Tokiro Ishikawa 石川時郎

Researcher Number	70632545
Other IDs	https://orcid.org/0000-0003-1718-6764
Affiliation (based on the past Project Information) *help	2016 – 2022: 京都大学, 理学研究科, 助教 2016: 京都大学, 大学院理学研究科, 助教 2015: 京都大学, 理学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 44010:Cell biology-related / Cell biology Except Principal Investigator Cell biology
Keywords	Principal Investigator メダカ / 小胞体ストレス応答 / IRE1 / 小胞体 / 寿命 / 老化 / ATF6 / UPR / 小胞体ストレス Except Principal Investigator エスコートタンパク質 … More / 膜結合性転写因子 / 小胞輸送 / 小胞体ストレス / 細部内情報伝達 / 進化 / エスコート / ゴルジ体 / 小胞体関連分解 / 分子シャペロン / 転写因子 / 小胞体 / タンパク質品質管理 Less

近接依存性ビオチン標識法による組織特異的小胞体ストレス原因タンパク質の探索Principal Investigator
- Principal Investigator
  
  石川時郎
- Project Period (FY)
  2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Kyoto University
Establishment of medaka lifespan measurement systemPrincipal Investigator
- Principal Investigator
  
  Ishikawa Tokiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Kyoto University
Analysis of the mechanism under the occurrence of bicephaly during development in medaka fish with a defective UPR pathwayPrincipal Investigator
- Principal Investigator
  
  Ishikawa Tokiro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Kyoto University
Screening of transport component of ATF6 by haploid medaka systemPrincipal Investigator
- Principal Investigator
  
  Tokiro Ishikawa
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Kyoto University
Elucidation of regulation mechanism of the endoplasmic reticulum membrane-bound transcription factor ATF6 and its role in the evolution of vertebrates
- Principal Investigator
  
  Mori Kazutoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Kyoto University

All 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Reinvestigation of Disulfide-bonded Oligomeric Forms of the Unfolded Protein Response Transducer ATF62020
- Author(s)
  Koba Hibiki、Jin Shengyu、Imada Nanami、Ishikawa Tokiro、Ninagawa Satoshi、Okada Tetsuya、Sakuma Tetsushi、Yamamoto Takashi、Mori Kazutoshi
- Journal Title
  
  Cell Struct. Funct.
  
  Volume: 45 Issue: 1 Pages: 9-21
- DOI
  10.1247/csf.19030
- NAID
  130007792116
- ISSN
  0386-7196, 1347-3700
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06658, KAKENHI-PROJECT-19K16111, KAKENHI-ORGANIZER-17H06413, KAKENHI-PROJECT-17H01432, KAKENHI-PROJECT-18K06216
[Journal Article] Antipsychotic olanzapine-induced misfolding of proinsulin in the endoplasmic reticulum accounts for atypical development of diabetes2020
- Author(s)
  Ninagawa Satoshi、Tada Seiichiro、Okumura Masaki、Inoguchi Kenta、Kinoshita Misaki、Kanemura Shingo、Imami Koshi、Umezawa Hajime、Ishikawa Tokiro、Mackin Robert B、Torii Seiji、Ishihama Yasushi、Inaba Kenji、Anazawa Takayuki、Nagamine Takahiko、Mori Kazutoshi
- Journal Title
  
  eLife
  
  Volume: 9 Pages: 23-31
- DOI
  10.7554/elife.60970
- NAID
  120006898101
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06658, KAKENHI-PROJECT-19K16092, KAKENHI-PLANNED-17H06419, KAKENHI-PUBLICLY-20H05310, KAKENHI-PROJECT-18H03978, KAKENHI-PROJECT-20H03241, KAKENHI-PROJECT-17K08528, KAKENHI-PROJECT-18K06216, KAKENHI-ORGANIZER-17H06413
[Journal Article] EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD2020
- Author(s)
  George Ginto、Ninagawa Satoshi、Yagi Hirokazu、Saito Taiki、Ishikawa Tokiro、Sakuma Tetsushi、Yamamoto Takashi、Imami Koshi、Ishihama Yasushi、Kato Koichi、Okada Tetsuya、Mori Kazutoshi
- Journal Title
  
  eLife
  
  Volume: 9
- DOI
  10.7554/elife.53455
- NAID
  120006817590
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06110, KAKENHI-PROJECT-19K06658, KAKENHI-PROJECT-19K16111, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06419, KAKENHI-PROJECT-17H01432, KAKENHI-PROJECT-18K06216, KAKENHI-PLANNED-17H06414
[Journal Article] Development of a Rapid <i>in vivo</i> Assay to Evaluate the Efficacy of IRE1-specific Inhibitors of the Unfolded Protein Response Using Medaka Fish2019
- Author(s)
  Jin Byungseok、Ishikawa Tokiro、Taniguchi Mai、Ninagawa Satoshi、Okada Tetsuya、Kagaya Shigehide、Mori Kazutoshi
- Journal Title
  
  Cell Struct. Funct.
  
  Volume: 45 Issue: 1 Pages: 23-31
- DOI
  10.1247/csf.19032
- NAID
  130007795672
- ISSN
  0386-7196, 1347-3700
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06658, KAKENHI-ORGANIZER-17H06413, KAKENHI-PROJECT-17H01432, KAKENHI-PROJECT-18J14647, KAKENHI-PROJECT-18K06216
[Journal Article] A Collection of Transgenic Medaka Strains for Efficient Site-Directed Transgenesis Mediated by phiC31 Integrase2018
- Author(s)
  Ishikawa Tokiro、Ansai Satoshi、Kinoshita Masato、Mori Kazutoshi
- Journal Title
  
  G3: Genes|Genomes|Genetics
  
  Volume: 8 Issue: 8 Pages: 2585-2593
- DOI
  10.1534/g3.118.200130
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06413, KAKENHI-PROJECT-17H01432, KAKENHI-PROJECT-17K15116
[Journal Article] Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish2017
- Author(s)
  Tokiro Ishikawa, Makoto Kashima, Atsushi J Nagano, Tomoko Ishikawa-Fujiwara, Yasuhiro Kamei, Takeshi Todo, Kazutoshi Mori
- Journal Title
  
  eLife
  
  Volume: 6:e26845 Pages: 1-29
- DOI
  10.7554/elife.26845
- NAID
  120006358815
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15116, KAKENHI-PROJECT-15H05713, KAKENHI-PLANNED-17H06419, KAKENHI-PROJECT-25220102, KAKENHI-PROJECT-17H01432, KAKENHI-PROJECT-16H06171, KAKENHI-ORGANIZER-17H06413, KAKENHI-PROJECT-20K20303
[Journal Article] UPR Transducer BBF2H7 Allows Export of Type II Collagen in a Cargo- and Developmental Stage-Specific Manner2017
- Author(s)
  Tokiro Ishikawa, Takuya Toyama, Yuki Nakamura, Kentaro Tamada, Hitomi Shimizu, Satoshi Ninagawa, Tetsuya Okada, Yasuhiro Kamei, Tomoko Ishikawa-Fujiwara, Takeshi Todo, Eriko Aoyama, Masaharu Takigawa, Akihiro Harada and Kazutoshi Mori
- Journal Title
  
  Journal of cell biology
  
  Volume: 印刷中 Issue: 6 Pages: 1761-1774
- DOI
  10.1083/jcb.201609100
- NAID
  120006343784
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K18529, KAKENHI-PROJECT-17K15116, KAKENHI-PROJECT-15H05713, KAKENHI-PROJECT-17H01432, KAKENHI-PROJECT-15H04668, KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-15K11038, KAKENHI-PROJECT-16K18538, KAKENHI-PLANNED-17H06422
[Journal Article] SEL1L-dependent Substrates Require Derlin2/3 and Herp1/2 for Endoplasmic Reticulum-associated Degradation2017
- Author(s)
  Takehiro Sugimoto, Satoshi Ninagawa, Shimpei Yamano, Tokiro Ishikawa, Tetsuya Okada, Shunichi Takeda, Kazutoshi Mori
- Journal Title
  
  Cell Struct. Funct.
  
  Volume: 42 Issue: 2 Pages: 81-94
- DOI
  10.1247/csf.17007
- NAID
  130005708193
- ISSN
  0386-7196, 1347-3700
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15116, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-17H01432, KAKENHI-PROJECT-15K06996, KAKENHI-PROJECT-16K18538
[Journal Article] Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway.2015
- Author(s)
  Ninagawa S, Okada T, Sumitomo Y, Horimoto S, Sugimoto T, Ishikawa T, Takeda S, Yamamoto T, Suzuki T, Kamiya Y, Kato K, Mori K.
- Journal Title
  
  The Journal of Cellular Biology
  
  Volume: 211 Issue: 4 Pages: 775-784
- DOI
  10.1083/jcb.201504109
- NAID
  120005672576
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06996, KAKENHI-PROJECT-15K18529, KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008, KAKENHI-PUBLICLY-26110725, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-26840065, KAKENHI-PROJECT-26291040
[Presentation] IRE1経路とPERK経路/ATF6経路の重複した生理的役割の解析2019
- Author(s)
  石川時郎、山崎鈴花、森和俊
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K06658
[Presentation] Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish2018
- Author(s)
  Tokiro Ishikawa
- Organizer
  International Symposium on ER stress, glycosylation, homeostasis and diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15116
[Presentation] A Collection of Transgenic Medaka Strains for Efficient Site-Directed Transgenesis Mediated by phiC31 Integrase2018
- Author(s)
  Ishikawa Tokiro、Ansai Satoshi、Kinoshita Masato、Mori Kazutoshi
- Organizer
  小型魚類研究会 2018
- Data Source
  KAKENHI-PROJECT-17K15116
[Presentation] メダカ発生過程におけるIRE1生理的機能の包括的解析2017
- Author(s)
  Tokiro Ishikawa, Tetsuya Okada, Tomoko Ishikawa-Fujiwara, Satoshi Ansai, Yasuhiro Kamei, Masato Kinoshita, Takeshi Todo, Kazutoshi Mori
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-17K15116
[Presentation] UPR Transducer BBF2H7 Allows Export of Type II Collagen in a Cargo- and Developmental Stage-Specific Manner2017
- Author(s)
  Tokiro Ishikawa, Takuya Toyama, Yuki Nakamura, Kentaro Tamada, Hitomi Shimizu, Satoshi Ninagawa, Tetsuya Okada, Yasuhiro Kamei, Tomoko Ishikawa-Fujiwara, Takeshi Todo, Eriko Aoyama, Masaharu Takigawa, Akihiro Harada and Kazutoshi Mori
- Organizer
  23rd JMZM
- Data Source
  KAKENHI-PROJECT-17K15116
[Presentation] Comprehensive Analysis of IRE1 Mediated UPR Pathway in Medaka Fish2016
- Author(s)
  Tokiro Ishikawa, Tetsuya Okada, Tomoko Ishikawa-Fujiwara, Satoshi Ansai, Yasuhiro Kamei, Masato Kinoshita, Takeshi Todo, Kazutoshi Mori
- Organizer
  International Meeting on Aquatic Model Organisms for Human Disease and Toxicology Research
- Place of Presentation
  岡崎
- Year and Date
  2016-03-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18529
[Presentation] メダカ発生過程におけるIRE1経路の生理的機能の包括的解析2015
- Author(s)
  石川時郎, 岡田徹也, 藤原-石川智子, 安齋賢, 亀井保博, 木下政人, 藤堂剛, 森和俊
- Organizer
  the 21st Japanese Medaka and Zebrafish Meeting
- Place of Presentation
  岡崎
- Year and Date
  2015-09-19
- Data Source
  KAKENHI-PROJECT-15K18529
[Presentation] Comprehensive analysis of the IRE1 pathway during development of medaka fish2015
- Author(s)
  Tokiro Ishikawa, Tetsuya Okada, Tomoko Ishikawa-Fujiwara, Satoshi Ansai, Yasuhiro Kamei, Masato Kinoshita, Takeshi Todo, Kazutoshi Mori
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K18529
[Presentation] phiC31インテグレースによる高効率遺伝子導入に用いる Landing site(attP) 導入メダカ系統の樹立2015
- Author(s)
  石川時郎, 安齋賢, 岡田徹也, 木下政人, 森和俊
- Organizer
  the 21st Japanese Medaka and Zebrafish Meeting
- Place of Presentation
  岡崎
- Year and Date
  2015-09-19
- Data Source
  KAKENHI-PROJECT-15K18529

1. Mori Kazutoshi (70182194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. OKADA Tetsuya (70378529)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. TAKEDA Shunichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. YAMAMOTO Takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KATO Koichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NINAGAWA Satoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Tokiro Ishikawa 石川 時郎

Research Projects

Research Products

Co-Researchers

近接依存性ビオチン標識法による組織特異的小胞体ストレス原因タンパク質の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of medaka lifespan measurement systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the mechanism under the occurrence of bicephaly during development in medaka fish with a defective UPR pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Screening of transport component of ATF6 by haploid medaka systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of regulation mechanism of the endoplasmic reticulum membrane-bound transcription factor ATF6 and its role in the evolution of vertebrates

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Reinvestigation of Disulfide-bonded Oligomeric Forms of the Unfolded Protein Response Transducer ATF62020

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Antipsychotic olanzapine-induced misfolding of proinsulin in the endoplasmic reticulum accounts for atypical development of diabetes2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Development of a Rapid <i>in vivo</i> Assay to Evaluate the Efficacy of IRE1-specific Inhibitors of the Unfolded Protein Response Using Medaka Fish2019

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] A Collection of Transgenic Medaka Strains for Efficient Site-Directed Transgenesis Mediated by phiC31 Integrase2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] UPR Transducer BBF2H7 Allows Export of Type II Collagen in a Cargo- and Developmental Stage-Specific Manner2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] SEL1L-dependent Substrates Require Derlin2/3 and Herp1/2 for Endoplasmic Reticulum-associated Degradation2017

Tokiro Ishikawa 石川時郎