Kozuka Chisayo 小塚智沙代

… Alternative Names

小塚智沙代コヅカチサヨ

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Researcher Number	70722370
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 研究員
Affiliation (based on the past Project Information) *help	2023 – 2024: 国立研究開発法人理化学研究所, 生命医科学研究センター, 研究員 2019 – 2022: 国立研究開発法人理化学研究所, 生命医科学研究センター, 基礎科学特別研究員 2016: 琉球大学, 医学(系)研究科(研究院), 非常勤講師 2015: 琉球大学, 医学(系)研究科(研究院), 講師
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 54040:Metabolism and endocrinology-related / Metabolomics Except Principal Investigator Basic Section 59020:Sports sciences-related
Keywords	Principal Investigator 次世代 / 肥満 / 生活習慣 / 遺伝 / 卵子 / 脂質 / エピゲノム / 胎盤 / 糖尿病 / 高脂肪食 … More / 分子栄養学 / 脂肪 / 玄米 / γ-オリザノール / 依存 / 食嗜好 / 肥満症 … More Except Principal Investigator 次世代 / ビタミンD / エピゲノム / 脂肪組織 / 糖代謝 / 肝臓 / エピジェネティクス / 運動 / 妊娠 / 習慣的運動 / 糖尿病 / 肥満 / SOD3 / エクサカイン / プラセントカイン / 胎盤 / 妊娠期運動 Less

Mechanism of obesity inheritance via lipid composition in oocytePrincipal Investigator
- Principal Investigator
  
  小塚智沙代
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Institute of Physical and Chemical Research
経胎盤アレルゲン輸送に注目した小児アレルギー発症機序の解明Principal Investigator
- Principal Investigator
  
  小塚智沙代
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Institute of Physical and Chemical Research
Mechanism of the beneficial effects of maternal exercise on next generation health focusing on maternal organs, placenta, and fetal tissues
- Principal Investigator
  
  Kusuyama Joji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Tokyo Medical and Dental University
  Tohoku University
Understanding the mechanism of intergenerational inheritance of metabolic disorders via placental functionPrincipal Investigator
- Principal Investigator
  
  Kozuka Chisayo
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Institute of Physical and Chemical Research
玄米有効成分を活用した脳内報酬系による食嗜好制御に関わるエピゲノム機構の解明Principal Investigator
- Principal Investigator
  
  小塚智沙代
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  University of the Ryukyus

All 2024 2023 2022 2021 2020 2017 2016 2015

All Journal Article Presentation

[Journal Article] Maternal Exercise-Induced SOD3 Reverses the Deleterious Effects of Maternal High Fat Diet on Offspring Metabolism Through Stabilization of H3K4me3 and Protection Against WDR82 Carbonylation2022
- Author(s)
  Kusuyama Joji、Makarewicz Nathan S.、Albertson Brent G.、Alves-Wagner Ana Barbara、Conlin Royce H.、Prince Noah B、Alves Christiano R. R.、Ramachandran Krithika、Kozuka Chisayo、Xiudong Yang、Xia Yang、Hirshman Michael F.、Hatta Toshihisa、Nagatomi Ryoichi、Nozik Eva S.、Goodyear Laurie J.
- Journal Title
  
  Diabetes
  
  Volume: － Issue: 6 Pages: 1170-1181
- DOI
  10.2337/db21-0706
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03315
[Journal Article] Bromodomain Inhibition Reveals FGF15/19 as a Target of Epigenetic Regulation and Metabolic Control2022
- Author(s)
  Kozuka C, Efthymiou V, Sales VM, Zhou L, Osataphan S, Yuchi Y, Chimene-Weiss J, Mulla C, Isganaitis E, Desmond J, Sanechika S, Kusuyama J, Goodyear L, Shi X, Gerszten RE, Aguayo-Mazzucato C, Carapeto P, Teixeira SD, Sandoval D, Alonso-Curbelo D, Wu L, Qi J, Patti ME.
- Journal Title
  
  Diabetes
  
  Volume: － Issue: 5 Pages: 1023-1033
- DOI
  10.2337/db21-0574
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03315
[Journal Article] Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health2021
- Author(s)
  Kusuyama J, Alves-Wagner AB, Conlin RH, Makarewicz NS, Albertson BG, Prince NB, Kobayashi S, Kozuka C, Moller M, Bjerre M, Fuglsang J, Miele E, Middelbeek RJW, Xiudong Y, Xia Y, Garneau L, Bhattacharjee J, Aguer C, Patti ME, Hirshman MF, Jessen N, Hatta T, Ovesen PG, Adamo KB, Nozik-Grayck E, Goodyear LJ.
- Journal Title
  
  Cell Metabolism
  
  Volume: Mar 19 Issue: 5 Pages: 939-956
- DOI
  10.1016/j.cmet.2021.03.004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17971, KAKENHI-PROJECT-21H03315, KAKENHI-PROJECT-19K22696
[Journal Article] H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos2021
- Author(s)
  Mei Hailiang、Kozuka Chisayo、Hayashi Ryoya、Kumon Mami、Koseki Haruhiko、Inoue Azusa
- Journal Title
  
  Nature Genetics
  
  Volume: 53 Issue: 4 Pages: 539-550
- DOI
  10.1038/s41588-021-00820-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05754, KAKENHI-PROJECT-18H02359, KAKENHI-PROJECT-20J21541, KAKENHI-PROJECT-19K17971, KAKENHI-PLANNED-19H05745, KAKENHI-ORGANIZER-19H05749
[Journal Article] Impact of brown rice-specific γ-oryzanol on epigenetic modulation of dopamine D2 receptors in brain striatum in high-fat-diet-induced obesity in mice.2017
- Author(s)
  Kozuka C, Kaname T, Shimizu-Okabe C, Takayama C, Tsutsui M, Matsushita M, Abe K, Masuzaki H
- Journal Title
  
  Diabetologia
  
  Volume: 60 Issue: 8 Pages: 1502-1511
- DOI
  10.1007/s00125-017-4305-4
- NAID
  120006937804
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19520, KAKENHI-PROJECT-17K07078, KAKENHI-PROJECT-17K09839, KAKENHI-PROJECT-17H01962, KAKENHI-PROJECT-16J40160
[Journal Article] Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice.2016
- Author(s)
  Kozuka C, Shimizu-Okabe C, Takayama C, Nakano K, Morinaga H, Kinjo A, Fukuda K, Kamei A, Yasuoka A, Kondo T, Abe K, Egashira K, Masuzaki H.
- Journal Title
  
  Drug Deliv.
  
  Volume: 24 Issue: 1 Pages: 558-568
- DOI
  10.1080/10717544.2017.1279237
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02905, KAKENHI-PROJECT-16J40160, KAKENHI-PROJECT-15K19520, KAKENHI-PROJECT-17K07078, KAKENHI-PROJECT-17K09839, KAKENHI-PROJECT-17H01962
[Presentation] Direct generation of germ cells from mouse ES cells by blastocyst complementation.2024
- Author(s)
  Kozuka C, Hayashi R, Inoue A
- Organizer
  Long-timescale Molecular Chronobiology Young Researchers Forum 2024
- Data Source
  KAKENHI-PROJECT-23K28009
[Presentation] Direct generation of germ cells from mouse ES cells by blastocyst complementation.2024
- Author(s)
  Kozuka C, Hayashi R, Inoue A
- Organizer
  The 27th Interdisciplinary Exchange Evening
- Data Source
  KAKENHI-PROJECT-23K28009
[Presentation] Parental lifestyle and susceptibility to obesity2023
- Author(s)
  Kozuka C
- Organizer
  1st OIST-RIKEN meeting
- Data Source
  KAKENHI-PROJECT-23K28009
[Presentation] Bromodomain-containing proteins regulate glucose metabolism via gut-liver FGF15/19 pathway2021
- Author(s)
  Chisayo Kozuka
- Organizer
  Keystone eSymposia on Obesity: From Cell to Patient joint with Diabetes: Many Faces of the Disease
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17971
[Presentation] エピゲノムを標的とした新しい肥満医療を目指して2021
- Author(s)
  小塚智沙代
- Organizer
  第41回日本肥満学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K17971
[Presentation] 留学はしたほうがよい？～留学のメリット・デメリット～2020
- Author(s)
  小塚智沙代
- Organizer
  第93回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K17971
[Presentation] 玄米有効成分による膵内分泌機能改善の新規分子メカニズムの解明と医療応用へのアプローチ2016
- Author(s)
  小塚智沙代, 益崎裕章
- Organizer
  第54回日本糖尿病学会九州地方会
- Place of Presentation
  鹿児島県鹿児島市 (かごしま県民交流センター)
- Invited
- Data Source
  KAKENHI-PROJECT-15K19520
[Presentation] Novel molecular mechanisms of brown rice-derived bioactive substance on anti-obesity and anti-diabetic properties.2016
- Author(s)
  Kozuka C, Masuzaki H.
- Organizer
  The 89th Annual Meeting of the Japanese Pharmacological Society
- Place of Presentation
  神奈川県横浜市 (パシフィコ横浜)
- Year and Date
  2016-03-11
- Invited
- Data Source
  KAKENHI-PROJECT-15K19520
[Presentation] 玄米成分が担う代謝・内分泌機能改善の分子メカニズム2016
- Author(s)
  小塚智沙代, 益崎裕章
- Organizer
  第89回日本内分泌学会
- Place of Presentation
  京都府京都市 (国立京都国際会館)
- Invited
- Data Source
  KAKENHI-PROJECT-15K19520
[Presentation] 玄米有効成分の分子栄養学と肥満症改善を目指す新しい神経行動科学2016
- Author(s)
  小塚智沙代, 益崎裕章
- Organizer
  第12回レドックス・ライフイノベーションシンポジウム
- Place of Presentation
  熊本県熊本市 (熊本大学医学部)
- Invited
- Data Source
  KAKENHI-PROJECT-15K19520
[Presentation] 玄米有効成分γ-オリザノールによるグルコース応答性インスリン分泌増強効果の分子メカニズム2016
- Author(s)
  小塚智沙代, 益崎裕章
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  京都府京都市 (国立京都国際会館)
- Invited
- Data Source
  KAKENHI-PROJECT-15K19520
[Presentation] Impact of a brown rice-derived bioactive product on feeding regulation and fuel metabolism.2016
- Author(s)
  Kozuka C, Masuzaki H.
- Organizer
  The 93rd Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  北海道札幌市 (札幌コンベンションセンター)
- Year and Date
  2016-03-24
- Invited
- Data Source
  KAKENHI-PROJECT-15K19520
[Presentation] 玄米由来有効成分を活用したメタボ・糖尿病予防の分子栄養学的アプローチ.2015
- Author(s)
  小塚智沙代, 益崎裕章.
- Organizer
  第88回日本内分泌学会学術総会
- Place of Presentation
  東京都千代田区 (ホテルニューオータニ東京)
- Year and Date
  2015-04-25
- Invited
- Data Source
  KAKENHI-PROJECT-15K19520
[Presentation] 玄米由来生理活性物質を活用した高脂肪食肥満・糖尿病の病態解明と新規の予防・治療戦略.2015
- Author(s)
  小塚智沙代、比嘉盛丈、田仲秀明、砂川澄人、植田玲、清水千草、高山千利、松下正之、親泊政一、島袋充生、益崎裕章.
- Organizer
  第36回日本肥満学会
- Place of Presentation
  愛知県名古屋市 (名古屋国際会議場)
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-15K19520
[Presentation] 天然食品由来有効成分による高脂肪食依存性改善の分子メカニズム.2015
- Author(s)
  小塚智沙代, 益崎裕章.
- Organizer
  第36回日本肥満学会
- Place of Presentation
  愛知県名古屋市 (名古屋国際会議場)
- Year and Date
  2015-10-02
- Invited
- Data Source
  KAKENHI-PROJECT-15K19520
[Presentation] 玄米由来生理活性物質が担う新規の膵島機能・インスリン分泌調節機構の解明.2015
- Author(s)
  小塚智沙代、比嘉盛丈、田仲秀明、砂川澄人、植田玲、清水千草、高山千利、松下正之、親泊政一、島袋充生、益崎裕章.
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  山口県下関市 (海峡メッセ下関)
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K19520
[Presentation] Unrefined Grain-derived Gamma-oryzanol Improves β-cell Dysfunction via Suppression of Dopamine Receptor Signaling and Endoplasmic Reticulum Stress in Mice.2015
- Author(s)
  Kozuka C, Higa M, Tanaka H, Takayama C, Matsushita M, Oyadomari S, Shimabukuro M, and Masuzaki H.
- Organizer
  75th Scientific Sessions of American Diabetes Association
- Place of Presentation
  Boston, USA
- Year and Date
  2015-06-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19520

1. Kusuyama Joji (70596105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 永富良一 (20208028)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 木村友彦 (50454830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 長名シオン (60868131)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 有田誠 (80292952)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YASUOKA Akihito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 近藤隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 井上梓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kozuka Chisayo 小塚 智沙代

小塚 智沙代 コヅカ チサヨ

Research Projects

Research Products

Co-Researchers

Mechanism of obesity inheritance via lipid composition in oocytePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

経胎盤アレルゲン輸送に注目した小児アレルギー発症機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of the beneficial effects of maternal exercise on next generation health focusing on maternal organs, placenta, and fetal tissues

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding the mechanism of intergenerational inheritance of metabolic disorders via placental functionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

玄米有効成分を活用した脳内報酬系による食嗜好制御に関わるエピゲノム機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Maternal Exercise-Induced SOD3 Reverses the Deleterious Effects of Maternal High Fat Diet on Offspring Metabolism Through Stabilization of H3K4me3 and Protection Against WDR82 Carbonylation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bromodomain Inhibition Reveals FGF15/19 as a Target of Epigenetic Regulation and Metabolic Control2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of brown rice-specific γ-oryzanol on epigenetic modulation of dopamine D2 receptors in brain striatum in high-fat-diet-induced obesity in mice.2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice.2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] Direct generation of germ cells from mouse ES cells by blastocyst complementation.2024

Author(s)

Organizer

Data Source

[Presentation] Direct generation of germ cells from mouse ES cells by blastocyst complementation.2024

Author(s)

Organizer

Data Source

[Presentation] Parental lifestyle and susceptibility to obesity2023

Author(s)

Organizer

Data Source

[Presentation] Bromodomain-containing proteins regulate glucose metabolism via gut-liver FGF15/19 pathway2021

Author(s)

Kozuka Chisayo 小塚智沙代

小塚智沙代コヅカチサヨ

[Presentation] 玄米由来有効成分を活用したメタボ・糖尿病予防の分子栄養学的アプローチ.2015