Yoshida Osamu 吉田理

… Alternative Names

YOSHIDA Osamu 吉田理

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Researcher Number	70746809
Affiliation (Current)	2025: 愛媛大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2025: 愛媛大学, 医学部附属病院, 講師 2021 – 2023: 愛媛大学, 医学部附属病院, 講師 2015 – 2018: 愛媛大学, 医学部附属病院, 講師
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 54030:Infectious disease medicine-related / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 細胞外ATP / 肝星細胞 / 肝線維化 / HBx抗原 / B型肝炎 / 治療ワクチン / HBV / 内科 / 線維化 / PKR … More / P2X7 / ＣＤ３９ / DAMP / CD39 Less

革新的経鼻ワクチンによる肝移植後のHBV再活性化予防Principal Investigator
- Principal Investigator
  
  吉田理
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Ehime University
Development of vaccine therapy for achieving HBsAg loss in chronic hepatitis BPrincipal Investigator
- Principal Investigator
  
  YOSHIDA Osamu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Ehime University
Role of extracellular ATP on Hepatic stellate cell activation and liver fibrosis developmentPrincipal Investigator
- Principal Investigator
  
  Yoshida Osamu
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Ehime University
Role of CD39 on development of liver fibrosis and application of CD39 in treating liver fibrosisPrincipal Investigator
- Principal Investigator
  
  Yoshida Osamu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Ehime University

All 2023 2022 2021 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Intranasal therapeutic vaccine containing HBsAg and HBcAg for patients with chronic hepatitis B; 18?months follow‐up results of phase IIa clinical study2022
- Author(s)
  Yoshida Osamu、Akbar Sheikh Mohammad Fazle、Imai Yusuke、Sanada Takahiro、Tsukiyama‐Kohara Kyoko、Miyazaki Takashi、Kamishita Taizou、Miyake Teruki、Tokumoto Yoshio、Hikita Hayato、Tsuge Masataka、Shimizu Masahito、Al Mahtab Mamun、Aguilar Julio Cesar、Guillen Gerardo、Kohara Michinori、Hiasa Yoichi
- Journal Title
  
  Hepatology Research
  
  Volume: 53 Issue: 3 Pages: 196-207
- DOI
  10.1111/hepr.13851
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07983, KAKENHI-PROJECT-21K08006, KAKENHI-PROJECT-22K07096, KAKENHI-PROJECT-19K16680
[Journal Article] Stimulated hepatic stellate cell promotes progression of hepatocellular carcinoma due to protein kinase R activation2019
- Author(s)
  Imai Y, Yoshida O, Watanabe T, Yukimoto A, Koizumi Y, Ikeda Y, Tokumoto Y, Hirooka M, Abe M, Hiasa Y
- Journal Title
  
  PLos One
  
  Volume: 14 Issue: 2 Pages: e0212589-e0212589
- DOI
  10.1371/journal.pone.0212589
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07911, KAKENHI-PROJECT-18K08007, KAKENHI-PROJECT-18K15818, KAKENHI-PROJECT-17K15952
[Journal Article] Orthotopic mouse liver transplantation to study liver biology and allograft tolerance.2016
- Author(s)
  Yokota S, Ueki S, Ono Y, Perez-Gutierrez A, Kimura S, Yoshida O, Murase N, Yasuda Y, Geller DA, Thomson AW
- Journal Title
  
  Nat Protc
  
  Volume: 11 Issue: 7 Pages: 1163-74
- DOI
  10.1038/nprot.2016.073
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19336
[Journal Article] Liver transplantation in the mouse: Insights into liver immunobiology, tissue injury and allograft tolerance2016
- Author(s)
  Yokota S, Yoshida O, Ono Y, Gellar DA, Thomson AW
- Journal Title
  
  Liver Transplantation
  
  Volume: 22 Issue: 4 Pages: 536-46
- DOI
  10.1002/lt.24394
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19336
[Presentation] HBVキャリアに対するHBs抗原とHBc抗原を含む経鼻治療ワクチン（CVP-NASVAC）再投与の24か月の効果の検討2023
- Author(s)
  吉田理、今井祐輔、日浅陽一
- Organizer
  第45回日本肝臓学会西部肝
- Data Source
  KAKENHI-PROJECT-21K07983
[Presentation] HBs抗原とHBc抗原を含む経鼻治療ワクチン（CVP-NASVAC）の再投与によるHBs抗体のブースト効果とHBs抗原低下作用2022
- Author(s)
  吉田理、白石佳奈、日浅陽一
- Organizer
  第30回　日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-21K07983
[Presentation] HBsAg reduction by re-treatment of nasal administrative therapeutic vaccine containing HBsAg/HBcAg in chronic HBV infected patients2022
- Author(s)
  Osamu Yoshida, Kana Shiraishi, Takahiro Sanada, Michinori Kohara, Kyoko Tsukiyama-Kohara, Takashi Miyzaki, Taizo Kamishita, Mamun Al Mahtab, Julio Cesar Aguilar, Gerardo Guillen, Yoshio Tokumoto, Sheikh Mohamed Fazle Akbar, Yoichi Hiasa
- Organizer
  AASLD The Liver Meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07983
[Presentation] Long term HBsAg reduction by a nasal administrative therapeutic vaccine containing HBsAg and HBcAg mixed with mucoadhesive CVP (CVP-NASVAC) in patients with chronic HBV infection: The results of 30 months follow up2021
- Author(s)
  Osamu Yoshida, Yusuke Imai, Kana Shiraishi, Takahiro Sanada, Michinori Kohara, Kyoko Tsukiyama-Kohara, Takashi Miyzaki, Taizo Kamishita, Mamun Al Mahtab, Julio Cesar Aguilar, Gerardo Guillen, Yoshio Tokumoto, Sheikh Mohamed Fazle Akbar, Yoichi Hiasa
- Organizer
  AASLD The Liver Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07983
[Presentation] HBsAg reduction was evident in 30 months follow-up after administration with therapeutic vaccine containing HBs/HBc antigen in chronic HBV carriers2021
- Author(s)
  Osamu Yoshida, Kana Shiraishi, Yoichi Hiasa
- Organizer
  第29回　日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-21K07983
[Presentation] 肝星細胞におけるProtein Kinase Rが肝細胞癌の進展に及ぼす影響2018
- Author(s)
  今井祐輔、吉田理、行本敦、渡辺崇夫、小泉洋平、徳本良雄、廣岡昌史、阿部雅則、日浅陽一
- Organizer
  第32回肝類洞壁細胞研究会
- Data Source
  KAKENHI-PROJECT-17K15952
[Presentation] Validation of the Globe Score and UK-PBC Risk Score in Japanese Patients2018
- Author(s)
  Osamu Yoshida, Masanori Abe, Kotaro Sunago, Atsushi Yukimoto, Yusuke Imai, Yoshiko Nakamura, Takao Watanabe, Yohei Koizumi, Masashi Hirooka, Teru Kumagi, Yoichi Hiasa
- Organizer
  27th Annual Conference of the Asian Pacific Association for the Study of the Liver
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15952
[Presentation] 肝形質細胞様樹状細胞による肝移植免疫寛容の誘導2017
- Author(s)
  吉田理
- Organizer
  肝類洞壁細胞研究会
- Data Source
  KAKENHI-PROJECT-17K15952
[Presentation] 当科のPBCおけるGLOBE ScoreとUK-PBC Risk Scoreの有用性の検討当科のPBCおけるGLOBE ScoreとUK-PBC Risk Scoreの有用性の検討2016
- Author(s)
  吉田理、阿部雅則、日浅陽一
- Organizer
  JDDW
- Place of Presentation
  東京
- Year and Date
  2016-11-03
- Data Source
  KAKENHI-PROJECT-15K19336
[Presentation] Promotion of liver transplant tolerance by liver plasmacytoid dendritic cells2015
- Author(s)
  Yoshida O, Kimura S, Matta BM, Imai Y, Abe M, Hiasa Y, Thoson AW
- Organizer
  AASLD the Liver Meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19336
[Presentation] CD39による肝樹状細胞機能と肝虚血再灌流障害の制御2015
- Author(s)
  吉田理、阿部雅則、日浅陽一
- Organizer
  第51回　日本肝臓学会総会
- Place of Presentation
  熊本市、熊本県
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K19336

1. Imai Yusuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 阿部雅則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yoshida Osamu 吉田 理

YOSHIDA Osamu 吉田 理

Research Projects

Research Products

Co-Researchers

革新的経鼻ワクチンによる肝移植後のHBV再活性化予防Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of vaccine therapy for achieving HBsAg loss in chronic hepatitis BPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of extracellular ATP on Hepatic stellate cell activation and liver fibrosis developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of CD39 on development of liver fibrosis and application of CD39 in treating liver fibrosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Intranasal therapeutic vaccine containing HBsAg and HBcAg for patients with chronic hepatitis B; 18?months follow‐up results of phase IIa clinical study2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stimulated hepatic stellate cell promotes progression of hepatocellular carcinoma due to protein kinase R activation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Orthotopic mouse liver transplantation to study liver biology and allograft tolerance.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Liver transplantation in the mouse: Insights into liver immunobiology, tissue injury and allograft tolerance2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] HBVキャリアに対するHBs抗原とHBc抗原を含む経鼻治療ワクチン（CVP-NASVAC）再投与の24か月の効果の検討2023

Author(s)

Organizer

Data Source

[Presentation] HBs抗原とHBc抗原を含む経鼻治療ワクチン（CVP-NASVAC）の再投与によるHBs抗体のブースト効果とHBs抗原低下作用2022

Author(s)

Organizer

Data Source

[Presentation] HBsAg reduction by re-treatment of nasal administrative therapeutic vaccine containing HBsAg/HBcAg in chronic HBV infected patients2022

Author(s)

Organizer

Data Source

[Presentation] Long term HBsAg reduction by a nasal administrative therapeutic vaccine containing HBsAg and HBcAg mixed with mucoadhesive CVP (CVP-NASVAC) in patients with chronic HBV infection: The results of 30 months follow up2021

Author(s)

Organizer

Data Source

[Presentation] HBsAg reduction was evident in 30 months follow-up after administration with therapeutic vaccine containing HBs/HBc antigen in chronic HBV carriers2021

Author(s)

Organizer

Data Source

[Presentation] 肝星細胞におけるProtein Kinase Rが肝細胞癌の進展に及ぼす影響2018

Author(s)

Organizer

Data Source

[Presentation] Validation of the Globe Score and UK-PBC Risk Score in Japanese Patients2018

Author(s)

Organizer

Data Source

[Presentation] 肝形質細胞様樹状細胞による肝移植免疫寛容の誘導2017

Author(s)

Organizer

Yoshida Osamu 吉田理

YOSHIDA Osamu 吉田理