Hara Yuichiro 原雄一郎

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HARA Yuichiro 原雄一郎

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Researcher Number	70709708
Other IDs
Affiliation (Current)	2025: 北里大学, 未来工学部, 准教授 2025: 公益財団法人東京都医学総合研究所, ゲノム医学研究センター, 研究員
Affiliation (based on the past Project Information) *help	2025: 北里大学, 未来工学部, 准教授 2020 – 2023: 公益財団法人東京都医学総合研究所, ゲノム医学研究センター, 主席研究員 2019: 名古屋大学, 環境医学研究所, 特任講師 2013: 独立行政法人理化学研究所, 発生・再生科学総合研究センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 43050:Genome biology-related Except Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Evolutionary biology
Keywords	Principal Investigator de novo gene / 偽遺伝子化 / 遺伝子レパートリー / シスエレメント / de novo 遺伝子 / 祖先配列 / エンハンサー / プロモーター / 超並列レポーターアッセイ / 偽遺伝子 / de novo遺伝子 … More Except Principal Investigator … More クロマチン / 転写 / 染色体構造 / ゲノミクス / DNA複製 / 慢性炎症 / リピドーム解析 / 慢性炎症生疾患 / 慢性炎症性疾患 / 自己免疫 / 脂質代謝 / 免疫代謝 / 分子進化 / バイオインフォマティクス / 突然変異 / 生物進化 / 超微小逆位 / 比較ゲノム Less

哺乳動物ゲノムDNAの複製制御機構解明
- Principal Investigator
  
  鐘巻将人
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  National Institute of Genetics
Elucidation of de novo gene birth and pseudogenization processes via reconstruction of ancestral transcriptional regulationPrincipal Investigator
- Principal Investigator
  
  HARA Yuichiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Immune cell lipid reprogramming in chronic inflammatory diseases
- Principal Investigator
  
  Ito Ayaka
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Nagoya University
Evolutionary genomics of ultramicro inversions.
- Principal Investigator
  
  IMANISHI Tadashi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Evolutionary biology
- Research Institution
  Tokai University

All 2024 2023 2022 2021 2014 2013 2012

All Journal Article Presentation Book

[Book] ヒトゲノム事典 12章「12.3 遺伝子変換」, 「12.6 逆位」2021
- Author(s)
  原雄一郎; (編) 井ノ上逸朗, 今西規, 河村正二, 斎藤成也, 颯田葉子, 田嶋敦
- Total Pages
  448
- Publisher
  一色出版
- ISBN
  9784910389127
- Data Source
  KAKENHI-PROJECT-21K06132
[Journal Article] The impact of local genomic properties on the evolutionary fate of genes2023
- Author(s)
  Hara Yuichiro、Kuraku Shigehiro
- Journal Title
  
  eLife
  
  Volume: 12 Pages: 82290-82290
- DOI
  10.7554/elife.82290
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06132
[Journal Article] Novel Therapeutic Potentials of Taxifolin for Obesity-Induced Hepatic Steatosis, Fibrogenesis, and Tumorigenesis2023
- Author(s)
  Inoue Takayuki、Fu Bin、Nishio Miwako、Tanaka Miyako、Kato Hisashi、Tanaka Masashi、Itoh Michiko、Yamakage Hajime、Ochi Kozue、Ito Ayaka、Shiraki Yukihiro、Saito Satoshi、Ihara Masafumi、Nishimura Hideo、Kawamoto Atsuhiko、Inoue Shian、Saeki Kumiko、Enomoto Atsushi、Suganami Takayoshi、Satoh-Asahara Noriko
- Journal Title
  
  Nutrients
  
  Volume: 15 Issue: 2 Pages: 350-350
- DOI
  10.3390/nu15020350
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08526, KAKENHI-PROJECT-21K08571, KAKENHI-PROJECT-22K07456, KAKENHI-PROJECT-22K08667, KAKENHI-PROJECT-22K11700, KAKENHI-PROJECT-22K11720, KAKENHI-PROJECT-22K19524, KAKENHI-PROJECT-22K19723, KAKENHI-PROJECT-21K17557, KAKENHI-PROJECT-19KK0249, KAKENHI-PUBLICLY-21H05625, KAKENHI-PROJECT-20H03447, KAKENHI-PROJECT-21H02835, KAKENHI-PROJECT-19K07905, KAKENHI-PROJECT-19K07927, KAKENHI-PUBLICLY-22H04806
[Journal Article] Gene fate spectrum as a reflection of local genomic properties2022
- Author(s)
  Hara Yuichiro、Kuraku Shigehiro
- Journal Title
  
  biorXiv
  
  Volume: -
- DOI
  10.1101/2022.08.08.502781
- Open Access
- Data Source
  KAKENHI-PROJECT-21K06132
[Journal Article] Ten years of collaborative progress in the Quest for Orthologs2021
- Author(s)
  Linard Benjamin、Ebersberger Ingo、McGlynn Shawn E、Glover Natasha、Mochizuki Tomohiro、Patricio Mateus、Lecompte Odile、Nevers Yannis、Thomas Paul D、Gabaldon Toni、Sonnhammer Erik、Dessimoz Christophe、Uchiyama Ikuo、QFO Consortium
- Journal Title
  
  Molecular Biology and Evolution
  
  Volume: - Issue: 8 Pages: 3033-3045
- DOI
  10.1093/molbev/msab098
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H01325, KAKENHI-PROJECT-21K06132, KAKENHI-PROJECT-16H06279
[Journal Article] Parallel evolution of trehalose production machinery in anhydrobiotic animals via recurrent gene loss and horizontal transfer2021
- Author(s)
  Hara Yuichiro、Shibahara Reira、Kondo Koyuki、Abe Wataru、Kunieda Takekazu
- Journal Title
  
  Open Biology
  
  Volume: 11 Issue: 7 Pages: 200413-200413
- DOI
  10.1098/rsob.200413
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H04332, KAKENHI-PROJECT-21K06132, KAKENHI-PROJECT-20K20580
[Journal Article] Reconstructing the Demographic History of the Human Lineage Using Whole-Genome Sequences from Human and Three Great Apes2012
- Author(s)
  Hara Y, Imanishi T, and Satta Y.
- Journal Title
  
  Genome Biology and Evolution,(この論文はGenome Biology and Evolution, Volume 4 Issue 11のハイライト論文として掲載された。Highlight : Family Ties—New Evidence Simplifies Human Evolutionary Tree. Genome Biology and Evolution, 4:1146-1147, 2012.)
  
  Volume: 4 Pages: 1133-1145
- Data Source
  KAKENHI-PROJECT-24657168
[Journal Article] Reconstructing the Demographic History of the Human Lineage Using Whole-Genome Sequences from Human and Three Great Apes.2012
- Author(s)
  Hara Y., Imanishi, T., and Satta, Y.
- Journal Title
  
  Genome Biology and Evolution
  
  Volume: 4 Issue: 11 Pages: 1133-1145
- DOI
  10.1093/gbe/evs075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24657168
[Presentation] Activation of α7 nicotinic acetylcholine receptor attenuates inflammation through decreasing cellular glutathione levels2024
- Author(s)
  Ito A, Nanahara Y, Shirakawa I, Kobayashi M, Arima H, Suganami T
- Organizer
  Keystone Symposia, Immunometabolism: From Mechanisms to Pathways to Therapies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0249
[Presentation] 祖先転写制御の実験的復元から遺伝子が生まれる・消える過程を探る2023
- Author(s)
  原雄一郎、吉沢直子、豊田敦、川路英哉
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06132
[Presentation] Single cell analysis of non-model organisms and cross-species comparison2023
- Author(s)
  原雄一郎
- Organizer
  第46回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06132
[Presentation] 祖先転写制御の実験的復元に基づく遺伝子の創成・消失過程の解明2023
- Author(s)
  原雄一郎
- Organizer
  先進ゲノム支援 2023年度拡大班会議
- Data Source
  KAKENHI-PROJECT-21K06132
[Presentation] Gene fate spectrum as a reflection of local genomic properties2023
- Author(s)
  Yuichiro Hara, Shigehiro Kuraku
- Organizer
  SMBE 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06132
[Presentation] 遺伝子の運命を左右するゲノムの場2022
- Author(s)
  原雄一郎
- Organizer
  国立遺伝学研究所研究会「生命科学を支える分子系統学」
- Invited
- Data Source
  KAKENHI-PROJECT-21K06132
[Presentation] 不均一なゲノムの場での突然変異と遺伝子進化のモード2022
- Author(s)
  原雄一郎
- Organizer
  日本進化学会年大会第24回沼津大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06132
[Presentation] FLAT-seq: Full-Length cDNA sequencing with Adaptive sampling of TSS2022
- Author(s)
  原雄一郎、齊藤紗希、和田涼子、川路英哉
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06132
[Presentation] 種間比較から明らかにされる遺伝子欠失を受容するゲノム領域2021
- Author(s)
  原雄一郎、工樂樹洋
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06132
[Presentation] Parallel evolution of trehalose biosynthesis machinery in metazoans.2021
- Author(s)
  Hara Yuichiro、Shibahara Reira、Kondo Koyuki、Abe Wataru、Kunieda Takekazu
- Organizer
  The 2nd AsiaEvo Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06132
[Presentation] Search for germline mutations from next-generation sequencing analysis2014
- Author(s)
  Hara Y
- Organizer
  International Symposium on "Germline Mutagenesis and Biodiversification
- Place of Presentation
  九州大学
- Invited
- Data Source
  KAKENHI-PROJECT-24657168
[Presentation] Search for germline mutations from next-generation sequencing analysis2014
- Author(s)
  Hara Y
- Organizer
  International Symposium on "Germline Mutagenesis and Biodiversification"
- Place of Presentation
  Kyushu University Oral Presentation
- Data Source
  KAKENHI-PROJECT-24657168
[Presentation] Identification and characterization of ultramicro inversions within local alignments between closely related species2013
- Author(s)
  Hara Y and Imanishi T
- Organizer
  Cold Spring Harbor Meetings, GENOME INFORMATICS
- Place of Presentation
  Cold Spring Harbor Laboratory, USA
- Data Source
  KAKENHI-PROJECT-24657168
[Presentation] Identification and characterization of ultramicro inversions within local alignments between closely related species2013
- Author(s)
  Hara Y and Imanishi T
- Organizer
  Cold Spring Harbor Meetings, GENOME INFORMATICS Cold Spring Harbor Laboratory
- Place of Presentation
  USA Oral Presentation
- Data Source
  KAKENHI-PROJECT-24657168
[Presentation] 近縁種間の全ゲノムアラインメント内に同定された多数の微小な逆位2012
- Author(s)
  原雄一郎、今西規
- Organizer
  日本進化学会第14回大会
- Place of Presentation
  首都大学東京南大沢キャンパス
- Invited
- Data Source
  KAKENHI-PROJECT-24657168
[Presentation] 近縁種間の全ゲノム比較による超微小逆位の同定とその生成機構2012
- Author(s)
  原雄一郎、今西規
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-24657168
[Presentation] Abundance of ultramicro inversions within local alignments between closely related species.2012
- Author(s)
  Hara Y. and Imanishi T.
- Organizer
  Molecular Biology and Evolution Conference 2012 (SMBE2012)
- Place of Presentation
  Dublin Convention Centre, Dublin, Ireland
- Data Source
  KAKENHI-PROJECT-24657168
[Presentation] ヒトゲノム配列中に同定された多数の超微小逆位2012
- Author(s)
  原雄一郎
- Organizer
  NGS現場の会・第二回研究会
- Place of Presentation
  ホテル阪急エキスポパーク
- Data Source
  KAKENHI-PROJECT-24657168
[Presentation] Abundance of ultramicro inversions within local alignments between closely related species2012
- Author(s)
  Hara Y and Imanishi T
- Organizer
  SMBE2012
- Place of Presentation
  Dublin, Ireland(ポスター発表)
- Data Source
  KAKENHI-PROJECT-24657168
[Presentation] 近縁種ゲノム比較によって明らかにされる超微小逆位2012
- Author(s)
  原雄一郎、今西規
- Organizer
  日本進化学会第14回大会
- Place of Presentation
  東京(ワークショップでの口頭発表)
- Data Source
  KAKENHI-PROJECT-24657168
[Presentation] 近縁種間の全ゲノム比較による超微小逆位の同定とその生成機構2012
- Author(s)
  原雄一郎,今西規
- Organizer
  日本分子生物学会年会
- Place of Presentation
  福岡(ワークショップでの口頭発表およびポスター発表)
- Data Source
  KAKENHI-PROJECT-24657168

1. IMANISHI Tadashi (80270461)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
2. Ito Ayaka (80508333)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 菅波孝祥 (50343752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 吉沢直子 (30344071)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 鐘巻将人 (20444507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 笹沼博之 (00531691)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 林謙一郎 (30289136)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. McGlynn Shawn・E.

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 須賀田直子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 國枝武和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 田中都

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hara Yuichiro 原 雄一郎

HARA Yuichiro 原 雄一郎

Research Projects

Research Products

Co-Researchers

哺乳動物ゲノムDNAの複製制御機構解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of de novo gene birth and pseudogenization processes via reconstruction of ancestral transcriptional regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Immune cell lipid reprogramming in chronic inflammatory diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evolutionary genomics of ultramicro inversions.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] ヒトゲノム事典 12章 「12.3 遺伝子変換」, 「12.6 逆位」2021

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] The impact of local genomic properties on the evolutionary fate of genes2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel Therapeutic Potentials of Taxifolin for Obesity-Induced Hepatic Steatosis, Fibrogenesis, and Tumorigenesis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gene fate spectrum as a reflection of local genomic properties2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ten years of collaborative progress in the Quest for Orthologs2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Parallel evolution of trehalose production machinery in anhydrobiotic animals via recurrent gene loss and horizontal transfer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reconstructing the Demographic History of the Human Lineage Using Whole-Genome Sequences from Human and Three Great Apes2012

Author(s)

Journal Title

Data Source

[Journal Article] Reconstructing the Demographic History of the Human Lineage Using Whole-Genome Sequences from Human and Three Great Apes.2012

Author(s)

Journal Title

DOI

Data Source

[Presentation] Activation of α7 nicotinic acetylcholine receptor attenuates inflammation through decreasing cellular glutathione levels2024

Author(s)

Organizer

Data Source

[Presentation] 祖先転写制御の実験的復元から遺伝子が生まれる・消える過程を探る2023

Author(s)

Organizer

Data Source

[Presentation] Single cell analysis of non-model organisms and cross-species comparison2023

Author(s)

Organizer

Hara Yuichiro 原雄一郎

HARA Yuichiro 原雄一郎

[Book] ヒトゲノム事典 12章「12.3 遺伝子変換」, 「12.6 逆位」2021