Yamahara Mako 山原真子

… Alternative Names

Yasuda-Yamahara Mako 山原真子

Yasuda Mako 安田真子

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Researcher Number	70731941
Other IDs
Affiliation (Current)	2025: 滋賀医科大学, 医学部, 特任講師
Affiliation (based on the past Project Information) *help	2020 – 2024: 滋賀医科大学, 医学部, 特任講師 2018 – 2019: 滋賀医科大学, 医学部, 助教 2015 – 2017: 滋賀医科大学, 医学部, 客員助教
Review Section/Research Field	Principal Investigator Basic Section 53040:Nephrology-related / Metabolomics
Keywords	Principal Investigator ポドサイト / リソソーム / 糸球体上皮細胞 / 糖尿病性腎症 / オートファジー / 糖尿病性腎臓病 / CKD / 慢性腎臓病

ポドサイトのリソソーム活性化に着目した新規糖尿病性腎臓病治療標的の探索Principal Investigator
- Principal Investigator
  
  山原真子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Shiga University of Medical Science
Development of therapeutic agents for diabetic kidney disease focusing on autophagyPrincipal Investigator
- Principal Investigator
  
  Yamahara Mako
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Shiga University of Medical Science
Elucidation of the mechanism of podocyte damage in chronic kidney disease by focusing on lysosomal damagePrincipal Investigator
- Principal Investigator
  
  Yasuda-Yamahara Mako
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Shiga University of Medical Science
Therapeutic possibility of autophagy-lysosome pathway in diabetic nephropathyPrincipal Investigator
- Principal Investigator
  
  Yasuda Mako
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Shiga University of Medical Science

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] 【糖尿病性腎症の克服を目指して～up to date～】糖尿病性腎症における細胞内代謝異常2016
- Author(s)
  久米真司, 安田真子, 山原康佑
- Total Pages
  4
- Publisher
  Pharma Medica
- Data Source
  KAKENHI-PROJECT-15K19511
[Book] 糖尿病腎症克服に残された課題～挑戦　発症メカニズムに立脚した治療の将来展望2015
- Author(s)
  久米真司、安田真子、山原康佑
- Total Pages
  7
- Publisher
  月刊糖尿病
- Data Source
  KAKENHI-PROJECT-15K19511
[Journal Article] A novel therapeutic target for kidney diseases: Lessons learned from starvation response.2024
- Author(s)
  Yamahara K, Yasuda-Yamahara M, Kume S.
- Journal Title
  
  Pharmacol Ther.
  
  Volume: - Pages: 108590-108590
- DOI
  10.1016/j.pharmthera.2024.108590
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08229, KAKENHI-PROJECT-23K21619
[Journal Article] SRGAP1 controls small Rho GTPases to regulate podocyte foot process maintenance.2021
- Author(s)
  Rogg M, Maier JI, Dotzauer R, Artelt N, Kretz O, Helmstaedter M, Abed A, Sammarco A, Sigle A, Sellung D, Dinse P, Reiche K, Yasuda-Yamahara M, Biniossek ML, Walz G, Werner M, Endlich N, Schilling O, Huber TB, Schell C
- Journal Title
  
  J Am Soc Nephrol
  
  Volume: 32 Issue: 3 Pages: 563-579
- DOI
  10.1681/asn.2020081126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15998
[Journal Article] Roles of mTOR in Diabetic Kidney Disease2021
- Author(s)
  Yasuda-Yamahara M, Kume S, Maegawa H.
- Journal Title
  
  Antioxidants
  
  Volume: 10 Issue: 2 Pages: 321-321
- DOI
  10.3390/antiox10020321
- NAID
  120006979532
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08241, KAKENHI-PROJECT-18K15998
[Journal Article] Pivotal role of podocyte autophagy against glomerular endothelial dysfunction in diabetes.2020
- Author(s)
  Yoshibayashi M, Kume S, Yasuda-Yamahara M, Yamahara K, Takeda N, Osawa N, Chin-Kanasaki M, Nakae Y, Yokoi H, Mukoyama M, Asanuma K, Maegawa H, Araki SI.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 525 Issue: 2 Pages: 319-325
- DOI
  10.1016/j.bbrc.2020.02.088
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15998, KAKENHI-PROJECT-17K09706, KAKENHI-PROJECT-20K08611, KAKENHI-PROJECT-20K08633, KAKENHI-PROJECT-18H02823
[Journal Article] SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition2020
- Author(s)
  Tomita Issei、Kume Shinji、Sugahara Sho、Osawa Norihisa、Yamahara Kosuke、Yasuda-Yamahara Mako、Takeda Naoko、Chin-Kanasaki Masami、Kaneko Tatsuroh、Mayoux Eric、Mark Michael、Yanagita Motoko、Ogita Hisakazu、Araki Shin-ichi、Maegawa Hiroshi
- Journal Title
  
  Cell Metabolism
  
  Volume: 32 Issue: 3 Pages: 404-404
- DOI
  10.1016/j.cmet.2020.06.020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08489, KAKENHI-PROJECT-20H03697, KAKENHI-PROJECT-18K08241, KAKENHI-PROJECT-19K22620, KAKENHI-PROJECT-18K15998, KAKENHI-PROJECT-16H06276
[Journal Article] Protein O-GlcNAcylation Is Essential for the Maintenance of Renal Energy Homeostasis and Function via Lipolysis during Fasting and Diabetes2019
- Author(s)
  Sugahara S, Kume S, Chin-Kanasaki M, Tomita I, Yasuda-Yamahara M, Yamahara K, Takeda N, Osawa N, Yanagita M, Araki SI, Maegawa H.
- Journal Title
  
  Journal of the American Society of Nephrology
  
  Volume: In press Issue: 6 Pages: 962-978
- DOI
  10.1681/asn.2018090950
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09612, KAKENHI-PROJECT-19K08724, KAKENHI-PROJECT-18K15998, KAKENHI-PROJECT-18H02862
[Journal Article] Role of dietary amino acid balance in diet restriction-mediated lifespan extension, renoprotection, and muscle weakness in aged mice.2018
- Author(s)
  Yoshida S, Yamahara K, Kume S, Koya D, Yasuda-Yamahara M, Takeda N, Osawa N, Chin-Kanasaki M, Adachi Y, Nagao K, Maegawa H, Araki SI.
- Journal Title
  
  Aging Cell.
  
  Volume: 17 Issue: 4
- DOI
  10.1111/acel.12796
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15998, KAKENHI-PROJECT-16K15472
[Journal Article] AIF1L regulates actomyosin contractility and filopodial extensions in human podocytes.2018
- Author(s)
  Yasuda-Yamahara M, Rogg M, Yamahara K, Maier JI, Huber TB, Schell C.
- Journal Title
  
  PLoS One.
  
  Volume: 13 Issue: 7 Pages: e0200487-e0200487
- DOI
  10.1371/journal.pone.0200487
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15998
[Journal Article] FERMT2 links cortical actin structures, plasma membrane tension and focal adhesion function to stabilize podocyte morphology2018
- Author(s)
  Yasuda-Yamahara M.、Rogg M.、Frimmel J.、Trachte P.、Helmstaedter M.、Schroder P.、Schiffer M.、Schell C.、Huber T.B.
- Journal Title
  
  Matrix Biology
  
  Volume: 印刷中 Pages: 30401-30408
- DOI
  10.1016/j.matbio.2018.01.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19511, KAKENHI-PROJECT-18K15998
[Journal Article] ARP3 controls the podocyte architecture at the kidney filtration barrier.2018
- Author(s)
  Schell C, Sabass B, Helmstaedter M, Geist F, Abed A, Yasuda-Yamahara M, Sigle A, Maier JI, Grahammer F, Siegerist F, Artelt N, Endlich N, Kerjaschki D, Arnold HH, Dengjel J, Rogg M, Huber TB.
- Journal Title
  
  Dev Cell.
  
  Volume: 47 Issue: 6 Pages: 741-757
- DOI
  10.1016/j.devcel.2018.11.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15998
[Journal Article] The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier2017
- Author(s)
  Schell Christoph、Rogg Manuel、Suhm Martina、Helmstaedter Martin、Sellung Dominik、Yasuda-Yamahara Mako、Huber Tobias B. et. al.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 114 Issue: 23
- DOI
  10.1073/pnas.1617004114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19511
[Journal Article] オートファジーと糖尿病性腎症、糸球体上皮細胞障害 (腎疾患とオートファジー) Role of Autophagy in Podocyte Injury in Diabetic Nephropathy2017
- Author(s)
  山原真子、山原康佑、久米真司
- Journal Title
  
  日本臨床検査医学会誌
  
  Volume: 65 Pages: 667-673
- Data Source
  KAKENHI-PROJECT-15K19511
[Journal Article] O-linked β-N-acetylglucosamine modification of proteins is essential for foot process maturation and survival in podocytes.2017
- Author(s)
  Ono S, Kume S, Yasuda-Yamahara M, Yamahara K, Takeda N, Chin-Kanasaki M, Araki H, Sekine O, Yokoi H, Mukoyama M, Uzu T, Araki SI, Maegawa H.
- Journal Title
  
  Nephrol Dial Transplant.
  
  Volume: 未定 Issue: 9 Pages: 000-000
- DOI
  10.1093/ndt/gfw463
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25713033, KAKENHI-PROJECT-26461226, KAKENHI-PROJECT-15K09383, KAKENHI-PROJECT-15K19511, KAKENHI-PROJECT-16K09612, KAKENHI-PROJECT-17K09706
[Journal Article] The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton2017
- Author(s)
  Rogg M.、Yasuda-Yamahara M.、Abed A.、Dinse P.、Helmstaedter M.、Conzelmann A. C.、Frimmel J.、Sellung D.、Biniossek M. L.、Kretz O.、Grahammer F.、Schilling O.、Huber T. B.、Schell C.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 1-15
- DOI
  10.1038/s41598-017-15844-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19511
[Journal Article] 糖尿病性腎症の発症進展におけるオートファジーの関与2017
- Author(s)
  山原康佑, 山原真子, 久米真司
- Journal Title
  
  日本腎臓学会誌
  
  Volume: 59 Pages: 50-57
- Data Source
  KAKENHI-PROJECT-15K19511
[Journal Article] Impaired podocyte autophagy exacerbates proteinuria in diabetic nephropathy.2016
- Author(s)
  Tagawa A, Yasuda M, Kume S, Ymahara K, Nakazawa J, Chin-Kanasaki M, Araki H, Araki SI, Koya D, Asanuma K, Kim EH, Haneda M, Kajiwara N, Hayashi K, Ohashi H, Ugi S, Maegawa H, Uzu T
- Journal Title
  
  Diabetes.
  
  Volume: - Issue: 3 Pages: 755-767
- DOI
  10.2337/db15-0473
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670431, KAKENHI-PROJECT-15K19511, KAKENHI-PROJECT-26893116, KAKENHI-PROJECT-26293217, KAKENHI-PROJECT-25713033
[Journal Article] Lamp-2 deficiency prevents high-fat diet-induced obese diabetes via enhancing energy expenditure.2015
- Author(s)
  Yasuda-Yamahara M, Kume S, Yamahara K, Nakazawa J, Chin-Kanasaki M, Araki H, Araki S, Koya D, Haneda M, Ugi S, Maegawa H, Uzu T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 18 Issue: 2 Pages: 249-255
- DOI
  10.1016/j.bbrc.2015.08.010
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19511, KAKENHI-PROJECT-26893116, KAKENHI-PROJECT-26293217
[Journal Article] Emerging role of podocyte autophagy in the progression of diabetic nephropathy.2015
- Author(s)
  Yasuda-Yamahara M, Kume S, Tagawa A, Maegawa H, Uzu T.
- Journal Title
  
  Autophagy
  
  Volume: 11 Issue: 12 Pages: 2385-2386
- DOI
  10.1080/15548627.2015.1115173
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19511, KAKENHI-PROJECT-26293217, KAKENHI-PROJECT-25713033
[Presentation] 糖尿病性腎臓病のポドサイトではリソソーム転写因子TFEBが抑制され細胞障害をきたす2023
- Author(s)
  山原　真子、吉林　護、桑形　尚吾、山原　康佑、佐々木　裕紀、金崎　雅美、藤田　征弘、久米　真司
- Organizer
  第66回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K08229
[Presentation] 糖尿病性腎症におけるポドサイト代謝異常の役割2023
- Author(s)
  山原　真子
- Organizer
  第38回日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-21K08229
[Presentation] Role of the lysosomal transcription factor TFEB in podocyte injury in diabetic kidney disease.2022
- Author(s)
  Yasuada-Yamahara M.
- Organizer
  International Congress of Diabetes and Metabolism.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08229
[Presentation] リソソーム転写因子TFEBの活性化は糖尿病性腎臓病のポドサイト障害を抑制する2022
- Author(s)
  山原　真子、桑形　尚吾、山原　康佑、佐々木　裕紀、金﨑　雅美、久米　真司、前川　聡
- Organizer
  第65回日本腎臓学会総会学術総会
- Data Source
  KAKENHI-PROJECT-21K08229
[Presentation] Role of the lysosomal transcription factor TFEB in podocyte injury in diabetic kidney disease.2022
- Author(s)
  Yasuada-Yamahara M
- Organizer
  The 19th Japan-Korea Diabetic Nephropathy Seminar.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08229
[Presentation] 『腎生100年』を目指した腎臓基礎研究の課題2022
- Author(s)
  山原　真子
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K08229
[Presentation] 糖尿病性腎臓病でのポドサイト障害におけるリソソーム転写因子TFEBの役割2021
- Author(s)
  山原真子, 久米真司, 荒木信一, 前川聡
- Organizer
  第32回日本糖尿病性腎症研究会
- Data Source
  KAKENHI-PROJECT-21K08229
[Presentation] Intracellular nutrient signals and diabetic kidney disease.2020
- Author(s)
  山原真子
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K15998
[Presentation] Whole-body energy metabolism and podocytopathy.2020
- Author(s)
  山原真子
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K15998
[Presentation] Autophagy protects podocytes from diabetes-related glomerular endothelial damage.2019
- Author(s)
  Yasuada-Yamahara M, Yoshibayashi M, Kume S, Araki SI, Maegawa H.
- Organizer
  International Diabetes Federation 2019 (IDF 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15998
[Presentation] 糸球体上皮細胞の接着機構における新規細胞接着分子FERMT2の同定2018
- Author(s)
  山原　真子
- Organizer
  第61回日本腎臓学会総会学術総会
- Data Source
  KAKENHI-PROJECT-18K15998
[Presentation] 蛋白O-GlcNAc修飾は糸球体上皮細胞(ポドサイト)の機能維持に不可欠である2016
- Author(s)
  小野真也, 山原真子, 久米真司, 中澤純, 金崎雅美, 荒木久澄, 荒木信一, 宇津貴, 前川聡
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜・横浜市・神奈川県
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-15K19511
[Presentation] 糸球体上皮細胞におけるオートファジー不全は糖尿病性腎症における蛋白尿を増悪させる2015
- Author(s)
  田川安都子、安田真子、久米真司、中澤純、金﨑雅美、荒木久澄、荒木信一、古屋大祐、羽田勝計、宇津貴、前川聡
- Organizer
  第58回日本腎臓学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-06-06
- Data Source
  KAKENHI-PROJECT-15K19511
[Presentation] 糸球体上皮細胞の維持における蛋白O-GlcNac修飾の役割2015
- Author(s)
  小野真也、安田真子、久米真司、関根理、中澤純、金﨑雅美、荒木久澄、荒木信一、古屋大祐、羽田勝計、宇津貴、前川聡
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  下関
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K19511
[Presentation] シャペロン介在性オートファジー欠損は高脂肪食負荷肥満糖尿病の発症を抑制する2015
- Author(s)
  安田真子、久米真司、中澤純、金﨑雅美、荒木久澄、荒木信一、Paul　Saftig、宇津貴、前川聡
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  下関
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K19511

1. ASANUMA Katsuhiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. Ono Shinya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. KANESAKI Masami

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. Kume Shinji

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
5. Sugahara Sho

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 扇田久和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamahara Mako 山原 真子

Yasuda-Yamahara Mako 山原 真子

Yasuda Mako 安田 真子

Research Projects

Research Products

Co-Researchers

ポドサイトのリソソーム活性化に着目した新規糖尿病性腎臓病治療標的の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of therapeutic agents for diabetic kidney disease focusing on autophagyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of podocyte damage in chronic kidney disease by focusing on lysosomal damagePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Therapeutic possibility of autophagy-lysosome pathway in diabetic nephropathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 【糖尿病性腎症の克服を目指して～up to date～】 糖尿病性腎症における細胞内代謝異常2016

Author(s)

Total Pages

Publisher

Data Source

[Book] 糖尿病腎症克服に残された課題～挑戦 発症メカニズムに立脚した治療の将来展望2015

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] A novel therapeutic target for kidney diseases: Lessons learned from starvation response.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SRGAP1 controls small Rho GTPases to regulate podocyte foot process maintenance.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Roles of mTOR in Diabetic Kidney Disease2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Pivotal role of podocyte autophagy against glomerular endothelial dysfunction in diabetes.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protein O-GlcNAcylation Is Essential for the Maintenance of Renal Energy Homeostasis and Function via Lipolysis during Fasting and Diabetes2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of dietary amino acid balance in diet restriction-mediated lifespan extension, renoprotection, and muscle weakness in aged mice.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] AIF1L regulates actomyosin contractility and filopodial extensions in human podocytes.2018

Author(s)

Journal Title

DOI

Yamahara Mako 山原真子

Yasuda-Yamahara Mako 山原真子

Yasuda Mako 安田真子

[Book] 【糖尿病性腎症の克服を目指して～up to date～】糖尿病性腎症における細胞内代謝異常2016

[Book] 糖尿病腎症克服に残された課題～挑戦　発症メカニズムに立脚した治療の将来展望2015