Mera Hisashi 目良恒

… Alternative Names

MERA Hisashi 目良恒

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Researcher Number	70650381
Other IDs
Affiliation (Current)	2025: 新潟大学, 医歯学総合病院, 特任講師
Affiliation (based on the past Project Information) *help	2018 – 2023: 新潟大学, 医歯学総合病院, 特任講師 2016: 新潟大学, 地域医療教育センター魚沼基幹病院, 講師 2014: 武庫川女子大学, スポーツ健康科学部, 博士研究員 2014: 武庫川女子大学, スポーツ健康科学部, 研究員 2013: 武庫川女子大学, 健康・スポーツ科学部, 博士研究員
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Orthopaedic surgery Except Principal Investigator Basic Section 38060:Applied molecular and cellular biology-related / Applied molecular and cellular biology / Morphological basic dentistry
Keywords	Principal Investigator マイクロRNA / 関節軟骨修復 / シングルセル解析 / 細胞外小胞体 / RNA / フローサイトメーター / 滑膜組織 / 関節内代謝 / 変形性膝関節症 / micro RNAs … More / Muse細胞 / 間葉系幹細胞 / エクソソーム / 組織修復・再生 / 軟骨修復・再生 / 脂肪由来幹細胞 / 幹細胞 / non-coding RNA / 軟骨分化能 / miR708-5p / 軟骨分化度マーカー / 骨髄細胞 / 関節軟骨修復・再生 … More Except Principal Investigator マクロファージ / 骨粗鬆症 / 遺伝子ノックアウト / CRISPR/Cas9 / ゲノム編集 / オーファンGPCR / 破骨細胞 / シグナル伝達 / リソソーム / 骨形態 / レンチウィルスベクター / RANKL / Raw264 / 骨髄細胞 / ノックアウトマウス / G蛋白質共役型受容体 / トランスクリプトーム / 医療・福祉 / 遺伝子 / 骨代謝 / オーファン受容体 / GPCR / マイクロアレイ / マクロファージ極性化 / 転写調節因子 / 間葉系細胞 / MAPK / p38シグナル / Wntシグナル / 軟骨細胞 / Irx3 Less

Exploration of the homeostatic mechanisms on the joint metabolism regulated via extracellular vesicles.Principal Investigator
- Principal Investigator
  
  目良恒
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Niigata University
Elucidation of the mechanism underlying osteoclastic differentiation and functional regulation by ligand-independent GPCR activation
- Principal Investigator
  
  ISHIBASHI OSAMU
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38060:Applied molecular and cellular biology-related
- Research Institution
  Osaka Metropolitan University
  Osaka Prefecture University
The investigation of the micro RNAs to contribute cartilage repair.Principal Investigator
- Principal Investigator
  
  Mera Hisashi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Niigata University
Functional analysis of an osteoclast-specific G protein-coupled receptor, GPR137B, and exploration of its regulatory molecules
- Principal Investigator
  
  Ishibashi Osamu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Osaka Prefecture University
Role of Irx3 in chondrogenic differentiation and chondrocyte maturation of mouse mesenchymal cells
- Principal Investigator
  
  Tamamura Yoshihiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Mukogawa Women's University
Identification of non-coding RNA associated with the proliferative and chondrogenic abilities of human bone marrow mesenchymal stem cellsPrincipal Investigator
- Principal Investigator
  
  MERA Hisashi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Mukogawa Women's University

All 2023 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Review of Caplan (1991) on cell-based therapeutic technology using Mesenchymal Stem Cells2023
- Author(s)
  Wakitani Shigeyuki、Mera Hisashi、Nakamura Norimasa、Gobbi Alberto
- Journal Title
  
  Journal of ISAKOS
  
  Volume: xxx Issue: 3 Pages: 426-430
- DOI
  10.1016/j.jisako.2023.08.010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09245
[Journal Article] 再生医療・幹細胞研究が切り拓く関節治療2023
- Author(s)
  目良恒
- Journal Title
  
  Seibutsu-kogaku Kaishi
  
  Volume: 101 Issue: 11 Pages: 595-595
- DOI
  10.34565/seibutsukogaku.101.11_595
- ISSN
  0919-3758, 2435-8630
- Year and Date
  2023-11-25
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-21K09245
[Journal Article] Irx3 and Bmp2 regulate mouse mesenchymal cell chondrogenic differentiation in both a Sox9-dependent and -independent manner2017
- Author(s)
  Tamamura Y, Katsube K, Mera H, Itokazu M, Wakitani S
- Journal Title
  
  J. Cell. Physiol.
  
  Volume: 印刷中 Issue: 12 Pages: 3317-3336
- DOI
  10.1002/jcp.25776
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462805, KAKENHI-PROJECT-17K01044, KAKENHI-PROJECT-17K11636
[Journal Article] Transplantation of Scaffold-free Cartilage-Like Cell Sheets Made from Human Bone Marrow Mesenchymal Stem Cells for Cartilage Repair: Preclinical Study2016
- Author(s)
  Maki Itokazu, Shigeyuki Wakitani, Hisashi Mera, Yoshihiro Tamamura, Yasushi Sato, Mutsumi Takagi, Hiroaki Nakamura
- Journal Title
  
  Cartilage
  
  Volume: 9 Issue: 4 Pages: 1-12
- DOI
  10.1177/1947603515627342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462805, KAKENHI-PROJECT-14J00491
[Journal Article] 骨髄間葉系幹細胞からの軟骨様細胞シートの作成および移植（前臨床試験）2015
- Author(s)
  糸数万紀、目良恒、玉村禎宏、高木睦、脇谷滋之
- Journal Title
  
  関節外科
  
  Volume: 34 Pages: 108-117
- Data Source
  KAKENHI-PROJECT-26462805
[Journal Article] Cartilage Repair With Autologous Bone Marrow Mesenchymal Stem Cell Transplantation: Review of Preclinical and Clinical Studies.2014
- Author(s)
  Yamasaki S., Mera H., Itokazu M., Hashimoto Y., Wakitani S.
- Journal Title
  
  Cartilage
  
  Volume: 5(4) Issue: 4 Pages: 196-202
- DOI
  10.1177/1947603514534681
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25893277
[Journal Article] Potential for Tumorigenesis and Repair Osteochondral Defects by iPS cell Transplantation in Rat.2014
- Author(s)
  Mera H., Takigami J., Tamamura Y., Itokazu M., Yamazoe M., Hashimoto Y., Endo N., Wakitani S.
- Journal Title
  
  American Journal of Tissue Engineering and Stem cell.
  
  Volume: 1(1) Pages: 39-50
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25893277
[Presentation] 骨髄間葉系細胞における軟骨分化能に関与するマイクロRNAの検討2018
- Author(s)
  目良　恒
- Organizer
  第18回　日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-18K09021
[Presentation] Identification of micro-RNA associated with the chondrogenic ability of human bone marrow mesenchymal stem cells.2018
- Author(s)
  Hisashi Mera
- Organizer
  TERMIS-kyoto
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09021
[Presentation] 骨髄間葉系細胞の軟骨分化能の個体差を規定するマイクロRNAの検討2018
- Author(s)
  目良　恒
- Organizer
  第32回　日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-18K09021
[Presentation] ヒト骨髄細胞由来scaffold-free再生軟骨様細胞シ-ト作製の工夫2014
- Author(s)
  糸数万紀、目良恒、佐藤康史、中村博亮、脇谷滋之
- Organizer
  第27回　日本軟骨代謝学会
- Place of Presentation
  京都府医師会館
- Data Source
  KAKENHI-PROJECT-25893277
[Presentation] ヒト骨髄細胞由来scaffold-free再生軟骨様細胞シ-ト作製の工夫2014
- Author(s)
  目良恒、糸数万紀、高木睦、脇谷滋之
- Organizer
  第217回　新潟整形外科研究会
- Place of Presentation
  新潟大学医学部有壬記念館
- Data Source
  KAKENHI-PROJECT-25893277
[Presentation] THE ENHANCEMENT OF HUMAN BONE MARROW DERIVED MESENCHYMAL STEM CELLS (HBMSCS) FOR SCAFFOLD-FREE CARTILAGE-LIKE CELL-SHEETS2014
- Author(s)
  Maki Itokazu, Hisashi Mera, Yasushi Sato, Hiroaki Nakamura, Mutsumi Takagi, Shigeyuki Wakitani
- Organizer
  2014 World congress on Osteoarturitis (OARSI)
- Place of Presentation
  The center of New Industries and Technologies, Paris, France
- Data Source
  KAKENHI-PROJECT-25893277
[Presentation] 変形性関節症と再生医療2014
- Author(s)
  目良恒、脇谷滋之
- Organizer
  第58回　日本リウマチ学会
- Place of Presentation
  グランドプリンスホテル新高輪
- Invited
- Data Source
  KAKENHI-PROJECT-25893277
[Presentation] The population of human bone　marrow mesenchymal stem cells supplemented with basic fibroblast growth factor for chondrogenic differentiation.
- Author(s)
  Hisashi Mera, Yoshihiro Tamamura, Maki Itokazu, Miki Asada, Shigeyuki Wakitani
- Organizer
  Osteoarthritis Research Society International
- Place of Presentation
  Washington State Convention Center, Seattle, WA, (USA)
- Year and Date
  2015-04-30 – 2015-05-03
- Data Source
  KAKENHI-PROJECT-25893277
[Presentation] 骨髄間葉系細胞を用いた関節軟骨再生治療の研究開発
- Author(s)
  目良恒、石橋宰、高木睦、脇谷滋之
- Organizer
  第7回　日本関節鏡・膝・スポーツ整形外科学会（JOSKAS）
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌市）
- Year and Date
  2015-06-18 – 2015-06-20
- Invited
- Data Source
  KAKENHI-PROJECT-25893277
[Presentation] 変形性関節症と再生医療
- Author(s)
  目良恒、脇谷滋之
- Organizer
  第58回　日本リウマチ学会総会・学術集会
- Place of Presentation
  グランドプリンスホテル新高輪（東京都・港区）
- Year and Date
  2014-04-24 – 2014-04-26
- Invited
- Data Source
  KAKENHI-PROJECT-25893277
[Presentation] 転写調節因子Irx3の初期軟骨細胞分化における役割について
- Author(s)
  玉村禎宏、目良恒、糸数万紀、脇谷滋之
- Organizer
  第28回日本軟骨代謝学会
- Place of Presentation
  東京医科歯科大学（東京都、文京区、湯島）
- Year and Date
  2015-03-06 – 2015-03-07
- Data Source
  KAKENHI-PROJECT-26462805

1. Ishibashi Osamu (70293214)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. 望月友晴 (00773607)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 谷藤理 (30748348)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 乾隆 (80352912)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. Tamamura Yoshihiro (70431963)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. WAKITANI Shigeyuki (70243243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. 池亀美華 (70282986)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YOSHIYA Shin-ichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. ISLAM Zohirul

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Mera Hisashi 目良 恒

MERA Hisashi 目良 恒

Research Projects

Research Products

Co-Researchers

Exploration of the homeostatic mechanisms on the joint metabolism regulated via extracellular vesicles.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism underlying osteoclastic differentiation and functional regulation by ligand-independent GPCR activation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The investigation of the micro RNAs to contribute cartilage repair.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of an osteoclast-specific G protein-coupled receptor, GPR137B, and exploration of its regulatory molecules

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of Irx3 in chondrogenic differentiation and chondrocyte maturation of mouse mesenchymal cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of non-coding RNA associated with the proliferative and chondrogenic abilities of human bone marrow mesenchymal stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Review of Caplan (1991) on cell-based therapeutic technology using Mesenchymal Stem Cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 再生医療・幹細胞研究が切り拓く関節治療2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Irx3 and Bmp2 regulate mouse mesenchymal cell chondrogenic differentiation in both a Sox9-dependent and -independent manner2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transplantation of Scaffold-free Cartilage-Like Cell Sheets Made from Human Bone Marrow Mesenchymal Stem Cells for Cartilage Repair: Preclinical Study2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 骨髄間葉系幹細胞からの軟骨様細胞シートの作成および移植（前臨床試験）2015

Author(s)

Journal Title

Data Source

[Journal Article] Cartilage Repair With Autologous Bone Marrow Mesenchymal Stem Cell Transplantation: Review of Preclinical and Clinical Studies.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Potential for Tumorigenesis and Repair Osteochondral Defects by iPS cell Transplantation in Rat.2014

Author(s)

Journal Title

Data Source

[Presentation] 骨髄間葉系細胞における 軟骨分化能に関与するマイクロRNAの検討2018

Author(s)

Organizer

Mera Hisashi 目良恒

MERA Hisashi 目良恒

[Presentation] 骨髄間葉系細胞における軟骨分化能に関与するマイクロRNAの検討2018

[Presentation] The population of human bone　marrow mesenchymal stem cells supplemented with basic fibroblast growth factor for chondrogenic differentiation.