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Umeki Nobuhisa  梅木 伸久

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梅木 伸久  ウメキ ノブヒサ

Nobuhisa Umeki  梅木 伸久

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Researcher Number 70647502
Other IDs
Affiliation (Current) 2025: 国立研究開発法人理化学研究所, 開拓研究所, 研究員
Affiliation (based on the past Project Information) *help 2018 – 2023: 国立研究開発法人理化学研究所, 開拓研究本部, 研究員
2015 – 2016: 国立研究開発法人理化学研究所, 佐甲細胞情報研究室, 研究員
2013 – 2014: 独立行政法人理化学研究所, 佐甲細胞情報研究室, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 43030:Functional biochemistry-related / Structural biochemistry
Keywords
Principal Investigator
低分子量Gタンパク質 / 構造多型 / 細胞内情報伝達 / 1分子計測 / Ras / 変異アクチン / 優性変異 / 細胞骨格 / 低分子量タンパク質 / 1分子計測 … More / 細胞増殖 / シグナル伝達 / 低分子量G蛋白質 / 一分子計測 / RalGDS Less
  • Research Projects

    (3 results)
  • Research Products

    (26 results)
  • Co-Researchers

    (8 People)
  •  変異アクチンの新規調製法の確立と疾病メカニズム解明に向けたアプローチPrincipal Investigator

    • Principal Investigator
      梅木 伸久
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43030:Functional biochemistry-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  分子認識反応における、R-Rasに特徴的なN末およびC末領域の役割Principal Investigator

    • Principal Investigator
      梅木 伸久
    • Project Period (FY)
      2018 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43030:Functional biochemistry-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  The novel molecular recognition mechanism of Ras by its structural polymorphismPrincipal Investigator

    • Principal Investigator
      Nobuhisa Umeki
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Structural biochemistry
    • Research Institution
      Institute of Physical and Chemical Research

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

  • [Journal Article] Evaluation of information flows in the RAS-MAPK system using transfer entropy measurements2023

    • Author(s)
      Umeki N.,Kabashima Y., Sako Y
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2023.08.06.552214

    • Open Access
    • Data Source
      KAKENHI-PROJECT-18K06123
  • [Journal Article] Assessing transfer entropy from biochemical data2022

    • Author(s)
      Imaizumi Takuya、Umeki Nobuhisa、Yoshizawa Ryo、Obuchi Tomoyuki、Sako Yasushi、Kabashima Yoshiyuki
    • Journal Title

      Physical Review E

      Volume: 105 Issue: 3 Pages: 1-13

    • DOI

      10.1103/physreve.105.034403

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K11463, KAKENHI-PROJECT-19H05647, KAKENHI-PROJECT-20H00620, KAKENHI-PROJECT-18K06123, KAKENHI-PROJECT-17H00764
  • [Journal Article] Biphasic spatiotemporal regulation of GRB2 dynamics by p52SHC for transient RAS activation2021

    • Author(s)
      Yoshizawa R., Umeki N., Yamamoto A., Murata M., Sako Y.
    • Journal Title

      Biophysics and Physicobiology

      Volume: 18 Issue: 0 Pages: 1-12

    • DOI

      10.2142/biophysico.bppb-v18.001

    • NAID

      130007981384

    • ISSN
      2189-4779
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06123, KAKENHI-PROJECT-19J11040
  • [Journal Article] p52Shc regulates the sustainability of ERK activation in a RAF-independent manner2021

    • Author(s)
      Yoshizawa Ryo、Umeki Nobuhisa、Yamamoto Akihiro、Okada Mariko、Murata Masayuki、Sako Yasushi
    • Journal Title

      Molecular Biology of the Cell

      Volume: 32 Issue: 19 Pages: 1838-1848

    • DOI

      10.1091/mbc.e21-01-0007

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H05647, KAKENHI-PROJECT-18K06123
  • [Journal Article] K336I mutant actin alters the structure of neighbouring protomers in filaments and reduces affinity for actin-binding proteins2019

    • Author(s)
      Umeki N., Shibata K., Noguchi TQP, Hirose K., Sako Y., Uyeda TQP.
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 5353-5353

    • DOI

      10.1038/s41598-019-41795-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06123, KAKENHI-PROJECT-19H01173
  • [Journal Article] Single-molecule fluorescence imaging of RalGDS on cell surfaces during signal transduction from Ras to Ral2017

    • Author(s)
      Yoshizawa R., Umeki N., Yanagawa M., Murata M., Sako Y.
    • Journal Title

      Biophysics and Physicobiology

      Volume: -

    • NAID

      130007040995

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25871145
  • [Journal Article] Interaction of a Novel Fluorescent GTP Analogue with the small G-protein K-Ras2016

    • Author(s)
      Seigo IWATA, Kaori MASUHARA, Nobuhisa UMEKI, Yasushi SAKO and Shinsaku MARUTA
    • Journal Title

      The Journal of Biochemistry

      Volume: 159 Issue: 1 Pages: 41-48

    • DOI

      10.1093/jb/mvv071

    • NAID

      40020725621

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K07060, KAKENHI-PROJECT-25871145, KAKENHI-PROJECT-15H02394
  • [Journal Article] Cofilin-induced cooperative conformational changes of actin subunits revealed using cofilin-actin fusion protein2016

    • Author(s)
      Umeki N., Hirose K., Uyeda TQ
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 20406-20406

    • DOI

      10.1038/srep20406

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25871145, KAKENHI-PLANNED-24117008
  • [Journal Article] Mutually exclusive cooperative binding of myosin and cofilin to actin filaments involves cooperative conformational changes of actin.2016

    • Author(s)
      Ngo KX, Umeki N, Kijima ST, Kodera N, Ueno H, Furutani-Umezu N, Nakajima J, Noguchi TQP, Nagasaki A, Tokuraku K, Uyeda TQP
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 35449-35449

    • DOI

      10.1038/srep35449

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-24117008, KAKENHI-PROJECT-15H04360, KAKENHI-PROJECT-16H03288, KAKENHI-PROJECT-25871145, KAKENHI-PROJECT-16K14704, KAKENHI-ORGANIZER-24117001
  • [Journal Article] The significance of membrane fluidity of feeder cell-derived substrates for maintenance of iPS cell stemness.2015

    • Author(s)
      Zhou Y, Mao H, Joddar B, Umeki N, Sako Y, Wada K, Nishioka C, Takahashi E, Wang Y, Ito Y.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 11386-11386

    • DOI

      10.1038/srep11386

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25871145
  • [Presentation] 蛍光イメージングによる、細胞内ERKの反応ダイナミクス計測2023

    • Author(s)
      梅木伸久・吉澤亮・佐甲靖志
    • Organizer
      第96回日本生化学大会
    • Data Source
      KAKENHI-PROJECT-23K05688
  • [Presentation] 細胞周期進行に伴い変化するRTK/RAS/MAPKシグナル伝達の計測2023

    • Author(s)
      吉澤亮、梅木伸久、佐甲靖志
    • Organizer
      第96回日本生化学大会
    • Data Source
      KAKENHI-PROJECT-18K06123
  • [Presentation] 蛍光イメージングによる、細胞内ERKの反応ダイナミクス計測2023

    • Author(s)
      梅木伸久、吉澤亮、佐甲靖志
    • Organizer
      第96回日本生化学大会
    • Data Source
      KAKENHI-PROJECT-18K06123
  • [Presentation] PI3K-PAK1 シグナル伝達はS-G2期におけるERK の活性化ダイナミクスを制御する2023

    • Author(s)
      吉澤亮、梅木伸久、佐甲靖志
    • Organizer
      第61回日本生物物理学会年会
    • Data Source
      KAKENHI-PROJECT-18K06123
  • [Presentation] PI3Kシグナル伝達はS-G2期のERKの時間的調節において重要な役割を果たす2022

    • Author(s)
      吉沢亮、梅木伸久、佐甲靖志
    • Organizer
      生物物理学会
    • Data Source
      KAKENHI-PROJECT-18K06123
  • [Presentation] 生化学反応データからの移動エントロピーの評価2022

    • Author(s)
      今泉・梅木・吉澤・小渕・佐甲・樺島
    • Organizer
      日本物理学会年会
    • Data Source
      KAKENHI-PROJECT-18K06123
  • [Presentation] p52SHC in the cytoplasm negatively regulates GRB2 translocation to the plasma membrane2020

    • Author(s)
      吉澤亮、梅木伸久、村田昌之、佐甲靖志
    • Organizer
      第58回日本生物物理学会年会
    • Data Source
      KAKENHI-PROJECT-18K06123
  • [Presentation] p52Shcは時間依存的にGrb2のシグナル伝達ダイナミクスを制御する2019

    • Author(s)
      吉澤亮、梅木伸久、柳川正隆、村田昌之、佐甲靖志
    • Organizer
      日本生物物理学会
    • Data Source
      KAKENHI-PROJECT-18K06123
  • [Presentation] MCF細胞内におけるp52ShcのGrb2シグナル伝達制御2018

    • Author(s)
      吉澤亮、梅木伸久、柳川正隆、村田昌之、佐甲靖志
    • Organizer
      日本生物物理学会
    • Data Source
      KAKENHI-PROJECT-18K06123
  • [Presentation] Photocontrol of small G-protein H-Ras multimer formation using caged compounds2016

    • Author(s)
      Iwata S., Hashimoto T., Umeki N., Sugimoto Y., Kondo K., Maruta S.
    • Organizer
      American biophysical society 60th annual meeting
    • Place of Presentation
      Los Angeles, USA
    • Year and Date
      2016-02-27
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25871145
  • [Presentation] Elucidation of the EGF dependent localization mechanism of RalGDS molecule to plasma membrane using TIRF microscopy2016

    • Author(s)
      Yoshizawa R., Umeki N., Yanagawa M., Murata M., Sako Y.
    • Organizer
      第54回日本生物物理学会年会
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-25
    • Data Source
      KAKENHI-PROJECT-25871145
  • [Presentation] Ras-RalGDS相互作用の1分子蛍光イメージング2015

    • Author(s)
      梅木伸久、吉澤亮、中村由樹、稲葉岳彦、前田亮、柳川正隆、佐甲靖志
    • Organizer
      第88回日本生化学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25871145
  • [Presentation] ケイジド化合物導入による低分子量Gタンパク質H-Rasの多量体形成の光制御2015

    • Author(s)
      岩田聖悟、橋本貴志、梅木伸久、近藤和典、丸田晋策
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢
    • Year and Date
      2015-09-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25871145
  • [Presentation] Photo-regulation of small G protein normal and oncogenic K-ras using Photochromic molecules.

    • Author(s)
      Iwata S, Masuhara K, Umeki N, Kondo K, Maruta S
    • Organizer
      American bio-physics 59th annual meeting
    • Place of Presentation
      Baltimore USA
    • Year and Date
      2015-02-07 – 2015-02-11
    • Data Source
      KAKENHI-PROJECT-25871145
  • [Presentation] Photo-regulation of the interaction between ras and ralgds using GTP analogues composed of photochromic molecules

    • Author(s)
      Masuhara K, Iwata S, Umeki N, Maruta S
    • Organizer
      American bio-physics 59th annual meeting
    • Place of Presentation
      Baltimore USA
    • Year and Date
      2015-02-07 – 2015-02-11
    • Data Source
      KAKENHI-PROJECT-25871145
  • [Presentation] photo-regulation of small G-pritein K-ras using photochromic molecules

    • Author(s)
      Iwata S, Masuhara K, Umeki N, Kondo K, Maruta S
    • Organizer
      日本生物物理学会第52回年会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-25871145
  • 1.  TOKURAKU Kiyotaka
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 2.  Ngo Xuan Kien
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  小渕 智之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  丸田 普策
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  上田 太郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  長崎 晃
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  野口 太郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  佐甲 靖志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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