Ohashi Nobuko 大橋宣子

Researcher Number	70706712
Other IDs
Affiliation (Current)	2025: 新潟大学, 医歯学総合病院, 助教
Affiliation (based on the past Project Information) *help	2019 – 2025: 新潟大学, 医歯学総合病院, 助教 2016 – 2017: 新潟大学, 医歯学総合病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 55050:Anesthesiology-related / 0905:Surgery of the organs maintaining homeostasis and related fields / Anesthesiology Except Principal Investigator Basic Section 55050:Anesthesiology-related / Basic Section 56020:Orthopedics-related
Keywords	Principal Investigator パッチクランプ記録 / 電気生理学実験 / 慢性疼痛 / 脊髄Ⅹ層 / 疼痛 / ノルアドレナリン / 脊髄ニューロン / 電位依存性カルシウムチャネル / N型電位依存性カルシウムチャネル / 脊髄後角ニューロン … More / 脊髄損傷後疼痛 / 免疫組織学実験 / 炎症性疼痛 / 脊髄X層 / 薬剤反応性 / 薬理学 / AM404 / TRPV1受容体 / 脊髄後角 / N-アシルフェノールアミン / アセトアミノフェン … More Except Principal Investigator 脊髄損傷後疼痛 / カルシウムイオン / 興奮毒性 / 脊髄損傷 / 脊髄後角 / 過分極活性化環状ヌクレオチド依存性チャネル / 電気生理学実験 / HCNチャネル / イバブラジン / 脊髄後角ニューロン / 脊髄保護 / リアノジン受容体 / 体性感覚 / フラビン / パッチクランプ記録 / レミマゾラム / 活性酸素 / オメガーコノトキシン / カルシウムチャネル / 脊髄保護療法 / 神経障害性疼痛 / 二次損傷 / カルシウム / アロディニア / コノトキシン / パッチクランプ / 電位依存性カルシウムチャネル / 疼痛 Less

脊髄損傷後疼痛における脳および脊髄の可塑性変化の機序解明と新規治療法の開発Principal Investigator
- Principal Investigator
  
  大橋宣子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Niigata University
レミマゾラムは体性感覚の伝導を抑制するか
- Principal Investigator
  
  出口浩之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Niigata University
Development of a novel treatment for acute spinal cord injury targeting ryanodine receptor
- Principal Investigator
  
  大橋正幸
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Niigata University
脊髄損傷後疼痛に対するイバブラジンの新規鎮痛薬としての有効性と作用機序の解明
- Principal Investigator
  
  山本知裕
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Niigata University
イバブラジンの脊髄後角における作用機序解明と新規鎮痛薬としての有効性の検討
- Principal Investigator
  
  西塔志乃
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Niigata University
脊髄損傷後疼痛における脊髄のシナプス可塑性変化の病態解明Principal Investigator
- Principal Investigator
  
  大橋宣子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Niigata University
Role of N-type voltage-gated calcium channel in mechanisms of neuropathic pain after spinal cord injury
- Principal Investigator
  
  Ohashi Masayuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Niigata University
Norepinephrine restores inhibitory tone of spinal lamina X circuitry, thus contributing to analgesia against inflammatory painPrincipal Investigator
- Principal Investigator
  
  Ohashi Nobuko
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Niigata University
Action of noradrenaline on lamina X of the spinal cordPrincipal Investigator
- Principal Investigator
  
  Ohashi Nobuko
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0905:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Niigata University
Acetaminophen Metabolite N-Acylphenolamine Induces Analgesia via Transient Receptor Potential Vanilloid 1 Receptors Expressed on the Primary Afferent Terminals of C-fibers in the Spinal Dorsal Horn.Principal Investigator
- Principal Investigator
  
  Ohashi Nobuko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology
- Research Institution
  Niigata University

All 2024 2023 2022 2020 2017 2016

All Journal Article Presentation

[Journal Article] Omega-conotoxin MVIIA reduces neuropathic pain after spinal cord injury by inhibiting N-type voltage-dependent calcium channels on spinal dorsal horn2024
- Author(s)
  Ohashi Nobuko、Uta Daisuke、Ohashi Masayuki、Hoshino Rintaro、Baba Hiroshi
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 18 Pages: 1366829-1366829
- DOI
  10.3389/fnins.2024.1366829
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09090, KAKENHI-PROJECT-21K09272
[Journal Article] Norepinephrine Restores Inhibitory Tone of Spinal Lamina X Circuitry, thus Contributing to Analgesia Against Inflammatory Pain2022
- Author(s)
  Nobuko Ohashi, Daisuke Uta, Masayuki Ohashi, Hiroshi Baba
- Journal Title
  
  Neuroscience
  
  Volume: 490 Pages: 224-235
- DOI
  10.1016/j.neuroscience.2022.03.023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17777, KAKENHI-PROJECT-20H03775, KAKENHI-PROJECT-21K19521, KAKENHI-PROJECT-19K09323, KAKENHI-PROJECT-22K09020
[Journal Article] Acetaminophen Metabolite N-Acylphenolamine Induces Analgesia via Transient Receptor Potential Vanilloid 1 Receptors Expressed on the Primary Afferent Terminals of C-fibers in the Spinal Dorsal Horn.2017
- Author(s)
  Ohashi N, Uta D, Sasaki M, Ohashi M, Kamiya Y, Kohno T
- Journal Title
  
  Anesthesiology.
  
  Volume: 127 Issue: 2 Pages: 355-371
- DOI
  10.1097/aln.0000000000001700
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08667, KAKENHI-PROJECT-16K20081
[Presentation] 脊髄損傷後疼痛における脊髄のN型電位依存性Ca2＋チャネルの役割2023
- Author(s)
  大橋宣子、大橋正幸、馬場洋
- Organizer
  日本麻酔科学会
- Data Source
  KAKENHI-PROJECT-21K09272
[Presentation] 脊髄損傷後疼痛におけるN型電位依存性Ca2＋チャネルの役割2023
- Author(s)
  大橋正幸、大橋宣子、歌大介、川島寛之、渡辺慶
- Organizer
  整形外科痛みを語る会
- Data Source
  KAKENHI-PROJECT-21K09272
[Presentation] 脊髄損傷後疼痛における脊髄のN型電位依存性Ca2＋チャネルの役割2023
- Author(s)
  大橋宣子、清水大喜、渡部達範、馬場洋、歌大介、大橋正幸
- Organizer
  日本ペインクリニック学会
- Data Source
  KAKENHI-PROJECT-21K09272
[Presentation] 脊髄損傷後疼痛における脊髄のN型電位依存性Ca2＋チャネルの役割2023
- Author(s)
  大橋宣子　大橋正幸　馬場洋
- Organizer
  日本麻酔科学会　第70回学術集会
- Data Source
  KAKENHI-PROJECT-22K09090
[Presentation] 脊髄損傷後疼痛における脊髄のN型電位依存性Ca2＋チャネルの役割―N型電位依存性Ca2+チャネル遮断薬の脊髄後角における鎮痛効果およびその機序―2023
- Author(s)
  大橋宣子　歌大介　大橋正幸　馬場洋
- Organizer
  日本ペインクリニック学会第57回学術集会
- Data Source
  KAKENHI-PROJECT-22K09090
[Presentation] 脊髄損傷後疼痛における脊髄のN型電位依存性Ca2＋チャネルの役割2022
- Author(s)
  大橋宣子
- Organizer
  第93回新潟麻酔科懇話会/第72回新潟ショックと蘇生・集中治療研究会
- Data Source
  KAKENHI-PROJECT-22K09090
[Presentation] 脊髄損傷後疼痛におけるN型電位依存性Ca2＋チャネルの役割と新規急性期治療の開発2022
- Author(s)
  大橋正幸
- Organizer
  Spine Expert Meeting
- Invited
- Data Source
  KAKENHI-PROJECT-21K09272
[Presentation] 脊髄Ⅹ層におけるノルアドレナリンの鎮痛機序2020
- Author(s)
  大橋宣子、大橋正幸、馬場洋
- Organizer
  日本麻酔科学会第67回学術集会
- Data Source
  KAKENHI-PROJECT-19K24008
[Presentation] 脊髄Ⅹ層におけるノルアドレナリンの鎮痛機序2020
- Author(s)
  大橋宣子、大橋正幸、馬場洋
- Organizer
  日本麻酔科学会第67回学術集会
- Data Source
  KAKENHI-PROJECT-20K17777
[Presentation] 脊髄Ⅹ層におけるノルアドレナリンの鎮痛機序2020
- Author(s)
  大橋宣子、大橋正幸、馬場洋
- Organizer
  日本麻酔科学会第67回学術集会
- Data Source
  KAKENHI-PROJECT-19K24008
[Presentation] アセトアミノフェンは炎症性疼痛に対しても脊髄レベルでより強い鎮痛効果を発揮する‐脊髄後角ニューロンにおけるin vivoおよびin vitroパッチクランプ記録を用いた検討‐2017
- Author(s)
  大橋宣子、歌大介、佐々木美佳、大橋正幸、紙谷義孝、河野達郎
- Organizer
  日本麻酔科学会第64回学術集会
- Data Source
  KAKENHI-PROJECT-16K20081
[Presentation] アセトアミノフェンの脊髄後角ニューロンにおける鎮痛機序2016
- Author(s)
  大橋宣子、佐々木美佳、河野達郎
- Organizer
  日本麻酔科学会第63回学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-05-26
- Data Source
  KAKENHI-PROJECT-16K20081
[Presentation] アセトアミノフェンの鎮痛機序2016
- Author(s)
  大橋宣子
- Organizer
  日本臨床麻酔学会第36回大会　シンポジウム神経炎症と組織炎症の観点から考える痛みのメカニズム
- Place of Presentation
  高知市文化プラザかるぽーと（高知県高知市）
- Year and Date
  2016-11-03
- Invited
- Data Source
  KAKENHI-PROJECT-16K20081
[Presentation] Underlying mechanisms of acetaminophen in the spinal dorsal horn neurons2016
- Author(s)
  Nobuko Ohashi, Daisuke Uta, Mika Sasaki, Yoshinori Kamiya, Tatsuro Kohno
- Organizer
  Society for Neuroscience 46th Annual Meeting
- Place of Presentation
  San Diego（アメリカ合衆国）
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20081

1. 馬場洋 (00262436)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
2. Ohashi Masayuki (70706720)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. 西塔志乃 (60624971)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 出口浩之 (30804562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 大西毅 (60804573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 山本知裕 (70596543)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 歌大介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohashi Nobuko 大橋 宣子

Research Projects

Research Products

Co-Researchers

脊髄損傷後疼痛における脳および脊髄の可塑性変化の機序解明と新規治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

レミマゾラムは体性感覚の伝導を抑制するか

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel treatment for acute spinal cord injury targeting ryanodine receptor

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脊髄損傷後疼痛に対するイバブラジンの新規鎮痛薬としての有効性と作用機序の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

イバブラジンの脊髄後角における作用機序解明と新規鎮痛薬としての有効性の検討

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脊髄損傷後疼痛における脊髄のシナプス可塑性変化の病態解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of N-type voltage-gated calcium channel in mechanisms of neuropathic pain after spinal cord injury

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Norepinephrine restores inhibitory tone of spinal lamina X circuitry, thus contributing to analgesia against inflammatory painPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Action of noradrenaline on lamina X of the spinal cordPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Acetaminophen Metabolite N-Acylphenolamine Induces Analgesia via Transient Receptor Potential Vanilloid 1 Receptors Expressed on the Primary Afferent Terminals of C-fibers in the Spinal Dorsal Horn.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Omega-conotoxin MVIIA reduces neuropathic pain after spinal cord injury by inhibiting N-type voltage-dependent calcium channels on spinal dorsal horn2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Norepinephrine Restores Inhibitory Tone of Spinal Lamina X Circuitry, thus Contributing to Analgesia Against Inflammatory Pain2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Acetaminophen Metabolite N-Acylphenolamine Induces Analgesia via Transient Receptor Potential Vanilloid 1 Receptors Expressed on the Primary Afferent Terminals of C-fibers in the Spinal Dorsal Horn.2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] 脊髄損傷後疼痛における脊髄のN型電位依存性Ca2＋チャネルの役割2023

Ohashi Nobuko 大橋宣子

[Presentation] 脊髄損傷後疼痛における脊髄のN型電位依存性Ca2＋チャネルの役割2023

[Presentation] 脊髄損傷後疼痛における脊髄のN型電位依存性Ca2＋チャネルの役割―N型電位依存性Ca2+チャネル遮断薬の脊髄後角における鎮痛効果およびその機序―2023