Murakami Gen 村上元

… Alternative Names

MURAKAMI Gen 村上元

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Researcher Number	70613727
Other IDs	https://orcid.org/0000-0001-7181-5475
Affiliation (Current)	2025: 埼玉医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2024: 埼玉医科大学, 医学部, 講師 2016 – 2021: 埼玉医科大学, 医学部, 講師 2015: 浜松医科大学, 医学部, 研究員 2011 – 2015: 浜松医科大学, 医学部, 特任研究員 2012: 浜松医科大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Applied pharmacology / Basic Section 52030:Psychiatry-related / Basic Section 47040:Pharmacology-related Except Principal Investigator Environmental physiology(including physical medicine and nutritional physiology) / Psychiatric science
Keywords	Principal Investigator ドーパミン / コカイン / 母胎免疫活性化 / 主要組織適合遺伝子複合体クラスI / 依存 / 自己投与 / schizophrenia / adhd / dopamine / developmental disorder … More / 主要組織適合性複合体抗原クラス１ / MHCI / 腹側被蓋野 / 薬物依存 / 主要組織適合遺伝子複合体 / MHC … More Except Principal Investigator トニックカレント / 細胞移動 / CRH / 正中隆起 / メチル化 / 母体ストレス / タウリン / GABA / 神経発生 / HPA / タウリントランスポーター / GAD67 / 不注意 / 注意機能 / 衝動性 / 多動性 / プレパルスインヒビション / 社会的行動 / マウス / MHC-I / メチルフェニデート / ドーパミン受容体 / 側坐核 / 注意欠如・多動性障害 / 主要組織適合遺伝子複合体 Less

Research on mechanisms underlying neurodevelopmental disorders focusing on MHCIIPrincipal Investigator
- Principal Investigator
  
  村上元
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Saitama Medical University
Analysis of neural mechanisms for neurodevelopmental disorders focusing on MHC expressed in dopaminergic neuronsPrincipal Investigator
- Principal Investigator
  
  村上元
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Saitama Medical University
The effect of maternal immune activation on drug addictionPrincipal Investigator
- Principal Investigator
  
  Murakami Gen
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Saitama Medical University
Involvement of immune molecule MHC expressed in the brain in attention deficit/hyperactivity disorder
- Principal Investigator
  
  NAKAHARA Daiichiro
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  University of Miyazaki
  Hamamatsu University School of Medicine
the effect of virus infection in the brain on cocaine addictionPrincipal Investigator
- Principal Investigator
  
  Murakami Gen
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Saitama Medical University
  Hamamatsu University School of Medicine
The development of gene therapy with neuroimmune protein against drug addictionPrincipal Investigator
- Principal Investigator
  
  MURAKAMI Gen
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Hamamatsu University School of Medicine
Multimodal GABA systems responding to environmental stress
- Principal Investigator
  
  Fukuda Atsuo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental physiology(including physical medicine and nutritional physiology)
- Research Institution
  Hamamatsu University School of Medicine
Novel therapeutic method for drug addictionPrincipal Investigator
- Principal Investigator
  
  MURAKAMI Gen
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Applied pharmacology
- Research Institution
  Hamamatsu University School of Medicine

All 2022 2021 2020 2019 2018 2015 2014 2013 2012 2011

All Journal Article Presentation Book

[Book] Neuro Methods2018
- Author(s)
  Murakami G *(corresponding author), Kawato S.
- Total Pages
  13
- Publisher
  Springer Nature
- ISBN
  9781493989850
- Data Source
  KAKENHI-PROJECT-17K08960
[Journal Article] 主要組織適合遺伝子複合体クラスI（MHCI）の機能欠損によるドーパミン系異常と精神疾患様行動2022
- Author(s)
  村上元
- Journal Title
  
  埼玉医科大学雑誌
  
  Volume: 48 Pages: 96-97
- Data Source
  KAKENHI-PROJECT-20K07089
[Journal Article] Functional MHCI deficiency in mice causes ADHD-like behaviors with increased accumbal dopamine D1 receptor expression2021
- Author(s)
  Meng H, Suenaga T, Edamura M, Fukuda A, Ishida Y, Nakahara D, Murakami G
- Journal Title
  
  Brain Behav Immun
  
  Volume: 97 Pages: 22-31
- DOI
  10.1016/j.bbi.2021.05.015
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10277, KAKENHI-PUBLICLY-21H05687, KAKENHI-PROJECT-19H01091, KAKENHI-PROJECT-21H02661, KAKENHI-PROJECT-20K07089, KAKENHI-PROJECT-21K07503
[Journal Article] MHC class I in dopaminergic neurons suppresses relapse to reward seeking2018
- Author(s)
  Murakami G, Edamura M, Furukawa T, Kawasaki H, Kosugi I, Fukuda A, Iwashita T, Nakahara D
- Journal Title
  
  Science Advances
  
  Volume: 4 Issue: 3 Pages: 7388-7388
- DOI
  10.1126/sciadv.aap7388
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09862, KAKENHI-PROJECT-16K08736, KAKENHI-PROJECT-17K08960, KAKENHI-PROJECT-17K19682, KAKENHI-INTERNATIONAL-15K21731, KAKENHI-ORGANIZER-15H05871, KAKENHI-PLANNED-15H05872, KAKENHI-PROJECT-17H04025, KAKENHI-PROJECT-15K09709, KAKENHI-PROJECT-15K19164, KAKENHI-PROJECT-17K08784
[Journal Article] Rapid nongenomic modulation by neurosteroids of dendritic spines in the hippocampus: Androgen, oestrogen and corticosteroid2018
- Author(s)
  Murakami G, Hojo Y, Kato A, Komatsuzaki Y, Horie S, Soma M, Kim J, Kawato S
- Journal Title
  
  J Neuroendocrinol
  
  Volume: 30 Issue: 2 Pages: 12561-12561
- DOI
  10.1111/jne.12561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08960, KAKENHI-PROJECT-15K19164
[Journal Article] Functional deficiency of MHC class I enhances LTP and abolishes LTD in the nucleus accumbens of mice.2014
- Author(s)
  Edamura, M., Murakami, G., Meng, H., Itakura, M., Shigemoto R., Fukuda, A. and Nakahara, D.
- Journal Title
  
  PLoS ONE
  
  Volume: 9 Issue: 9 Pages: e107099-e107099
- DOI
  10.1371/journal.pone.0107099
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293052, KAKENHI-PROJECT-25860392, KAKENHI-PUBLICLY-26110705, KAKENHI-PROJECT-26670512
[Journal Article] Modulation of synaptic plasticity in the hippocampus by hippocampus-derived estrogen and androgen.2012
- Author(s)
  Ooishi Y, Kawato S, Hojo Y, Hatanaka Y, Higo S, Murakami G, Komatsuzaki Y, Ogiue-Ikeda M, Kimoto T, Mukai H.
- Journal Title
  
  J Steroid Biochem Mol Biol.
  
  Volume: 131 Pages: 37-51
- Data Source
  KAKENHI-PROJECT-23890076
[Journal Article] Hunter R, Murakami G, Dewell S, Seligsohn M, Baker M, Datson N, McEwen BS, Pfaff D2012
- Author(s)
  Hunter R, Murakami G, Dewell S, Seligsohn M, Baker M, Datson N, McEwen BS, Pfaff D
- Journal Title
  
  PNAS
  
  Volume: 109 Pages: 10657-62
- Data Source
  KAKENHI-PROJECT-23890076
[Journal Article] Corticosterone Induces Rapid Spinogenesis via Synaptic Glucocorticoid Receptors and Kinase Networks in Hippocampus.2012
- Author(s)
  Komatsuzaki Y, Hatanaka Y, Murakami G, Mukai H, Hojo Y, Saito M, Kimoto T, Kawato S
- Journal Title
  
  PLoS One
  
  Volume: 7
- Data Source
  KAKENHI-PROJECT-23890076
[Journal Article] Effects of Chronic Social Defeat on Physiology and Behavior; Vasopressin, Oxytocin and the Vasopressinergic V1b Receptor2011
- Author(s)
  Litvin Y, Murakami G, Pfaff D
- Journal Title
  
  Physiol Behav.
  
  Volume: 103 Pages: 393-403
- Data Source
  KAKENHI-PROJECT-23890076
[Journal Article] Estradiol Rapidly Rescues Synaptic Transmission from Corticosterone-induced Suppression via Synaptic/Extranuclear Steroid Receptors in the Hippocampus2011
- Author(s)
  Ooishi Y, Mukai H, Hojo Y, Murakami G, Hasegawa Y, Shindo T, Morrison JH, Kimoto T, Kawato S
- Journal Title
  
  Cereb Cortex
  
  Volume: 22 Pages: 926-36
- Data Source
  KAKENHI-PROJECT-23890076
[Journal Article] Endogenous synthesis of corticosteroids in the hippocampus2011
- Author(s)
  Higo S, Hojo Y, Ishii H, Komatsuzaki Y, Ooishi Y, Murakami G, Mukai H, Yamazaki T, Nakahara D, Barron A, Kimoto T, Kawato S.
- Journal Title
  
  PLoS One
  
  Volume: 6
- NAID
  120005300503
- Data Source
  KAKENHI-PROJECT-23890076
[Journal Article] Murakami G, Ribeiro A, Fontaine C, Hunter R, Pfaff D2011
- Author(s)
  Murakami G, Ribeiro A, Fontaine C, Hunter R, Pfaff D
- Journal Title
  
  Eur J Neurosci
  
  Volume: 34 Pages: 469-77
- Data Source
  KAKENHI-PROJECT-23890076
[Journal Article] Automated analysis of spines from confocal laser microscopy images: application to the discrimination of androgen and estrogen effects on spinogenesis2011
- Author(s)
  Mukai H, Hatanaka Y, Mitsuhashi K, Hojo Y, Komatsuzaki Y, Sato R, Murakami G, Kimoto T, Kawato S
- Journal Title
  
  Cereb Cortex
  
  Volume: 21 Pages: 2704-11
- Data Source
  KAKENHI-PROJECT-23890076
[Presentation] 主要組織適合遺伝子複合体クラスI（MHCI）の機能欠損によるドーパミン系異常と精神疾患様行動2021
- Author(s)
  村上元
- Organizer
  オール埼玉医大研究の日
- Invited
- Data Source
  KAKENHI-PROJECT-20K07089
[Presentation] 母胎免疫活性化による発達障害モデルマウスの遺伝子発現変化の解析2020
- Author(s)
  Murakami G., Hirasaki M. and Murakoshi T.
- Organizer
  日本神経科学会
- Data Source
  KAKENHI-PROJECT-17K08960
[Presentation] 母胎免疫活性化による発達障害モデルマウスの行動とドーパミン回路の解析2019
- Author(s)
  Murakami G., Murakoshi T.
- Organizer
  日本神経科学会
- Data Source
  KAKENHI-PROJECT-17K08960
[Presentation] MHCI機能欠損マウスの側坐核ドーパミンD1受容体の発現量増加がADHD様行動を引き起こす2019
- Author(s)
  村上　元、中原　大一郎
- Organizer
  埼玉医科大学RCGMシンポジウム
- Data Source
  KAKENHI-PROJECT-17K08960
[Presentation] 薬物依存の新たなメカニズム－ドーパミン神経細胞に発現する免疫分子MHCクラスIの関与2015
- Author(s)
  村上元、中原大一郎
- Organizer
  アルコール薬物依存関連学会合同学術総会
- Place of Presentation
  神戸
- Year and Date
  2015-10-11
- Invited
- Data Source
  KAKENHI-PROJECT-15K19164
[Presentation] Persistent reduction of MHC-I in dopamine neurons underlies enduring potentiation of its synaptic inputs in cocaine-seeking behavior2015
- Author(s)
  Murakami G, Edamura M, Furukawa T, Fukuda A, Iwashita T, Nakahara D
- Organizer
  Society for neuroscience
- Place of Presentation
  Chicago, US
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19164
[Presentation] Persistent reduction of MHC-I in dopamine neurons underlies enduring potentiation of its synaptic inputs in cocaine-seeking behavior2015
- Author(s)
  Murakami G, Fukuda A, Iwashita T and Nakahara D
- Organizer
  第38回日本神経科学会
- Place of Presentation
  神戸
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15K19164
[Presentation] Persistent reduction of MHC class I in dopamine neurons contributes to robust cocaine-seeking behavior.2015
- Author(s)
  Murakami, G., Fukuda, A., Iwashita, T. and Nakahara, D.
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際会議場・展示場（兵庫県・神戸市）
- Year and Date
  2015-07-29
- Data Source
  KAKENHI-PROJECT-25293052
[Presentation] 免疫分子であるMHCクラス1がドーパミン神経細胞を修飾しマウスのコカイン探索行動を維持する2014
- Author(s)
  村上元
- Organizer
  第14回浜松医科学シンポジウム
- Place of Presentation
  静岡県
- Year and Date
  2014-11-06
- Invited
- Data Source
  KAKENHI-PROJECT-25860392
[Presentation] Involvement of Immune Protein MHC class I in The Development of Cocaine Self-Administration2014
- Author(s)
  Murakami Gen
- Organizer
  Society for neuroscience
- Place of Presentation
  Washington D.C.
- Year and Date
  2014-11-15
- Data Source
  KAKENHI-PROJECT-25860392
[Presentation] Involvement of Immune Protein MHC class I in The Development of Cocaine Self-Administration2014
- Author(s)
  村上元
- Organizer
  第37回日本神経科学会
- Place of Presentation
  神奈川県
- Year and Date
  2014-09-12
- Data Source
  KAKENHI-PROJECT-25860392
[Presentation] Involvement of Immune Protein MHC class I in Cocaine-seeking Behavior2014
- Author(s)
  村上元
- Organizer
  第19会静岡健康・長寿学術フォーラム
- Place of Presentation
  静岡県
- Year and Date
  2014-11-07
- Data Source
  KAKENHI-PROJECT-25860392
[Presentation] Cellular Mechanisms of Enhanced Cocaine Self-Administration in MHC Class Ι Deficient Mice2013
- Author(s)
  Murakami Gen
- Organizer
  Society for Neuroscience
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-25860392
[Presentation] Enhanced cocaine self administration in functional mhc class Ι deficient mice2012
- Author(s)
  Murakami G, MENG H, Edamura M, Nakahara D.
- Organizer
  Society for neuroscience
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-23890076
[Presentation] Enhanced cocaine self administration in functional mhc class Ι deficient mice2012
- Author(s)
  村上元
- Organizer
  Society for neuroscience
- Place of Presentation
  New Oleans
- Data Source
  KAKENHI-PROJECT-23890076

1. NAKAHARA Daiichiro (80128389)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. Fukuda Atsuo (50254272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. AKITA TENPEI (00522202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. WATANABE MIHO (10399321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. HATA KENICHIRO (60360335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SUENAGA Toshiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 石田康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Murakami Gen 村上 元

MURAKAMI Gen 村上 元

Research Projects

Research Products

Co-Researchers

Research on mechanisms underlying neurodevelopmental disorders focusing on MHCIIPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of neural mechanisms for neurodevelopmental disorders focusing on MHC expressed in dopaminergic neuronsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The effect of maternal immune activation on drug addictionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of immune molecule MHC expressed in the brain in attention deficit/hyperactivity disorder

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

the effect of virus infection in the brain on cocaine addictionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The development of gene therapy with neuroimmune protein against drug addictionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Multimodal GABA systems responding to environmental stress

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel therapeutic method for drug addictionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Neuro Methods2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] 主要組織適合遺伝子複合体クラスI（MHCI）の機能欠損によるドーパミン系異常と精神疾患様行動2022

Author(s)

Journal Title

Data Source

[Journal Article] Functional MHCI deficiency in mice causes ADHD-like behaviors with increased accumbal dopamine D1 receptor expression2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MHC class I in dopaminergic neurons suppresses relapse to reward seeking2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rapid nongenomic modulation by neurosteroids of dendritic spines in the hippocampus: Androgen, oestrogen and corticosteroid2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional deficiency of MHC class I enhances LTP and abolishes LTD in the nucleus accumbens of mice.2014

Author(s)

Murakami Gen 村上元

MURAKAMI Gen 村上元

[Presentation] MHCI機能欠損マウスの側坐核ドーパミンD1受容体の発現量増加がADHD様行動を引き起こす2019