Umeki Nobuhisa 梅木伸久

… Alternative Names

梅木伸久ウメキノブヒサ

Nobuhisa Umeki 梅木伸久

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Researcher Number	70647502
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 開拓研究所, 研究員
Affiliation (based on the past Project Information) *help	2018 – 2023: 国立研究開発法人理化学研究所, 開拓研究本部, 研究員 2015 – 2016: 国立研究開発法人理化学研究所, 佐甲細胞情報研究室, 研究員 2013 – 2014: 独立行政法人理化学研究所, 佐甲細胞情報研究室, 研究員
Review Section/Research Field	Principal Investigator Basic Section 43030:Functional biochemistry-related / Structural biochemistry
Keywords	Principal Investigator 低分子量Gタンパク質 / 構造多型 / 細胞内情報伝達 / 1分子計測 / Ras / 変異アクチン / 優性変異 / 細胞骨格 / 低分子量タンパク質 / １分子計測 … More / 細胞増殖 / シグナル伝達 / 低分子量G蛋白質 / 一分子計測 / RalGDS Less

変異アクチンの新規調製法の確立と疾病メカニズム解明に向けたアプローチPrincipal Investigator
- Principal Investigator
  
  梅木伸久
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
分子認識反応における、R-Rasに特徴的なN末およびC末領域の役割Principal Investigator
- Principal Investigator
  
  梅木伸久
- Project Period (FY)
  2018 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
The novel molecular recognition mechanism of Ras by its structural polymorphismPrincipal Investigator
- Principal Investigator
  
  Nobuhisa Umeki
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Institute of Physical and Chemical Research

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Evaluation of information flows in the RAS-MAPK system using transfer entropy measurements2023
- Author(s)
  Umeki N.,Kabashima Y., Sako Y
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2023.08.06.552214
- Open Access
- Data Source
  KAKENHI-PROJECT-18K06123
[Journal Article] Assessing transfer entropy from biochemical data2022
- Author(s)
  Imaizumi Takuya、Umeki Nobuhisa、Yoshizawa Ryo、Obuchi Tomoyuki、Sako Yasushi、Kabashima Yoshiyuki
- Journal Title
  
  Physical Review E
  
  Volume: 105 Issue: 3 Pages: 1-13
- DOI
  10.1103/physreve.105.034403
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11463, KAKENHI-PROJECT-19H05647, KAKENHI-PROJECT-20H00620, KAKENHI-PROJECT-18K06123, KAKENHI-PROJECT-17H00764
[Journal Article] Biphasic spatiotemporal regulation of GRB2 dynamics by p52SHC for transient RAS activation2021
- Author(s)
  Yoshizawa R., Umeki N., Yamamoto A., Murata M., Sako Y.
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: 18 Issue: 0 Pages: 1-12
- DOI
  10.2142/biophysico.bppb-v18.001
- NAID
  130007981384
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06123, KAKENHI-PROJECT-19J11040
[Journal Article] p52Shc regulates the sustainability of ERK activation in a RAF-independent manner2021
- Author(s)
  Yoshizawa Ryo、Umeki Nobuhisa、Yamamoto Akihiro、Okada Mariko、Murata Masayuki、Sako Yasushi
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: 32 Issue: 19 Pages: 1838-1848
- DOI
  10.1091/mbc.e21-01-0007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H05647, KAKENHI-PROJECT-18K06123
[Journal Article] K336I mutant actin alters the structure of neighbouring protomers in filaments and reduces affinity for actin-binding proteins2019
- Author(s)
  Umeki N., Shibata K., Noguchi TQP, Hirose K., Sako Y., Uyeda TQP.
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 5353-5353
- DOI
  10.1038/s41598-019-41795-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06123, KAKENHI-PROJECT-19H01173
[Journal Article] Single-molecule fluorescence imaging of RalGDS on cell surfaces during signal transduction from Ras to Ral2017
- Author(s)
  Yoshizawa R., Umeki N., Yanagawa M., Murata M., Sako Y.
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: -
- NAID
  130007040995
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25871145
[Journal Article] Interaction of a Novel Fluorescent GTP Analogue with the small G-protein K-Ras2016
- Author(s)
  Seigo IWATA, Kaori MASUHARA, Nobuhisa UMEKI, Yasushi SAKO and Shinsaku MARUTA
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 159 Issue: 1 Pages: 41-48
- DOI
  10.1093/jb/mvv071
- NAID
  40020725621
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07060, KAKENHI-PROJECT-25871145, KAKENHI-PROJECT-15H02394
[Journal Article] Cofilin-induced cooperative conformational changes of actin subunits revealed using cofilin-actin fusion protein2016
- Author(s)
  Umeki N., Hirose K., Uyeda TQ
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 20406-20406
- DOI
  10.1038/srep20406
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25871145, KAKENHI-PLANNED-24117008
[Journal Article] Mutually exclusive cooperative binding of myosin and cofilin to actin filaments involves cooperative conformational changes of actin.2016
- Author(s)
  Ngo KX, Umeki N, Kijima ST, Kodera N, Ueno H, Furutani-Umezu N, Nakajima J, Noguchi TQP, Nagasaki A, Tokuraku K, Uyeda TQP
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 35449-35449
- DOI
  10.1038/srep35449
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-24117008, KAKENHI-PROJECT-15H04360, KAKENHI-PROJECT-16H03288, KAKENHI-PROJECT-25871145, KAKENHI-PROJECT-16K14704, KAKENHI-ORGANIZER-24117001
[Journal Article] The significance of membrane fluidity of feeder cell-derived substrates for maintenance of iPS cell stemness.2015
- Author(s)
  Zhou Y, Mao H, Joddar B, Umeki N, Sako Y, Wada K, Nishioka C, Takahashi E, Wang Y, Ito Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Issue: 1 Pages: 11386-11386
- DOI
  10.1038/srep11386
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25871145
[Presentation] 蛍光イメージングによる、細胞内ERKの反応ダイナミクス計測2023
- Author(s)
  梅木伸久・吉澤亮・佐甲靖志
- Organizer
  第96回日本生化学大会
- Data Source
  KAKENHI-PROJECT-23K05688
[Presentation] 細胞周期進行に伴い変化するRTK/RAS/MAPKシグナル伝達の計測2023
- Author(s)
  吉澤亮、梅木伸久、佐甲靖志
- Organizer
  第96回日本生化学大会
- Data Source
  KAKENHI-PROJECT-18K06123
[Presentation] 蛍光イメージングによる、細胞内ERKの反応ダイナミクス計測2023
- Author(s)
  梅木伸久、吉澤亮、佐甲靖志
- Organizer
  第96回日本生化学大会
- Data Source
  KAKENHI-PROJECT-18K06123
[Presentation] PI3K-PAK1 シグナル伝達はS-G2期におけるERK の活性化ダイナミクスを制御する2023
- Author(s)
  吉澤亮、梅木伸久、佐甲靖志
- Organizer
  第61回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-18K06123
[Presentation] PI3Kシグナル伝達はS-G2期のERKの時間的調節において重要な役割を果たす2022
- Author(s)
  吉沢亮、梅木伸久、佐甲靖志
- Organizer
  生物物理学会
- Data Source
  KAKENHI-PROJECT-18K06123
[Presentation] 生化学反応データからの移動エントロピーの評価2022
- Author(s)
  今泉・梅木・吉澤・小渕・佐甲・樺島
- Organizer
  日本物理学会年会
- Data Source
  KAKENHI-PROJECT-18K06123
[Presentation] p52SHC in the cytoplasm negatively regulates GRB2 translocation to the plasma membrane2020
- Author(s)
  吉澤亮、梅木伸久、村田昌之、佐甲靖志
- Organizer
  第58回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-18K06123
[Presentation] p52Shcは時間依存的にGrb2のシグナル伝達ダイナミクスを制御する2019
- Author(s)
  吉澤亮、梅木伸久、柳川正隆、村田昌之、佐甲靖志
- Organizer
  日本生物物理学会
- Data Source
  KAKENHI-PROJECT-18K06123
[Presentation] MCF細胞内におけるp52ShcのGrb2シグナル伝達制御2018
- Author(s)
  吉澤亮、梅木伸久、柳川正隆、村田昌之、佐甲靖志
- Organizer
  日本生物物理学会
- Data Source
  KAKENHI-PROJECT-18K06123
[Presentation] Photocontrol of small G-protein H-Ras multimer formation using caged compounds2016
- Author(s)
  Iwata S., Hashimoto T., Umeki N., Sugimoto Y., Kondo K., Maruta S.
- Organizer
  American biophysical society 60th annual meeting
- Place of Presentation
  Los Angeles, USA
- Year and Date
  2016-02-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25871145
[Presentation] Elucidation of the EGF dependent localization mechanism of RalGDS molecule to plasma membrane using TIRF microscopy2016
- Author(s)
  Yoshizawa R., Umeki N., Yanagawa M., Murata M., Sako Y.
- Organizer
  第54回日本生物物理学会年会
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-25871145
[Presentation] Ras-RalGDS相互作用の1分子蛍光イメージング2015
- Author(s)
  梅木伸久、吉澤亮、中村由樹、稲葉岳彦、前田亮、柳川正隆、佐甲靖志
- Organizer
  第88回日本生化学会年会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25871145
[Presentation] ケイジド化合物導入による低分子量Gタンパク質H-Rasの多量体形成の光制御2015
- Author(s)
  岩田聖悟、橋本貴志、梅木伸久、近藤和典、丸田晋策
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  金沢
- Year and Date
  2015-09-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25871145
[Presentation] Photo-regulation of small G protein normal and oncogenic K-ras using Photochromic molecules.
- Author(s)
  Iwata S, Masuhara K, Umeki N, Kondo K, Maruta S
- Organizer
  American bio-physics 59th annual meeting
- Place of Presentation
  Baltimore USA
- Year and Date
  2015-02-07 – 2015-02-11
- Data Source
  KAKENHI-PROJECT-25871145
[Presentation] Photo-regulation of the interaction between ras and ralgds using GTP analogues composed of photochromic molecules
- Author(s)
  Masuhara K, Iwata S, Umeki N, Maruta S
- Organizer
  American bio-physics 59th annual meeting
- Place of Presentation
  Baltimore USA
- Year and Date
  2015-02-07 – 2015-02-11
- Data Source
  KAKENHI-PROJECT-25871145
[Presentation] photo-regulation of small G-pritein K-ras using photochromic molecules
- Author(s)
  Iwata S, Masuhara K, Umeki N, Kondo K, Maruta S
- Organizer
  日本生物物理学会第52回年会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25871145

1. TOKURAKU Kiyotaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. Ngo Xuan Kien

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 小渕智之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 丸田普策

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# of Collaborated Products: 1 results
5. 上田太郎

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# of Collaborated Products: 1 results
6. 長崎晃

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# of Collaborated Products: 1 results
7. 野口太郎

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# of Collaborated Products: 1 results
8. 佐甲靖志

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# of Collaborated Products: 1 results

Umeki Nobuhisa 梅木 伸久

梅木 伸久 ウメキ ノブヒサ

Nobuhisa Umeki 梅木 伸久

Research Projects

Research Products

Co-Researchers

変異アクチンの新規調製法の確立と疾病メカニズム解明に向けたアプローチPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

分子認識反応における、R-Rasに特徴的なN末およびC末領域の役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The novel molecular recognition mechanism of Ras by its structural polymorphismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Evaluation of information flows in the RAS-MAPK system using transfer entropy measurements2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Assessing transfer entropy from biochemical data2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biphasic spatiotemporal regulation of GRB2 dynamics by p52SHC for transient RAS activation2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] p52Shc regulates the sustainability of ERK activation in a RAF-independent manner2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] K336I mutant actin alters the structure of neighbouring protomers in filaments and reduces affinity for actin-binding proteins2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single-molecule fluorescence imaging of RalGDS on cell surfaces during signal transduction from Ras to Ral2017

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Interaction of a Novel Fluorescent GTP Analogue with the small G-protein K-Ras2016

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Cofilin-induced cooperative conformational changes of actin subunits revealed using cofilin-actin fusion protein2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutually exclusive cooperative binding of myosin and cofilin to actin filaments involves cooperative conformational changes of actin.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The significance of membrane fluidity of feeder cell-derived substrates for maintenance of iPS cell stemness.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] 蛍光イメージングによる、細胞内ERKの反応ダイナミクス計測2023

Author(s)

Umeki Nobuhisa 梅木伸久

梅木伸久ウメキノブヒサ

Nobuhisa Umeki 梅木伸久