Kuroha Masatake 黒羽正剛

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KUROHA MASATAKE 黒羽正剛

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Researcher Number	70709469
Other IDs
Affiliation (Current)	2025: 東北大学, 医学系研究科, 大学院非常勤講師
Affiliation (based on the past Project Information) *help	2022 – 2023: 東北大学, 医学系研究科, 大学院非常勤講師 2020 – 2021: 東北大学, 医学系研究科, 非常勤講師 2017 – 2019: 東北大学, 大学病院, 助教 2016: 東北大学, 大学病院, 特任助手 2015: 東北大学, 東北メディカル・メガバンク機構, 助教 2015: 東北大学, 東北メディカル・メガバンク機構, 非常勤講師
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 55020:Digestive surgery-related / Gastroenterology
Keywords	Principal Investigator 大腸癌幹細胞 / 大腸癌 / 再生医療 / オルガノイド / 小腸移植 / エクソソーム / 幹細胞 Except Principal Investigator クローン病 / オルガノイド / 潰瘍性大腸炎 … More / 炎症性腸疾患 / 個別化医療 / ERK阻害薬 / MAPK / 大腸癌 / 体細胞モザイク変異 / チオプリン製剤 / 染色体異常モザイク / 全ゲノムシーケンス解析 / 染色体変異モザイク / 染色体異常 / モザイク変異 / タイトジャンクション / 単層培養 / RAP1A / 感受性遺伝子 / 消化器内科学 / 遺伝学 / 疾患感受性遺伝子 Less

Functional analysis of disease susceptibility gene RAP1A using organoid monolayer from Crohn's Disease
- Principal Investigator
  
  Moroi RIntaro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tohoku University
Analysis of the Onset and Pathological Changes of Crohn's Disease through Somatic Mosaicism Mediated by Genomic Instability
- Principal Investigator
  
  Kakuta Yoichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tohoku University
Organoid Culture for Next Generation Personalized Medicine against Colorectal Cancer
- Principal Investigator
  
  Karasawa Hideaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
Can small intestinal epithelial autologous organoid transplantation avoid rejection after small intestinal transplantation?Principal Investigator
- Principal Investigator
  
  Kuroha Masatake
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tohoku University
Exosomes derived from colorectal cancer are associated with niche formations.Principal Investigator
- Principal Investigator
  
  Kuroha Masatake
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tohoku University
Analysis of niche forming factors (paneth cells) for colon cancer stem cells.Principal Investigator
- Principal Investigator
  
  KUROHA MASATAKE
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
Genome-wide association study of inflammatory bowel disease using population optimized array and reference panel in Japanese
- Principal Investigator
  
  Kakuta Yoichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University

All 2024 2023 2022 2019 2018 2017 2015

All Journal Article Presentation

[Journal Article] Dickkopf 1 is expressed in normal fibroblasts during early stages of colorectal tumorigenesis2024
- Author(s)
  Inomata Yushi、Kuroha Masatake、Shimoyama Yusuke、Naito Takeo、Moroi Rintaro、Shiga Hisashi、Kakuta Yoichi、Karasawa Hideaki、Onuma Shinobu、Kinouchi Yoshitaka、Masamune Atsushi
- Journal Title
  
  Cancer Medicine
  
  Volume: 13 Issue: 2
- DOI
  10.1002/cam4.6992
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08679
[Journal Article] Usefulness and difficulties with the thiopurine pharmacogenomic NUDT15 genotyping test: Analysis of real-world data in Japan2023
- Author(s)
  Kakuta Yoichi、Kato Motohiro、Shimoyama Yusuke、Naito Takeo、Moroi Rintaro、Kuroha Masatake、Shiga Hisashi、Kinouchi Yoshitaka、Masamune Atsushi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 153 Issue: 3 Pages: 161-169
- DOI
  10.1016/j.jphs.2023.09.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08024, KAKENHI-PROJECT-21K07955
[Journal Article] Crohn’s Disease and Early Exposure to Thiopurines are Independent Risk Factors for Mosaic Chromosomal Alterations in Patients with Inflammatory Bowel Diseases2022
- Author(s)
  Kakuta Y、Iwaki H、Umeno J、Kawai Y、Kawahara M、Takagawa T、Shimoyama Y、Naito T、Moroi R、Kuroha M、Shiga H、Watanabe K、Nakamura S、Nakase H、Sasaki M、Hanai H、Fuyuno Y、Hirano At、Matsumoto T、Kudo H、Minegishi N、Nakamura M、Hisamatsu T、Andoh A、Nagasaki M、Tokunaga K、Kinouchi Y、Masamune A
- Journal Title
  
  Journal of Crohn's and Colitis
  
  Volume: 16 Issue: 4 Pages: 643-655
- DOI
  10.1093/ecco-jcc/jjab199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07955
[Journal Article] Clinical and genetic risk factors for decreased bone mineral density in Japanese patients with inflammatory bowel disease2018
- Author(s)
  Naito T, Yokoyama N, Kakuta Y, Ueno K, Kawai Y, Onodera M, Moroi R, Kuroha M, Kanazawa Y, Kimura T, Shiga H, Endo K, Nagasaki M, Masamune A, Kinouchi Y, Shimosegawa T
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 印刷中 Issue: 11 Pages: 1873-1881
- DOI
  10.1111/jgh.14149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04805
[Journal Article] Allele-specific DNA methylation of disease susceptibility genes in Japanese patients with inflammatory bowel disease2018
- Author(s)
  Chiba Hirofumi、Kakuta Yoichi、Kinouchi Yoshitaka、Kawai Yosuke、Watanabe Kazuhiro、Nagao Munenori、Naito Takeo、Onodera Motoyuki、Moroi Rintaro、Kuroha Masatake、Kanazawa Yoshitake、Kimura Tomoya、Shiga Hisashi、Endo Katsuya、Negoro Kenichi、Nagasaki Masao、Unno Michiaki、Shimosegawa Tooru
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 3 Pages: e0194036-e0194036
- DOI
  10.1371/journal.pone.0194036
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04805, KAKENHI-PROJECT-15K19311
[Journal Article] Increased expression of IL12B mRNA transcribed from the risk haplotype for Crohn’s disease is a risk factor for disease relapse in Japanese patients2017
- Author(s)
  Kakuta Yoichi、Kimura Tomoya、Negoro Kenichi、Kuroha Masatake、Shiga Hisashi、Endo Katsuya、Kinouchi Yoshitaka、Shimosegawa Tooru
- Journal Title
  
  J Gastroenterol
  
  Volume: 52 Issue: 12 Pages: 1230-1239
- DOI
  10.1007/s00535-017-1322-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04805
[Presentation] Exosome released from patiens-derived organoids contain different microRNA profiles between colorectal cancer and adenoma2019
- Author(s)
  永井博 , 黒羽正剛 , 正宗淳
- Organizer
  Digestive Disease Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15803
[Presentation] 大腸癌三次元オルガノイド培養を用いたエクソソーム研究2019
- Author(s)
  黒羽正剛
- Organizer
  第27回日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-18K15803
[Presentation] Population-optimized SNP array reveals RAP1A as a novel candidate susceptibility gene for Crohn’s disease in Japanese individuals2017
- Author(s)
  Yoichi Kakuta, Yosuke Kawai, Takeo Naito, Atsushi Hirano, Junji Umeno, Keiichiro Hiramoto, Masatake Kuroha, Yoshitake Kanazawa, Tomoya Kimura1 Katsuya Endo, Yoshitaka Kinouchi, Motohiro Esaki, Masao Nagasaki, Tooru Shimosegawa
- Organizer
  Digestive Disease Week 2017
- Place of Presentation
  Chicago, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04805
[Presentation] Population-optimized SNP array reveals RAP1A as a novel candidate susceptibility gene for Crohn’s disease in Japanese individuals2017
- Author(s)
  Yoichi Kakuta, Yosuke Kawai, Takeo Naito, Atsushi Hirano, Junji Umeno, Keiichiro Hiramoto, Masatake Kuroha, Yoshitake Kanazawa, Tomoya Kimura, Katsuya Endo, Yoshitaka Kinouchi, Motohiro Esaki, Masao Nagasaki, Tooru Shimosegawa
- Organizer
  Digestive Disease Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04805
[Presentation] 人種最適化ジェノタイピングアレイによるゲノム解析から見えた日本人炎症性腸疾患の病因・病態にかかわる新たなDisease Pathway2015
- Author(s)
  ○角田洋一、木内喜孝、内藤健夫、黒羽正剛、木村智哉、遠藤克哉、下瀬川徹
- Organizer
  G-plus2015
- Place of Presentation
  ホテルイースト２１（東京）
- Year and Date
  2015-12-19
- Data Source
  KAKENHI-PROJECT-15H04805

1. Kakuta Yoichi (50509205)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
2. 木内喜孝 (20250780)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. Moroi RIntaro (90803594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Karasawa Hideaki (30547401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 工藤博典 (00723032)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 和田基 (80372291)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 梅田みか (20292344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 大沼忍 (70451565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 山村明寛 (30814678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 小峰啓吾 (10725807)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 岡村容伸 (00837495)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SHIGA Hisashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kuroha Masatake 黒羽 正剛

KUROHA MASATAKE 黒羽 正剛

Research Projects

Research Products

Co-Researchers

Functional analysis of disease susceptibility gene RAP1A using organoid monolayer from Crohn's Disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the Onset and Pathological Changes of Crohn's Disease through Somatic Mosaicism Mediated by Genomic Instability

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Organoid Culture for Next Generation Personalized Medicine against Colorectal Cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Can small intestinal epithelial autologous organoid transplantation avoid rejection after small intestinal transplantation?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exosomes derived from colorectal cancer are associated with niche formations.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of niche forming factors (paneth cells) for colon cancer stem cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genome-wide association study of inflammatory bowel disease using population optimized array and reference panel in Japanese

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Dickkopf 1 is expressed in normal fibroblasts during early stages of colorectal tumorigenesis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Usefulness and difficulties with the thiopurine pharmacogenomic NUDT15 genotyping test: Analysis of real-world data in Japan2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crohn’s Disease and Early Exposure to Thiopurines are Independent Risk Factors for Mosaic Chromosomal Alterations in Patients with Inflammatory Bowel Diseases2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical and genetic risk factors for decreased bone mineral density in Japanese patients with inflammatory bowel disease2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Allele-specific DNA methylation of disease susceptibility genes in Japanese patients with inflammatory bowel disease2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased expression of IL12B mRNA transcribed from the risk haplotype for Crohn’s disease is a risk factor for disease relapse in Japanese patients2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] Exosome released from patiens-derived organoids contain different microRNA profiles between colorectal cancer and adenoma2019

Author(s)

Organizer

Kuroha Masatake 黒羽正剛

KUROHA MASATAKE 黒羽正剛