Kishimoto Keishi 岸本圭史

Researcher Number	70700029
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員 2018 – 2024: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員 2018: 国立研究開発法人理化学研究所, その他部局等, 研究員 2017: 国立研究開発法人理化学研究所, 多細胞システム形成研究センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Developmental biology / Basic Section 44020:Developmental biology-related
Keywords	Principal Investigator 間充織 / 気管 / オルガノイド / 幹細胞 / ヒトES細胞 / 食道 / 細胞極性 / マウス気管 / 極性 / 上皮間充織相互作用 … More / 多能性幹細胞 / １細胞転写解析 / 自己組織化 / 気管軟骨 / Wnt signaling / 上皮 / Wnt / 極性化 / 呼吸器 / 中胚葉 / 内胚葉 / 平滑筋 / マウス Less

上皮間充織相互作用を反映した気管食道オルガノイド開発による気管食道形成不全の理解Principal Investigator
- Principal Investigator
  
  岸本圭史
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Institute of Physical and Chemical Research
Understanding the principle of self-organization which directs respiratory organPrincipal Investigator
- Principal Investigator
  
  岸本圭史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Institute of Physical and Chemical Research
Establishing 3-dimentional structure of trachea and esophageal organoid toward understanding the mechanism underlying mesenchymal polarizationPrincipal Investigator
- Principal Investigator
  
  Kishimoto Keishi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Research Field
  
  Developmental biology
- Research Institution
  Institute of Physical and Chemical Research
Elucidating the mechanism underlying the mesenchymal polarization of the trachea through Wnt signalingPrincipal Investigator
- Principal Investigator
  
  Kishimoto Keishi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  Institute of Physical and Chemical Research
The mechanism of mesenchymal cell polarity in mouse tracheal smooth musclePrincipal Investigator
- Principal Investigator
  
  Kishimoto Keishi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Developmental biology
- Research Institution
  Institute of Physical and Chemical Research

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book Patent

[Book] 決定版　オルガノイド実験スタンダード2019
- Author(s)
  岸本　圭史、森本　充
- Total Pages
  372
- Publisher
  羊土社
- ISBN
  9784758122399
- Data Source
  KAKENHI-PROJECT-17K15133
[Book] 実験医学2018年11月号2018
- Author(s)
  岸本　圭史、森本　充
- Total Pages
  145
- Publisher
  羊土社
- ISBN
  9784758125130
- Data Source
  KAKENHI-PROJECT-17K15133
[Journal Article] Deciphering Endothelial and Mesenchymal Organ Specification in Vascularized Lung and Intestinal Organoids2024
- Author(s)
  Miao Y, Tan C, Pek NM, Yu Z, Iwasawa K, Kechele DO, Sundaram N, Pastrana-Gomez V, Kishimoto K, Yang M, Jiang C, Tchieu J, Whitsett JA, McCracken KW, Rottier RJ, Kotton DN, Helmrath MA, Wells JM, Takebe T, Zorn AM, Chen Y, Guo M, Gu M
- Journal Title
  
  Biorxiv
  
  Volume: -
- DOI
  10.1101/2024.02.06.577460
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24344
[Journal Article] Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems.2022
- Author(s)
  Keishi Kishimoto, Kentaro Iwasawa, Alice Sorel, Carlos Ferran-Heredia, Lu Han, Mitsuru Morimoto, James M Wells, Takanori Takebe and Aaron M Zorn
- Journal Title
  
  nature protocols
  
  Volume: -
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0423
[Journal Article] Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems2022
- Author(s)
  Kishimoto K, Iwasawa K, Sorel A, Ferran-Heredia C, Han L, Morimoto M, Wells JM, Takebe T, Zorn AM.
- Journal Title
  
  Nat Protoc
  
  Volume: 17 Issue: 11 Pages: 2699-2719
- DOI
  10.1038/s41596-022-00733-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04822, KAKENHI-PROJECT-18KK0423, KAKENHI-PUBLICLY-22H05640, KAKENHI-PROJECT-20H03693, KAKENHI-PROJECT-23K24344
[Journal Article] Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells2022
- Author(s)
  Eicher Alexandra K.、Kechele Daniel O.、Sundaram Nambirajan、Berns H. Matthew、Poling Holly M.、Haines Lauren E.、Sanchez J. Guillermo、Kishimoto Keishi、Krishnamurthy Mansa、Han Lu、Zorn Aaron M.、Helmrath Michael A.、Wells James M.
- Journal Title
  
  Cell Stem Cell
  
  Volume: 29 Issue: 1 Pages: 36-51.e6
- DOI
  10.1016/j.stem.2021.10.010
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16156, KAKENHI-PROJECT-18KK0423
[Journal Article] Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems.2022
- Author(s)
  Keishi Kishimoto, Kentaro Iwasawa, Alice Sorel, Carlos Ferran-Heredia, Lu Han, Mitsuru Morimoto, James M Wells, Takanori Takebe and Aaron M Zorn
- Journal Title
  
  nature protocols
  
  Volume: -
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16156
[Journal Article] Mammalian tracheal development and reconstruction: insights from <i>in vivo</i> and <i>in vitro</i> studies2021
- Author(s)
  Kishimoto Keishi、Morimoto Mitsuru
- Journal Title
  
  Development
  
  Volume: 148 Issue: 13
- DOI
  10.1242/dev.198192
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16156, KAKENHI-PROJECT-18KK0423, KAKENHI-PROJECT-20H03693
[Journal Article] Single cell transcriptomics reveals a signaling roadmap coordinating endoderm and mesoderm diversification during foregut organogenesis2020
- Author(s)
  Lu Han, Praneet Chaturvedi, Keishi Kishimoto, Hiroyuki Koike, Talia Nasr, Kentaro Iwasawa, Kirsten Giesbrecht, Phillip C Witcher, Alexandra Eicher, Lauren Haines, Yarim Lee, John M Shannon, Mitsuru Morimoto, James M Wells, Takanori Takebe, Aaron M Zorn
- Journal Title
  
  Biorxiv
  
  Volume: 861781 Pages: 1-49
- DOI
  10.1101/756825
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16156, KAKENHI-PROJECT-18KK0423
[Journal Article] Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells.2020
- Author(s)
  Kishimoto K, Furukawa KT, Luz-Madrigal A, Yamaoka A, Matsuoka C, Habu M, Alev C, Zorn AM, Morimoto M.
- Journal Title
  
  Nature communications
  
  Volume: 11(1) Issue: 1 Pages: 4159-4159
- DOI
  10.1038/s41467-020-17969-w
- NAID
  120006882430
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16156, KAKENHI-PROJECT-18KK0423, KAKENHI-PROJECT-20H03693
[Journal Article] Bidirectional Wnt signaling between endoderm and mesoderm confer tracheal identity in mouse and human2020
- Author(s)
  Keishi Kishimoto, Kana T. Furukawa, Agustin Luz Madrigal, Akira Yamaoka, Chisa Matsuoka, Masanobu Habu, Cantas Alev, Aaron M. Zorn, Mitsuru Morimoto
- Journal Title
  
  Biorxiv
  
  Volume: 756825 Pages: 1-31
- DOI
  10.1101/758235
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16156, KAKENHI-PROJECT-18KK0423
[Journal Article] Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis.2020
- Author(s)
  Han L, Chaturvedi P, Kishimoto K, Koike H, Nasr T, Iwasawa K, Giesbrecht K, Witcher PC, Eicher A, Haines L, Lee Y, Shannon JM, Morimoto M, Wells JM, Takebe T, Zorn AM.
- Journal Title
  
  Nature communications
  
  Volume: 11(1) Issue: 1 Pages: 4158-4158
- DOI
  10.1038/s41467-020-17968-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16156, KAKENHI-PROJECT-18KK0423, KAKENHI-PROJECT-18H02800, KAKENHI-PROJECT-19K22416, KAKENHI-PROJECT-20H03693
[Journal Article] Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus2018
- Author(s)
  Kishimoto, K., Tamura, M., Nishita, M., Minami, Y., Matsuoka, A., Abe, T., Shigeta, M., Morimoto, M.
- Journal Title
  
  Nat. Commun.
  
  Volume: 9 Issue: 1 Pages: 2816-2816
- DOI
  10.1038/s41467-018-05189-2
- NAID
  120006496738
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05152, KAKENHI-PROJECT-17K15133
[Journal Article] The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis2018
- Author(s)
  Yin Wenguang、Kim Hyun-Taek、Wang ShengPeng、Gunawan Felix、Wang Lei、Kishimoto Keishi、Zhong Hua、Roman Dany、Preussner Jens、Guenther Stefan、Graef Viola、Buettner Carmen、Grohmann Beate、Looso Mario、Morimoto Mitsuru、Mardon Graeme、Offermanns Stefan、Stainier Didier Y. R.
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 2815-2815
- DOI
  10.1038/s41467-018-05043-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15133
[Patent] ORGANOID MESODERM LINEAGE DIVERSIFICATION2020
- Inventor(s)
  Zorn AM,Kishimoto K,Morimoto M
- Industrial Property Rights Holder
  Zorn AM,Kishimoto K,Morimoto M
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Acquisition Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-18KK0423
[Presentation] 気管の発生機構と幹細胞からの再構成2024
- Author(s)
  岸本　圭史
- Organizer
  Young Respiratory Scientists Spring Seminar
- Invited
- Data Source
  KAKENHI-PROJECT-23K24344
[Presentation] 発生学を応用したヒト臓器間充織細胞の誘導2024
- Author(s)
  岸本　圭史
- Organizer
  第64回呼吸器学会学術講演会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24344
[Presentation] Mechanism and reconstitution of trachea and esophageal patterning in mouse and human2024
- Author(s)
  Keishi Kishimoto
- Organizer
  2024 RIKEN BDR-CuSTOM Joint Organoid Symposium
- Data Source
  KAKENHI-PROJECT-23K24344
[Presentation] Understanding and recapitulating trachea-esophageal development2023
- Author(s)
  Keishi Kishimoto, Aaron M Zorn, Mitsuru Morimoto
- Organizer
  RIKEN BDR-CuSTOM Joint Organoid Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0423
[Presentation] Mechanism and in vitro reconstruction of mammalian trachea-esophageal development2023
- Author(s)
  Keishi Kishimoto
- Organizer
  CLEAR Consortium Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0423
[Presentation] Mechanism and in vitro reconstruction of mammalian trachea-esophageal development2023
- Author(s)
  Keishi Kishimoto
- Organizer
  2023 CLEAR Consortium Symposium, Cincinnati
- Data Source
  KAKENHI-PROJECT-23K24344
[Presentation] Understanding early respiratory and esophageal development toward in vitro modeling organogenesis with human pluripotent stem cells2022
- Author(s)
  Kishimoto K, Zorn AM and Morimoto M
- Organizer
  The 45th Annual Meeting of the Molecular Biology Society of Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0423
[Presentation] Induction of organ specific splanchnic mesoderm from human embryonic stem cell2020
- Author(s)
  Keishi Kishimoto
- Organizer
  CLEAR consortium 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16156
[Presentation] Induction of organ specific splanchnic mesoderm from human embryonic stem cell2020
- Author(s)
  Keishi Kishimoto
- Organizer
  CLEAR consortium 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0423
[Presentation] Orientated mesenchymal cell polarization and differentiation shape the trachea2018
- Author(s)
  Keishi Kishimoto
- Organizer
  Keystone Symposia Endoderm Development and Desease：Cross Organ Comparison and Interplay
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15133
[Presentation] 気管の形態形成における間充織極性化の重要性2018
- Author(s)
  岸本　圭史
- Organizer
  第５８回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K15133
[Presentation] 気管の形態形成における間充織極性化の重要性2018
- Author(s)
  岸本　圭史, 森本　充
- Organizer
  日本呼吸器学会
- Data Source
  KAKENHI-PROJECT-17K15133
[Presentation] Synchronized mesenchymal cell polarization and differentiation shape the trachea2018
- Author(s)
  Keishi Kishimoto
- Organizer
  the Joint Annual Meeting of 70th JSCB and 51st JSDB
- Data Source
  KAKENHI-PROJECT-17K15133
[Presentation] Synchronized mesenchymal cell polarization and differentiation shape the trachea2018
- Author(s)
  Kishimoto K, and Morimoto M
- Organizer
  Joint Annual Meeting of the Japanese Society of Developmental Biologists 51th and the Japan Society for Cell Biology 70th
- Data Source
  KAKENHI-PROJECT-17K15133
[Presentation] Orientated mesenchymal cell polarization and differentiation shape the trachea2018
- Author(s)
  Keishi Kishimoto, Masaru Tamura, Michiru Nishita, Yasuhiro Minami and Mitsuru Morimoto
- Organizer
  Keystone Symposia Endoderm Development and Disease: Cross-Organ Comparison and Interplay
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15133
[Presentation] Oriented mesenchymal cells drive tracheal tubulogenesis.2017
- Author(s)
  Keishi Kishimoto
- Organizer
  18th International Congress of Developmental Biology, 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15133
[Presentation] Oriented mesenchymal cells drive tracheal tubulogenesis.2017
- Author(s)
  Keishi Kishimoto
- Organizer
  50th Annual Meeting of the Japanese Society of Developmental Biologists, 2017
- Data Source
  KAKENHI-PROJECT-17K15133
[Presentation] Mesenchymal cell polarity and differentiation shape mouse airway2017
- Author(s)
  Keishi Kishimoto
- Organizer
  Consortium of Biological Sciences 2017
- Data Source
  KAKENHI-PROJECT-17K15133

1. NISHITA MICHIRU

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 南康博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 武部貴則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kishimoto Keishi 岸本 圭史

Research Projects

Research Products

Co-Researchers

上皮間充織相互作用を反映した気管食道オルガノイド開発による気管食道形成不全の理解Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding the principle of self-organization which directs respiratory organPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishing 3-dimentional structure of trachea and esophageal organoid toward understanding the mechanism underlying mesenchymal polarizationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidating the mechanism underlying the mesenchymal polarization of the trachea through Wnt signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The mechanism of mesenchymal cell polarity in mouse tracheal smooth musclePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 決定版 オルガノイド実験スタンダード2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 実験医学2018年11月号2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Deciphering Endothelial and Mesenchymal Organ Specification in Vascularized Lung and Intestinal Organoids2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems.2022

Author(s)

Journal Title

Data Source

[Journal Article] Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems.2022

Author(s)

Journal Title

Data Source

[Journal Article] Mammalian tracheal development and reconstruction: insights from <i>in vivo</i> and <i>in vitro</i> studies2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single cell transcriptomics reveals a signaling roadmap coordinating endoderm and mesoderm diversification during foregut organogenesis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells.2020

Kishimoto Keishi 岸本圭史

[Book] 決定版　オルガノイド実験スタンダード2019