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Kozuka Chisayo  小塚 智沙代

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小塚 智沙代  コヅカ チサヨ

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Researcher Number 70722370
Other IDs
Affiliation (Current) 2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 研究員
Affiliation (based on the past Project Information) *help 2023 – 2024: 国立研究開発法人理化学研究所, 生命医科学研究センター, 研究員
2019 – 2022: 国立研究開発法人理化学研究所, 生命医科学研究センター, 基礎科学特別研究員
2016: 琉球大学, 医学(系)研究科(研究院), 非常勤講師
2015: 琉球大学, 医学(系)研究科(研究院), 講師
Review Section/Research Field
Principal Investigator
Basic Section 59040:Nutrition science and health science-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 54040:Metabolism and endocrinology-related / Metabolomics
Except Principal Investigator
Basic Section 59020:Sports sciences-related
Keywords
Principal Investigator
次世代 / 肥満 / 生活習慣 / 遺伝 / 卵子 / 脂質 / エピゲノム / 胎盤 / 糖尿病 / 高脂肪食 … More / 分子栄養学 / 脂肪 / 玄米 / γ-オリザノール / 依存 / 食嗜好 / 肥満症 … More
Except Principal Investigator
次世代 / ビタミンD / エピゲノム / 脂肪組織 / 糖代謝 / 肝臓 / エピジェネティクス / 運動 / 妊娠 / 習慣的運動 / 糖尿病 / 肥満 / SOD3 / エクサカイン / プラセントカイン / 胎盤 / 妊娠期運動 Less
  • Research Projects

    (5 results)
  • Research Products

    (23 results)
  • Co-Researchers

    (8 People)
  •  Mechanism of obesity inheritance via lipid composition in oocytePrincipal Investigator

    • Principal Investigator
      小塚 智沙代
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  経胎盤アレルゲン輸送に注目した小児アレルギー発症機序の解明Principal Investigator

    • Principal Investigator
      小塚 智沙代
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  Mechanism of the beneficial effects of maternal exercise on next generation health focusing on maternal organs, placenta, and fetal tissues

    • Principal Investigator
      Kusuyama Joji
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59020:Sports sciences-related
    • Research Institution
      Tokyo Medical and Dental University
      Tohoku University
  •  Understanding the mechanism of intergenerational inheritance of metabolic disorders via placental functionPrincipal Investigator

    • Principal Investigator
      Kozuka Chisayo
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  玄米有効成分を活用した脳内報酬系による食嗜好制御に関わるエピゲノム機構の解明Principal Investigator

    • Principal Investigator
      小塚 智沙代
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Metabolomics
    • Research Institution
      University of the Ryukyus

All 2024 2023 2022 2021 2020 2017 2016 2015

All Journal Article Presentation

  • [Journal Article] Maternal Exercise-Induced SOD3 Reverses the Deleterious Effects of Maternal High Fat Diet on Offspring Metabolism Through Stabilization of H3K4me3 and Protection Against WDR82 Carbonylation2022

    • Author(s)
      Kusuyama Joji、Makarewicz Nathan S.、Albertson Brent G.、Alves-Wagner Ana Barbara、Conlin Royce H.、Prince Noah B、Alves Christiano R. R.、Ramachandran Krithika、Kozuka Chisayo、Xiudong Yang、Xia Yang、Hirshman Michael F.、Hatta Toshihisa、Nagatomi Ryoichi、Nozik Eva S.、Goodyear Laurie J.
    • Journal Title

      Diabetes

      Volume: - Issue: 6 Pages: 1170-1181

    • DOI

      10.2337/db21-0706

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03315
  • [Journal Article] Bromodomain Inhibition Reveals FGF15/19 as a Target of Epigenetic Regulation and Metabolic Control2022

    • Author(s)
      Kozuka C, Efthymiou V, Sales VM, Zhou L, Osataphan S, Yuchi Y, Chimene-Weiss J, Mulla C, Isganaitis E, Desmond J, Sanechika S, Kusuyama J, Goodyear L, Shi X, Gerszten RE, Aguayo-Mazzucato C, Carapeto P, Teixeira SD, Sandoval D, Alonso-Curbelo D, Wu L, Qi J, Patti ME.
    • Journal Title

      Diabetes

      Volume: - Issue: 5 Pages: 1023-1033

    • DOI

      10.2337/db21-0574

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03315
  • [Journal Article] Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health2021

    • Author(s)
      Kusuyama J, Alves-Wagner AB, Conlin RH, Makarewicz NS, Albertson BG, Prince NB, Kobayashi S, Kozuka C, Moller M, Bjerre M, Fuglsang J, Miele E, Middelbeek RJW, Xiudong Y, Xia Y, Garneau L, Bhattacharjee J, Aguer C, Patti ME, Hirshman MF, Jessen N, Hatta T, Ovesen PG, Adamo KB, Nozik-Grayck E, Goodyear LJ.
    • Journal Title

      Cell Metabolism

      Volume: Mar 19 Issue: 5 Pages: 939-956

    • DOI

      10.1016/j.cmet.2021.03.004

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K17971, KAKENHI-PROJECT-21H03315, KAKENHI-PROJECT-19K22696
  • [Journal Article] H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos2021

    • Author(s)
      Mei Hailiang、Kozuka Chisayo、Hayashi Ryoya、Kumon Mami、Koseki Haruhiko、Inoue Azusa
    • Journal Title

      Nature Genetics

      Volume: 53 Issue: 4 Pages: 539-550

    • DOI

      10.1038/s41588-021-00820-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-19H05754, KAKENHI-PROJECT-18H02359, KAKENHI-PROJECT-20J21541, KAKENHI-PROJECT-19K17971, KAKENHI-PLANNED-19H05745, KAKENHI-ORGANIZER-19H05749
  • [Journal Article] Impact of brown rice-specific γ-oryzanol on epigenetic modulation of dopamine D2 receptors in brain striatum in high-fat-diet-induced obesity in mice.2017

    • Author(s)
      Kozuka C, Kaname T, Shimizu-Okabe C, Takayama C, Tsutsui M, Matsushita M, Abe K, Masuzaki H
    • Journal Title

      Diabetologia

      Volume: 60 Issue: 8 Pages: 1502-1511

    • DOI

      10.1007/s00125-017-4305-4

    • NAID

      120006937804

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K19520, KAKENHI-PROJECT-17K07078, KAKENHI-PROJECT-17K09839, KAKENHI-PROJECT-17H01962, KAKENHI-PROJECT-16J40160
  • [Journal Article] Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice.2016

    • Author(s)
      Kozuka C, Shimizu-Okabe C, Takayama C, Nakano K, Morinaga H, Kinjo A, Fukuda K, Kamei A, Yasuoka A, Kondo T, Abe K, Egashira K, Masuzaki H.
    • Journal Title

      Drug Deliv.

      Volume: 24 Issue: 1 Pages: 558-568

    • DOI

      10.1080/10717544.2017.1279237

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H02905, KAKENHI-PROJECT-16J40160, KAKENHI-PROJECT-15K19520, KAKENHI-PROJECT-17K07078, KAKENHI-PROJECT-17K09839, KAKENHI-PROJECT-17H01962
  • [Presentation] Direct generation of germ cells from mouse ES cells by blastocyst complementation.2024

    • Author(s)
      Kozuka C, Hayashi R, Inoue A
    • Organizer
      Long-timescale Molecular Chronobiology Young Researchers Forum 2024
    • Data Source
      KAKENHI-PROJECT-23K28009
  • [Presentation] Direct generation of germ cells from mouse ES cells by blastocyst complementation.2024

    • Author(s)
      Kozuka C, Hayashi R, Inoue A
    • Organizer
      The 27th Interdisciplinary Exchange Evening
    • Data Source
      KAKENHI-PROJECT-23K28009
  • [Presentation] Parental lifestyle and susceptibility to obesity2023

    • Author(s)
      Kozuka C
    • Organizer
      1st OIST-RIKEN meeting
    • Data Source
      KAKENHI-PROJECT-23K28009
  • [Presentation] Bromodomain-containing proteins regulate glucose metabolism via gut-liver FGF15/19 pathway2021

    • Author(s)
      Chisayo Kozuka
    • Organizer
      Keystone eSymposia on Obesity: From Cell to Patient joint with Diabetes: Many Faces of the Disease
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K17971
  • [Presentation] エピゲノムを標的とした新しい肥満医療を目指して2021

    • Author(s)
      小塚智沙代
    • Organizer
      第41回 日本肥満学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K17971
  • [Presentation] 留学はしたほうがよい?~留学のメリット・デメリット~2020

    • Author(s)
      小塚智沙代
    • Organizer
      第93回 日本内分泌学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K17971
  • [Presentation] 玄米有効成分による膵内分泌機能改善の新規分子メカニズムの解明と医療応用へのアプローチ2016

    • Author(s)
      小塚智沙代, 益崎裕章
    • Organizer
      第54回 日本糖尿病学会九州地方会
    • Place of Presentation
      鹿児島県鹿児島市 (かごしま県民交流センター)
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K19520
  • [Presentation] Novel molecular mechanisms of brown rice-derived bioactive substance on anti-obesity and anti-diabetic properties.2016

    • Author(s)
      Kozuka C, Masuzaki H.
    • Organizer
      The 89th Annual Meeting of the Japanese Pharmacological Society
    • Place of Presentation
      神奈川県横浜市 (パシフィコ横浜)
    • Year and Date
      2016-03-11
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K19520
  • [Presentation] 玄米成分が担う代謝・内分泌機能改善の分子メカニズム2016

    • Author(s)
      小塚智沙代, 益崎裕章
    • Organizer
      第89回 日本内分泌学会
    • Place of Presentation
      京都府京都市 (国立京都国際会館)
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K19520
  • [Presentation] 玄米有効成分の分子栄養学と肥満症改善を目指す新しい神経行動科学2016

    • Author(s)
      小塚智沙代, 益崎裕章
    • Organizer
      第12回 レドックス・ライフイノベーションシンポジウム
    • Place of Presentation
      熊本県熊本市 (熊本大学医学部)
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K19520
  • [Presentation] 玄米有効成分γ-オリザノールによるグルコース応答性インスリン分泌増強効果の分子メカニズム2016

    • Author(s)
      小塚智沙代, 益崎裕章
    • Organizer
      第59回 日本糖尿病学会年次学術集会
    • Place of Presentation
      京都府京都市 (国立京都国際会館)
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K19520
  • [Presentation] Impact of a brown rice-derived bioactive product on feeding regulation and fuel metabolism.2016

    • Author(s)
      Kozuka C, Masuzaki H.
    • Organizer
      The 93rd Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      北海道札幌市 (札幌コンベンションセンター)
    • Year and Date
      2016-03-24
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K19520
  • [Presentation] 玄米由来有効成分を活用した メタボ・糖尿病予防の分子栄養学的アプローチ.2015

    • Author(s)
      小塚智沙代, 益崎裕章.
    • Organizer
      第88回日本内分泌学会学術総会
    • Place of Presentation
      東京都千代田区 (ホテルニューオータニ東京)
    • Year and Date
      2015-04-25
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K19520
  • [Presentation] 玄米由来生理活性物質を活用した高脂肪食肥満・糖尿病の病態解明と新規の予防・治療戦略.2015

    • Author(s)
      小塚智沙代、比嘉盛丈、田仲秀明、砂川澄人、植田玲、清水千草、高山千利、松下正之、親泊政一、島袋充生、益崎裕章.
    • Organizer
      第36回 日本肥満学会
    • Place of Presentation
      愛知県名古屋市 (名古屋国際会議場)
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PROJECT-15K19520
  • [Presentation] 天然食品由来有効成分による高脂肪食依存性改善の分子メカニズム.2015

    • Author(s)
      小塚智沙代, 益崎裕章.
    • Organizer
      第36回 日本肥満学会
    • Place of Presentation
      愛知県名古屋市 (名古屋国際会議場)
    • Year and Date
      2015-10-02
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K19520
  • [Presentation] 玄米由来生理活性物質が担う新規の膵島機能・インスリン分泌調節機構の解明.2015

    • Author(s)
      小塚智沙代、比嘉盛丈、田仲秀明、砂川澄人、植田玲、清水千草、高山千利、松下正之、親泊政一、島袋充生、益崎裕章.
    • Organizer
      第58回 日本糖尿病学会年次学術集会
    • Place of Presentation
      山口県下関市 (海峡メッセ下関)
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PROJECT-15K19520
  • [Presentation] Unrefined Grain-derived Gamma-oryzanol Improves β-cell Dysfunction via Suppression of Dopamine Receptor Signaling and Endoplasmic Reticulum Stress in Mice.2015

    • Author(s)
      Kozuka C, Higa M, Tanaka H, Takayama C, Matsushita M, Oyadomari S, Shimabukuro M, and Masuzaki H.
    • Organizer
      75th Scientific Sessions of American Diabetes Association
    • Place of Presentation
      Boston, USA
    • Year and Date
      2015-06-05
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19520
  • 1.  Kusuyama Joji (70596105)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 2.  永富 良一 (20208028)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  木村 友彦 (50454830)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  長名 シオン (60868131)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  有田 誠 (80292952)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  YASUOKA Akihito
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  近藤 隆
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  井上 梓
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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