Kuwahara Shoji 桑原頌治

Researcher Number	70645209
Other IDs
Affiliation (Current)	2025: 滋賀県立大学, 人間文化学部, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 滋賀県立大学, 人間文化学部, 准教授 2020: 新潟大学, 医歯学総合研究科, 特任助教 2019 – 2020: 滋賀県立大学, 人間文化学部, 講師 2016 – 2018: 新潟大学, 医歯学総合研究科, 特任助教 2013 – 2015: 新潟大学, 医歯(薬)学総合研究科, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 53040:Nephrology-related / Kidney internal medicine Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Basic Section 53040:Nephrology-related / Kidney internal medicine
Keywords	Principal Investigator リン代謝 / 腎臓 / エンドサイトーシス / メガリン / klotho / 慢性腎臓病 / FGF23 / 近位尿細管 / リン代謝調節 / センサー … More / グルコース代謝 / 腎機能低下 / 糖尿病性腎臓病 / ミネラル代謝 / リン / 糖尿病 / 輸送 / Klotho / 再吸収 / トランスポーター / 腎障害 / megalinとリン代謝調節 / megalinとklotho代謝 … More Except Principal Investigator CKD / Nampt / リン / 慢性腎臓病 / メガリン / バイオマーカー / 日内リズム / 概日リズム / 時間栄養 / ミネラル代謝 / ミネラル / 加齢 / 栄養 / 骨細胞 / 創薬 / 急性腎障害 / 尿中バイオマーカー / エクソソーム / 近位尿細管 / 糖尿病性腎症 Less

New Developments in Nutritional Therapy of Chronic Kidney Disease by Elucidating the Mechanism of Tissue Distribution of Inorganic Phosphate
- Principal Investigator
  
  辰巳佐和子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  The University of Shiga Prefecture
多臓器による腎障害の進展抑制機構：糖－ミネラル代謝の制御連関Principal Investigator
- Principal Investigator
  
  桑原頌治
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  The University of Shiga Prefecture
A New Organ for Preventing Systemic Aging: Elucidating the Nutrient Network of Osteocytes
- Principal Investigator
  
  Tatsumi Sawako
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  The University of Shiga Prefecture
Strategy for Prevention of Chronic Kidney Disease (CKD) Severity: Analysis of Phosphorus Time Nutrition
- Principal Investigator
  
  Sawako Tatsumi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  The University of Shiga Prefecture
Elucidation of a novel phosphate metabolism regulatory mechanism based on megalin involving a-klotho and FGF23Principal Investigator
- Principal Investigator
  
  Kuwahara Shoji
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  The University of Shiga Prefecture
Development of megalin-targeted strategies for diagnosis, prevention, and treatment of chronic kidney disease and acute kidney injury
- Principal Investigator
  
  Saito Akihiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Niigata University
A novel megalin mediated phosphate metabolism in proximal tubule and elucidation of phosphate related kidney injury mechanism.Principal Investigator
- Principal Investigator
  
  Kuwahara Shoji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Niigata University
Investigation of the mechanism underlying urinary excretion of megalin, a novel biomarker of diabetic kidney disease
- Principal Investigator
  
  Hosojima Michihiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Niigata University
Interaction of klotho/megalin/NaPi2a, a novel regulating mechanism of phosphate homeostasis.Principal Investigator
- Principal Investigator
  
  Kuwahara Shoji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Niigata University

All 2024 2023 2022 2021 2020 2017 2016 2015

All Journal Article Presentation

[Journal Article] Regulation of Plasma Phosphate Concentration and Diurnal Rhythm2021
- Author(s)
  TATSUMI Sawako、KUWAHARA Shoji、SEGAWA Hiroko、MIYAMOTO Ken-ichi
- Journal Title
  
  Oleoscience
  
  Volume: 21 Issue: 4 Pages: 135-140
- DOI
  10.5650/oleoscience.21.135
- NAID
  130008021863
- ISSN
  1345-8949, 2187-3461
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-20H04127, KAKENHI-PROJECT-20K21767
[Journal Article] Combination therapy of cisplatin with cilastatin enables an increased dose of cisplatin, enhancing its antitumor effect by suppression of nephrotoxicity2021
- Author(s)
  Arita M, Watanabe S, Aoki N, Kuwahara S, Suzuki R, Goto S, Abe Y, Takahashi M, Sato M, Hokari S, Ohtsubo A, Shoji S, Nozaki K, Ichikawa K, Kondo R, Hayashi M, Ohshima Y, Kabasawa H, Hosojima M, Koya T, Saito A, Kikuchi T.
- Journal Title
  
  Sci Rep
  
  Volume: 11 Issue: 1 Pages: 750-750
- DOI
  10.1038/s41598-020-80853-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KT0019, KAKENHI-PROJECT-19K08673, KAKENHI-PROJECT-20H04127, KAKENHI-PROJECT-23K20323
[Journal Article] Effects of DPP-4 Inhibitors on Blood Glucose Variability in Japanese Patients with Type 2 Diabetes on Maintenance Hemodialysis: A Prospective Observational Exploratory Study2020
- Author(s)
  Ishikawa-Tanaka Tomomi、Hosojima Michihiro、Kabasawa Hideyuki、Kaseda Ryohei、Yasukawa Ryota、Yata Yusuke、Kuwahara Shoji、Kono Emiko、Takata Takuma、Iino Noriaki、Tanaka Takahiro、Kitamura Nobutaka、Suzuki Yoshiki、Saito Akihiko、Narita Ichiei
- Journal Title
  
  Diabetes Therapy
  
  Volume: 11 Issue: 12 Pages: 2845-2861
- DOI
  10.1007/s13300-020-00928-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H04127
[Journal Article] Exocytosis-Mediated Urinary Full-Length Megalin Excretion is Linked with the Pathogenesis of Diabetic Nephropathy2017
- Author(s)
  De S, Kuwahara S, Hosojima M, Ishikawa T, Kaseda R, Sarkar P, Yoshioka Y, Kabasawa H, Iida T, Goto S, Toba K, Higuchi Y, Suzuki Y, Hara M, Kurosawa H, Narita I, Hirayama Y, Ochiya T, Saito A
- Journal Title
  
  Diabetes
  
  Volume: in press Issue: 5 Pages: 1391-1404
- DOI
  10.2337/db16-1031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293201, KAKENHI-PROJECT-26461216, KAKENHI-PROJECT-26670429, KAKENHI-PROJECT-26860630
[Presentation] Interaction of megalin with α-klotho, a senescence-related hormone, for the regulation of urinary phosphate excretion2024
- Author(s)
  Shoji Kuwahara, Michihiro Hosojima, Hideyuki Kabasawa, Sawako Tatsumi, Akihiko Saito
- Organizer
  Kidney Health In Aging and Aged Societies: JSN/ERA Symposium in Collaboration with JSDT
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08674
[Presentation] 高リン血症改善における肝臓Nampt/NAD合成系の関与2023
- Author(s)
  外池奈実，鶴谷拓仁，今村萌々果，安澤俊紀，桑原頌治，辰巳佐和子
- Organizer
  第26回日本病態栄養学会学術集会
- Data Source
  KAKENHI-PROJECT-20H04127
[Presentation] 糖尿病性腎臓病発症メカニズムの検討　糖尿病がリン代謝に与える影響2023
- Author(s)
  桑原頌治
- Organizer
  第７回　日本Uremic Toxin研究会　学術集会
- Data Source
  KAKENHI-PROJECT-22K08314
[Presentation] 尿中のcalciprotein particle(CPP)測定による腎機能低下の早期発見2022
- Author(s)
  桑原頌治，八幡大希，外池奈実，雜賀果南，木越菜々恵，安澤俊紀，辰巳佐和子
- Organizer
  第61回日本栄養・食糧学会近畿支部会
- Data Source
  KAKENHI-PROJECT-20K21767
[Presentation] 食餌のタイミングの違いが血中リン濃度の日内リズムにおよぼす影響:慢性腎臓病モデルマウスの検討2022
- Author(s)
  木越菜々恵, 桑原頌治, 外池奈実, 辰巳佐和子
- Organizer
  第9回日本時間栄養学会学術集会
- Data Source
  KAKENHI-PROJECT-20H04127
[Presentation] 慢性腎臓病におけるリン組織移行の検討2022
- Author(s)
  外池奈実, 桑原頌治，室岡響，田口裕子，木越菜々恵，雜賀果南，辰巳佐和子
- Organizer
  第76回日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-20K21767
[Presentation] 慢性腎臓病におけるリン組織移行の検討2022
- Author(s)
  外池奈実，木越菜々恵，安澤俊紀，桑原頌治，辰巳佐和子
- Organizer
  第61回日本栄養・食糧学会近畿支部会
- Data Source
  KAKENHI-PROJECT-20H04127
[Presentation] 尿中のcalciprotein particle(CPP)測定による腎機能低下の早期発見2022
- Author(s)
  桑原頌治，八幡大希，外池奈実，雜賀果南，木越菜々恵，安澤俊紀，辰巳佐和子
- Organizer
  第61回日本栄養・食糧学会近畿支部会
- Data Source
  KAKENHI-PROJECT-20H04127
[Presentation] 慢性腎臓病におけるリン代謝異常と肝臓NamptーNAD合成系について2022
- Author(s)
  室岡響，田口裕子，外池奈美，桑原頌治，辰巳佐和子
- Organizer
  第24・25回日本病態栄養学会
- Data Source
  KAKENHI-PROJECT-20K21767
[Presentation] 腸管リン吸収におけるNampt/NAD系の関与2022
- Author(s)
  田口裕子，室岡響，桑原頌治，辰巳佐和子
- Organizer
  第24・25回日本病態栄養学会
- Data Source
  KAKENHI-PROJECT-20K21767
[Presentation] CPP測定による腎機能低下の早期発見2022
- Author(s)
  桑原頌治，外池奈美，河瀬瑞生，古川菜摘，廣瀬かなこ，田口裕子，室岡響，辰巳佐和子
- Organizer
  第24・25回日本病態栄養学会
- Data Source
  KAKENHI-PROJECT-20K21767
[Presentation] 腸管リン吸収におけるNampt/NAD系の関与2022
- Author(s)
  田口裕子，室岡響，桑原頌治，辰巳佐和子
- Organizer
  第24・25回日本病態栄養学会
- Data Source
  KAKENHI-PROJECT-20H04127
[Presentation] 慢性腎臓病におけるリン組織移行の異常2022
- Author(s)
  外池奈実, 桑原頌治，室岡響，田口裕子，木越菜々恵，雜賀果南，辰巳佐和子
- Organizer
  第76回日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-20H04127
[Presentation] 食餌のタイミングが血中リン濃度の日内リズムにおよぼす影響：慢性腎臓病モデルマウスの検討2022
- Author(s)
  木越菜々恵，外池奈実，安澤俊紀，桑原頌治，辰巳佐和子
- Organizer
  第61回日本栄養・食糧学会近畿支部会
- Data Source
  KAKENHI-PROJECT-20H04127
[Presentation] 尿中のcalciprotein particle(CPP)測定による腎機能低下の早期発見2022
- Author(s)
  桑原頌治
- Organizer
  第61回日本栄養・食糧学会近畿支部会
- Data Source
  KAKENHI-PROJECT-22K08314
[Presentation] CPP測定による腎機能低下の早期発見2022
- Author(s)
  桑原頌治，外池奈美，河瀬瑞生，古川菜摘，廣瀬かなこ，田口裕子，室岡響，辰巳　佐和子
- Organizer
  第24・25回日本病態栄養学会
- Data Source
  KAKENHI-PROJECT-20H04127
[Presentation] 慢性腎臓病におけるリン代謝異常と肝臓NamptーNAD合成系について2022
- Author(s)
  室岡響，田口裕子，外池奈美，桑原頌治，辰巳佐和子
- Organizer
  第24・25回日本病態栄養学会
- Data Source
  KAKENHI-PROJECT-20H04127
[Presentation] CPPによる腎機能低下の早期発見2021
- Author(s)
  桑原頌治
- Organizer
  第９回日本腎栄養代謝研究会学術集会・総会
- Data Source
  KAKENHI-PROJECT-19K08674
[Presentation] 血中リン濃度の日内リズムにおける肝臓Namptの役割2021
- Author(s)
  辰巳佐和子，室岡響，桑原頌治
- Organizer
  日本時間栄養学会
- Data Source
  KAKENHI-PROJECT-20H04127
[Presentation] CPPによる腎機能低下の早期発見2021
- Author(s)
  桑原頌治
- Organizer
  日本病態栄養学会
- Data Source
  KAKENHI-PROJECT-19K08674
[Presentation] 血中リン濃度の日内リズムにおける肝臓Namptの役割2021
- Author(s)
  辰巳佐和子，室岡響，桑原頌治
- Organizer
  日本時間栄養学会
- Data Source
  KAKENHI-PROJECT-20K21767
[Presentation] CPP測定系の樹立:腎機能低下の早期発見2020
- Author(s)
  桑原頌治，辰巳佐和子　他
- Organizer
  第59回日本栄養・食糧学会近畿支部大会
- Data Source
  KAKENHI-PROJECT-20H04127
[Presentation] CPP測定系の樹立：腎機能低下の早期発見2020
- Author(s)
  桑原頌治
- Organizer
  第59回日本栄養食糧学会近畿支部大会
- Data Source
  KAKENHI-PROJECT-19K08674
[Presentation] CPP測定系の樹立：腎機能低下の早期発見2020
- Author(s)
  桑原頌治
- Organizer
  第18回日本栄養改善学会近畿支部学術総会
- Data Source
  KAKENHI-PROJECT-19K08674
[Presentation] Mechanisms underlying urinary excretion of full-length and extracellular domain forms of megalin2016
- Author(s)
  Shankhajit De，Shoji Kuwahara，Michihiro Hosojima，Tomomi Ishikawa，Ryohei Kaseda，Yusuke Yoshioka，Yoshiki Suzuki，Ichiei Narita，Takahiro Ochiya，Hiroyuki Kurosawa, Yoshiaki Hirayama, Akihiko Saito
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-26860630
[Presentation] Mechanism of Increased Urinary Full-Length Megalin Excretion in Type 2 Diabetes Mellitus Patients with Nephropathy2015
- Author(s)
  Shankhajit De, Shoji Kuwahara, Michihiro Hosojima, MD, PhD, Tomomi Ishikawa, MD, Ryohei Kaseda, MD, PhD, Yusuke Yoshioka, PhD, Yoshiki Suzuki, Ichiei Narita, MD, PhD, Takahiro Ochiya, PhD, Akihiko Saito, MD, PhD.
- Organizer
  American Society of Nephrology 48th Annual Meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2015-11-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860630

1. Tatsumi Sawako (80420545)

# of Collaborated Projects: 4 results

# of Collaborated Products: 17 results
2. SAITO Akihiko (80293207)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. Hosojima Michihiro (50464003)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. KABASAWA Hideyuki (20794639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. DE Shankhajit

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 成田一衛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 後藤眞

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 菊地利明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 阿部貴志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kuwahara Shoji 桑原 頌治

Research Projects

Research Products

Co-Researchers

New Developments in Nutritional Therapy of Chronic Kidney Disease by Elucidating the Mechanism of Tissue Distribution of Inorganic Phosphate

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

多臓器による腎障害の進展抑制機構：糖－ミネラル代謝の制御連関Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A New Organ for Preventing Systemic Aging: Elucidating the Nutrient Network of Osteocytes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Strategy for Prevention of Chronic Kidney Disease (CKD) Severity: Analysis of Phosphorus Time Nutrition

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of a novel phosphate metabolism regulatory mechanism based on megalin involving a-klotho and FGF23Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of megalin-targeted strategies for diagnosis, prevention, and treatment of chronic kidney disease and acute kidney injury

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel megalin mediated phosphate metabolism in proximal tubule and elucidation of phosphate related kidney injury mechanism.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the mechanism underlying urinary excretion of megalin, a novel biomarker of diabetic kidney disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Interaction of klotho/megalin/NaPi2a, a novel regulating mechanism of phosphate homeostasis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Regulation of Plasma Phosphate Concentration and Diurnal Rhythm2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Combination therapy of cisplatin with cilastatin enables an increased dose of cisplatin, enhancing its antitumor effect by suppression of nephrotoxicity2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of DPP-4 Inhibitors on Blood Glucose Variability in Japanese Patients with Type 2 Diabetes on Maintenance Hemodialysis: A Prospective Observational Exploratory Study2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exocytosis-Mediated Urinary Full-Length Megalin Excretion is Linked with the Pathogenesis of Diabetic Nephropathy2017

Author(s)

Journal Title

DOI

Kuwahara Shoji 桑原頌治

[Presentation] 糖尿病性腎臓病発症メカニズムの検討　糖尿病がリン代謝に与える影響2023

[Presentation] 食餌のタイミングの違いが血中リン濃度の日内リズムにおよぼす影響:慢性腎臓病モデルマウスの検討2022

[Presentation] 慢性腎臓病におけるリン代謝異常と肝臓NamptーNAD合成系について2022

[Presentation] 食餌のタイミングが血中リン濃度の日内リズムにおよぼす影響：慢性腎臓病モデルマウスの検討2022

[Presentation] 慢性腎臓病におけるリン代謝異常と肝臓NamptーNAD合成系について2022