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Kobuchi Shinji  河渕 真治

Researcher Number 70747237
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-4694-4651
Affiliation (Current) 2025: 京都薬科大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help 2025: 京都薬科大学, 薬学部, 助教
2015 – 2023: 京都薬科大学, 薬学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 47060:Clinical pharmacy-related / Medical pharmacy
Except Principal Investigator
Basic Section 47060:Clinical pharmacy-related
Keywords
Principal Investigator
がん化学療法 / 薬物動態-薬力学的(PK-PD)モデル解析 / 個別化医療 / ファーマコメトリクス / 母集団薬物動態解析 / PKモデル / FOLFIRINOX療法 / 膵がん化学療法 / トランスレーショナルアプローチ / ハイブリッドPK-PD/TDモデル … More / モデリング&シミュレーション / トランスレーショナルリサーチ / 血液毒性 / 制吐療法 / 数理モデル解析 / 薬物動態-毒性学的(PK-TD)モデル解析 / バイオマーカー / スペシャルポピュレーション / オキサリプラチン / S-1 / 腎障害 / TDM / Chronopharmacokinetics / Onconephrology / 母集団薬物動態(PPK)解析 / 代謝酵素活性 / 生理学的(PBPK)モデル解析 / 腎機能障害 / 薬物動態―薬力学的(PK-PD)モデル解析 / 特定患者集団 / 5-フルオロウラシル / 抗がん剤 / 骨髄抑制 / 薬物動態-薬力学的(PK-PD)解析 / 母集団解析 / 経口フッ化ピリミジン系抗がん剤 / 日内変動 / フッ化ピリミジン系抗がん剤 / 薬物動態-薬力学的(PK-PD)モデル解析 … More
Except Principal Investigator
chronic heart failure / dapagliflozin / SGLT2 inhibitor Less
  • Research Projects

    (5 results)
  • Research Products

    (111 results)
  • Co-Researchers

    (4 People)
  •  膵癌予後予測マーカーとファーマコメトリクスに基づく化学療法の個別化Principal Investigator

    • Principal Investigator
      河渕 真治
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kyoto Pharmaceutical University
  •  Therapeutic efficacy of dapagliflozin, a selective inhibitor of sodium–glucose co-transporter type 2, for chronic heart failure in Japanese patients with type 2 diabetes mellitus

    • Principal Investigator
      栄田 敏之
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kyoto Pharmaceutical University
  •  Personalization of antiemetic therapy based on pharmacokinetic-pharmacodynamic/toxicodynamic modeling and simulationPrincipal Investigator

    • Principal Investigator
      Kobuchi Shinji
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kyoto Pharmaceutical University
  •  Establishment of therapeutic strategy for cancer treatment in special population using pharmacokinetic-pharmacodynamic (PK-PD) modelPrincipal Investigator

    • Principal Investigator
      Kobuchi Shinji
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kyoto Pharmaceutical University
  •  Population pharmacokinetic-pharmacodynamic model analysis of drug plasma concentration in cancer chemotherapyPrincipal Investigator

    • Principal Investigator
      Kobuchi Shinji
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Kyoto Pharmaceutical University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

  • [Journal Article] Pharmacokinetic-toxicodynamic Modeling to Elucidate the Involvement of Dorsal Root Ganglion Neuron in Oxaliplatin-induced Peripheral Neuropathy2024

    • Author(s)
      TSUKUSHI YASUHITO、KOBUCHI SHINJI、ITO YUKAKO、SAKAEDA TOSHIYUKI
    • Journal Title

      Anticancer Research

      Volume: 44 Issue: 2 Pages: 575-584

    • DOI

      10.21873/anticanres.16846

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K06679, KAKENHI-PROJECT-21K06720
  • [Journal Article] A Pharmacokinetic-Pharmacodynamic Model Predicts Uracil-tegafur Effect on Tumor Shrinkage and Myelosuppression in a Colorectal Cancer Rat Model2023

    • Author(s)
      KOBUCHI SHINJI、TSUDA MOTOI、OKAMURA MAKI、NAKAMURA TAKANORI、ITO YUKAKO
    • Journal Title

      Anticancer Research

      Volume: 43 Issue: 3 Pages: 1121-1130

    • DOI

      10.21873/anticanres.16257

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K06679, KAKENHI-PROJECT-21K06720
  • [Journal Article] Pharmacokinetic evaluation of oxaliplatin combined with S-1 (SOX) chemotherapy in a rat model of colorectal cancer with acute kidney injury: predictive renal biomarkers for dose optimisation2023

    • Author(s)
      Tanaka Takumi、Kobuchi Shinji、Ito Yukako、Sakaeda Toshiyuki
    • Journal Title

      Xenobiotica

      Volume: 53 Issue: 10-11 Pages: 613-620

    • DOI

      10.1080/00498254.2023.2283736

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K06679, KAKENHI-PROJECT-21K06720
  • [Journal Article] Translational PK-PD/TD modeling of antitumor effects and peripheral neuropathy in gemcitabine and nab-paclitaxel chemotherapy from xenograft mice to patients for optimal dose and schedule2023

    • Author(s)
      Kobuchi Shinji、Morita Atsuko、Jonan Shizuka、Amagase Kikuko、Ito Yukako
    • Journal Title

      Cancer Chemotherapy and Pharmacology

      Volume: 93 Issue: 4 Pages: 365-379

    • DOI

      10.1007/s00280-023-04625-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K06679, KAKENHI-PROJECT-21K06720
  • [Journal Article] Predictive marker for exposure-driven haematological toxicity of tegafur-uracil and proposed modified-dosage regimen by pharmacometric approach in rats2022

    • Author(s)
      Kobuchi Shinji、Matsui Megumi、Ito Yukako
    • Journal Title

      Xenobiotica

      Volume: 52 Issue: 7 Pages: 697-706

    • DOI

      10.1080/00498254.2022.2142696

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K06679, KAKENHI-PROJECT-21K06720
  • [Journal Article] Assessment of Drug?drug Interaction and Optimization in Capecitabine and Irinotecan Combination Regimen using a Physiologically Based Pharmacokinetic Model2022

    • Author(s)
      Sakai Shuhei、Kobuchi Shinji、Ito Yukako、Sakaeda Toshiyuki
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 111 Issue: 5 Pages: 1522-1530

    • DOI

      10.1016/j.xphs.2021.12.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K06679, KAKENHI-PROJECT-21K06720
  • [Journal Article] Population Pharmacokinetic Model-Based Evaluation of Intact Oxaliplatin in Rats with Acute Kidney Injury2021

    • Author(s)
      Kobuchi Shinji、Kai Miyu、Ito Yukako
    • Journal Title

      Cancers

      Volume: 13 Issue: 24 Pages: 6382-6382

    • DOI

      10.3390/cancers13246382

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K06679, KAKENHI-PROJECT-21K06720
  • [Journal Article] A Physiologically Based Pharmacokinetic-Pharmacodynamic Model for Capecitabine in Colorectal Cancer Rats: Simulation of Antitumor Efficacy at Various Administration Schedules2021

    • Author(s)
      Sakai Shuhei、Kobuchi Shinji、Ito Yukako、Sakaeda Toshiyuki
    • Journal Title

      European Journal of Drug Metabolism and Pharmacokinetics

      Volume: 46 Issue: 2 Pages: 301-315

    • DOI

      10.1007/s13318-021-00674-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K14963, KAKENHI-PROJECT-21K06679
  • [Journal Article] Assessment of pharmacokinetic variations of capecitabine after multiple administration in rats: a physiologically based pharmacokinetic model2020

    • Author(s)
      Sakai Shuhei、Kobuchi Shinji、Ito Yukako、Sakaeda Toshiyuki
    • Journal Title

      Cancer Chemotherapy and Pharmacology

      Volume: 85 Issue: 5 Pages: 869-880

    • DOI

      10.1007/s00280-020-04057-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06765, KAKENHI-PROJECT-18K14963
  • [Journal Article] Application of Pharmacometrics of 5-Fluorouracil to Personalized Medicine: A Tool for Predicting Pharmacokinetic-Pharmacodynamic/Toxicodynamic Responses2020

    • Author(s)
      Kobuchi Shinji、Ito Yukako
    • Journal Title

      Anticancer Research

      Volume: 40 Issue: 12 Pages: 6585-6597

    • DOI

      10.21873/anticanres.14683

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Journal Article] Semi-Mechanism-Based Pharmacokinetic-Toxicodynamic Model of Oxaliplatin-Induced Acute and Chronic Neuropathy2020

    • Author(s)
      Kobuchi Shinji、Shimizu Risa、Ito Yukako
    • Journal Title

      Pharmaceutics

      Volume: 12 Issue: 2 Pages: 125-125

    • DOI

      10.3390/pharmaceutics12020125

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K14963, KAKENHI-PROJECT-18K06765
  • [Journal Article] Effect of intact oxaliplatin in plasma on a cold allodynia after multiple administrations in colorectal cancer model rats.2020

    • Author(s)
      Yukako Ito, Shinji Kobuchi, Mako Takesada, Miki Morimoto.
    • Journal Title

      Ann. Palliat. Med.,

      Volume: 9(5) Issue: 5 Pages: 3000-3006

    • DOI

      10.21037/apm-20-542

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06765, KAKENHI-PROJECT-18K14963
  • [Journal Article] Population Pharmacokinetic Model-Based Evaluation of Circadian Variations in Plasma 5-Fluorouracil Concentrations During Long-Term Infusion in Rats: A Comparison With Oral Anticancer Prodrugs2020

    • Author(s)
      Kobuchi Shinji、Matsumura Eisuke、Ito Yukako、Sakaeda Toshiyuki
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: - Issue: 7 Pages: 2356-2361

    • DOI

      10.1016/j.xphs.2020.04.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K14963, KAKENHI-PROJECT-18K06765
  • [Journal Article] Assessment of oxaliplatin-induced chronic neuropathy and anticancer efficacy through pharmacokinetic and toxicodynamic evaluation of a rat model of colorectal cancer.2019

    • Author(s)
      1)Yukako Ito, Shinji Kobuchi, Waki Takesada, Chiharu Takahashi.
    • Journal Title

      Anticancer Res.

      Volume: 39 Issue: 8 Pages: 4207-4213

    • DOI

      10.21873/anticanres.13581

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06765, KAKENHI-PROJECT-18K14963
  • [Journal Article] Mechanism-based pharmacokinetic?pharmacodynamic (PK/PD) modeling and simulation of oxaliplatin for hematological toxicity in rats2019

    • Author(s)
      Kobuchi Shinji、Katsuyama Yosuke、Ito Yukako
    • Journal Title

      Xenobiotica

      Volume: in press Issue: 2 Pages: 146-153

    • DOI

      10.1080/00498254.2019.1601790

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06765, KAKENHI-PROJECT-18K14963
  • [Journal Article] Association between the pharmacokinetics of capecitabine and the plasma dihydrouracil to uracil ratio in rat: A surrogate biomarker for dihydropyrimidine dehydrogenase activity2019

    • Author(s)
      Kobuchi Shinji、Akutagawa Mako、Ito Yukako、Sakaeda Toshiyuki
    • Journal Title

      Biopharmaceutics & Drug Disposition

      Volume: 40 Issue: 1 Pages: 44-48

    • DOI

      10.1002/bdd.2168

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K14963, KAKENHI-PROJECT-18K06765
  • [Journal Article] Association between circadian and chemotherapeutic cycle effects on plasma concentration of 5-fluorouracil and the clinical outcome following definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in patients with esophageal squamous cell carcinoma2019

    • Author(s)
      Kuwahara Akiko、Kobuchi Shinji、Tamura Takao
    • Journal Title

      Oncology Letters

      Volume: 17(1) Pages: 668-675

    • DOI

      10.3892/ol.2018.9586

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Journal Article] Circadian variations in the pharmacokinetics of capecitabine and its metabolites in rats.2018

    • Author(s)
      Shinji Kobuchi, Yukiko Yazaki, Yukako Ito, and Toshiyuki Sakaeda
    • Journal Title

      Eur. J. Pharm. Sci.

      Volume: 112 Pages: 152-158

    • DOI

      10.1016/j.ejps.2017.11.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K18937, KAKENHI-PROJECT-18K06765
  • [Journal Article] Pharmacokinetic and toxicodynamic evaluation of oxaliplatin-induced neuropathy and hematological toxicity in rats.2018

    • Author(s)
      Yukako Ito, Shinji Kobuchi, Risa Shimizu, Yosuke Katsuyama:
    • Journal Title

      Cancer Chemother. Pharmacol.,

      Volume: 81(1): Issue: 1 Pages: 155-161

    • DOI

      10.1007/s00280-017-3485-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08085, KAKENHI-PROJECT-15K18937, KAKENHI-PROJECT-18K06765
  • [Journal Article] Circadian variations in the pharmacokinetics of the oral anticancer agent tegafur-uracil (UFT) and its metabolites in rats2018

    • Author(s)
      Kobuchi Shinji、Ito Yukako、Takamatsu Daiki、Sakaeda Toshiyuki
    • Journal Title

      European Journal of Pharmaceutical Sciences

      Volume: 123 Pages: 452-458

    • DOI

      10.1016/j.ejps.2018.08.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06765, KAKENHI-PROJECT-18K14963
  • [Journal Article] Effects of a bolus injection of 5-fluorouracil on dihydropyrimidine dehydrogenase activity in rats receiving continuous infusion of 5-fluorouracil.2016

    • Author(s)
      Shinji Kobuchi, Asuka Hayashi, Mayu Taniguchi, Yukako Ito, Takao Tamura and Toshiyuki Sakaeda
    • Journal Title

      Cancer Chemother. Pharmacol.,

      Volume: 78 Issue: 3 Pages: 517-523

    • DOI

      10.1007/s00280-016-3105-8

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08085, KAKENHI-PROJECT-15K18937
  • [Journal Article] Population pharmacokinetic-pharmacodynamic modeling of 5-fluorouracil for toxicities in rats2016

    • Author(s)
      Shinji Kobuchi, Yukako Ito, and Toshiyuki Sakaeda
    • Journal Title

      Eur. J. Drug Metab. Pharmacokinet.

      Volume: 印刷中 Issue: 4 Pages: 707-718

    • DOI

      10.1007/s13318-016-0389-3

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K18937, KAKENHI-PROJECT-15K08085
  • [Journal Article] Population pharmacokinetic modelling and simulation of 5-fluorouracil incorporating a circadian rhythm in rats.2016

    • Author(s)
      Kobuchi S, Ito Y, Nakano Y, and Sakaeda T.
    • Journal Title

      Xenobiotica

      Volume: 46 Issue: 7 Pages: 597-604

    • DOI

      10.3109/00498254.2015.1100767

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K18937, KAKENHI-PROJECT-15K08085
  • [Presentation] 慢性腎臓病患者におけるXELOX療法施行時の用量設定因子に関する基礎的検討2024

    • Author(s)
      磯橋 七帆、内田 光理、中山 怜、久川 かりん、田中 拓実、河渕 真治、栄田 敏之、伊藤 由佳子
    • Organizer
      日本薬学会第143年会
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] SOX療法時の時間治療導入による治療効果改善の可能性2024

    • Author(s)
      西村 響子、筑紫 康人、田中 拓実、河渕 真治、栄田 敏之、伊藤 由佳子
    • Organizer
      日本薬学会第143年会
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] 数理学的モデルに基づくクロノセラピー導入XELOX療法の有用性2024

    • Author(s)
      瀨川 湖都、筑紫 康人、河渕 真治、栄田 敏之、伊藤 由佳子
    • Organizer
      日本薬学会第143年会
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] オキサリプラチン長期投与時の後根神経節中白金分布に対する概日リズムの影響2024

    • Author(s)
      小森 優月、伊藤 ひな、筑紫 康人、河渕 真治、栄田 敏之、伊藤 由佳子
    • Organizer
      日本薬学会第143年会
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] ナトリウム・グルコース共輸送体2 阻害剤dapagliflozinによる血清亜鉛濃度の上昇に関する臨床的、基礎的研究2024

    • Author(s)
      安達彩璃、河渕真治、伊藤由佳子、加藤健一郎、早川哲雄、栄田敏之
    • Organizer
      第144回日本薬学会年会
    • Data Source
      KAKENHI-PROJECT-23K06224
  • [Presentation] GEM/nab-PTX療法時の血液毒性による減量・中止基準のための予測モデルの構築2024

    • Author(s)
      吉岡 宏祐、寺内 涼音、河渕 真治、栄田 敏之、伊藤 由佳子
    • Organizer
      日本薬学会第143年会
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] Preventive effect of omeprazole as drug repositioning strategy on onset of OIPN2023

    • Author(s)
      Yasuhito Tsukushi, Shinji Kobuchi, Yukako Ito and Toshiyuki Sakaeda
    • Organizer
      日本薬物動態学会第38回年会/第23回シトクロムP450国際会議国際合同大会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] FOLFIRINOX長期治療時のモデリング&シミュレーションアプローチによる予後予測の検討2023

    • Author(s)
      登坂一樹、川北亜実莉、伊藤由佳子、河渕真治、栄田敏之
    • Organizer
      日本薬学会第143年会
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] 急性腎障害発症時のXELOX療法の用量調節に関する検討2023

    • Author(s)
      新里海翔、吉本朱里、田中拓実、河渕真治、栄田敏之、伊藤由佳子
    • Organizer
      日本薬学会第143年会
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] ナトリウム・グルコース共輸送体2阻害剤dapagliflozin投与後のHbA1cの経時的変化に関する母集団薬物動態-薬力学的解析2023

    • Author(s)
      西岡啓太、河渕真治、伊藤由佳子、加藤健一郎、早川哲雄、栄田敏之
    • Organizer
      第11回くすりと糖尿病学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K06224
  • [Presentation] Pharmacokinetics and biomarker analysis of SOX chemotherapy in chronic kidney disease model rats2023

    • Author(s)
      Takumi Tanaka, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
    • Organizer
      日本薬物動態学会第38回年会/第23回シトクロムP450国際会議国際合同大会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] Risk factor analysis for acute kidney injury during cancer chemotherapy in colorectal cancer with AKI model rats2023

    • Author(s)
      Akari Yoshimoto, Kaito Shinzatio, Takumi Tanaka, Shinji Kobuchi, Yuuki Otsuka, Kikuko Amagase, Toshiyuki Sakaeda, Yukako Ito
    • Organizer
      第82回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] 膵癌化学療法中の骨髄抑制予防のための用量調節の可能性2023

    • Author(s)
      寺内涼音、吉岡宏祐、河渕真治、栄田敏之、伊藤由佳子
    • Organizer
      第73回日本薬学会関西支部総会・大会
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] 末梢神経障害マネジメントに向けたクロノセラピー導入XELOX療法の提案2023

    • Author(s)
      竹若政国、河渕真治、栄田敏之、伊藤由佳子
    • Organizer
      第97回日本薬理学会年会/第44回日本臨床薬理学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] Ⅱ型糖尿病モデルラットにおけるナトリウム・グルコース共輸送体2阻害剤dapagliflozin の血漿中濃度と insulin 濃度低下2023

    • Author(s)
      溝田莉夕、寺尾美優、 河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      第73回日本薬学会関西支部総会・大会
    • Data Source
      KAKENHI-PROJECT-23K06224
  • [Presentation] Ⅱ型糖尿病患者におけるナトリウム・グルコース共輸送体2阻害dapagliflozin投与後のHbA1cの推移の変動要因の解明2023

    • Author(s)
      栄井修平、河渕真治、伊藤由佳子、藤野秀樹、加藤健一郎、早川哲雄、栄田敏之
    • Organizer
      第39回日本 TDM 学会・学術大会
    • Data Source
      KAKENHI-PROJECT-23K06224
  • [Presentation] ナトリウム・グルコース共輸送体2阻害剤 dapagliflozinの血漿中濃度とtriglyceride値低下作用との関係性について2023

    • Author(s)
      廣井貴一、西脇敬書、河渕真治、伊藤由佳子、加藤健一郎、早川哲雄、栄田敏之
    • Organizer
      第44回日本臨床薬理学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K06224
  • [Presentation] ナトリウム・グルコース共輸送体2阻害剤 dapagliflozin による脂質プロファイル改善作用について2023

    • Author(s)
      西脇敬書、廣井貴一、河渕真治、伊藤由佳子、加藤健一郎、早川哲雄、栄田敏之
    • Organizer
      第11回くすりと糖尿病学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K06224
  • [Presentation] 急性腎障害発症が及ぼすSOX ( S-1 + オキサリプラチン)療法の予後への影響2022

    • Author(s)
      田中拓実、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      第96回日本薬理学会年会/第43回日本臨床薬理学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] FOLFIRINOX療法の骨髄抑制に関する薬物動態/毒性薬力学的評価2022

    • Author(s)
      三井和樹、水本萌、河渕真治、栄田敏之、伊藤由佳子
    • Organizer
      第96回日本薬理学会年会/第43回日本臨床薬理学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] Explorative study for dose limiting factor in acute kidney injury during SOX treatment by population pharmacokinetic approach2022

    • Author(s)
      Michi Kouno, Takumi Tanaka, Shinji Kobuchi, Toshiyuki Sakaeda, Yukako Ito
    • Organizer
      日本薬物動態学会第37回年会
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] がん診療時の急性腎障害発症によるcapecitabine体内動態の変動2022

    • Author(s)
      上浦順子、河渕真治、栄田敏之、伊藤由佳子
    • Organizer
      第96回日本薬理学会年会/第43回日本臨床薬理学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] Role of uracil and dihydrouracil plasma ratio as a fluoropyrimidine-related toxicity biomarker in FOLFIRINOX treatment to pancreatic cancer model rats2022

    • Author(s)
      Moe Mizumoto, Shinji Kobuchi, Toshiyuki Sakaeda, Yukako Ito
    • Organizer
      日本薬物動態学会第37回年会
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] Alternative proposal of dose reduction method of capecitabine for cancer patients with pre-existing chronic kidney disease2022

    • Author(s)
      Moe Taraki, Shinji Kobuchi, Toshiyuki Sakaeda, Yukako Ito
    • Organizer
      日本薬物動態学会第37回年会
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] 母集団薬物動態解析に基づくTS-1ベース化学療法時の慢性腎障害マネジメントの検討2021

    • Author(s)
      山本彩音、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      日本薬学会第141年会(広島)
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] Pharmacokinetic-pharmacodynamic approach to predict paclitaxel-induced peripheral neuropathy in pancreatic cancer rats2021

    • Author(s)
      Uno Ritsuka、Kobuchi Shinji、Ito Yukako、Sakaeda
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] Risk management of peripheral neuropathy by platinum localization in dorsal root ganglion neurons with FOLFIRINOX2021

    • Author(s)
      Kitamoto Takaaki、Kobuchi Shinji、Ito Yukako、Sakaeda Toshiyuki
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] FOLFIRINOX療法時の末梢神経障害リスクマネジメントに対するmodeling and simulationの利活用2021

    • Author(s)
      木村寿々奈、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      第42回日本臨床薬理学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] Physiologically based pharmacokinetic model for drug-drug interaction in XELIRI regimen2021

    • Author(s)
      Sakai Shuhei、Kobuchi Shinji、Ito Yukako、Sakaeda Toshiyuki
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] 後根神経節中オキサリプラチン分布に対する日内変動の影響2021

    • Author(s)
      上田竣太、河渕真治、伊藤由佳子、西田健太郎、栄田敏之
    • Organizer
      日本薬学会第141年会(広島)
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] 母集団薬物動態解析によるTS-1投与後の5-fluorouracilの日内変動の評価2021

    • Author(s)
      佐竹智規、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      第71回日本薬学会関西支部総会・大会
    • Data Source
      KAKENHI-PROJECT-21K06720
  • [Presentation] Effect of platinum accumulation in dorsal root ganglia to neurotoxicity in colorectal cancer rats treated with XELOX2020

    • Author(s)
      Yasuhito Tsukushi, Shinji Kobuchi, Yukako Ito, and Toshiyuki Sakaeda
    • Organizer
      第79回日本癌学会学術総会(広島)
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] 膵がんモデルラットに対するゲムシタビン・ナブパクリタキセル療法時のモデリング&シミュレーションの有用性2020

    • Author(s)
      中村謙吾、藤井優佳、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] オキサリプラチンベース化学療法時の慢性腎障害マネジメントのための母集団薬物動態的解析2020

    • Author(s)
      田中愛花、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      第41回日本臨床薬理学会学術総会(福岡)
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] Physiologically based pharmacokinetic-pharmacodynamic model for capecitabine antitumor profile in colorectal cancer rats2020

    • Author(s)
      Shuhei Sakai, Shinji Kobuchi, Yukako Ito, and Toshiyuki Sakaeda
    • Organizer
      第79回日本癌学会学術総会(広島)
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] 5-fluorouracil持続点滴投与による日内変動への影響2019

    • Author(s)
      松村栄祐、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] Effects of metabolic enzymes on the pharmacokinetics and pharmacodynamics of capecitabine in colorectal cancer rats2019

    • Author(s)
      Shuhei Sakai, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] 膵がんモデルラットに対するゲムシタビン・ナブパクリタキセル療法時の薬物動態と抗腫瘍効果2019

    • Author(s)
      藤井優佳、中村謙吾、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      第69回日本薬学会関西支部総会・大会, 神戸
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] SOX療法時の血漿中および腫瘍中薬物濃度と腫瘍縮小効果2019

    • Author(s)
      石井恵嘉、清水優輝、森匡史、河渕真冶、伊藤由佳子、栄田敏之
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] Risk comparison of fluorouracil-based regimens in myelosuppression and pharmacokinetic profiles2019

    • Author(s)
      Shiho Araki, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
    • Organizer
      日本薬物動態学会第34回年会
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] 母集団薬物動態解析によるフッ化ピリミジン系抗がん剤の血漿中濃度の日内変動把握2019

    • Author(s)
      河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      第69回日本薬学会関西支部総会・大会
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] Effect of biomarker on pharmacokinetic parameters in FOLFIRINOX treatment to pancreatic cancer model rats2019

    • Author(s)
      Shun Nakamura, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
    • Organizer
      日本薬物動態学会第34回年会
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] 腎機能障害を有する大腸がんモデルラットにおけるオキサリプラチンの母集団薬物動態解析2019

    • Author(s)
      疇地優香、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      第40回日本臨床薬理学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] PK-TD modeling for hematologic toxicity in FOLFIRINOX treatment to pancreatic cancer model rats2019

    • Author(s)
      Shinya Takei, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
    • Organizer
      日本薬物動態学会第34回年会
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] Pharmacokinetic study of SOX (S-1 + Oxaliplatin) regimen to colorectal cancer rats with renal disorder2019

    • Author(s)
      Takumi Tanaka, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] TS-1隔日療法と連日療法における血漿中抗がん剤濃度と代謝酵素活性2019

    • Author(s)
      清益早葵、田野遥、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      第69回日本薬学会関西支部総会・大会
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] 膵がんモデルラットにおけるFOLFIRINOX療法時の骨髄抑制に関する薬物動態学的・毒性薬理学的評価2019

    • Author(s)
      武井慎也、中村俊、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      第69回日本薬学会関西支部総会・大会, 神戸
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] Physiologically based pharmacokinetic modeling of capecitabine using in vitro enzyme activity after multiple administrations in colorectal cancer rats2019

    • Author(s)
      Shuhei Sakai, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
    • Organizer
      日本薬物動態学会第34回年会
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] 腎障害時のオキサリプラチン体内動態に関する検討2018

    • Author(s)
      甲斐美優、古家真優、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] XELOX療法の骨髄抑制に関する薬物動態/毒性薬力学的評価2018

    • Author(s)
      有本茉佑香、勝山陽介、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      第39回日本臨床薬理学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] FOLFIRINOX療法における抗癌剤の体内動態とバイオマーカーに関する検討2018

    • Author(s)
      森わかな、伊藤由佳子、河渕真治、栄田敏之
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] Pharmacokinetic modeling and simulation of S-1 for precision dosing based on the biomarker in rats2018

    • Author(s)
      Haruka Tano, Shinji Kobuchi, Yukako Ito and Toshiyuki Sakaeda
    • Organizer
      2018 International Meeting on 22nd MDO and 33rd JSSX
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] TS-1 反復投与後の体内動態と DPD 活性に関する基礎的検討2018

    • Author(s)
      田野遥、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] Pharmacokinetic evaluation of TS-1 in renal dysfunction model rats2018

    • Author(s)
      Mayu Furuke, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
    • Organizer
      2018 International Meeting on 22nd MDO and 33rd JSSX
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] Population pharmacokinetic analysis of oxaliplatin in renal dysfunction model rats2018

    • Author(s)
      Miyu Kai, Mayu Furuke, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
    • Organizer
      2018 International Meeting on 22nd MDO and 33rd JSSX
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] 腎障害モデルラットにおける TS-1 の体内動態に関する基礎的検討2018

    • Author(s)
      古家真優、甲斐美優、河渕真治、伊藤由佳子、栄田 敏之
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] 癌化学療法における細胞間質液モニタリングの有用性に関する検討2018

    • Author(s)
      徳永寛人、鶴田弘明、河渕真治、伊藤 由佳子、栄田 敏之
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] 大腸癌モデルラットにおけるオキサリプラチン誘発急性末梢神経障害と血漿中薬 物濃度に関する基礎的検討2018

    • Author(s)
      森本実希、武貞和希、高橋千春、武田茉子、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] UFT-induced myelosuppression and its pharmacokinetic-toxicodynamic model in rats2018

    • Author(s)
      Megumi Matsui, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
    • Organizer
      18th World Congress of basic and Clinical Pharmacology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] Pharmacokinetics and pharmacodynamics of S-1 plus oxaliplatin treatment in colorectal cancer rats2018

    • Author(s)
      Masashi Mori, Shinji Kobuchi, Yukako Ito and Toshiyuki Sakaeda
    • Organizer
      2018 International Meeting on 22nd MDO and 33rd JSSX
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] 膵癌化学療法における治療選択バイオマーカーに関する検討2018

    • Author(s)
      柄田佐和子、伊藤由佳子、河渕真治、堀口繁、加藤博也、白羽英則、栄田敏之
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] Pharmacokinetics and hematotoxicity of UFT after repeated administration in colorectal cancer model rats2018

    • Author(s)
      Maki Okamura, Takanori Nakamura, Motoi Tsuda, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
    • Organizer
      18th World Congress of basic and Clinical Pharmacology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] Association between plasma concentration and myelosuppression of S-1 in Colorectal cancer model rats with SOX regimen2018

    • Author(s)
      Yuki Shimizu, Shinji Kobuchi, Yukako Ito, and Toshiyuki Sakaeda
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K14963
  • [Presentation] オキサリプラチン投与による骨髄抑制発現と体内動態の関連性2017

    • Author(s)
      勝山陽介、清水理紗、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] Population pharmacokinetic-pharmacodynamic model of 5-fluorouracil for myelosuppression and body weight loss2017

    • Author(s)
      Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
    • Organizer
      15th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] UFTの体内動態に及ぼす日内変動の影響2017

    • Author(s)
      髙松大基、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      第67回日本薬学会近畿支部総会・大会
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] 大腸がんモデルラットにおけるオキサリプラチン反復投与後の抗腫瘍効果に関する薬物動態学的/薬力学的評価2017

    • Author(s)
      高橋千春、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      第38回日本臨床薬理学会学術総会
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] 大腸がん化学療法における5-フルオロウラシルの血漿中濃度維持に及ぼすイリノテカンの影響2017

    • Author(s)
      西尾夏美、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      日本薬剤学会第32年会
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] Pharmacokinetic-pharmacodynamic (PK-PD) modeling and simulation of UFT on multiple dosing in colorectal cancer rats2017

    • Author(s)
      Motoi Tsuda, Maki Okamura, Takanori Nakamura, Shinji Kobuchi, Yukako Ito and Toshiyuki Sakaeda
    • Organizer
      日本薬物動態学会第32回年会
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] イリノテカンの骨髄抑制に関する薬物動態学的/毒性薬力学的評価2017

    • Author(s)
      森賢也、西尾夏美、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      第67回日本薬学会近畿支部総会・大会
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] Tumoral distribution of tegafur and 5-fluorouracil after UFT administration to colorectal cancer rats2017

    • Author(s)
      Takanori Nakamura, Shinji Kobuchi, Yukako Ito, and Toshiyuki Sakaeda
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] 大腸癌モデルラットにおけるオキサリプラチンの体内動態と蓄積性末梢神経障害の評価2017

    • Author(s)
      武貞和希、清水理紗、高橋千春、武田茉子、森本実希、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] Pharmacokinetic-pharmacodynamic modeling of oxaliplatin for hematological toxicity in rats2017

    • Author(s)
      Yosuke Katsuyama, Shinji Kobuchi, Yukako Ito and Toshiyuki Sakaeda
    • Organizer
      日本薬物動態学会第32回年会
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] オキサリプラチン誘発蓄積性末梢神経障害の発現予測に関する血漿中オキサリプラチン濃度と総白金濃度との比較2017

    • Author(s)
      武田茉子、武貞和希、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      第27回日本医療薬学会年会
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] 大腸がんラットにおけるUFTの薬物動態学的/薬力学的評価2017

    • Author(s)
      津田基、佐藤孝和、岡村真生、中村貴憲、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] Pharmacokinetics and toxicodynamics of oxaliplatin-induced peripheral neuropathy in colorectal cancer model rats2017

    • Author(s)
      Waki Takesada, Mako Takeda, Miki Morimoto, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
    • Organizer
      日本薬物動態学会第32回年会
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] EGFR遺伝子変異陽性肺癌におけるafatinibの母集団薬物動態解析2017

    • Author(s)
      中尾桂子、金津正樹、西條伸彦、園延尚子、直木陽子、小林岳彦、竹内奈緒子、田宮基裕、伊佐俊一 、田宮朗裕、大町直樹、沖塩協一、今井公江、河渕真治、栄田敏之、平島智徳、安宅信二
    • Organizer
      第58回日本肺癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] Preclinical and clinical studies on establishment of invasive marker of dihydropyrimidine dehydrogenase activity and its usefulness in 5-fluorouracil-based chemotherapy2017

    • Author(s)
      Yukako Ito, Shinji Kobuchi, Shigeru Horiguchi, Hironari Kato, Hidenori Shiraha, Toshiyuki Sakaeda
    • Organizer
      15th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] 母集団薬物動態解析によるカペシタビン投与後の5-fluorouracilの日内変動把握2016

    • Author(s)
      矢崎由希子、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      第37回日本臨床薬理学会学術総会
    • Place of Presentation
      鳥取
    • Year and Date
      2016-12-01
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] カペシタビン反復投与後のカペシタビンの体内動態及び腫瘍内濃度の変動2016

    • Author(s)
      佐藤孝和、能勢祐輔、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      第1回日本臨床薬理学会近畿地方会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] Capecitabineの体内動態に及ぼす5-fluorouracil先行急速静脈内投与の影響2016

    • Author(s)
      芥川真子、河渕真治、伊藤由佳子、栄田敏之
    • Organizer
      第66回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] Tumoral distribution of capecitabine and 5-fluorouracil after capecitabine administration to colorectal cancer rats2016

    • Author(s)
      Yusuke Nose, Takakazu Sato, Shinji Kobuchi, Yukako Ito and Toshiyuki Sakaeda
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] Population pharmacokinetic analysis of capecitabine for circadian variations in rats2016

    • Author(s)
      Yukiko Yazaki, Shinji Kobuchi, Yukako Ito and Toshiyuki Sakaeda
    • Organizer
      日本薬物動態学会第31回年会
    • Place of Presentation
      東京
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] 5-FUの体内動態に影響を及ぼす肥満の影響2015

    • Author(s)
      児玉亮二、春名真理子、河渕真治、伊藤由佳子、田村孝雄、栄田敏之
    • Organizer
      第25回日本医療薬学会年会
    • Place of Presentation
      神奈川県横浜市 パシフィコ横浜
    • Year and Date
      2015-11-21
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] 5-fluorouracilの急速静脈内投与によるdihydropyrimidine dehydrogenase活性への影響2015

    • Author(s)
      林明日香、谷口真優、河渕真治、伊藤由佳子、田村孝雄、栄田敏之
    • Organizer
      第36回日本臨床薬理学会学術総会
    • Place of Presentation
      東京都 京王プラザホテル
    • Year and Date
      2015-12-09
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] Pharmacokinetic alterations of capecitabine and 5-fluorouracil after repeated administration of capecitabine to rats with colorectal cancer2015

    • Author(s)
      Sato T, Shinohara K, Kobuchi S, Ito Y, and Sakaeda T.
    • Organizer
      日本薬物動態学会第30回年会
    • Place of Presentation
      東京都 タワーホール船堀
    • Year and Date
      2015-11-12
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] Increase in steady-state plasma concentrations of 5-fluorouracil (5-FU) via the suppression of dihydropyrimidine dehydrogenase activity by a bolus injection of 5-FU in advance2015

    • Author(s)
      Kobuchi S, Ito Y, Tamura T, and Sakaeda T.
    • Organizer
      14th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology
    • Place of Presentation
      Rotterdam, Netherlands
    • Year and Date
      2015-10-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18937
  • [Presentation] 5-フルオロウラシルの血漿中濃度の日内変動に関する基礎的検討2015

    • Author(s)
      中野佑也,河渕真治,吉岡涼輔,中野一樹,伊藤由佳子,田村孝雄,栄田敏之
    • Organizer
      第32回日本TDM学会・学術大会
    • Place of Presentation
      長野県松本市 キッセイ文化ホール
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PROJECT-15K18937
  • 1.  栄田 敏之 (00304098)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 2.  豕瀬 諒 (10868152)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  村木 優一 (50571452)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  ITO Yukako
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 14 results

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