sugiki toshihiko 杉木俊彦

… Alternative Names

杉木俊彦スギキトシヒコ

SUGIKI Toshihiko 杉木俊彦

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Researcher Number	70635698
Other IDs
Affiliation (Current)	2025: 北里大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2023: 北里大学, 薬学部, 准教授 2017: 大阪大学, 蛋白質研究所, 特任助教 2014 – 2015: 大阪大学, 蛋白質研究所, 助教 2013 – 2015: 大阪大学, たんぱく質研究所, 助教 2013: 大阪大学, たんぱく質研究所, 招へい研究員 2012: 武蔵野大学, 薬学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related / Biophysics / Physical pharmacy Except Principal Investigator Structural biochemistry / Environmental and hygienic pharmacy
Keywords	Principal Investigator NMR / トリプレットDNP / 創薬 / 核ラミン / 分子間相互作用 / IL-1 / HMGB / 構造生物学 Except Principal Investigator 立体構造 / 蛋白質 … More / NMR / in situ / 自動構造決定 / 自動化 / HeLa細胞 / プレスクトリン相同ドメイン / ゲノム編集 / 脂質輸送 / クラミジア菌 / 性感染症 / ゲノム / ワクチン細胞基材 / Vero細胞 / 細胞内寄生 / 感染症 / ホスホイノシチド / プレクストリン相同ドメイン / セラミド / クラミジア / 輸送 / 脂質 Less

創薬および生体系のための溶液NMRの高感度化研究Principal Investigator
- Principal Investigator
  
  杉木俊彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Kitasato University
NMR Molecular Replacement Method
- Principal Investigator
  
  Kojima Chojiro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Yokohama National University
Comprehensive study of structure and dynamics of laminopathy-causing LMNA mutants for elucidation of LaminopathyPrincipal Investigator
- Principal Investigator
  
  SUGIKI Toshihiko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  Osaka University
Protein NMR method developed for macromolecular complex
- Principal Investigator
  
  Kojima Chojiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
In situ Protein NMR Structure Analysis
- Principal Investigator
  
  Kojima Chojiro
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Yokohama National University
  Osaka University
Molecular strategy for the prevention of Chlamydia hijacking of a host lipid transport system
- Principal Investigator
  
  HANADA KENTARO
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  National Institute of Infectious Diseases
Structural analyses of inflammatory HMGB1-IL1beta complexPrincipal Investigator
- Principal Investigator
  
  SUGIKI Toshihiko
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University
  Musashino University

All 2023 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Protein-Ligand Interaction Analyses with Nuclear Magnetic Resonance Spectroscopy Enhanced by Dissolution Triplet Dynamic Nuclear Polarization2023
- Author(s)
  Miyanishi, K.; Sugiki, T.; Matsui, T.; Ozawa, R.; Hatanaka, Y.; Enozawa, H.; Nakamura, Y.; Murata, T.; Kagawa, A.; Morita, Y.; Fujiwara, T.; Kitagawa, M.; Negoro, M.
- Journal Title
  
  J. Phys. Chem. Lett.
  
  Volume: 14 Issue: 27 Pages: 6241-6247
- DOI
  10.1021/acs.jpclett.3c01002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K04710, KAKENHI-PROJECT-23K05654, KAKENHI-PUBLICLY-23H04043, KAKENHI-PROJECT-23K23334
[Journal Article] Current NMR Techniques for Structure-Based Drug Discovery2018
- Author(s)
  Sugiki Toshihiko、Furuita Kyoko、Fujiwara Toshimichi、Kojima Chojiro
- Journal Title
  
  Molecules
  
  Volume: 23 Issue: 1 Pages: 148-148
- DOI
  10.3390/molecules23010148
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26291013, KAKENHI-PUBLICLY-17H05836, KAKENHI-PROJECT-16K14681
[Journal Article] Cold-Shock Expression System in E. coli for Protein NMR Studies2017
- Author(s)
  Sugiki Toshihiko、Fujiwara Toshimichi、Kojima Chojiro
- Journal Title
  
  Methods Mol Biol
  
  Volume: 1586 Pages: 345-357
- DOI
  10.1007/978-1-4939-6887-9_23
- ISBN
  9781493968855, 9781493968879
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26291013, KAKENHI-PUBLICLY-17H05836, KAKENHI-PROJECT-16K14681
[Journal Article] Protein 19F-labeling using transglutaminase for the NMR study of intermolecular interactions2017
- Author(s)
  Hattori Yoshikazu、Heidenreich David、Ono Yuki、Sugiki Toshihiko、Yokoyama Kei-ichi、Suzuki Ei-ichiro、Fujiwara Toshimichi、Kojima Chojiro
- Journal Title
  
  Journal of Biomolecular NMR
  
  Volume: 68 Issue: 4 Pages: 271-279
- DOI
  10.1007/s10858-017-0125-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291013, KAKENHI-PROJECT-26291029, KAKENHI-PUBLICLY-17H05836, KAKENHI-PROJECT-16K14681, KAKENHI-PUBLICLY-17H05873, KAKENHI-PROJECT-17H03641
[Journal Article] Noncovalent forces tune the electron transfer complex between ferredoxin and sulfite reductase to optimize enzymatic activity2016
- Author(s)
  Ju Yaen Kim, Misaki Kinoshita, Satoshi Kume, Guy T. Hanke, Toshihiko Sugiki, John E. Ladbury, Chojiro Kojima, Takahisa Ikegami, Genji Kurisu, Yuji Goto, Toshiharu Hase, and Young-Ho Lee
- Journal Title
  
  Biochem. J.
  
  Volume: 473 Pages: 3837-3854
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291013
[Journal Article] Amorphous Aggregation of Cytochrome c with Inherently Low Amyloidogenicity Is Characterized by the Metastability of Supersaturation and the Phase Diagram2016
- Author(s)
  Lin Yuxi, Kardos József, Imai Mizue, Ikenoue Tatsuya, Kinoshita Misaki, Sugiki Toshihiko, Ishimori Koichiro, Goto Yuji, and Lee Young-Ho
- Journal Title
  
  Langmuir
  
  Volume: 32 Issue: 8 Pages: 2010-2022
- DOI
  10.1021/acs.langmuir.5b03810
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18518, KAKENHI-PROJECT-14J04433, KAKENHI-PROJECT-26840050, KAKENHI-PROJECT-15K07038
[Journal Article] Noncovalent forces tune the electron transfer complex between ferredoxin and sulfite reductase to optimize enzymatic activity2016
- Author(s)
  Ju Yaen Kim, Misaki Kinoshita, Satoshi Kume, Guy T. Hanke, Toshihiko Sugiki, John E. Ladbury, Chojiro Kojima, Takahisa Ikegami, Genji Kurisu, Yuji Goto, Toshiharu Hase, and Young-Ho Lee
- Journal Title
  
  Biochem. J.
  
  Volume: 473 Pages: 3837-3854
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14681
[Journal Article] Solution NMR structure and inhibitory effect against amyloid-β fibrillation of Humanin containing a D-isomerized serine residue2016
- Author(s)
  Nesreen Alsanousi, Toshihiko Sugiki, Kyoko Furuita, Masatomo So, Young-Ho Lee, Toshimichi Fujiwara, and Chojiro Kojima
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 477 Issue: 4 Pages: 647-653
- DOI
  10.1016/j.bbrc.2016.06.114
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26291013, KAKENHI-PROJECT-15K18518, KAKENHI-PROJECT-16K14681
[Journal Article] Utilization of paramagnetic relaxation enhancements for high-resolution NMR structure determination of a soluble loop-rich protein with sparse NOE distance restraints2015
- Author(s)
  Kyoko Furuita, Saori Kataoka, Toshihiko Sugiki, Yoshikazu Hattori, Naohiro Kobayashi, Takahisa Ikegami, Kazuhiro Shiozaki, Toshimichi Fujiwara and Chojiro Kojima
- Journal Title
  
  J. Biomol. NMR
  
  Volume: 61 Issue: 1 Pages: 55-64
- DOI
  10.1007/s10858-014-9882-7
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26291013, KAKENHI-PROJECT-26291024, KAKENHI-PROJECT-26650018, KAKENHI-PROJECT-26840050
[Journal Article] Physicochemical Nature of Interfaces Controlling Ferredoxin NADP+ Reductase Activity through Its Interprotein Interactions with Ferredoxin2015
- Author(s)
  Kinoshita Misaki, Kim Ju Yaen, Kume Satoshi, Sakakibara Yukiko, Sugiki Toshihiko, Kojima Chojiro, Kurisu Genji, Ikegami Takahisa, Hase Toshiharu, Kimata-Ariga Yoko, Lee Young-Ho
- Journal Title
  
  Biochimica et Biophysica Acta-Bioenergetics
  
  Volume: 1847 Issue: 10 Pages: 1200-1211
- DOI
  10.1016/j.bbabio.2015.05.023
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18518, KAKENHI-PROJECT-26650018, KAKENHI-PROJECT-26840050, KAKENHI-PROJECT-26291013
[Journal Article] The crystal structure of the plant small GTPase OsRacl reveals its mode of binding to NADPH oxidase.2015
- Author(s)
  Kosami KI, Ohki I, Nagano M, Furuita F, Sugiki T, Kawano Y, Kawasaki T, Fujiwara T, Nakagawa A, Shimamoto K, Kojima C
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 289 Issue: 41 Pages: 28569-78
- DOI
  10.1074/jbc.m114.603282
- Description
  (in press)(印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J03241, KAKENHI-PROJECT-24570133, KAKENHI-PUBLICLY-25114517, KAKENHI-PROJECT-26291013, KAKENHI-PROJECT-26291029, KAKENHI-PROJECT-26450055, KAKENHI-PROJECT-26520307, KAKENHI-PROJECT-26650018, KAKENHI-PROJECT-26840050, KAKENHI-PROJECT-26850232
[Journal Article] Latest approaches for efficient protein production in drug discovery2014
- Author(s)
  Toshihiko Sugiki, Toshimichi Fujiwara and Chojiro Kojima
- Journal Title
  
  Expert Opin. Drug Discov.
  
  Volume: 9 Issue: 10 Pages: 1189-1204
- DOI
  10.1517/17460441.2014.941801
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26291013, KAKENHI-PROJECT-26650018, KAKENHI-PROJECT-26840050
[Journal Article] Site-specific aspartic acid isomerization regulates self-assembly and neurotoxicity of amyloid-β2013
- Author(s)
  Toshihiko Sugiki, Naoki Utsunomiya-Tate
- Journal Title
  
  Biochem.Biophys.Res.Commun
  
  Volume: 441 Pages: 493-498
- URL
  http://www.sciencedirect.com/science/article/pii/S0006291X13017658
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890263
[Journal Article] Perdeuteration and methyl-selective (1)H,(13)C-labeling by using a Kluyveromyces lactis expression system2013
- Author(s)
  Mayumi Miyazawa-Onami, Koh Takeuchi, Toshiaki Takano, Toshihiko Sugiki, Ichio Shimada, Hideo Takahashi
- Journal Title
  
  J.Biomol.NMR
  
  Volume: 57 Pages: 297-304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890263
[Journal Article] Perdeuteration and methyl-selective 1H, 13C-labeling by using a Kluyveromyces lactis expression system2013
- Author(s)
  Miyazawa-Onami M, Takeuchi K, Takano T, Sugiki T, Shimada I, and Takahashi H
- Journal Title
  
  Journal of Biomolecular NMR
  
  Volume: 57 Pages: 297-304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890263
[Journal Article] Site-specific aspartic acid isomerization regulates self-assembly and neurotoxicity of amyloid-β2013
- Author(s)
  Sugiki T and Utsunomiya-Tate N
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 441 Pages: 493-498
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890263
[Journal Article] Structural basis for the Golgi association by the pleckstrin homology domain of the ceramide trafficking protein (CERT)2012
- Author(s)
  Toshihiko Sugiki, Koh Takeuchi, Toshiyuki Yamaji
- Journal Title
  
  J.Biol.Chem
  
  Volume: 287 Pages: 33706-33718
- URL
  http://www.jbc.org/content/287/40/33706.long
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890263
[Journal Article] Structural basis for the Golgi association by the pleckstrin homology domain of the ceramide trafficking protein (CERT)2012
- Author(s)
  Sugiki T, Takeuchi K, Yamaji T, Takano T, Tokunaga Y, Kumagai K, Hanada K, Takahashi H, and Shimada I
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Issue: 40 Pages: 33706-33718
- DOI
  10.1074/jbc.m112.367730
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370054, KAKENHI-PROJECT-23770164, KAKENHI-PROJECT-23790064, KAKENHI-PROJECT-23790118, KAKENHI-PROJECT-24370048, KAKENHI-PROJECT-24890263, KAKENHI-PUBLICLY-23107735, KAKENHI-PUBLICLY-24102524
[Presentation] ヒト内在性神経保護ペプチドHumaninの立体構造および機能発現に関するNMR解析2015
- Author(s)
  杉木俊彦、Alsanousi Nesreen1、古板恭子、藤原敏道、児嶋長次郎
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26840050
[Presentation] 微生物による組換え蛋白質発現2015
- Author(s)
  杉木俊彦
- Organizer
  日本蛋白質科学会
- Place of Presentation
  あわぎんホール（徳島県、徳島市）
- Year and Date
  2015-06-25
- Invited
- Data Source
  KAKENHI-PROJECT-26840050
[Presentation] Scrambling-freeなアミノ酸選択的13C標識法と13C標識の高選択性を利用したアミノ酸選択的2015
- Author(s)
  杉木俊彦、藤原敏道、児嶋長次郎
- Organizer
  第54回NMR討論会
- Place of Presentation
  千葉工業大学（千葉県、習志野市）
- Year and Date
  2015-11-06
- Data Source
  KAKENHI-PROJECT-26840050
[Presentation] 核膜タンパク質A型ラミンの電子顕微鏡構造解析2015
- Author(s)
  三尾宗代、角田舞、山下隼人、杉木俊彦、三尾和弘
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド（兵庫県、神戸市）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-26840050
[Presentation] HMGBタンパク質の立体構造形成とDNA結合機構に関する研究2013
- Author(s)
  杉木俊彦
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-29
- Data Source
  KAKENHI-PROJECT-24890263
[Presentation] HMGBタンパク質の立体構造形成の分子基盤に関する構造化学的解析2012
- Author(s)
  杉木俊彦
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Year and Date
  2012-12-15
- Data Source
  KAKENHI-PROJECT-24890263
[Presentation] D-Asp含有アミロイドβペプチドのオリゴマー形成と神経細胞毒性に関する解析
- Author(s)
  杉木　俊彦
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-24890263
[Presentation] 酵母発現系など大腸菌以外の発現系など
- Author(s)
  杉木　俊彦
- Organizer
  NMR discussion in KYOTO 2012 October
- Place of Presentation
  京都大学
- Invited
- Data Source
  KAKENHI-PROJECT-24890263
[Presentation] D-Asp含有アミロイドβペプチドの会合体形成と神経細胞毒性の相関解析
- Author(s)
  杉木　俊彦
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24890263

1. Kojima Chojiro (50333563)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
2. FURUITA Kyoko (30727665)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. FUJIWARA Toshimichi (20242381)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. MATSUKI Yoh (70551498)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. HANADA KENTARO (30192701)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. KUMAGAI Keigo (40443105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. YAMAJI Toshiyuki (50332309)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. SAITO Kyoko (70235034)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KOBAYASHI Naohiro (80272160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 宮西孝一郎 (60909399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MURATA Tsuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 李映昊

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

sugiki toshihiko 杉木 俊彦

杉木 俊彦 スギキ トシヒコ

SUGIKI Toshihiko 杉木 俊彦

Research Projects

Research Products

Co-Researchers

創薬および生体系のための溶液NMRの高感度化研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

NMR Molecular Replacement Method

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comprehensive study of structure and dynamics of laminopathy-causing LMNA mutants for elucidation of LaminopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Protein NMR method developed for macromolecular complex

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

In situ Protein NMR Structure Analysis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular strategy for the prevention of Chlamydia hijacking of a host lipid transport system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural analyses of inflammatory HMGB1-IL1beta complexPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Protein-Ligand Interaction Analyses with Nuclear Magnetic Resonance Spectroscopy Enhanced by Dissolution Triplet Dynamic Nuclear Polarization2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Current NMR Techniques for Structure-Based Drug Discovery2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cold-Shock Expression System in E. coli for Protein NMR Studies2017

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Protein 19F-labeling using transglutaminase for the NMR study of intermolecular interactions2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Noncovalent forces tune the electron transfer complex between ferredoxin and sulfite reductase to optimize enzymatic activity2016

Author(s)

Journal Title

Data Source

[Journal Article] Amorphous Aggregation of Cytochrome c with Inherently Low Amyloidogenicity Is Characterized by the Metastability of Supersaturation and the Phase Diagram2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Noncovalent forces tune the electron transfer complex between ferredoxin and sulfite reductase to optimize enzymatic activity2016

Author(s)

sugiki toshihiko 杉木俊彦

杉木俊彦スギキトシヒコ

SUGIKI Toshihiko 杉木俊彦