Sugawara Kenji 菅原健二

Researcher Number	70645217
Other IDs
Affiliation (Current)	2025: 神戸大学, 医学部附属病院, 特命助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 神戸大学, 医学部附属病院, 特命助教 2021 – 2022: 神戸大学, 医学部附属病院, 特定助教 2020: 神戸大学, 医学部附属病院, 助教 2016 – 2018: 神戸大学, 医学部附属病院, 医員 2013 – 2015: 神戸大学, 医学(系)研究科(研究院), 研究員
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Metabolomics Except Principal Investigator Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Keywords	Principal Investigator 糖尿病 / メトホルミン / インスリン分泌 / 逆行性グルコース輸送 / キレート / 金属 / ミトコンドリア機能 / キレート作用 / ケミカルプロテオミクス / Epac2A Except Principal Investigator 腸管グルコース排泄 / メトホルミン

Analysis of the molecular mechanism of intestinal glucose excretion and its physiological significance.
- Principal Investigator
  
  小川渉
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Kobe University
Elucidation of the molecular mechanism and physiological significance of retrograde glucose transport in the intestine.Principal Investigator
- Principal Investigator
  
  菅原健二
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kobe University
A novel mechanism of metformin through iron chelationPrincipal Investigator
- Principal Investigator
  
  Sugawara Kenji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kobe University
A chemical proteomics approach to identify the novel mechanism of insulin secretion.Principal Investigator
- Principal Investigator
  
  Sugawara Kenji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kobe University
Identification of Epac2A agonists as novel anti-diabetic agents.Principal Investigator
- Principal Investigator
  
  Sugawara Kenji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kobe University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] 糖尿病最新の治療2019-20212018
- Author(s)
  菅原健二, 小川渉
- Total Pages
  2
- Publisher
  南江堂
- ISBN
  4524245561
- Data Source
  KAKENHI-PROJECT-16K19537
[Book] 糖尿病学2015
- Author(s)
  菅原健二、清野　進.
- Total Pages
  12
- Publisher
  西村書店
- Data Source
  KAKENHI-PROJECT-25860749
[Book] Diabetes Frontier 25巻5号2014
- Author(s)
  菅原健二、清野進
- Total Pages
  128
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-25860749
[Book] 成人病と生活習慣病42巻12号　インクレチン関連薬による糖尿病治療の新時代2013
- Author(s)
  菅原健二、清野進
- Total Pages
  140
- Publisher
  東京医学社
- Data Source
  KAKENHI-PROJECT-25860749
[Journal Article] New mechanism of metformin action mediated by lysosomal presenilin enhancer 2.2023
- Author(s)
  Kenji Sugawara, Wataru Ogawa
- Journal Title
  
  Journal of diabetes investigation
  
  Volume: 14 Issue: 1 Pages: 12-14
- DOI
  10.1111/jdi.13925
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08884
[Journal Article] Stimulatory effect of imeglimin on incretin secretion.2023
- Author(s)
  Quan Yingyue, Kenji Sugawara, Harumi Takahashi, Norihide Yokoi, Kento Ohbayashi, Yusaku Iwasaki, Susumu Seino, Wataru Ogawa
- Journal Title
  
  Journal of diabetes investigation
  
  Volume: in press Issue: 6 Pages: 746-755
- DOI
  10.1111/jdi.14001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08884, KAKENHI-PROJECT-23K08007, KAKENHI-PROJECT-21H02390
[Journal Article] Effects of imeglimin on mitochondrial function, AMPK activity, and gene expression in hepatocytes2023
- Author(s)
  Hozumi Kaori、Sugawara Kenji、Ishihara Takaya、Ishihara Naotada、Ogawa Wataru
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 746-746
- DOI
  10.1038/s41598-023-27689-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06066, KAKENHI-PROJECT-20K08884
[Journal Article] A novel view of the insulin signaling pathway based on prediction of protein structure by the AI platform AlphaFold.2023
- Author(s)
  Kyosuke Sato, Kenji Sugawara, Wataru Ogawa
- Journal Title
  
  Journal of diabetes investigation
  
  Volume: 14 Issue: 5 Pages: 635-639
- DOI
  10.1111/jdi.13988
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08884
[Journal Article] A case of α-chain variant hemoglobin (Hb Chad) with falsely high HbA1c levels measured by immunoassay2022
- Author(s)
  Kei Yoshino, Yushi Hirota, Wataru Ogawa, Kenji Sugawara, Akira Kawaguchi, Hiroshi Yoshino, Midori Ishibashi, Gen Yoshino, Masafumi Koga
- Journal Title
  
  Diabetology International
  
  Volume: 13 Issue: 1 Pages: 330-335
- DOI
  10.1007/s13340-021-00529-y
- NAID
  40022803092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08884
[Journal Article] The gut microbial metabolite imidazole propionate inhibits metformin action.2021
- Author(s)
  Kenji Sugawara, Wataru Ogawa
- Journal Title
  
  Journal of diabetes investigation
  
  Volume: 12 Issue: 8 Pages: 1319-1321
- DOI
  10.1111/jdi.13566
- NAID
  120007153061
- Open Access
- Data Source
  KAKENHI-PROJECT-20K08884
[Journal Article] Enhanced Release of Glucose Into the Intraluminal Space of the Intestine Associated With Metformin Treatment as Revealed by [18F]Fluorodeoxyglucose PET-MRI2020
- Author(s)
  Morita Yasuko、Nogami Munenobu、Sakaguchi Kazuhiko、Okada Yuko、Hirota Yushi、Sugawara Kenji、Tamori Yoshikazu、Zeng Feibi、Murakami Takamichi、Ogawa Wataru
- Journal Title
  
  Diabetes Care
  
  Volume: 43 Issue: 8 Pages: 1796-1802
- DOI
  10.2337/dc20-0093
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07714, KAKENHI-PROJECT-20K08884
[Journal Article] Dose‐dependent accumulation of glucose in the intestinal wall and lumen induced by metformin as revealed by 18 F‐labelled fluorodeoxyglucose positron emission tomography‐ MRI2020
- Author(s)
  Ito Jun、Nogami Munenobu、Morita Yasuko、Sakaguchi Kazuhiko、Komada Hisako、Hirota Yushi、Sugawara Kenji、Tamori Yoshikazu、Zeng Feibi、Murakami Takamichi、Ogawa Wataru
- Journal Title
  
  Diabetes, Obesity and Metabolism
  
  Volume: 23 Issue: 3 Pages: 692-699
- DOI
  10.1111/dom.14262
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07714, KAKENHI-PROJECT-20K08884
[Journal Article] Relation between metformin use and vitamin B12 status in patients with type 2 diabetes in Japan2020
- Author(s)
  Sugawara K, Okada Y, Hirota Y, Sakaguchi K, Ogawa W
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 11 Issue: 4 Pages: 917-922
- DOI
  10.1111/jdi.13200
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08884
[Journal Article] In silico and in vitro analyses of the pathological relevance of the R258H mutation of hepatocyte nuclear factor 4alpha identified in MODY1.2019
- Author(s)
  Sugawara K, Nomura K, Okada Y, Sugano A, Matsumoto M, Takarada T, Takeuchi A, Awano H, Hirota Y, Nishio H, Takaoka Y, Ogawa W.
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 10 Issue: 3 Pages: 680-684
- DOI
  10.1111/jdi.12960
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19537, KAKENHI-PROJECT-18K07414
[Journal Article] Phenotypic differences and similarities of monozygotic twins with maturity-onset diabetes of the young type?52019
- Author(s)
  Ohara Yasuko、Okada Yuko、Yamada Tomoko、Sugawara Kenji、Kanatani Masayuki、Fukuoka Hidenori、Hirota Yushi、Maeda Takaki、Morisada Naoya、Iijima Kazumoto、Ogawa Wataru
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: - Issue: 4 Pages: 1112-1115
- DOI
  10.1111/jdi.13004
- NAID
  120006709586
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08243, KAKENHI-PROJECT-16K19537
[Journal Article] β-cell signaling and insulin secretagogues: a path for improved diabetes therapy2017
- Author(s)
  Seino S, Sugawara K, Yokoi N, Takahashi H
- Journal Title
  
  Diabetes Obes Metab
  
  Volume: 印刷中 Issue: S1 Pages: 22-29
- DOI
  10.1111/dom.12995
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229007, KAKENHI-PROJECT-16K09749, KAKENHI-PROJECT-16K09751, KAKENHI-PROJECT-17K09831, KAKENHI-PROJECT-16K19537, KAKENHI-PROJECT-15K06800, KAKENHI-PROJECT-15K08176
[Journal Article] A novel diphenylthiosemicarbazide is a potential insulin secretagogue for anti-diabetic agent2016
- Author(s)
  Sugawara k, Honda K, Reien Y, Yokoi N, Seki C, Takahashi H, Minami K, Mori I, Matsumoto A, Nakaya H, Seino S
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 10 Pages: e0164785-e0164785
- DOI
  10.1371/journal.pone.0164785
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229007, KAKENHI-PROJECT-26460334, KAKENHI-PROJECT-15K06800, KAKENHI-PROJECT-15K08176, KAKENHI-PROJECT-16K09749, KAKENHI-PROJECT-16K15315, KAKENHI-PROJECT-16K19537
[Journal Article] Structure and functional roles of Epac2 (Rapgef4)2015
- Author(s)
  Sugawara K, Shibasaki T, Takahashi H, Seino S
- Journal Title
  
  Gene
  
  Volume: 505 Issue: 2 Pages: 577-583
- DOI
  10.1016/j.gene.2015.09.029
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08176, KAKENHI-PROJECT-25461351, KAKENHI-PROJECT-25860749, KAKENHI-PROJECT-24229007, KAKENHI-PROJECT-16K09749
[Journal Article] Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion2014
- Author(s)
  Gheni G, Ogura M, Iwasaki M, Yokoi N, Minami K, Nakayama Y, Harada K, Hastoy B, Wu X, Takahashi H, Kimura K, Matsubara T, Hoshikawa R, Hatano N, Sugawara K, Shibasaki T, Inagaki N, Bamba T, Mizoguchi A, Fukusaki E, Rorsman P, Seino S
- Journal Title
  
  Cell Rep
  
  Volume: 9 Issue: 2 Pages: 661-673
- DOI
  10.1016/j.celrep.2014.09.030
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229007, KAKENHI-PROJECT-24500491, KAKENHI-PROJECT-24590320, KAKENHI-PROJECT-24591330, KAKENHI-PROJECT-25293210, KAKENHI-PROJECT-25461351, KAKENHI-PROJECT-25640022, KAKENHI-PROJECT-25860749, KAKENHI-PROJECT-26430143
[Journal Article] Antidiabetic Sulfonylureas and cAMP cooperatively activate Epac2A.2013
- Author(s)
  Takahashi T, Shibasaki T, Takahashi H, Sugawara K, Ono A, Inoue N, Furuya T, Seino S
- Journal Title
  
  Sci Signal
  
  Volume: 6 Issue: 298
- DOI
  10.1126/scisignal.2004581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229007, KAKENHI-PROJECT-24590320, KAKENHI-PROJECT-25461351, KAKENHI-PROJECT-25860749
[Presentation] 肝細胞におけるイメグリミンのミトコンドリア機能、AMPK活性化、遺伝子発現における効果2023
- Author(s)
  穂積かおり, 菅原健二, 石原孝也, 石原直忠, 小川渉
- Organizer
  第58回日本臨床分子医学会学術総会
- Data Source
  KAKENHI-PROJECT-23K08007
[Presentation] Similarity and difference of intestinal actions of metformin and imeglimin2023
- Author(s)
  Sugawara K, Mizuma H, Sasaki D, Kondo A, Watanabe Y, Ogawa W
- Organizer
  59th EASD Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K08007
[Presentation] Quantitative analysis of metformin-induced glucose excretion in the intestine2023
- Author(s)
  Hosokawa Y, Sakaguchi K, Ito J, Morita Y, Sugawara K, Ogawa W
- Organizer
  The 83rd American Diabetes Association Scientific Sessions.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K08007
[Presentation] Effects of Imeglimin on Mitochondrial Function, AMPK Activation, and Gene Expression in Hepatocytes and Myocytes2023
- Author(s)
  Hozumi K, Sugawara K, Hirata Y, Nomura K, Ogawa W
- Organizer
  The 50th European Muscle Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K08007
[Presentation] The effects of imeglimin on incretin secretion2023
- Author(s)
  権映月, 菅原健二, 高橋晴美, 横井伯英, 大林健人, 岩崎有作, 清野進, 小川渉
- Organizer
  第66回日本糖尿病学会年次学術総会
- Data Source
  KAKENHI-PROJECT-23K08007
[Presentation] HNF1AとNEUROD1の変異を認めた若年発症糖尿病の1例2022
- Author(s)
  高吉倫史, 廣田勇士, 竹内健人, 芳村魁, 西影星二, 浜口哲矢, 菅原健二, 高岡裕, 佐竹渉, 小川渉
- Organizer
  第65回糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-20K08884
[Presentation] 肝臓におけるイメグリミンとメトホルミンの作用の類似性と相違性2022
- Author(s)
  穂積かおり, 菅原健二, 石原孝也, 石原直忠, 小川渉
- Organizer
  第95回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08884
[Presentation] 耐糖能の変遷を長期間観察し得た反応性低血糖を呈するA型インスリン抵抗症の1例2022
- Author(s)
  芳村魁, 廣田勇士, 西影星二, 上田真莉子, 山本あかね, 高吉倫史, 竹内健人, 中川靖, 浜口哲矢, 菅原健二, 小川渉
- Organizer
  第65回糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-20K08884
[Presentation] PET/MRI連続撮像法によるメトホルミン依存性腸管FDG排泄動態の解析2022
- Author(s)
  森田靖子, 坂口一彦, 野上宗伸, 伊藤潤, 金子景弘, 山田倫子, 駒田久子, 菅原健二, 廣田勇士, 小川渉
- Organizer
  第65回糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-20K08884
[Presentation] 新規FDG-PET/MRI撮像法の開発によるメトホルミン服用者における腸管ブドウ糖排泄の定量的解析2022
- Author(s)
  伊藤潤, 坂口一彦, 野上宗伸, 金子景弘, 森田靖子, 山田倫子, 駒田久子, 菅原健二, 廣田勇士, 小川渉
- Organizer
  第65回糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-20K08884
[Presentation] 肝臓におけるイメグリミンとメトホルミンの作用の類似性と相違性2022
- Author(s)
  穂積かおり, 菅原健二, 石原孝也, 石原直忠, 小川渉
- Organizer
  第65回糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-20K08884
[Presentation] 新規FDG-PET/MRI撮像法の開発によるメトホルミンの消化管ブドウ糖排泄作用の定量的分析2022
- Author(s)
  伊藤潤, 坂口一彦, 野上宗伸, 金子景弘, 森田靖子, 山田倫子, 駒田久子, 菅原健二, 廣田勇士, 小川渉
- Organizer
  第95回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08884
[Presentation] PET-MRI連続撮像法によるメトホルミン依存性腸管FDG排泄動態の解析2022
- Author(s)
  森田靖子, 野上宗伸, 坂口一彦, 伊藤潤, 金子景弘, 山田倫子, 駒田久子, 菅原健二, 廣田勇士, 村上卓道, 小川渉
- Organizer
  第43回日本肥満学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08884
[Presentation] 新規PET-MRI撮像法の開発によるメトホルミンによる腸管FDG集積の解析2022
- Author(s)
  伊藤潤, 野上宗伸, 坂口一彦, 金子景弘, 森田靖子, 山田倫子, 駒田久子, 菅原健二, 廣田勇士, 村上卓道, 小川渉
- Organizer
  第43回日本肥満学会
- Data Source
  KAKENHI-PROJECT-20K08884
[Presentation] メトホルミン内服患者におけるビタミンB12欠乏の実態調査2018
- Author(s)
  菅原健二, 岡田裕子, 野村和弘, 山田倫子, 中川靖, 福岡秀規, 廣田勇士, 細岡哲也, 坂口一彦, 木戸良明, 小川渉
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K19537
[Presentation] インスリノーマ新規変異型HNF4AによるMODY1の症例の分泌特性を規定する遺伝子の検討2017
- Author(s)
  菅原健二, 岡田裕子, 坂本洋一, 廣田勇士, 坂口一彦, 松本真明, 粟野宏之, 菅野亜紀, 髙岡裕, 小川渉
- Organizer
  第54回日本糖尿病学会近畿地方会
- Data Source
  KAKENHI-PROJECT-16K19537
[Presentation] Approaches to identification of novel small molecules that can be insulin secretagogues.2017
- Author(s)
  Takahashi H, Sugawara K, Honda K, Yokoi N, Mori I, Nakaya H, Seino S
- Organizer
  2nd Joint Meeting of the EASD Islet Study Group & Beta Cell Workshop
- Data Source
  KAKENHI-PROJECT-16K19537
[Presentation] 持効型インスリンが不要となった１型糖尿病の一例2017
- Author(s)
  苛原彩, 岡田裕子, 坂本洋一, 菅原健二, 福岡秀規, 廣田勇士, 坂口一彦, 小川渉
- Organizer
  第15回1型糖尿病研究会
- Data Source
  KAKENHI-PROJECT-16K19537
[Presentation] Chronic arsenic exposure impairs pancreatic beta cell function.2017
- Author(s)
  Carmean CM, Kirkley AG, Yokoi N, Hoshikawa R, Sugawara K, Sargis RM, Seino S.
- Organizer
  Society of Environmental Toxicology and Chemistry Conference.
- Data Source
  KAKENHI-PROJECT-16K19537
[Presentation] インスリノーマの分泌特性を規定する遺伝子の検討2017
- Author(s)
  菅原健二, 岡田裕子, 松田友和, 坂本洋一, 岩橋泰幸, 村前直和, 山田倫子, 中村友昭, 福岡秀規, 廣田勇士, 坂口一彦, 小川渉
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K19537
[Presentation] Chronic arsenic exposure impairs pancreatic beta cell function.2017
- Author(s)
  Carmean CM, Kirkley AG, Yokoi N, Hoshikawa R, Sugawara K, Sargis RM, Seino S.
- Organizer
  The 9th Scientific Meeting of Asian Association for the Study of Diabetes.
- Data Source
  KAKENHI-PROJECT-16K19537
[Presentation] 持効型インスリンが不要となった１型糖尿病の一例2017
- Author(s)
  苛原彩, 岡田裕子, 坂本洋一, 菅原健二, 福岡秀規, 廣田勇士, 坂口一彦, 小川渉
- Organizer
  第54回日本糖尿病学会近畿地方会
- Data Source
  KAKENHI-PROJECT-16K19537
[Presentation] インスリン分泌不全を基盤としてケトーシス発症し、MODY5の診断に至った一卵性双生児の例2017
- Author(s)
  小原靖子, 山田倫子, 岡田裕子, 坂本洋一, 菅原健二, 福岡秀規
- Organizer
  第54回日本糖尿病学会近畿地方会
- Data Source
  KAKENHI-PROJECT-16K19537
[Presentation] インスリン治療中の2型糖尿病患者におけるSGLT2阻害薬投与によるインスリン減量効果についての検討2017
- Author(s)
  岩橋泰幸, 岡田裕子, 坂本洋一, 村前直和, 山田倫子, 菅原健二, 中村友昭, 福岡秀規, 廣田勇士, 坂口一彦, 小川渉
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K19537
[Presentation] 1型糖尿病合併妊娠におけるCSIIとSensor Augmented Pump(SAP)療法のインスリン必要量の変化についての検討2017
- Author(s)
  坂本洋一, 岡田裕子, 山田倫子, 西本祐希, 苛原彩, 小原靖子, 瀬尾あかね, 中野温子, 藤原えり, 菅原健二, 福岡秀規, 廣田勇士, 坂口一彦, 小川渉
- Organizer
  第34回日本糖尿病・妊娠学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K19537
[Presentation] Insulin secretagogues and their signaling mechanisms.2017
- Author(s)
  Takahashi H, Sugawara K, Yokoi N, Seino S.
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K19537
[Presentation] 周期性が疑われた嗅神経芽細胞腫による異所性ACTH症候群の一例2017
- Author(s)
  金谷雅之,福岡秀規, 菅原健二, 岡田裕子, 井口元三, 小川渉, 高橋裕
- Organizer
  第90回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K19537
[Presentation] 1型糖尿病合併妊娠におけるCSIIとSensor Augmented Pump(SAP)療法のインスリン必要量の変化についての検討2017
- Author(s)
  坂本洋一, 岡田裕子, 山田倫子, 西本祐希, 岩橋泰幸, 村前直和, 菅原健二, 中村友昭, 福岡秀規, 廣田勇士, 坂口一彦, 小川渉
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K19537
[Presentation] 手術によって寛解後30年目に再発を認めたCushing病の一例2017
- Author(s)
  瀬尾あかね, 福岡秀規, 吉田健一, 小原靖子, 苛原彩, 中野温子, 藤原えり, 坂本洋一, 菅原健二, 岡田裕子, 廣田勇士, 井口元三, 小川渉, 高橋裕
- Organizer
  第27回臨床内分泌代謝Update
- Data Source
  KAKENHI-PROJECT-16K19537
[Presentation] Chronic Arsenic Exposure Impairs Pancreatic Function.2016
- Author(s)
  Carmean CM, Kirkley AG, Yokoi N, Hoshikawa R, Honda K, Gheni G, Sugawara K, Takahashi H, Sargis RM, Seino S.
- Organizer
  17th International Group on Insulin Secretion Conference
- Place of Presentation
  Nice, France
- Year and Date
  2016-04-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19537
[Presentation] Antidiabetic effect of trans-S-1-propenyl-L-cysteine sulfoxide from Allium cepa.2016
- Author(s)
  Okechi OS, Sugawara K, Takahashi H, Yokoi N, Nakayama M, Seino S.
- Organizer
  The 76th scientific sessions of the American Diabetes Association
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-05-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19537
[Presentation] KATPチャネルを標的とした新規低分子化合物の同定とその特性解析.2016
- Author(s)
  菅原健二、本田洸平、霊園良恵、松本明郎、森一郎、中谷晴昭、清野進
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  京都
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16K19537
[Presentation] Evaluation of the pharmacokinetics of a novel anti-diabetic agent using conventional LC/MS/MS.2016
- Author(s)
  Sugawara K, Yokoi N, Hoshikawa R, Matsubara T, Seino S.
- Organizer
  The 64th ASMS Conference on Mass Spectrometry and Allied Topics
- Place of Presentation
  San Antonio, Texas
- Year and Date
  2016-06-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860749
[Presentation] Antidiabetic effect of a sulfur compound, trans-S-1-propenyl-l-cysteine sulfoxide, in Allium cepa.2016
- Author(s)
  Okechi OS, Sugawara K, Takahashi H, Yokoi N, Nakayama M, Seino S
- Organizer
  The 59th Annual meeting of the Japan Diabetes Society
- Place of Presentation
  京都
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16K19537
[Presentation] Evaluation of the pharmacokinetics of a novel anti-diabetic agent using conventional LC/MS/MS.2016
- Author(s)
  Sugawara K, Yokoi N, Hoshikawa R, Matsubara T, Seino S.
- Organizer
  The 64th ASMS Conference on Mass Spectrometry and Allied Topics
- Place of Presentation
  San Antonio, USA
- Year and Date
  2016-06-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19537
[Presentation] KATPチャネルを標的とした新規低分子化合物の同定とその特性解析.2016
- Author(s)
  菅原健二、本田洸平、霊園良恵、松本明郎、森一郎、中谷晴昭、清野進.
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  京都
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-25860749
[Presentation] Chronic Arsenic Exposure Impairs Pancreatic Function.2016
- Author(s)
  Carmean CM, Kirkley AG, Yokoi N, Hoshikawa R, Honda K, Gheni G, Sugawara K, Takahashi H, Sargis RM, Seino S.
- Organizer
  17th International Group on Insulin Secretion Conference
- Place of Presentation
  Nice, France
- Year and Date
  2016-04-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860749
[Presentation] Antidiabetic effect of trans-S-1-propenyl-L-cysteine sulfoxide from Allium cepa.2016
- Author(s)
  Okechi OS, Sugawara K, Takahashi H, Yokoi N, Nakayama M, Seino S.
- Organizer
  The 76th scientific sessions of the American Diabetes Association
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860749
[Presentation] Identification of a novel small molecule targeting KATP channels to stimulate insulin secretion.2015
- Author(s)
  Sugawara K, Shibasaki T, Minami K, Matsumoto A, Seki C, Mori I, Nakaya H, Seino S.
- Organizer
  16th International group on insulin secretion
- Place of Presentation
  Nice, France
- Year and Date
  2015-04-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860749
[Presentation] インスリン分泌増強効果を有する新規低分子化合物の同定とその特性解析2014
- Author(s)
  下野琴絵、菅原健二、柴崎忠雄、清野進
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-24
- Data Source
  KAKENHI-PROJECT-25860749
[Presentation] インスリン分泌増強効果を有する新規低分子化合物の同定とその特性解析2014
- Author(s)
  下野琴絵、菅原健二、柴崎忠雄、清野進
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  大阪
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-25860749
[Presentation] スルホニル尿素（SU）薬とcAMPの協調作用によるEpac2A活性化2014
- Author(s)
  柴崎忠雄、高橋利匡、高橋晴美、菅原健二、清野進
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-23
- Data Source
  KAKENHI-PROJECT-25860749
[Presentation] Clarification of molecular mechanism underlying Epac2A activation by antidiabetic sulfonylurea drugs
- Author(s)
  Shibasaki T, Takahashi T, Takahashi H, Sugawara K, Seino S
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25860749
[Presentation] Identification and characterization of the binding site and properties of antidiabetic sulfonylurea drugs in the cAMP sensor Epac2A.
- Author(s)
  Takahashi T, Shibasaki T, Takahashi H, Sugawara K, Ono A, Seino S
- Organizer
  Beta Cell Workshop 2013 Kyoto
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-25860749
[Presentation] The role of Malate-aspartate shuttle derived glutamate in incretin potentiated insulin secretion.
- Author(s)
  Gheni G, Iwasaki M, Ogura M, Minami K, Yokoi N, Shibasaki T, Takahashi H, Sugawara K, Seino S
- Organizer
  5th International Uyghur Academy Conference
- Place of Presentation
  Istanbul, Turkey
- Data Source
  KAKENHI-PROJECT-25860749
[Presentation] Sulfonylureas act as an enhancer of Epac2 activation in cAMP-induced insulin secretion
- Author(s)
  Takahashi T, Shibasaki T, Takahashi H, Sugawara K, Ono A, Seino S
- Organizer
  American Diabetes Association's 73rd Scientific Sessions
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-25860749

1. 小川渉 (40294219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 坂口一彦 (20444573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. TAKAHASHI Harumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. MORISADA Naoya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 野上宗伸

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 横井伯英

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. 南幸太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 清野進

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
9. 柴崎忠雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
10. 石原孝也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sugawara Kenji 菅原 健二

Research Projects

Research Products

Co-Researchers

Analysis of the molecular mechanism of intestinal glucose excretion and its physiological significance.

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Elucidation of the molecular mechanism and physiological significance of retrograde glucose transport in the intestine.Principal Investigator

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A novel mechanism of metformin through iron chelationPrincipal Investigator

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A chemical proteomics approach to identify the novel mechanism of insulin secretion.Principal Investigator

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Identification of Epac2A agonists as novel anti-diabetic agents.Principal Investigator

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[Book] 糖尿病最新の治療2019-20212018

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[Book] 糖尿病学2015

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[Book] Diabetes Frontier 25巻5号2014

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[Book] 成人病と生活習慣病42巻12号 インクレチン関連薬による糖尿病治療の新時代2013

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[Journal Article] New mechanism of metformin action mediated by lysosomal presenilin enhancer 2.2023

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[Journal Article] Stimulatory effect of imeglimin on incretin secretion.2023

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[Journal Article] Effects of imeglimin on mitochondrial function, AMPK activity, and gene expression in hepatocytes2023

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[Journal Article] A novel view of the insulin signaling pathway based on prediction of protein structure by the AI platform AlphaFold.2023

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[Journal Article] A case of α-chain variant hemoglobin (Hb Chad) with falsely high HbA1c levels measured by immunoassay2022

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NAID

Sugawara Kenji 菅原健二

[Book] 成人病と生活習慣病42巻12号　インクレチン関連薬による糖尿病治療の新時代2013