MATSUNARI Hitomi 松成ひとみ

… Alternative Names

MATSUNARI HITOMI 松成ひとみ

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Researcher Number	70639517
Affiliation (Current)	2025: 明治大学, 研究・知財戦略機構(生田), 研究推進員(客員研究員)
Affiliation (based on the past Project Information) *help	2015 – 2016: 明治大学, 研究・知財戦略機構, 特任講師 2015: 明治大学, 研究・知財戦略機構, 講師 2014 – 2015: 明治大学, 公私立大学の部局等, 講師 2013: 明治大学, 公私立大学の部局等, 研究員
Review Section/Research Field	Principal Investigator Integrative animal science Except Principal Investigator General surgery
Keywords	Principal Investigator トランスレーショナルリサーチ / 移植・再生医療 / 遺伝子ノックアウト / 臓器移植 / 体細胞核移植 / ゲノム編集 / ブタ / 異種移植 Except Principal Investigator 膵島移植 / 膵ランゲルハンス島 … More / 膵島シート / ガラス化凍結 / 凍結保存 / 膵頭シート / ヒト糖尿病モデルモデル / 赤紫蛍光蛋白Plum / ヒト糖尿病モデル / クローンブタ / 糖尿病 / 膵ランゲルハンス糖 / 移植 / 拒絶 / トランスジェニックブタ Less

Establishing a new cryopreservation method for pig pancreatic islet sheet by vitrification and an evaluation method by a high-throughput sequencing.
- Principal Investigator
  
  Masaki Nagaya
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Meiji University
Generation of alpha1,3-galactosyltransferase and cytidine monophospho-N-acetylneuraminic acid hydroxylase gene double-knockout pigsPrincipal Investigator
- Principal Investigator
  
  Matsunari Hitomi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Integrative animal science
- Research Institution
  Meiji University
A transgenic-cloned pig model expressing fluorescent or non-fluorescent modified Plum gene for the evaluation of islet transplantation
- Principal Investigator
  
  Masaki Nagaya
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Meiji University

All 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] An Effective New Cryopreservation Procedure for Pancreatic Islets Using Hollow Fiber Vitrification.2016
- Author(s)
  Nagaya M, Matsunari H, Kanai T, Maehara M, Nakano K, Umeki I, Katsumata Y, Kasai Y, Sakai R, Kobayashi M, Honda M, Abe N, Watanabe M, Umeyama K, Nagashima H.
- Journal Title
  
  Horm Metab Res.
  
  Volume: 48 Issue: 08 Pages: 540-9
- DOI
  10.1055/s-0042-102628
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15480
[Journal Article] A transgenic-cloned pig model expressing non-fluorescent modified Plum.2016
- Author(s)
  Nagaya M, Watanabe M, Kobayashi M, Nakano K, Arai Y, Asano Y, Takeishi T, Umeki I, Fukuda T, Yashima S, Takayanagi S, Watanabe N, Onodera M, Matsunari H, Umeyama K, Nagashima H.
- Journal Title
  
  J Reprod Dev.
  
  Volume: 62 Pages: 511-520
- NAID
  130005431253
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15480
[Journal Article] Production of transgenic cloned pigs expressing the far-red fluorescent protein monomeric Plum.2015
- Author(s)
  1.Watanabe M, Kobayashi M, Nagaya M, Matsunari H, Nakano K, Maehara M, Hayashida G, Takayanagi S, Sakai R, Umeyama K, Watanabe N, Onodera M, Nagashima H.
- Journal Title
  
  Journal of Reproduction and Development
  
  Volume: -
- NAID
  130005077737
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293279
[Journal Article] Production of transgenic cloned pigs expressing the far-red fluorescent protein monomeric Plum2015
- Author(s)
  Watanabe M, Kobayashi M, Nagaya M, Matsunari H, Nakano K, Maehara M, Hayashida G, Takayanagi S, Sakai R, Umeyama K, Watanabe N, Onodera M, Nagashima H.
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 61 Issue: 3 Pages: 169-177
- DOI
  10.1262/jrd.2014-153
- NAID
  130005077737
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293279
[Journal Article] Generation of α1,3-galactosyltransferase and cytidine monophospho-<i>N</i>-acetylneuraminic acid hydroxylase gene double-knockout pigs2015
- Author(s)
  Miyagawa S, Matsunari H, Watanabe M, Nakano K, Umeyama K, Sakai R, Takayanagi S, Takeishi T, Fukuda T, Yashima S, Maeda A, Eguchi H, Okuyama H, Nagaya M, Nagashima H.
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 61 Issue: 5 Pages: 449-457
- DOI
  10.1262/jrd.2015-058
- NAID
  130005104116
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26870630
[Journal Article] A New System to Evaluate the Influence of Immunosuppressive Drugs on Pancreatic Islets Using Epigenetic Analysis in a 3-Dimensional Culture.2015
- Author(s)
  Nagaya M, Arai Y, Matsunari H, Honda M, Nakano K, Maehara M, Sugimoto N, Kobayashi M, Sakai R, Asano Y, Watanabe M, Umeyama K, Nagashima H.
- Journal Title
  
  Pancreas.
  
  Volume: 44 Issue: 5 Pages: 778-85
- DOI
  10.1097/mpa.0000000000000366
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293279
[Journal Article] Transgenic pigs with pancres-specific expression of green fluorescent protein.2014
- Author(s)
  2.Matsunari H, Kobayashi T, Watanabe K, Umeyama K, Nakano K, Kanai T, Matsuda T, Nagaya M, Hara M, Nakauchi H, Nagashima H: Transgenic pigs with pancres-specific expression of green fluorescent protein.
- Journal Title
  
  Journal of Reproduction and Development
  
  Volume: 60 Pages: 230-237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293279
[Journal Article] Transgenic pigs with pancreas specific expression of green fluorescent protein.2014
- Author(s)
  Matsunari H, Kobayashi T., Watanabe M, Umeyama K, Nakano K, Kanai T, Matsuda T, Nagaya M, Hara M, Nakauchi H, Nagashima H
- Journal Title
  
  J Reprod Dev
  
  Volume: [Epub ahead of print]
- NAID
  130003390840
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293279
[Journal Article] A conserved rule for pancreatic islet rganization.2014
- Author(s)
  3.Hoang D-T, Matsunari H, Nagaya M, Nagashima H, Millis JM, Witkowski P, Periwal V, Hara M, Jo J
- Journal Title
  
  PLOS ONE
  
  Volume: 9 Issue: 10 Pages: e110384-e110384
- DOI
  10.1371/journal.pone.0110384
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293279
[Journal Article] Generation of interleukin-2 receptor gamma gene knockout pigs from so matic cells genetically modified by zinc finger nuclease-encoding mRNA.2013
- Author(s)
  Watanabe M, Nakano K, Matsunari H, Matsuda T, Maehara M, Kanai T, Kobayashi M, Matsumura Y, Sakai R, Kuramoto M, Hayashida G, Asano Y, Takayanagi S, Arai Y, Umeyama K., Nagaya M, Hanazono Y, Nagashima H
- Journal Title
  
  PLOS ONE
  
  Volume: 8 Issue: 10 Pages: e76478-e76478
- DOI
  10.1371/journal.pone.0076478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J06509, KAKENHI-PROJECT-25293279
[Journal Article] Production of diabetic offspring using cryopreserved epididymal sperm by in vitro fertilization and intrafallopian insemination techniques in transgenic pigs.2013
- Author(s)
  Umeyama K, Honda K, Matsunari H, Nakano K, Hidaka T, Sekiguchi K, Mochizuki H, Takeuchi Y, Fujiwara T, Watanabe M, Nagaya M, Nagashima H.
- Journal Title
  
  J Reprod Dev.
  
  Volume: 59 Pages: 599-603
- NAID
  130003361059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293279
[Presentation] ブタにおけるゲノム編集技術を用いた遺伝子ノックアウト2016
- Author(s)
  1.渡邊將人、松成ひとみ、中野和明、梅山一大、高柳就子、長屋昌樹、宮川周士、花園豊、中内啓光、長嶋比呂志
- Organizer
  日本ゲノム編集学会第1回大会
- Place of Presentation
  広島
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-15K15480
[Presentation] α-ガラクトシル抗原およびH-D抗原を発現しない遺伝子ノックアウトブタの作出2015
- Author(s)
  松成ひとみ，渡邊將人，中野和明，内倉鮎子，浅野吉則，武石透輝，福田暢，八島紗耶香，梅山一大，高柳就子，坂井理恵子，前田晃，江口寛，奥山宏臣，宮川周士，長嶋比呂志
- Organizer
  第17回日本異種移植研究会
- Place of Presentation
  自治医科大学(栃木県・下野市)
- Year and Date
  2015-03-14
- Data Source
  KAKENHI-PROJECT-26870630
[Presentation] Production efficiency of gene knockout pigs using genome editing and somatic cell cloning2015
- Author(s)
  Hitomi Matsunari, Masahito Watanabe, Kazuaki Nakano, Ayuko Uchikura, Yoshinori Asano, Shota Hatae, Toki Takeishi, Kazuhiro Umeyama, Masaki Nagaya, Shuji Miyagawa, Yutaka Hanazono, Hiromitsu Nakauchi, Hiroshi Nagashima
- Organizer
  41st Annual Conference of the International Embryo Transfer Society
- Place of Presentation
  Versailles (France)
- Year and Date
  2015-01-12
- Data Source
  KAKENHI-PROJECT-26870630
[Presentation] Production of alpha 1,3-galactosyltransferase and cytidine monophosphate-N-acetylneuraminic acid hydroxylase gene double-knockout pigs by genome editing and somatic cell cloning2015
- Author(s)
  Matsunari H, Watanabe M, Nakano K, Uchikura A, Asano Y, Hatae S, Takeishi T, Yashima S, Fukuda T, Sakai S, Umeyama K, Nagaya M, Maeda A, Eguchi H, Okuyama H, Miyagawa S, Nagashima H.
- Organizer
  2015 IPITA・IXA・CTS JOINT CONGRESS
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2015-11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870630
[Presentation] ブタにおけるキメラ胚の発達動態2015
- Author(s)
  1.畑江将太, 中野和明, 松成ひとみ, 内倉鮎子, 浅野吉則, 武石透輝, 渡邊將人, 梅山一大, 長屋昌樹, 長嶋比呂志
- Organizer
  第108回日本繁殖生物学会
- Place of Presentation
  宮崎
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-25293279
[Presentation] Blastocyst complementation restore apancreatic phenotype of pdx1 pigs.2015
- Author(s)
  1.Matsunari H, Watanabe M, Nakano K, Uchikura A, Asano Y, Umeyama K, Yamaguchi T, Nagaya M, Nakauchi H, Nagashima H
- Organizer
  International Society for Stem Cell Research 2015 Annual Meeting
- Place of Presentation
  Stockholm, Sweden.
- Year and Date
  2015-06-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293279
[Presentation] Generation and characterization of transgenic-cloned pigs expressing the far-red fluorescent protein monomeric plum.2014
- Author(s)
  Kobayashi M, Watanabe M, Matsunari H, Nakano K, Kanai T, Hayashida G, Matsumura Y, Kuramoto M, Sakai R, Arai Y, Umeyama K, Watanabe N, Onodera M, Nagaya M, Nagashima H.
- Organizer
  40th Annual Conference of the International Embryo Transfer Society
- Place of Presentation
  Reno, USA.
- Data Source
  KAKENHI-PROJECT-25293279
[Presentation] In vivo exogenic organ generation with organogenesis-disabled cloned pigs as a platform.2014
- Author(s)
  Matsunari H, Nakano K, Kanai T, Matsuda T, Maehara M, Watanabe M, Umeyama K, Nagaya M, Nakauchi H, Nagashima H
- Organizer
  40th Annual Conference of the International Embryo Transfer Society
- Place of Presentation
  Reno, USA.
- Data Source
  KAKENHI-PROJECT-25293279
[Presentation] 膵臓欠損ブタ胎仔を用いた外来性細胞由来膵臓形成の試み.2014
- Author(s)
  松成ひとみ、浅野吉則、小林美里奈、内倉鮎子、渡邊將人、梅山一大、長屋昌樹、中内啓光、長嶋比呂志.
- Organizer
  第13回日本再生医療学会総会.
- Place of Presentation
  京都.
- Data Source
  KAKENHI-PROJECT-25293279
[Presentation] ガラス化保存された体外成熟／体外受精胚を用いた糖尿病モデル遺伝子改変ブタの作出.2013
- Author(s)
  松村幸奈, 前原美樹, 本田香澄, 林田豪太, 倉本桃子, 中野和明, 松成ひとみ, 小林美里奈, 内倉鮎子, 浅野吉則, 渡邊将人, 梅山一大, 長屋昌樹, 長嶋比呂志.
- Organizer
  第106回日本繁殖生物学会大会.
- Place of Presentation
  東京.
- Data Source
  KAKENHI-PROJECT-25293279
[Presentation] 細胞周期可視化蛍光プローブFucci を発現するブタ体細胞核移植胚の作出.2013
- Author(s)
  林田豪太, 渡邊将人, 松成ひとみ, 中野和明, 金井貴博, 小林美里奈, 松村幸奈, 倉本桃子, 坂井理恵子, 浅野吉則, 内倉鮎子, 前原美樹, 新井良和, 梅山一大, 長屋昌樹, 沢野朝子, 宮脇敦史, 長嶋比呂志.
- Organizer
  第106回日本繁殖生物学会大会.
- Place of Presentation
  東京.
- Data Source
  KAKENHI-PROJECT-25293279
[Presentation] 異種移植研究における遺伝子改変ブタの作出への人工生殖技術の利用.2013
- Author(s)
  坂井理恵子, 中野和明, 松成ひとみ, 新井良和, 渡邊將人, 梅山一大, 佐原寿史, 山田和彦, 長屋昌樹, 宮川周士, 長嶋比呂志.
- Organizer
  第1回日本先進医工学ブタ研究会.
- Place of Presentation
  大阪.
- Data Source
  KAKENHI-PROJECT-25293279
[Presentation] Application of blastocyst complementation to development of genetically modified pigs for xenotransplantation.2013
- Author(s)
  Nakano K, Matsunari H, Matsuda T, Kanai T, Hayashida G, Matsumura K, Kobayashi M, Kuramoto M, Asano Y, Sakai R, Uchikura A, Arai Y, Watanabe M, Umeyama K, Nagaya M, Nagashima H.
- Organizer
  12th Congress of International Xenotransplantation Association (IXA).
- Place of Presentation
  Osaka, Japan.
- Data Source
  KAKENHI-PROJECT-25293279
[Presentation] 遺伝子改変クローンブタ開発における人工生殖技術を利用した遺伝的バックグラウンドの更新.2013
- Author(s)
  坂井理恵子, 中野和明, 松成ひとみ, 新井良和, 渡邊將人, 梅山一大, 長屋昌樹, 宮川周士, 長嶋比呂志.
- Organizer
  第16回日本異種移植研究会.
- Place of Presentation
  大阪.
- Data Source
  KAKENHI-PROJECT-25293279
[Presentation] ブタ卵におけるmRNA injection法を用いたZinc Finger Nucleasesによる遺伝子ノックアウト.2013
- Author(s)
  松田泰輔, 渡邊將人, 中野和明, 松成ひとみ, 小林美里奈, 林田豪太, 倉本桃子, 金井貴博, 山口智之, 中内啓光, 長屋昌樹, 長嶋比呂志.
- Organizer
  第36回日本分子生物学会.
- Place of Presentation
  神戸.
- Data Source
  KAKENHI-PROJECT-25293279
[Presentation] Zinc finger nuclease発現mRNAによるIL2RG遺伝子ノックアウトブタの作出.2013
- Author(s)
  渡邊將人, 中野和明, 松成ひとみ, 松田泰輔, 金井貴博, 小林美里奈, 松村幸奈, 坂井理恵子, 倉本桃子, 林田豪太, 浅野吉則, 高柳就子, 新井良和, 梅山一大, 長屋昌樹, 豊花, 長嶋比呂志
- Organizer
  第36回日本分子生物学会.
- Place of Presentation
  神戸.
- Data Source
  KAKENHI-PROJECT-25293279
[Presentation] In vivo generation of exogenic pancreas in apancreatic cloned pigs via blastocyst complementation.2013
- Author(s)
  Matsunari H, Nakano K, Kanai T, Matsuda T, Maehara M, Watanabe M, Umeyama K, Nagaya M, Nakauchi H, Nagashima H.
- Organizer
  12th Congress of International Xenotransplantation Association (IXA).
- Place of Presentation
  Osaka, Japan.
- Data Source
  KAKENHI-PROJECT-25293279
[Presentation] 細胞周期可視化蛍光プローブFucci導入トランスジェニック・クローンブタの作出
- Author(s)
  3.渡邊將人, 林田豪太, 松成ひとみ, 中野和明, 小林美里奈, 松村幸奈, 倉本桃子, 坂井理恵子, 浅野吉則, 内倉鮎子, 新井良和, 梅山一大, 長屋昌樹, 阪上‐沢野朝子, 宮脇敦史, 長嶋比呂志
- Organizer
  第107回日本繁殖生物学会大会
- Place of Presentation
  帯広
- Year and Date
  2014-08-21 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-25293279
[Presentation] Production efficiency of gene knockout pigs using genome editing and somatic cell cloning
- Author(s)
  1.Matsunari H, Watanabe M, Nakano K, Uchikura A, Asano Y, Hatae S, Takeishi T, Umeyama K, Nagaya M, Miyagawa S, Hanazono Y, Nakauchi H, Nagashima H
- Organizer
  41th Annual Conference of the International Embryo Transfer Society
- Place of Presentation
  Versailles, France
- Year and Date
  2015-01-10 – 2015-01-13
- Data Source
  KAKENHI-PROJECT-25293279
[Presentation] 遠赤色蛍光タンパクmonomeric Plum を全身発現するトランスジェニック・クローンブタの作出
- Author(s)
  2.小林美里奈, 渡邊將人, 松成ひとみ, 中野和明, 林田豪太, 坂井理恵子, 松村幸奈, 倉本桃子, 梅山一大, 渡辺信之, 小野寺雅史, 長屋昌樹, 長嶋比呂志
- Organizer
  第107回日本繁殖生物学会大会
- Place of Presentation
  帯広
- Year and Date
  2014-08-21 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-25293279
[Presentation] 糖尿病発症トランスジェニックブタ凍結精子の体外受精能の評価.
- Author(s)
  1.倉本桃子, 小林美里奈, 林田豪太, 松村幸奈, 松成ひとみ, 中野和明, 鞍本友香, 一山琴世, 浅野吉則, 内倉鮎子, 渡邊將人, 梅山一大, 長屋昌樹, 長嶋比呂志
- Organizer
  第107回日本繁殖生物学会大会
- Place of Presentation
  帯広
- Year and Date
  2014-08-21 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-25293279
[Presentation] Development of apancreatic pig by genome editing and its application in organ regeneration research
- Author(s)
  3.Matsunari H, Watanabe M, Nakano K, Uchikura A, Asano Y, Kobayashi M, Umeyama K, Nagaya M, Nakauchi H, Nagashima H
- Organizer
  Swine in Biomedical Research International Conference
- Place of Presentation
  Raleigh, USA
- Year and Date
  2014-07-06 – 2014-07-08
- Data Source
  KAKENHI-PROJECT-25293279
[Presentation] Transmission of lethal phenotype in a Mendelian fashion by genetically modified pigs that underwent blastocyst complementatio
- Author(s)
  2.Matsunari H, Watanabe M, Umeyama K, Nakano K, Nagaya M, Nakauchi H, Nagashima H
- Organizer
  World Congress of Reproductive Biology
- Place of Presentation
  Edinburgh, UK
- Year and Date
  2014-09-02 – 2014-09-04
- Data Source
  KAKENHI-PROJECT-25293279

1. WATANABE MASATO (00321688)

# of Collaborated Projects: 2 results

# of Collaborated Products: 27 results
2. Masaki Nagaya (90329300)

# of Collaborated Projects: 2 results

# of Collaborated Products: 28 results
3. NAGASHIMA HIROSHI (50318664)

# of Collaborated Projects: 2 results

# of Collaborated Products: 28 results
4. UMEYAMA KAZUHIRO (70342699)

# of Collaborated Projects: 2 results

# of Collaborated Products: 26 results
5. ARAI YOSHIKAZU (90614769)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results

MATSUNARI Hitomi 松成 ひとみ

MATSUNARI HITOMI 松成 ひとみ

Research Projects

Research Products

Co-Researchers

Establishing a new cryopreservation method for pig pancreatic islet sheet by vitrification and an evaluation method by a high-throughput sequencing.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Generation of alpha1,3-galactosyltransferase and cytidine monophospho-N-acetylneuraminic acid hydroxylase gene double-knockout pigsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A transgenic-cloned pig model expressing fluorescent or non-fluorescent modified Plum gene for the evaluation of islet transplantation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] An Effective New Cryopreservation Procedure for Pancreatic Islets Using Hollow Fiber Vitrification.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A transgenic-cloned pig model expressing non-fluorescent modified Plum.2016

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Production of transgenic cloned pigs expressing the far-red fluorescent protein monomeric Plum.2015

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[Journal Article] Production of transgenic cloned pigs expressing the far-red fluorescent protein monomeric Plum2015

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[Journal Article] A New System to Evaluate the Influence of Immunosuppressive Drugs on Pancreatic Islets Using Epigenetic Analysis in a 3-Dimensional Culture.2015

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[Journal Article] Transgenic pigs with pancres-specific expression of green fluorescent protein.2014

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[Journal Article] Transgenic pigs with pancreas specific expression of green fluorescent protein.2014

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[Journal Article] A conserved rule for pancreatic islet rganization.2014

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[Journal Article] Generation of interleukin-2 receptor gamma gene knockout pigs from so matic cells genetically modified by zinc finger nuclease-encoding mRNA.2013

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[Journal Article] Production of diabetic offspring using cryopreserved epididymal sperm by in vitro fertilization and intrafallopian insemination techniques in transgenic pigs.2013

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MATSUNARI Hitomi 松成ひとみ

MATSUNARI HITOMI 松成ひとみ