Yamamoto Takayoshi 山元孝佳

Researcher Number	70724699
Other IDs	https://orcid.org/0000-0001-8028-6050
Affiliation (Current)	2025: 東京学芸大学, 教育学部, 講師 2025: 東京大学, 大学院総合文化研究科, 助教
Affiliation (based on the past Project Information) *help	2018 – 2023: 東京大学, 大学院総合文化研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 44020:Developmental biology-related Except Principal Investigator Basic Section 44020:Developmental biology-related
Keywords	Principal Investigator 濃度勾配 / ヘパラン硫酸 / モルフォゲン / アフリカツメガエル / 細胞分化 / Toll様受容体経路 / 発生・形態形成 / 頭部形成 / Xenopus / Toll-like receptor … More Except Principal Investigator … More ツメガエル / アフリカツメガエル / 細胞張力 / 外胚葉パターニング / 細胞内シグナル伝達 / 胚パターニング / ヒトiPS細胞 / 予定プラコード / 力 / プラコード / 物理的な力 / 遺伝子発現 / 外胚葉 / 胚発生 / モータータンパク質 / 伸展刺激 / 平面内細胞極性 / 細胞骨格 Less

神経外胚葉分化における、ヘパラン硫酸修飾酵素によるモルフォゲンの分布制御Principal Investigator
- Principal Investigator
  
  山元孝佳
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  The University of Tokyo
Regulation of force-dependent signal pathways during ectodermal patterning in Xenopus embryo
- Principal Investigator
  
  Michiue Tatsuo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  The University of Tokyo
A role of Toll/Irak1: a novel mechanism of head inductionPrincipal Investigator
- Principal Investigator
  
  Yamamoto Takayoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  The University of Tokyo
The effect of physical force on cell fate determination in vertebrate embryos
- Principal Investigator
  
  MICHIUE TATSUO
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2019 2018

All Journal Article Presentation

[Journal Article] Evaluation of Pancreatic β-cell Differentiation Efficiency of Human iPSC Lines for Clinical Use.2024
- Author(s)
  Horikawa A, Tsuda K, Yamamoto T, Michiue T.
- Journal Title
  
  Curr Stem Cell Res Ther.
  
  Volume: - Issue: 11 Pages: 1449-1460
- DOI
  10.2174/011574888x267226231126185532
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06183
[Journal Article] Enhancement of neural crest formation by mechanical force in Xenopus development.2024
- Author(s)
  Kaneshima T, Ogawa M, Yamamoto T, Tsuboyama Y, Miyata Y, Kotani M, Okajima T, Michiue T.
- Journal Title
  
  Int. J. Dev. Biol
  
  Volume: 68 Issue: 1 Pages: 25-37
- DOI
  10.1387/ijdb.230273tm
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06183
[Journal Article] Chemical inhibitors of cyclin-dependent kinase (CDKi) improve pancreatic endocrine differentiation of iPS cells.2023
- Author(s)
  Ning H, Horikawa A, Yamamoto T, Michiue T.
- Journal Title
  
  In Vitro Cell Dev Biol Anim.
  
  Volume: 59 Issue: 6 Pages: 410-419
- DOI
  10.1007/s11626-023-00776-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06183
[Journal Article] Heparan sulfate modification enzyme, Hs6st1, is essential for neuroectodermal patterning in Xenopus embryos.2023
- Author(s)
  Yamamoto T, Kaneshima T, Tsukano K, Michiue T
- Journal Title
  
  Dev. Biol.
  
  Volume: 496 Pages: 87-94
- DOI
  10.1016/j.ydbio.2023.01.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06183
[Journal Article] Identification of tumor-related genes via RNA sequencing of tumor tissues in Xenopus tropicalis2023
- Author(s)
  Kitamura Kazuki、Yamamoto Takayoshi、Ochi Haruki、Suzuki Makoto、Suzuki Nanoka、Igawa Takeshi、Yoshida Tadashi、Futakuchi Mitsuru、Ogino Hajime、Michiue Tatsuo
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 13214-13214
- DOI
  10.1038/s41598-023-40193-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06125, KAKENHI-PROJECT-22K06233, KAKENHI-PROJECT-22K06318, KAKENHI-PROJECT-23K06646, KAKENHI-PROJECT-21K06183, KAKENHI-ORGANIZER-22H05069, KAKENHI-PLANNED-22H05070
[Journal Article] Ndst1, a heparan sulfate modification enzyme, regulates neuroectodermal patterning by enhancing Wnt signaling in Xenopus2023
- Author(s)
  Yamamoto T, Kambayashi Y, Tsukano K, Michiue T.
- Journal Title
  
  Dev. Growth. Diff.
  
  Volume: 65 Issue: 3 Pages: 153-160
- DOI
  10.1111/dgd.12843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06183
[Journal Article] Xenopus Dusp6 modulates FGF signaling to precisely pattern pre-placodal ectoderm2022
- Author(s)
  Tsukano K, Yamamoto T, Watanabe T, Michiue T
- Journal Title
  
  Dev. Biol.
  
  Volume: 488 Pages: 81-90
- DOI
  10.1016/j.ydbio.2022.05.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06183
[Journal Article] Positive feedback regulation of frizzled-7 expression robustly shapes a steep Wnt gradient in Xenopus heart development, together with sFRP1 and heparan sulfate2022
- Author(s)
  Yamamoto T, Kambayashi Y, Afouda B, Otsuka Y, Ciuraniuc C, Michiue T, Hoppler S
- Journal Title
  
  elife
  
  Volume: 11
- DOI
  10.7554/elife.73818
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06183
[Journal Article] Positive Feedback Regulation of fzd7 Expression Robustly Shapes Wnt Signaling Range in Early Heart Development2021
- Author(s)
  Yamamoto Takayoshi、Kambayashi Yuta、Afouda Boni、Otsuka Yuta、Giuraniuc Claudiu、Michiue Tatsuo、Hoppler Stefan
- Journal Title
  
  bioRxiv
  
  Volume: NA Pages: 1-35
- DOI
  10.1101/2021.09.12.458649
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16138
[Journal Article] A simple method of hiPSCs differentiation into insulin-producing cells is improved with vitamin C and RepSox.2021
- Author(s)
  Horikawa A, Mizuo K, Tsuda K, Yamamoto T, Michiue T.
- Journal Title
  
  PLoS ONE
  
  Volume: 16 Issue: 7 Pages: e0254373-e0254373
- DOI
  10.1371/journal.pone.0254373
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06183
[Journal Article] FRET-based tension measurement across actin-associated mechanotransductive structures using Lima12018
- Author(s)
  Hirano S, Yamamoto T, Michiue T
- Journal Title
  
  Int. J. Dev. Biol.
  
  Volume: 62 Issue: 9-10 Pages: 631-636
- DOI
  10.1387/ijdb.180110tm
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06244, KAKENHI-PUBLICLY-18H04967, KAKENHI-ORGANIZER-15H05935
[Journal Article] Fam46a regulates BMP-dependent pre-placodal ectoderm differentiation in Xenopus.2018
- Author(s)
  Watanabe T, Yamamoto T, Tsukano K. Hirano S. Horikawa A, Michiue T
- Journal Title
  
  Development
  
  Volume: 145 Issue: 20
- DOI
  10.1242/dev.166710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06244
[Presentation] 力学的刺激がツメガエル神経胚の神経堤領域決定に及ぼす影響2023
- Author(s)
  小川真生、金島時、山元孝佳、道上達男
- Organizer
  第46回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21K06183
[Presentation] 細胞外分子によるモルフォゲン分布制御2023
- Author(s)
  山元孝佳、道上達男
- Organizer
  第46回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21K06183
[Presentation] ツメガエル外胚葉パターニングにおける物理的な力の関与2023
- Author(s)
  金島時、小川真生、山元孝佳、道上達男
- Organizer
  第９４回日本動物学会年会
- Data Source
  KAKENHI-PROJECT-21K06183
[Presentation] 機械的刺激によるツメガエル神経堤形成の促進2022
- Author(s)
  金島時、小川真生、山元孝佳、道上達男
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06183
[Presentation] Wnt-受容体フィードバックによるロバストな心膜形成―ウェットとドライの相補的アプローチ2022
- Author(s)
  山元孝佳、上林勇太、大塚祐太、道上達男、Stefan Hoppler
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06183
[Presentation] FGFリガンド量のゆらぎに強いパターン形成機構ーツメガエル予定プラコード形成におけるDusp6の機能解析ー2022
- Author(s)
  塚野皓平、山元孝佳、渡邊朋子、道上達男
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06183
[Presentation] ネッタイツメガエルを用いた、がん形成関連遺伝子の網羅的探索2022
- Author(s)
  北村和輝、山元孝佳、越智陽城、道上達男
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06183
[Presentation] ツメガエル胚の神経領域決定における物理的な力な関与2021
- Author(s)
  道上達男、金島時、小川真生、山元孝佳
- Organizer
  日本動物学会年会
- Data Source
  KAKENHI-PROJECT-21K06183
[Presentation] Positive Feedback Regulation of Fzd7 Expression Shapes Wnt6 Signal Range in Early Heart Development2021
- Author(s)
  Takayoshi Yamamoto
- Organizer
  Wnt meeting 2021
- Invited
- Data Source
  KAKENHI-PROJECT-19K16138
[Presentation] 頭部プラコード形成におけるBMPシグナル伝達経路の活性制御機構の解明2021
- Author(s)
  名古屋由夏、金島時、山元孝佳、道上達男
- Organizer
  日本動物学会関東支部第７３回大会
- Data Source
  KAKENHI-PROJECT-19K16138
[Presentation] Dusp6 is required for robust patterning of pre-placodal ectoderm by regulating FGF signal activity in Xenopus embryos2021
- Author(s)
  Kohei Tsukano, Tomoko Watanabe, Takayoshi Yamamoto, Tatsuo Michiue
- Organizer
  18th International Xenopus Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16138
[Presentation] Ndst1はへパラン硫酸の修飾を介して神経堤分化を促進する2021
- Author(s)
  上林勇太、塚野皓平、山元孝佳、道上達男
- Organizer
  日本動物学会関東支部第７３回大会
- Data Source
  KAKENHI-PROJECT-19K16138
[Presentation] ツメガエル初期発生の外胚葉パターニングにおける物理的な力の関与2019
- Author(s)
  道上達男、金島　時、中桐悠一郞、山元　孝
- Organizer
  第90回日本動物学会年会
- Data Source
  KAKENHI-PROJECT-18K06244
[Presentation] 機械的刺激によりツメガエル胚の予定プラコード分化が亢進される2019
- Author(s)
  金島　時、山元孝佳、道上達男
- Organizer
  日本動物学会関東支部会
- Data Source
  KAKENHI-PROJECT-18K06244
[Presentation] アフリカツメガエルの心臓形成におけるWnt経路を介したFrizzled7の発現誘導2019
- Author(s)
  上林勇太, Boni Afouda, Stefan Hoppler, 道上達男, 山元孝佳
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16138
[Presentation] ツメガエル胚において機械的刺激が予定プラコード分化を亢進する2019
- Author(s)
  金島時, 山元孝佳, 道上達男
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16138
[Presentation] CRISPR/Cas9法を用いた、ツメガエル胚におけるがん形成に必要な遺伝子の組み合わせの探索2019
- Author(s)
  北村和輝, 山元孝佳, 越智陽城, 道上達男
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16138
[Presentation] ツメガエル初期胚の外胚葉パターニングにおける物理的な力の関与2019
- Author(s)
  道上達男, 金島時, 中桐悠一郎, 山元孝佳
- Organizer
  日本動物学会第90回大阪大会
- Data Source
  KAKENHI-PROJECT-19K16138
[Presentation] ツメガエル胚において機械的刺激が予定プラコード分化を亢進する2019
- Author(s)
  金島時、山元孝佳、道上達男
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-18K06244
[Presentation] Toll様受容体/IL-1受容体経路構成因子であるヒトIRAK1はWnt/β-カテニン経路を活性化する2019
- Author(s)
  三村恭弘, 乾雅子, 山元孝佳, 大坪孝平, 平良眞規, 日笠弘基
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16138
[Presentation] 脊椎動物胚の左右非対称性を生み出すNodalシグナル長距離伝達機構とその進化過程2019
- Author(s)
  池田貴史, 山元孝佳, 平良眞規, 武田洋幸
- Organizer
  日本動物学会第90回大阪大会
- Data Source
  KAKENHI-PROJECT-19K16138
[Presentation] アクチン結合タンパク質Lima1を用いたFRET張力センサーの開発2018
- Author(s)
  平野咲雪、山元孝佳、道上達男
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-18K06244
[Presentation] FRET張力センサーを用いたツメガエル神経胚の張力観察2018
- Author(s)
  平野咲雪、山元孝佳、道上達男
- Organizer
  第89回日本動物学会年会
- Data Source
  KAKENHI-PROJECT-18K06244

1. MICHIUE TATSUO (10282724)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
2. IGAWA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. SUZUKI Makoto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 荻野肇

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamamoto Takayoshi 山元 孝佳

Research Projects

Research Products

Co-Researchers

神経外胚葉分化における、ヘパラン硫酸修飾酵素によるモルフォゲンの分布制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of force-dependent signal pathways during ectodermal patterning in Xenopus embryo

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A role of Toll/Irak1: a novel mechanism of head inductionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The effect of physical force on cell fate determination in vertebrate embryos

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Evaluation of Pancreatic β-cell Differentiation Efficiency of Human iPSC Lines for Clinical Use.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhancement of neural crest formation by mechanical force in Xenopus development.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chemical inhibitors of cyclin-dependent kinase (CDKi) improve pancreatic endocrine differentiation of iPS cells.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Heparan sulfate modification enzyme, Hs6st1, is essential for neuroectodermal patterning in Xenopus embryos.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of tumor-related genes via RNA sequencing of tumor tissues in Xenopus tropicalis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ndst1, a heparan sulfate modification enzyme, regulates neuroectodermal patterning by enhancing Wnt signaling in Xenopus2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Xenopus Dusp6 modulates FGF signaling to precisely pattern pre-placodal ectoderm2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Positive feedback regulation of frizzled-7 expression robustly shapes a steep Wnt gradient in Xenopus heart development, together with sFRP1 and heparan sulfate2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Positive Feedback Regulation of fzd7 Expression Robustly Shapes Wnt Signaling Range in Early Heart Development2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A simple method of hiPSCs differentiation into insulin-producing cells is improved with vitamin C and RepSox.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] FRET-based tension measurement across actin-associated mechanotransductive structures using Lima12018

Author(s)

Yamamoto Takayoshi 山元孝佳