Osakabe Akihisa 越阪部晃永

Researcher Number	70632107
Other IDs
External Links
Affiliation (Current)	2025: 千葉大学, 大学院理学研究院, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 東京大学, 大学院理学系研究科(理学部), 特任助教 2015: 早稲田大学, 理工学術院, 次席研究員(研究院助教) 2013 – 2015: 早稲田大学, 理工学術院, 助教 2012 – 2013: 早稲田大学, 理工学術院, 助手
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (III) / Basic Section 43050:Genome biology-related / 0701:Biology at molecular to cellular levels, and related fields / Structural biochemistry / Biological Sciences / Biophysics Except Principal Investigator Transformative Research Areas, Section (III) / Sections That Are Subject to Joint Review: Basic Section45010:Genetics-related ,Basic Section45020:Evolutionary biology-related / Basic Section 45010:Genetics-related / Basic Section 45020:Evolutionary biology-related
Keywords	Principal Investigator クロマチン / トランスポゾン / エピジェネティクス / ヌクレオソーム / ヒストンバリアント / クロマチンリモデリング / ヘテロクロマチン / ペリセントロメア / メチル化DNA / ヒストン … More / CpGダイヌクレオチド / DNAメチル化 / 遺伝情報 / ゲノム / 染色体 / 6-4光産物 / ヌクレオチド除去修復 / 紫外線損傷 / 結晶構造解析 / クロマトソーム / リンカーヒストン … More Except Principal Investigator 環境適応 / クロモメチラーゼ / DNAメチル化 / ライブイメージング / タンパク質間相互作用構造 / 花粉管誘引 / 受精シグナル因子 / リガンド-受容体 / 異分野技術融合 / 国際活動支援 / 異分野コア技術群支援 / ゲノム動態 / 繁殖適応戦略 / 両性花 Less

トランスポゾン特異的な抑制型エピコードの解読に関わる分子機構解明Principal Investigator
- Principal Investigator
  
  越阪部晃永
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
クロマチンリモデリングを介したトランスポゾン自己同一性確立と喪失機構の解明Principal Investigator
- Principal Investigator
  
  越阪部晃永
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  The University of Tokyo
A study of the evolutionary process of the epigenome via regulation of a novel plant chromomethylase, CDCA7, in Arabidopsis thaliana
- Principal Investigator
  
  佐々木江理子
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 45020:Evolutionary biology-related
  Basic Section 45010:Genetics-related
  Sections That Are Subject to Joint Review: Basic Section45010:Genetics-related ,Basic Section45020:Evolutionary biology-related
- Research Institution
  Kyushu University
トランスポゾン由来非ドメイン型バイオポリマーによるトランスポゾン脱抑制機構の解明Principal Investigator
- Principal Investigator
  
  越阪部晃永
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
Genomic dynamics underlying the plastic hermaphroditism in plants: the basis of exploratory reproductive adaptations
- Principal Investigator
  
  赤木剛士
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Okayama University
両性花の可塑性を支える受精分子群の破壊と再構築
- Principal Investigator
  
  奥田哲弘
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
Identification of protein complex containing the chromatin remodeling factor DDM1 and characterization of its targeting mechanism on transposonsPrincipal Investigator
- Principal Investigator
  
  Osakabe Akihisa
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0701:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo
Structural analysis of nucleosome containing methylated DNAPrincipal Investigator
- Principal Investigator
  
  Osakabe Akihisa
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Waseda University
ヌクレオソームにおける紫外線DNA損傷の収納と認識の分子機構Principal Investigator
- Principal Investigator
  
  越阪部晃永
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Waseda University
高次クロマチン形成の構造生物学的解析Principal Investigator
- Principal Investigator
  
  越阪部晃永
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biophysics
- Research Institution
  Waseda University

All 2023 2022 2021 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Book

[Book] 実験医学2021年9月号　Current Topics 「クロマチンリモデリング因子DDM1によるパラサイトDNAの鎮静化機構」2021
- Author(s)
  越阪部晃永、Frederic Berger
- Total Pages
  4
- Publisher
  羊土社
- ISBN
  9784758125475
- Data Source
  KAKENHI-PROJECT-21K20628
[Book] エピジェネティクスキーワード事典2013
- Author(s)
  胡桃坂仁志,越阪部晃永,有村泰宏
- Total Pages
  4
- Publisher
  羊土社
- Data Source
  KAKENHI-PUBLICLY-25131720
[Journal Article] Histone renegades: Unusual H2A histone variants in plants and animals2023
- Author(s)
  Osakabe Akihisa、Molaro Antoine
- Journal Title
  
  Seminars in Cell & Developmental Biology
  
  Volume: 135 Pages: 35-42
- DOI
  10.1016/j.semcdb.2022.05.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20628
[Journal Article] Elongation factor 1 is a component of the Arabidopsis RNA polymerase elongation complex and associates with a subset of transcribed genes2023
- Author(s)
  Markusch Hanna、Michl‐Holzinger Philipp、Obermeyer Simon、Thorbecke Claudia、Bruckmann Astrid、Babl Sabrina、Langst Gernot、Osakabe Akihisa、Berger Frederic、Grasser Klaus D.
- Journal Title
  
  New Phytologist
  
  Volume: 238 Issue: 1 Pages: 113-124
- DOI
  10.1111/nph.18724
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20628
[Journal Article] Phosphorylation of the FACT histone chaperone subunit SPT16 affects chromatin at RNA polymerase II transcriptional start sites in Arabidopsis2022
- Author(s)
  Michl-Holzinger Philipp、Obermeyer Simon、Markusch Hanna、Pfab Alexander、Ettner Andreas、Bruckmann Astrid、Babl Sabrina、Langst Gernot、Schwartz Uwe、Tvardovskiy Andrey、Jensen Ole N、Osakabe Akihisa、Berger Frederic、Grasser Klaus D
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 50 Issue: 9 Pages: 5014-5028
- DOI
  10.1093/nar/gkac293
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20628
[Journal Article] The chromatin remodeler DDM1 prevents transposon mobility through deposition of histone variant H2A.W2021
- Author(s)
  Osakabe Akihisa、Jamge Bhagyshree、Axelsson Elin、Montgomery Sean A.、Akimcheva Svetlana、Kuehn Annika Luisa、Pisupati Rahul、Lorkovic Zdravko J.、Yelagandula Ramesh、Kakutani Tetsuji、Berger Frederic
- Journal Title
  
  Nature Cell Biology
  
  Volume: 23 Issue: 4 Pages: 391-400
- DOI
  10.1038/s41556-021-00658-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H00995, KAKENHI-PROJECT-21K20628
[Journal Article] The C-terminal acidic domain of histone chaperone human NAP1 is an efficient binding-assistant for histone H2A-H2B but not H3-H4.2016
- Author(s)
  Ohtomo, H., Akashi, S., Moriwaki, Y., Okuwaki, M., Osakabe, A., Nagata, K., Kurumizaka, H., Nishimura, Y.
- Journal Title
  
  Genes Cells
  
  Volume: 21 Issue: 3 Pages: 252-264
- DOI
  10.1111/gtc.12339
- NAID
  120007135590
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26505009, KAKENHI-PROJECT-26840025
[Journal Article] Crystal structure of the nucleosome containing ultraviolet light-induced cyclobutane pyrimidine dimer.2016
- Author(s)
  Horikoshi N, Tachiwana H, Kagawa W, Osakabe A, Matsumoto S, Iwai S, Sugasawa K, Kurumizaka H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 471 Issue: 1 Pages: 117-122
- DOI
  10.1016/j.bbrc.2016.01.170
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-25116002, KAKENHI-PUBLICLY-26116521, KAKENHI-PROJECT-26840025
[Journal Article] Structure and function of human histone H3.Y nucleosome.2016
- Author(s)
  Kujirai, T., Horikoshi, N., Sato, K., Maehara, K., Machida, S., Osakabe, A., Kimura, H., Ohkawa, Y. and Kurumizaka, H.
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 1 Issue: 13 Pages: 1-15
- DOI
  10.1093/nar/gkw202
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26890023, KAKENHI-PROJECT-15J06807, KAKENHI-PROJECT-26840025, KAKENHI-PLANNED-25116002, KAKENHI-PLANNED-25116005
[Journal Article] Histone H3.5 forms an unstable nucleosome and accumulates around transcription start sites in human testis.2016
- Author(s)
  Urahama T, Harada A, Maehara K, Horikoshi N, Sato K, Sato Y, Shiraishi K, Sugino N, Osakabe A, Tachiwana H, Kagawa W, Kimura H, Ohkawa Y, Kurumizaka H.
- Journal Title
  
  Epigenetics Chromatin
  
  Volume: 9 Issue: 1 Pages: 1-16
- DOI
  10.1186/s13072-016-0051-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18457, KAKENHI-PLANNED-25116002, KAKENHI-PLANNED-25116005, KAKENHI-PLANNED-25116010, KAKENHI-PUBLICLY-26116521, KAKENHI-PROJECT-15J06922, KAKENHI-PROJECT-13J04024, KAKENHI-PROJECT-26830128, KAKENHI-PROJECT-26840025, KAKENHI-PROJECT-26290064, KAKENHI-PROJECT-15K10642
[Journal Article] Influence of DNA methylation on positioning and DNA flexibility of nucleosomes with pericentric satellite DNA.2015
- Author(s)
  Osakabe A, Adachi F, Arimura Y, Maehara K, Ohkawa Y, Kurumizaka H.
- Journal Title
  
  Open Biol.
  
  Volume: 5 Issue: 10 Pages: 150128-150128
- DOI
  10.1098/rsob.150128
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-25116002, KAKENHI-PLANNED-25116010, KAKENHI-PROJECT-25250023, KAKENHI-PROJECT-15H06691, KAKENHI-PROJECT-26840025, KAKENHI-PROJECT-26290064
[Journal Article] Structural basis of pyrimidine-pyrimidone (6-4) photoproduct recognition by UV-DDB in the nucleosome.2015
- Author(s)
  Osakabe, A., Tachiwana, H., Kagawa, W., Horikoshi, N., Matsumoto, S., Hasegawa, M., Matsumoto, N., Toga, T., Yamamoto, J., Hanaoka, F., Thoma, N.H., Sugasawa, K., Iwai, S., Kurumizaka, H.
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Issue: 1 Pages: 16330-16330
- DOI
  10.1038/srep16330
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23116008, KAKENHI-PLANNED-25116002, KAKENHI-PUBLICLY-26116521, KAKENHI-PROJECT-25250023, KAKENHI-PROJECT-26840025, KAKENHI-PROJECT-15H02654, KAKENHI-PROJECT-15H04646
[Journal Article] Dynamic changes in CCAN organization through CENP-C during cell-cycle progression.2015
- Author(s)
  Nagpal H, Hori T, Furukawa A, Sugase K, Osakabe A, Kurumizaka H, Fukagawa T
- Journal Title
  
  Molecular biology of the cell
  
  Volume: 26 Issue: 21 Pages: 3768-3776
- DOI
  10.1091/mbc.e15-07-0531
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26440190, KAKENHI-PUBLICLY-15H01477, KAKENHI-PLANNED-15H05972, KAKENHI-PLANNED-25116002, KAKENHI-PROJECT-25221106, KAKENHI-PROJECT-26840025
[Journal Article] Stable complex formation of CENP-B with the CENP-A nucleosome.2015
- Author(s)
  Fujita R, Otake K, Arimura Y, Horikoshi N, Miya Y, Shiga T, Osakabe A, Tachiwana H, Ohzeki JI, Larionov V, Masumoto H, Kurumizaka H.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: in press Issue: 10 Pages: 4949-4922
- DOI
  10.1093/nar/gkv405
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J03931, KAKENHI-PLANNED-23114008, KAKENHI-PLANNED-25116002, KAKENHI-PROJECT-26840025
[Journal Article] Human tNASP promotes in vitro nucleosome assembly with histone H3.3.2015
- Author(s)
  Kato, D., Osakabe, A., Tachiwana, H., Tanaka, H., and Kurumizaka, H.
- Journal Title
  
  Biochemistry
  
  Volume: 54 Issue: 5 Pages: 1171-1179
- DOI
  10.1021/bi501307g
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-25116002, KAKENHI-PUBLICLY-25131720, KAKENHI-PROJECT-25250023
[Journal Article] DNA binding properties of the actin-related protein Arp8 and its role in DNA repair.2014
- Author(s)
  Osakabe, A., Takahashi, Y., Murakami, H., Otawa, K., Tachiwana, H., Oma, Y., Hitoshi Nishijima, H., Shibahara, K., Kurumizaka, H., Harata, M.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 10 Pages: e108354-e108354
- DOI
  10.1371/journal.pone.0108354
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24380183, KAKENHI-PLANNED-25116002, KAKENHI-PLANNED-25116009, KAKENHI-PUBLICLY-25118503, KAKENHI-PUBLICLY-25125703, KAKENHI-PUBLICLY-25131720, KAKENHI-PROJECT-25660286, KAKENHI-PROJECT-25850242
[Journal Article] Crystal structure of human nucleosome containing the testis-specific histone variant TSH2B.2014
- Author(s)
  Urahama, T., Horikoshi, N., Osakabe, A., Tachiwana, H., and Kurumizaka, H.
- Journal Title
  
  Acta Cryst.
  
  Volume: F70 Issue: 4 Pages: 444-449
- DOI
  10.1107/s2053230x14004695
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-25116002, KAKENHI-PROJECT-26840025
[Journal Article] N-terminal phosphorylation of HP1α increases its nucleosome-binding specificity.2014
- Author(s)
  Nishibuchi G, Machida S, Osakabe A, Murakoshi H, Hiragami-Hamada K, Nakagawa R, Fischle W, Nishimura Y, Kurumizaka H, Tagami H, Nakayama JI.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 42 Issue: 20 Pages: 12498-12511
- DOI
  10.1093/nar/gku995
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-23114001, KAKENHI-PLANNED-23114005, KAKENHI-PLANNED-25116002, KAKENHI-PROJECT-26840025, KAKENHI-PROJECT-26890023
[Journal Article] Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1.2014
- Author(s)
  Machida, S., Takaku, M., Ikura, M., Sun, J., Suzuki, H., Kobayashi, W., Kinomura, A., Osakabe, A., Tachiwana, H., Horikoshi, Y., Fukuto, A., Matsuda, R., Ura, K., Tashiro, S., Ikura, T., and Kurumizaka, H.
- Journal Title
  
  Scientific Rep.
  
  Volume: 4 Issue: 1 Pages: 4863-4863
- DOI
  10.1038/srep04863
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J03652, KAKENHI-PLANNED-22131004, KAKENHI-PLANNED-25116002, KAKENHI-PUBLICLY-25131720, KAKENHI-PROJECT-25250023, KAKENHI-PROJECT-25640066, KAKENHI-PUBLICLY-26116514, KAKENHI-PROJECT-26281020, KAKENHI-PROJECT-26430114, KAKENHI-PROJECT-26550028
[Journal Article] Structural basis of a nucleosome containing histone H2A. B/H2A. Bbd that transiently associates with reorganized chromatin.2013
- Author(s)
  Arimura Y., Kimura H., Oda T., Sato K., Osakabe A., Tachiwana H., Sato Y., Kinugasa Y., Ikura T., Sugiyama M., Sato M., Kurumizaka H.
- Journal Title
  
  Sci Rep.
  
  Volume: 3 Issue: 1 Pages: 3510-3510
- DOI
  10.1038/srep03510
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J03931, KAKENHI-ORGANIZER-21113001, KAKENHI-PLANNED-21113002, KAKENHI-PLANNED-22131004, KAKENHI-PROJECT-23510061, KAKENHI-PLANNED-25116002, KAKENHI-PLANNED-25116005, KAKENHI-PUBLICLY-25118714, KAKENHI-PUBLICLY-25131720, KAKENHI-PROJECT-25291037, KAKENHI-PROJECT-25650009
[Journal Article] Contribution of histone N-terminal tails to the structure and stability of nucleosomes.2013
- Author(s)
  Wakana Iwasaki, Yuta Miya, Naoki Horikoshi, Akihisa Osakabe, Hiroyuki Taguchi, Hiroaki Tachiwana, Takehiko Shibata, Wataru Kagawa and Hitoshi Kurumizaka.
- Journal Title
  
  FEBS Open Bio
  
  Volume: 3 Issue: 1 Pages: 363-369
- DOI
  10.1016/j.fob.2013.08.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06154, KAKENHI-PROJECT-24570138, KAKENHI-PLANNED-25116002, KAKENHI-PUBLICLY-25131720
[Journal Article] The centromeric nucleosome-like CENP-T-W-S-X complex induces positive supercoils into DNA.2013
- Author(s)
  Kozo Takeuchi, Tatsuya Nishino, Kouta Mayanagi, Naoki Horikoshi, Akihisa Osakabe, Hiroaki Tachiwana, Tetsuya Hori, Hitoshi Kurumizaka and Tatsuo Fukagawa.
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 42 Issue: 3 Pages: 1644-1655
- DOI
  10.1093/nar/gkt1124
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-11J06154, KAKENHI-PROJECT-13J05186, KAKENHI-PROJECT-24370046, KAKENHI-PROJECT-24651151, KAKENHI-PLANNED-25116002, KAKENHI-PUBLICLY-25121735, KAKENHI-PUBLICLY-25131720, KAKENHI-PROJECT-25280109, KAKENHI-PROJECT-25291018
[Journal Article] Vertebrate Spt2 is a novel nucleolar histone chaperone that assists in ribosomal DNA transcription2013
- Author(s)
  Osakabe A, Tachiwana H, Takaku M, Hori T, Obuse C, Kimura H, Fukagawa T, Kurumizaka H
- Journal Title
  
  J. Cell Sci
  
  Volume: 126 Pages: 1323-1332
- DOI
  10.1242/jcs.112623
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-20114001, KAKENHI-PLANNED-20114006, KAKENHI-PROJECT-22370063, KAKENHI-PROJECT-22570008, KAKENHI-PROJECT-24370071, KAKENHI-PROJECT-24870027, KAKENHI-PROJECT-25221106, KAKENHI-PUBLICLY-23114711, KAKENHI-PUBLICLY-23114722
[Journal Article] Structural polymorphism in the L1 loop regions of human H2A. Z. 1 and H2A. Z. 2.2013
- Author(s)
  Naoki Horikoshi, Koichi Sato, Keisuke Shimada, Yasuhiro Arimura, Akihisa Osakabe, Hiroaki Tachiwana, Yoko Hayashi-Takanaka, Wakana Iwasaki, Wataru Kagawa, Masahiko Harata, Hiroshi Kimura and Hitoshi Kurumizaka.
- Journal Title
  
  Acta Crystallographica Section D
  
  Volume: 69 Issue: 12 Pages: 2431-2439
- DOI
  10.1107/s090744491302252x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06154, KAKENHI-PROJECT-13J03931, KAKENHI-PROJECT-23658281, KAKENHI-PROJECT-24380183, KAKENHI-PROJECT-24570138, KAKENHI-PLANNED-25116002, KAKENHI-PLANNED-25116005, KAKENHI-PLANNED-25116009, KAKENHI-PUBLICLY-25118503, KAKENHI-PUBLICLY-25125703, KAKENHI-PUBLICLY-25131720, KAKENHI-PROJECT-25503002, KAKENHI-PROJECT-25660286
[Journal Article] Nap1 regulates proper CENP-B binding to nucleosomes2013
- Author(s)
  Tachiwana H, Miya Y, Shono N, Ohzeki J, Osakabe A, Otake K, Larionov V, Earnshaw WC, Kimura H, Masumoto H, Kurumizaka H
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 5 Issue: 5 Pages: 2869-2880
- DOI
  10.1093/nar/gks1464
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-20114001, KAKENHI-PROJECT-22370063, KAKENHI-PLANNED-23114008, KAKENHI-PROJECT-23247030, KAKENHI-PROJECT-24870027, KAKENHI-PLANNED-20114005
[Journal Article] Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair2012
- Author(s)
  Koichi Sato. Masamichi Ishiai, Kazue Toda, Satoshi Furukoshi, Akihisa Osakabe, Hiroaki Tachiwana, Yoshimasa Takizawa, Wataru Kagawa, Hiroyuki Kitao, Naoshi Dohmae, Chikashi Obuse, Hiroshi Kimura, Minoru Takata, Hitoshi Kurumizaka
- Journal Title
  
  The EMBO Journal
  
  Volume: 31 Issue: 17 Pages: 3524-3536
- DOI
  10.1038/emboj.2012.197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J02700, KAKENHI-ORGANIZER-20114001, KAKENHI-PLANNED-20114006, KAKENHI-PROJECT-22370063, KAKENHI-PROJECT-23590380, KAKENHI-PROJECT-23591964, KAKENHI-PROJECT-23651046, KAKENHI-PROJECT-24310042, KAKENHI-PROJECT-24370071, KAKENHI-PROJECT-24570138, KAKENHI-PROJECT-24870027, KAKENHI-PLANNED-20114005, KAKENHI-PLANNED-23114010, KAKENHI-PUBLICLY-23114711, KAKENHI-PUBLICLY-23131505
[Presentation] DDM1 silences transposons by deposition of the histone variant H2A.W2023
- Author(s)
  Akihisa Osakabe, Bhagyshree Jamge, Elin Axelsson, Sean A Montgomery, Svetlana Akimcheva, Annika Luisa Kuehn, Rahul Pisupati, Zdravko J Lorkovic, Ramesh Yelagandula, Tetsuji Kakutani, and Frederic Berger
- Organizer
  International symposium on chromatin architecture: structure and function
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20628
[Presentation] Structural and biochemical analyses for the chromatin remodeling activity of DDM12022
- Author(s)
  Akihisa Osakabe, Yoshimasa Takizawa, Naoki Horikoshi, Frederic Berger, Hitoshi Kurumizaka, and Tetsuji Kakutani
- Organizer
  CHSA meeting on Integrative Epigenetics in Plants
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20628
[Presentation] クロマチンリモデリング因子によるヒストンバリアントダイナミクスを介したトランスポゾン調節機構2022
- Author(s)
  越阪部晃永、山﨑慈恵、Jamge Bhagyshree、田中祐梨子、小川公美、Lorkovic Zdravko、Berger Frederic、角谷徹仁
- Organizer
  第15回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-21K20628
[Presentation] DDM1によるクロマチンリモデリング活性とそのヒストンバリアント嗜好性2022
- Author(s)
  越阪部晃永、滝沢由政、堀越直樹、Berger Frederic 、胡桃坂仁志、角谷徹仁
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K20628
[Presentation] 遺伝子様エピゲノムを獲得したトランスポゾンの発現調節機構2022
- Author(s)
  越阪部晃永、山﨑慈恵、Jamge Bhagyshree、田中祐梨子、小川公美、Lorkovic Zdravko、Berger Frederic、角谷徹仁
- Organizer
  第94回日本遺伝学会大会
- Data Source
  KAKENHI-PROJECT-21K20628
[Presentation] ヒストンバリアントのダイナミクスを介したトランスポゾン調節機構2022
- Author(s)
  越阪部晃永、山﨑慈恵、Jamge Bhagyshree、田中祐梨子、小川公美、Lorkovic Zdravko、Berger Frederic、角谷徹仁
- Organizer
  第95回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K20628
[Presentation] クロマチンリモデリング因子によるトランスポゾン鎮静化機構2021
- Author(s)
  越阪部晃永、Bhagyshree Jamge、Elin Axelsson、Annika Luisa Kuehn、Sean Akira Montgomery、Svetlana Akimcheva、Rahul Pisupati、Ramesh Yelagandula、角谷徹仁、Frederic Berger
- Organizer
  日本遺伝学会第93回大会
- Data Source
  KAKENHI-PROJECT-21K20628
[Presentation] ヒストンバリアントのダイナミクスを介したトランスポゾン発現制御機構2021
- Author(s)
  越阪部晃永、山﨑慈恵、田中祐梨子、Bhagyshree Jamge、Zdravko Lorkovic、Frederic Berger、角谷徹仁
- Organizer
  第44回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K20628
[Presentation] The chromatin remodeling factor DDM1 mediates the deposition of heterochromatic histone variant for TE silencing2021
- Author(s)
  Akihisa Osakabe, Bhagyshree Jamge, Elin Axelsson, Sean A Montgomery, Svetlana Akimcheva, Annika Luisa Kuehn, Rahul Pisupati, Zdravko J Lorkovic, Ramesh Yelagandula, Tetsuji Kakutani, Frederic Berger
- Organizer
  Cold Spring Harbor Asia, Integrative Epigenetics in Plants Pre-conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20628
[Presentation] ヒストンバリアントによるトランスポゾン発現制御機構2021
- Author(s)
  越阪部晃永、山﨑慈恵、田中祐梨子、Bhagyshree Jamge、Zdravko Lorkovic、Frederic Berger、角谷徹仁
- Organizer
  第39回染色体ワークショップ・第20回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-21K20628
[Presentation] クロマチンにおける紫外線損傷DNA認識機構の解析2016
- Author(s)
  越阪部晃永、立和名博昭、堀越直樹、香川亘、松本翔太、山元淳平、花岡文雄、菅澤薫、岩井成憲、胡桃坂仁志
- Organizer
  第33回染色体ワークショップ・第14回核ダイナミクス研究会
- Place of Presentation
  松島
- Year and Date
  2016-01-12
- Data Source
  KAKENHI-PROJECT-26840025
[Presentation] Structural and biochemical analyses for accommodation and recognition of UV-damaged bases within nucleosome2015
- Author(s)
  Akihisa Osakabe, Hiroaki Tachiwana, Wataru Kagawa, Naoki Horikoshi, Syota Matsumoto, Junpei Yamamoto, Fumio Hanaoka, Kaoru Sugasawa, Shigenori Iwai, Hitoshi Kurumizaka
- Organizer
  International Symposium on Chromatin Structure, Dynamics, and Function
- Place of Presentation
  淡路島
- Year and Date
  2015-08-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26840025
[Presentation] Structural and biochemical analyses of the nucleosome containing UV-damaged DNA2014
- Author(s)
  Osakabe A, Tachiwana H, Horikoshi N, Kagawa W, Yasuda T, Hanaoka F, Sugasawa K, Iwai S, Kurumizaka H
- Organizer
  International Conference: Replication, Repair and Transcription
- Place of Presentation
  京都
- Data Source
  KAKENHI-PUBLICLY-25131720
[Presentation] 紫外線損傷DNAを含むヌクレオソームの構造生物学・生化学的解析2013
- Author(s)
  越阪部晃永, 立和名博昭, 堀越直樹, 香川亘, 安田武嗣, 花岡文雄, 菅澤薫, 岩井成憲, 胡桃坂仁志
- Organizer
  第22回 DNA複製・組換え・修復ワークショップ
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PUBLICLY-25131720
[Presentation] メチル化DNAを含むヌクレオソームの再構成および生化学的物理学的解析2013
- Author(s)
  越阪部晃永, 足立風水也, 加藤大貴, 町田晋一, 堀越直樹, 林田亮太, 胡桃坂仁志
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PUBLICLY-25131720
[Presentation] メチル化DNAを含むヌクレオソームの生化学的解析2013
- Author(s)
  越阪部晃永, 足立風水也, 加藤大貴, 堀越直樹, 齋藤義正, 胡桃坂仁志
- Organizer
  第7回日本エピジェネティクス研究会年会
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PUBLICLY-25131720
[Presentation] DNAのメチル化がヌクレオソーム構造に与える影響2013
- Author(s)
  越阪部晃永
- Organizer
  大阪大学蛋白質研究所セミナー「DNAメチル化の制御機構-メチル化模様形成、維持と消去-」
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PUBLICLY-25131720
[Presentation] メチル化DNAを含むヌクレオソームの再構成および生化学的解析2013
- Author(s)
  越阪部晃永, 足立風水也, 竹田瑶弥, 有村泰宏, 堀越直樹, 胡桃坂仁志
- Organizer
  第31回染色体ワークショップ・第12回核ダイナミクス研究会
- Place of Presentation
  箱根
- Data Source
  KAKENHI-PUBLICLY-25131720
[Presentation] 紫外線損傷DNAを含むヌクレオソームの生化学的解析2013
- Author(s)
  越阪部晃永, 堀越直樹, 立和名博昭, 香川亘, 安田武嗣, 花岡文雄, 菅澤薫, 岩井成憲, 胡桃坂仁志
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PUBLICLY-25131720
[Presentation] リンカーヒストンH1サブタイプを含むクロマトソームの生化学的解析2012
- Author(s)
  越阪部晃永、加藤大貴、高久誉大、町田晋一、林田亮太、立和名博昭、胡桃坂仁志
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24870027
[Presentation] 新規ヒストン相互作用因子hsSpt2の核小体クロマチンダイナミクスにおける機能2012
- Author(s)
  越阪部晃永、立和名博昭、高久誉大、堀哲也、小布施力史、木村宏、深川竜郎、胡桃坂仁志
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24870027
[Presentation] Biochemical and structural analyses of the nucleosome containing methylated DNA
- Author(s)
  Akihisa Osakabe, Fumiya Adachi, Yasuhiro Arimura, Naoki Horikoshi, Yasuyuki Ohkawa, Hitoshi Kurumizaka
- Organizer
  EMBO Workshop: Histone Variants
- Place of Presentation
  Strasbourg
- Year and Date
  2014-06-02 – 2014-06-04
- Data Source
  KAKENHI-PROJECT-26840025
[Presentation] メチル化DNAを含むヌクレオソームの生化学的・構造生物学的機能解析
- Author(s)
  越阪部晃永、足立風水也、有村泰宏、堀越直樹、大川恭行、胡桃坂仁志
- Organizer
  第8回日本エピジェネティクス研究会年会
- Place of Presentation
  東京
- Year and Date
  2014-05-25 – 2014-05-27
- Data Source
  KAKENHI-PROJECT-26840025
[Presentation] ヌクレオソームにおける紫外線損傷塩基の収納およびその認識機構の解析
- Author(s)
  越阪部晃永、立和名博昭、堀越直樹、香川亘、山元淳平、安田武嗣、花岡文雄、菅澤薫、岩井成憲、胡桃坂仁志
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PUBLICLY-25131720
[Presentation] Structures of the nucleosomes containing UV-damaged DNA bases and the damaged base recognition mechanism by DNA repair proteins
- Author(s)
  Akihisa Osakabe, Hiroaki Tachiwana, Naoki Horikoshi, Wataru Kagawa, Junpei Yamamoto, Takeshi Yasuda, Fumio Hanaoka, Kaoru Sugasawa, Shigenori Iwai, Hitoshi Kurumizaka
- Organizer
  5th US-Japan DNA Repair Meeting
- Place of Presentation
  徳島
- Year and Date
  2014-10-28 – 2014-10-31
- Invited
- Data Source
  KAKENHI-PUBLICLY-25131720

1. 奥田哲弘 (90727702)

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19. HORI Tetsuya

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20. MATSUMOTO Syota

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21. KIMURA Akatsuki

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22. 明石知子

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23. 原田昌彦

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24. 胡桃坂仁志

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25. 岩井成憲

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28. 町田晋一

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29. 中山潤一

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31. 原田哲仁

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Osakabe Akihisa 越阪部 晃永

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トランスポゾン特異的な抑制型エピコードの解読に関わる分子機構解明Principal Investigator

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クロマチンリモデリングを介したトランスポゾン自己同一性確立と喪失機構の解明Principal Investigator

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A study of the evolutionary process of the epigenome via regulation of a novel plant chromomethylase, CDCA7, in Arabidopsis thaliana

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トランスポゾン由来非ドメイン型バイオポリマーによるトランスポゾン脱抑制機構の解明Principal Investigator

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Genomic dynamics underlying the plastic hermaphroditism in plants: the basis of exploratory reproductive adaptations

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両性花の可塑性を支える受精分子群の破壊と再構築

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Identification of protein complex containing the chromatin remodeling factor DDM1 and characterization of its targeting mechanism on transposonsPrincipal Investigator

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Structural analysis of nucleosome containing methylated DNAPrincipal Investigator

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ヌクレオソームにおける紫外線DNA損傷の収納と認識の分子機構Principal Investigator

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高次クロマチン形成の構造生物学的解析Principal Investigator

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[Book] 実験医学2021年9月号 Current Topics 「クロマチンリモデリング因子DDM1によるパラサイトDNAの鎮静化機構」2021

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[Book] エピジェネティクスキーワード事典2013

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[Journal Article] Histone renegades: Unusual H2A histone variants in plants and animals2023

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Osakabe Akihisa 越阪部晃永

[Book] 実験医学2021年9月号　Current Topics 「クロマチンリモデリング因子DDM1によるパラサイトDNAの鎮静化機構」2021