Kakuguchi Wataru 格口渉

Researcher Number	70740645
Other IDs
Affiliation (Current)	2025: 北海道大学, 大学病院, 講師
Affiliation (based on the past Project Information) *help	2024 – 2025: 北海道大学, 歯学研究院, 助教 2022 – 2023: 北海道大学, 大学病院, 助教 2016 – 2018: 北海道大学, 大学病院, 助教 2015: 北海道大学, 大学病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 57020:Oral pathobiological science-related / Pathobiological dentistry/Dental radiology Except Principal Investigator Basic Section 20010:Mechanics and mechatronics-related
Keywords	Principal Investigator HuR / Suramin / ARE-mRNA / Oral cancer / cancer / biomarker / tongue carcinoma / WPOI / TB / YK分類 … More / 浸潤様式 / 舌癌 / リンパ節転移 / PCNA / CyclinB1 / RNA binding protein / drug / approved / 承認薬ライブラリー / 創薬 / SPR / DSF / suramin / approved drug library / screening … More Except Principal Investigator 骨切削 / 顎変形症手術 / 時系列解析 / 振動モニタリング Less

HMGB1とHMGB2を用いた舌がん治療・診断・予後予測への新しいバイオマーカーの開発Principal Investigator
- Principal Investigator
  
  格口渉
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Hokkaido University
ベイズモデリングによるデータ同化と位相的データ解析を用いた顎骨切削手術技能評価
- Principal Investigator
  
  中野寛
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 20010:Mechanics and mechatronics-related
- Research Institution
  Tokyo Institute of Technology
Development of new tongue carcinoma treatment and new biomarker using suraminPrincipal Investigator
- Principal Investigator
  
  格口渉
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Hokkaido University
Suramin, a HuR-targeted drug, has potential as a new therapeutic agent.Principal Investigator
- Principal Investigator
  
  格口渉
- Project Period (FY)
  2018
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Hokkaido University
The development of a HuR-targeted drug as a new therapeutics agentPrincipal Investigator
- Principal Investigator
  
  Kakuguchi Wataru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Hokkaido University

All 2024 2023 2022 2018 2017

All Journal Article Presentation

[Journal Article] Human antigen R knockdown attenuates the invasive activity of oral cancer cells through inactivation of matrix metalloproteinase-1 gene expression2024
- Author(s)
  Kakuguchi Wataru、Kitamura Tetsuya、Takahashi Tomomi、Yanagawa-Matsuda Aya、Fang Chih-Yuan、Ohiro Yoichi、Higashino Fumihiro
- Journal Title
  
  Journal of Dental Sciences
  
  Volume: 19 Issue: 1 Pages: 154-161
- DOI
  10.1016/j.jds.2023.05.014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09922, KAKENHI-PROJECT-22K09957
[Journal Article] Significant association of Yamamoto-Kohama classification and pathological depth of invasion with cervical lymph node metastasis in early-stage tongue squamous cell carcinoma (Stage I/II)2023
- Author(s)
  Kakuguchi Wataru、Ashikaga Yuichi、Yanagawa-Matsuda Aya、Kuribayashi Kazuyo、Shinohara Saki、Ogawa Naohiro、Maishi Nako、Hida Kyoko、Fang Chih-Yuan、Ohiro Yoichi
- Journal Title
  
  Journal of Dental Sciences
  
  Volume: 18 Issue: 4 Pages: 1663-1668
- DOI
  10.1016/j.jds.2023.01.036
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09922
[Journal Article] Suramin, screened from an approved drug library, inhibits HuR functions and attenuates malignant phenotype of oral cancer cells2018
- Author(s)
  Kakuguchi Wataru、Nomura Takao、Kitamura Tetsuya、Otsuguro Satoko、Matsushita Kazuhiro、Sakaitani Masahiro、Maenaka Katsumi、Tei Kanchu
- Journal Title
  
  Cancer Medicine
  
  Volume: 7 Issue: 12 Pages: 6269-6280
- DOI
  10.1002/cam4.1877
- NAID
  120006559018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05329, KAKENHI-PROJECT-18K17022
[Presentation] 早期舌扁平上皮癌(StageⅠ/Ⅱ)におけるリンパ節後発転移とCyclin B1/cytoplasmic PCNAとの関わり2024
- Author(s)
  格口渉 , 足利雄一 , 栗林和代 , 関口珠希 , 箭原元基 , 由良周子 , 大廣洋一
- Organizer
  第42回日本口腔腫瘍学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-22K09922
[Presentation] Association of cyclinB1 and cytoplasmic PCNA with cervical lymph node metastasis in early-stage tongue squamous cell carcinoma (Stage I/II)2024
- Author(s)
  Wataru Kakuguchi , Yuichi Ashikaga , Kazuyo Kuribayashi , Chikako Yura , Aya Yanagawa-Matsuda , Yoichi Ohiro
- Organizer
  TAOMS, The 36th Annual Congress On Oral and Maxillofacial Surgery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09922
[Presentation] 舌扁平上皮癌T1-2N0(UICC 第8版)におけるリンパ節後発転移の有無に関する臨床病理学的検討2022
- Author(s)
  格口渉, 足利雄一，松田　彩, 栗林和代, 間石奈湖, 樋田京子, 大廣洋一
- Organizer
  第46回日本頭頸部癌学会
- Data Source
  KAKENHI-PROJECT-22K09922
[Presentation] 抗トリパノソーマ薬SuraminはHuRの機能を阻害し,舌癌細胞の悪性形質を著しく減弱する2018
- Author(s)
  格口渉, 北村哲也, 鄭漢忠
- Organizer
  第72回NPO法人日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-18K17022
[Presentation] 既存薬ライブラリーを用いたHuR標的化合物のスクリーニングと舌癌細胞への効果2017
- Author(s)
  格口渉
- Organizer
  第62回(公社)日本口腔外科学会総会
- Data Source
  KAKENHI-PROJECT-15K20822

1. 中野寛 (70433068)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 大井一浩 (90451450)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 大廣洋一 (40301915)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NOMURA Takao

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kakuguchi Wataru 格口 渉

Research Projects

Research Products

Co-Researchers

HMGB1とHMGB2を用いた舌がん治療・診断・予後予測への新しいバイオマーカーの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ベイズモデリングによるデータ同化と位相的データ解析を用いた顎骨切削手術技能評価

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new tongue carcinoma treatment and new biomarker using suraminPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Suramin, a HuR-targeted drug, has potential as a new therapeutic agent.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The development of a HuR-targeted drug as a new therapeutics agentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Human antigen R knockdown attenuates the invasive activity of oral cancer cells through inactivation of matrix metalloproteinase-1 gene expression2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Significant association of Yamamoto-Kohama classification and pathological depth of invasion with cervical lymph node metastasis in early-stage tongue squamous cell carcinoma (Stage I/II)2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Suramin, screened from an approved drug library, inhibits HuR functions and attenuates malignant phenotype of oral cancer cells2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] 早期舌扁平上皮癌(StageⅠ/Ⅱ)におけるリンパ節後発転移とCyclin B1/cytoplasmic PCNAとの関わり2024

Author(s)

Organizer

Data Source

[Presentation] Association of cyclinB1 and cytoplasmic PCNA with cervical lymph node metastasis in early-stage tongue squamous cell carcinoma (Stage I/II)2024

Author(s)

Organizer

Data Source

[Presentation] 舌扁平上皮癌T1-2N0(UICC 第8版)におけるリンパ節後発転移の有無に関する臨床病理学的検討2022

Author(s)

Organizer

Data Source

[Presentation] 抗トリパノソーマ薬SuraminはHuRの機能を阻害し,舌癌細胞の悪性形質を著しく減弱する2018

Author(s)

Organizer

Data Source

[Presentation] 既存薬ライブラリーを用いたHuR標的化合物のスクリーニングと舌癌細胞への効果2017

Author(s)

Organizer

Data Source

Kakuguchi Wataru 格口渉