  130005066234
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19479
[Journal Article] ALSにおけるGEM小体と U snRNA異常～RNA代謝異常は運動神経変性の共通した病態機序となるか2015
- Author(s)
  小池佑佳，石原智彦，西澤正豊，小野寺理
- Journal Title
  
  神経内科
  
  Volume: 83 Pages: 175-184
- Data Source
  KAKENHI-PROJECT-15K19479
[Journal Article] Varicella-zoster virus encephalitis localized to the bilateral medial temporal lobes2015
- Author(s)
  Yajima, R， Ishihara, T，Nishizawa, M
- Journal Title
  
  Neurology-Neuroimmunology Neuroinflammation
  
  Volume: 2 Issue: 4
- DOI
  10.1212/nxi.0000000000000108
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19479
[Journal Article] Minor splicing pathway is not minor any more: Implications for thepathogenesis of motor neuron diseases.2014
- Author(s)
  Onodera O，Ishihara T, Shiga A, Nishizawa M, et.al.
- Journal Title
  
  Neuropathology.
  
  Volume: 1 Pages: 99-107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860703
[Journal Article] Aberration of the spliceosome in amyotrophic lateral sclerosis2014
- Author(s)
  Ishihara T, Onodera O.et al.
- Journal Title
  
  臨床神経学
  
  Volume: 54 Pages: 1155-7
- Open Access
- Data Source
  KAKENHI-PROJECT-25860703
[Journal Article] [Aberration of the spliceosome in amyotrophic lateral sclerosis].2014
- Author(s)
  Ishihara T, Kakita A, Takahashi H, Onodera O, Nishizawa M.
- Journal Title
  
  Rinsho Shinkeigaku.
  
  Volume: 54 Pages: 1155-1157
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253065
[Journal Article] Minor splicing pathway is not minor any more: implications for the pathogenesis of motor neuron diseases.2014
- Author(s)
  Onodera O, Ishihara T, Shiga A, Ariizumi Y, Yokoseki A, Nishizawa M.
- Journal Title
  
  Neuropathology
  
  Volume: 34 Issue: 1 Pages: 99-107
- DOI
  10.1111/neup.12070
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25110714, KAKENHI-PROJECT-25253065
[Journal Article] Decreased number of Gemini of coiled bodies and U12 snRNA levelin amyotrophic lateral sclerosis．2013
- Author(s)
  Ishihara T, Ariizumi Y, Shiga A, Onodera O， et.al.
- Journal Title
  
  Hum Mol Genet．
  
  Volume: 20 Pages: 4136-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860703
[Journal Article] Decreased number of Gemini of coiled bodies and U12 snRNA level in amyotrophic lateral sclerosis.2013
- Author(s)
  Ishihara T, Ariizumi Y, Shiga A, et al ;
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 22 Issue: 20 Pages: 4136-4147
- DOI
  10.1093/hmg/ddt262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J07914, KAKENHI-PROJECT-22249036, KAKENHI-PROJECT-23240049, KAKENHI-PROJECT-24790875, KAKENHI-PUBLICLY-25110714, KAKENHI-PROJECT-25253065
[Journal Article] Alteration of POLDIP3 splicing associated with loss of function of TDP-43 in tissues affected with ALS2012
- Author(s)
  Shiga,A. Ishihara,T.Onodera,O. et al
- Journal Title
  
  PLoS One
  
  Volume: vol.2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23890060
[Presentation] MOVA: A method of missense variant pathogenicity usingAlphaFold22023
- Author(s)
  石原智彦
- Organizer
  Human Genetics Asia 2023（HGA2023）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07272
[Presentation] Alteration of DNA methylation status of TARDBP 3 'UTR in sporadic ALS brain2019
- Author(s)
  Yuka Koike, Akihiro Sugai , Akio Yokoseki, Tomohiko Ishihara, Norikazu Hara, Junko Ito Ikeuchi, Takeshi, Akiyoshi Kakita, Osamu Onodera
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09751
[Presentation] Exome analysis in 54 autopsied Japanese sporadic ALS patients.2019
- Author(s)
  石原智彦
- Organizer
  29th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09750
[Presentation] Efficacy evaluation of nusinersen in an adult spinal muscular atrophy case using peripheral blood mRNA.2018
- Author(s)
  Tomohiko Ishihara
- Organizer
  29th international symposium on ALS/MND，
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09750
[Presentation] The SMN2 gene copy number states can affect the onset risk and survival time in Japanese ALS.2018
- Author(s)
  Tomohiko Ishihara
- Organizer
  PACTALS 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09750
[Presentation] The SMN2 gene copy number states can affect the onset risk and survival time in Japanese ALS.2017
- Author(s)
  Ishihara T
- Organizer
  28th international symposium on ALS/MND，
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09750
[Presentation] The SMN2 gene copy number states can affect the onset risk and survival time in Japanese ALS.2017
- Author(s)
  Ishihara T
- Organizer
  XXⅢ World Congress of Neurology.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09750
[Presentation] A non-genetically modified iPSC-derived neuron model with an increased expression of intrinsic TDP-432017
- Author(s)
  Akihiro Sugai, Genri Tohyama, Taisuke Kato, Tomohiko Ishihara, Osamu Onodera
- Organizer
  Gordon Research Conferences 2017 Amyotrophic Lateral Sclerosis (ALS) & Related Motor Neuron Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09751
[Presentation] A non-genetically modified human neuronal model of ALS with an increased expression of intrinsic TDP-432017
- Author(s)
  Akihiro Sugai, Taisuke Kato, Tomohiko Ishihara, Osamu Onodera
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09751
[Presentation] The expression of endogenous Human retrovirus-K in the affected tissues of ALS patients.2016
- Author(s)
  Tomohiko Ishihara
- Organizer
  Keystone Symposia for the 2016 conference
- Place of Presentation
  Colorado．USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19479
[Presentation] The SMN gene copy number states in Japanese ALS patients2016
- Author(s)
  石原智彦
- Organizer
  第57回　日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-15K19479
[Presentation] The SMN gene copy number states in Japanese ALS patients.2015
- Author(s)
  Ishihara, T
- Organizer
  3rd RNA Metabolism in Neurological Disease Meeting
- Place of Presentation
  Chicago (USA)
- Year and Date
  2015-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19479
[Presentation] Droplet digital PCR 法を用いたSMN遺伝子コピー数の解析2015
- Author(s)
  石原智彦
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ（新潟・新潟市）
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-15K19479
[Presentation] The SMN gene copy number states in Japanese ALS patients.2015
- Author(s)
  T.Ishihara, S.Toyoda, A.Koyama, R.Nakamura, G. Tohnai, N.Atsuta, G.Sobue, M.Nishizawa, O. Onodera
- Organizer
  10th Brain Research Conference: RNA Metabolism in Neurological Disease
- Place of Presentation
  Chicag (USA)
- Year and Date
  2015-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253065
[Presentation] The reduction of minor spliceosome and aberrant splicing in ALS.2014
- Author(s)
  石原智彦
- Organizer
  Cell symposia Regulatory RNAｓ
- Place of Presentation
  バークリー（USA)・Claremont Hotel & Spa
- Year and Date
  2014-10-21
- Data Source
  KAKENHI-PROJECT-25860703
[Presentation] ALSでのStasimonヒトホモログ mRNAのスプライシング異常の検討2014
- Author(s)
  石原智彦
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡，福岡国際会議場
- Year and Date
  2014-05-21
- Data Source
  KAKENHI-PROJECT-25860703
[Presentation] ALSにおけるspliceosome異常（シンポジウム発表）2014
- Author(s)
  石原智彦
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡，福岡国際会議場
- Year and Date
  2014-05-24
- Invited
- Data Source
  KAKENHI-PROJECT-25860703
[Presentation] Reduction of U11/U12 small nuclear ribonucleoprotein in amyotrophic lateral sclerosis2013
- Author(s)
  石原智彦
- Organizer
  the 24th International Symposium on ALS/MND
- Place of Presentation
  ミラノ, イタリア
- Data Source
  KAKENHI-PROJECT-25860703
[Presentation] TDP-43 is autoregulated by multiple excisions of introns in exon6 and reservation of mRNA in nucleus by TDP-432013
- Author(s)
  Akihide Koyama, Akihiro Sugai, Taisuke Kato, Takuya Konno, Tomohiko Ishihara, Masatoyo Nishizawa, Osamu Onodera
- Organizer
  24th International Symposium on ALS/MND
- Place of Presentation
  Milan　イタリア
- Data Source
  KAKENHI-PROJECT-25253065
[Presentation] Alternative splicing or polyadenylation, which is the major mechanism for auto-regulation of TDP-43?2013
- Author(s)
  Akihiro Sugai, Akihide Koyama, Taisuke Kato, Takuya Konno, Tomohiko Ishihara, Masatoyo Nishizawa, Osamu Onodera
- Organizer
  RNA Metabolism in Neurological Disease:8th Brain Research Conference
- Place of Presentation
  SanDiego アメリカ合衆国
- Data Source
  KAKENHI-PROJECT-25253065
[Presentation] Reduction of U12 snRNAs in nervous tissues with TDP-43 pathology in amyotrophic lateral sclerosis2012
- Author(s)
  石原智彦
- Organizer
  第42回米国神経科学会
- Year and Date
  2012-10-15
- Data Source
  KAKENHI-PROJECT-23890060
[Presentation] ALS患者神経組織ではスプライシング関連機能性RNAが低下する2012
- Author(s)
  石原智彦
- Organizer
  第53回神経学会総会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-23890060
[Presentation] ALS患者神経組織ではスプライシング関連機能性RNAが低下する2012
- Author(s)
  石原智彦
- Organizer
  第53回神経学会総会
- Year and Date
  2012-05-23
- Data Source
  KAKENHI-PROJECT-23890060
[Presentation] Reduction of U12 snRNAs in nervous tissues with TDP-43 pathology in amyotrophic lateral sclerosis2012
- Author(s)
  石原智彦
- Organizer
  第42回　米国神経科学会
- Place of Presentation
  米国　ニューオーリンズ
- Data Source
  KAKENHI-PROJECT-23890060
[Presentation] ALSにおけるGEM小体の異常： SMNとの関連2012
- Author(s)
  石原智彦
- Organizer
  平成24年度　神経変性疾患に関する調査研究班　班会議
- Place of Presentation
  東京　都市センターホテル
- Data Source
  KAKENHI-PROJECT-23890060
[Presentation] Alteration of snRNAs in amyotrophic lateral sclerosis.2011
- Author(s)
  石原智彦
- Organizer
  第41回　米国神経科学会
- Place of Presentation
  ワシントン（USA）
- Data Source
  KAKENHI-PROJECT-23890060
[Presentation] AlterationofsnRNAsinamyotrophiclateralsclerosis2011
- Author(s)
  石原智彦
- Organizer
  第41回米国神経科学会
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-23890060
[Presentation] ALS患者神経組織におけるU12 snRNAの減少とスプライシング異常
- Author(s)
  石原　智彦
- Organizer
  第５４回日本神経学会学術大会
- Place of Presentation
  東京，日本
- Data Source
  KAKENHI-PROJECT-25860703
[Presentation] Coordinated autoregulation of TDP-43 and its implication for TDP-43 pathology
- Author(s)
  須貝章弘　小山哲秀　加藤泰介　志賀篤　今野卓哉　小山美咲　石原智彦　西澤正豊　小野寺理
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-05-21 – 2014-05-24
- Invited
- Data Source
  KAKENHI-PROJECT-25253065
[Presentation] The reduction of minor spliceosome and aberrant splicing in ALS.
- Author(s)
  T. Ishihara., A. Koyama M., Nishizawa. O. Onodera.
- Organizer
  Cell Symposium
- Place of Presentation
  Berkeley, CA, USA
- Year and Date
  2014-10-19 – 2014-10-21
- Data Source
  KAKENHI-PROJECT-25253065
[Presentation] Aberration of the spliceosome in amyotrophic lateral sclerosis
- Author(s)
  石原智彦，柿田明美，高橋均，小野寺理，西澤正豊
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-05-21 – 2014-05-24
- Invited
- Data Source
  KAKENHI-PROJECT-25253065

1. 他田真理 (30646394)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. Nishizawa Masatoyo (80198457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
3. ONODERA Osamu (20303167)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
4. KAKITA Akiyoshi (80281012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. SATO Toshiya (90359703)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. Sugai Akihiro (70758903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 畠野雄也 (10943540)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. KATO Takahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. TOYOSHIMA Yasuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 高橋均

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ishihara Tomohiko 石原 智彦

ISHIHARA Tomohiko 石原 智彦

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AIと剖検組織を用いたALSの新規原因遺伝子同定Principal Investigator

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Exploring genetic factors that define TDP-43 pathological polymorphisms in ALS.Principal Investigator

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The disease mechanism and biomarker of ALS, the view from TDP-43 alternative splicingPrincipal Investigator

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Therapeutic strategy for ALS with nucleic acid technology focusing on the vulnerability of TDP-43 autoregulation

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Elucidation of a mechanism of ALS system selectivity focusing on TDP-43 function in interneurons.Principal Investigator

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Autoreguation of TDP-43 in ALS

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The pathogenesis of GEM bodies reduction in ALS affected tissues.Principal Investigator

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Alteration of snRNAs in amyotrophic lateral sclerosisPrincipal Investigator

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[Book] Neurodegenerative Disorders as Systemic Diseases2015

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[Book] 新領域別症候群27 神経症候群II2014

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[Journal Article] Slow disease progression and characteristic TDP-43 inclusions in a patient with familial amyotrophic lateral sclerosis carrying a TARDBP G357S variant2024

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[Journal Article] Accuracy of a machine learning method based on structural and locational information from AlphaFold2 for predicting the pathogenicity of TARDBP and FUS gene variants in ALS2023

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[Journal Article] Endogenous human retrovirus-K is not increased in the affected tissues of Japanese ALS patients2022

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[Journal Article] Molecular mechanism of amyotrophic lateral sclerosis (ALS) from the viewpoint of the formation and degeneration of transactive response DNA-binding protein 43 kDa (TDP-43) inclusions2020

Author(s)

Ishihara Tomohiko 石原智彦

ISHIHARA Tomohiko 石原智彦