Onishi Iichiroh 大西威一郎

Researcher Number	70750214
Other IDs
Affiliation (Current)	2025: 東京科学大学, 東京科学大学病院, 助教
Affiliation (based on the past Project Information) *help	2023: 東京医科歯科大学, 東京医科歯科大学病院, 助教 2021 – 2022: 東京医科歯科大学, 医学部附属病院, 助教 2019 – 2020: 東京医科歯科大学, 大学院医歯学総合研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 49030:Experimental pathology-related / Basic Section 49020:Human pathology-related
Keywords	Principal Investigator CRISPR library / 骨髄異形成症候群 / CRISPR screeningデータベース / 乳癌 / in silico screening / 乳癌細胞株 / 合成致死 / ヒト化骨髄微小環境 / 骨髄間葉幹細胞 / 骨髄間葉幹細胞株 … More / 骨髄間葉系幹細胞株 / 脱細胞化骨 / 病理診断 / 予後層別化 / オートファジー / 予後解析 / LC3B / オートファゴソーム Less

CRISPR screeningデータベースを用いた、BRCA変異乳癌の新たな合成致死因子同定Principal Investigator
- Principal Investigator
  
  大西威一郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo Medical and Dental University
Establishment of human bone-marrow microenvironment model using Decellularized bonePrincipal Investigator
- Principal Investigator
  
  Iichiroh Onishi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Tokyo Medical and Dental University
Analysis of autophagosome formation in myelodysplastic syndromePrincipal Investigator
- Principal Investigator
  
  Onishi Iichiroh
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Tokyo Medical and Dental University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Indirect CRISPR screening with photoconversion revealed key factors of drug resistance with cell?cell interactions2023
- Author(s)
  Sugita Keisuke、Onishi Iichiroh、Nakayama Ran、Ishibashi Sachiko、Ikeda Masumi、Inoue Miori、Narita Rina、Oshima Shiori、Shimizu Kaho、Saito Shinichiro、Sato Shingo、Moriarity Branden S.、Yamamoto Kouhei、Largaespada David A.、Kitagawa Masanobu、Kurata Morito
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 582-582
- DOI
  10.1038/s42003-023-04941-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06760, KAKENHI-PROJECT-21K06945, KAKENHI-PROJECT-21K19556, KAKENHI-PROJECT-23K24455
[Journal Article] Identification of NRAS Downstream Genes with CRISPR Activation Screening2022
- Author(s)
  Tatsumi Akiya、Hirakochi Haruka、Inoue Satomi、Tanaka Yosuke、Furuno Hidehiro、Ikeda Masumi、Ishibashi Sachiko、Taguchi Towako、Yamamoto Kouhei、Onishi Iichiroh、Sachs Zohar、Largaespada David A.、Kitagawa Masanobu、Kurata Morito
- Journal Title
  
  Biology
  
  Volume: 11 Issue: 11 Pages: 1551-1551
- DOI
  10.3390/biology11111551
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06945, KAKENHI-PROJECT-21K15414
[Journal Article] Identification of the Factor That Leads Human Mesenchymal Stem Cell Lines into Decellularized Bone2022
- Author(s)
  Koyanagi Anri、Onishi Iichiroh、Muraoka Karin、Sato Ikue、Sato Shingo、Kimura Tsuyoshi、Kishida Akio、Yamamoto Kouhei、Kitagawa Masanobu、Kurata Morito
- Journal Title
  
  Bioengineering
  
  Volume: 9 Issue: 10 Pages: 490-490
- DOI
  10.3390/bioengineering9100490
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19556, KAKENHI-PROJECT-21K15414, KAKENHI-PROJECT-21H04954, KAKENHI-PROJECT-23K24455
[Journal Article] Efficient Identification of the MYC Regulator with the Use of the CRISPR Library and Context-Matched Database Screenings2022
- Author(s)
  Tanaka Yosuke、Kambayashi Hidetaka、Yamamoto Akiko、Onishi Iichiroh、Sugita Keisuke、Matsumura Miwa、Ishibashi Sachiko、Ikeda Masumi、Yamamoto Kouhei、Kitagawa Masanobu、Kurata Morito
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 14 Pages: 7723-7723
- DOI
  10.3390/ijms23147723
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15414, KAKENHI-PROJECT-21K16800
[Journal Article] C/EBPβ induces B‐cell acute lymphoblastic leukemia and cooperates with <i>BLNK</i> mutations2021
- Author(s)
  Kurata Morito、Onishi Iichiro、Takahara Tomoko、Yamazaki Yukari、Ishibashi Sachiko、Goitsuka Ryo、Kitamura Daisuke、Takita Junko、Hayashi Yasuhide、Largaesapda David A、Kitagawa Masanobu、Nakamura Takuro
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 12 Pages: 4920-4930
- DOI
  10.1111/cas.15164
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01035, KAKENHI-PROJECT-20H00510, KAKENHI-PROJECT-20H00528, KAKENHI-PROJECT-21H02372, KAKENHI-PROJECT-20K08744, KAKENHI-PROJECT-20K21533, KAKENHI-PROJECT-21K19405, KAKENHI-PROJECT-21K15414
[Journal Article] To Discover the Efficient and Novel Drug Targets in Human Cancers Using CRISPR/Cas Screening and Databases2021
- Author(s)
  Onishi Iichiroh、Yamamoto Kouhei、Kinowaki Yuko、Kitagawa Masanobu、Kurata Morito
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 22 Pages: 12322-12322
- DOI
  10.3390/ijms222212322
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15414
[Journal Article] CRISPR screening identifies M1AP as a new MYC regulator with a promoter-reporter system2020
- Author(s)
  Yamamoto Akiko、Kurata Morito、Onishi Iichiroh、Sugita Keisuke、Matsumura Miwa、Ishibashi Sachiko、Ikeda Masumi、Yamamoto Kouhei、Kitagawa Masanobu
- Journal Title
  
  PeerJ
  
  Volume: 8 Pages: e9046-e9046
- DOI
  10.7717/peerj.9046
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06953, KAKENHI-PROJECT-18K07040, KAKENHI-PROJECT-19K16582
[Journal Article] SECISBP2 is a novel prognostic predictor that regulates selenoproteins in diffuse large B-cell lymphoma2020
- Author(s)
  Taguchi Towako、Kurata Morito、Onishi Iichiroh、Kinowaki Yuko、Sato Yunosuke、Shiono Sayuri、Ishibashi Sachiko、Ikeda Masumi、Yamamoto Masahide、Kitagawa Masanobu、Yamamoto Kouhei
- Journal Title
  
  Laboratory Investigation
  
  Volume: 101 Issue: 2 Pages: 218-227
- DOI
  10.1038/s41374-020-00495-0
- Data Source
  KAKENHI-PROJECT-18K07063, KAKENHI-PROJECT-19K16582
[Journal Article] Bone marrow niches in myeloid neoplasms2020
- Author(s)
  Kitagawa Masanobu、Kurata Morito、Onishi Iichiroh、Yamamoto Kouhei
- Journal Title
  
  Pathology International
  
  Volume: 70 Issue: 2 Pages: 63-71
- DOI
  10.1111/pin.12870
- Data Source
  KAKENHI-PROJECT-19K16582
[Presentation] データベースを用いた、遺伝性乳がんの新たな合成致死因子の探索2023
- Author(s)
  韓知佑、　大西威一郎
- Organizer
  第109回　日本病理学会総会
- Data Source
  KAKENHI-PROJECT-23K06760
[Presentation] Identification of a new synthetic lethal factor for BRCA- mutated breast cancer using CRISPR screening database2023
- Author(s)
  Iichiroh Onishi
- Organizer
  第82回　日本癌学会総会
- Data Source
  KAKENHI-PROJECT-23K06760
[Presentation] CRISPR activation libraryを用いたMYCの発現調節因子の探求2022
- Author(s)
  田中陽典, 倉田盛人, 上林秀孝, 山本亜希子, 山本浩平, 大西威一郎, 北川昌伸
- Organizer
  第111回　病理学会総会
- Data Source
  KAKENHI-PROJECT-21K15414
[Presentation] CRISPR activation libraryより同定された脱細胞化骨への間葉系幹細胞の進展因子SHC4の解析2022
- Author(s)
  小柳杏莉, 大西威一郎, 倉田盛人, 村岡香琳, 木村剛, 岸田晶夫, 北川昌伸
- Organizer
  第111回　病理学会総会
- Data Source
  KAKENHI-PROJECT-21K15414
[Presentation] Establishment of human bone-marrow microenvironment model using Decellularized bone2022
- Author(s)
  Iichiroh Onishi, Morito Kurata , Kouhei Yamamoto, Masanobu Kitagawa
- Organizer
  第81回　日本癌学会総会
- Data Source
  KAKENHI-PROJECT-21K15414
[Presentation] CRISPR KO libraryを用いた細胞相互作用における薬剤耐性機序の解明2022
- Author(s)
  杉田佳祐, 倉田盛人, 中山蘭, 大西威一郎, 山本浩平, 北川昌伸
- Organizer
  第81回　日本癌学会総会
- Data Source
  KAKENHI-PROJECT-21K15414
[Presentation] 脱細胞化骨を用いた、ヒト骨髄微小環境構築の試み2021
- Author(s)
  大西威一郎, 倉田盛人, 村岡香琳, 小柳杏莉, 木村剛, 岸田晶夫, 山本浩平, 北川昌伸
- Organizer
  第80回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-21K15414
[Presentation] 骨髄の病理:基礎から病理診断まで　骨髄の病理診断2021
- Author(s)
  大西威一郎, 倉田盛人, 山本浩平, 北川昌伸
- Organizer
  第110回　日本病理学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15414
[Presentation] Establishment of human bone-marrow microenvironment model using Decellularized bone2020
- Author(s)
  Iichiroh Onishi, Morito Kurata , Kouhei Yamamoto , Tsuyoshi Kimura , Akio Kishida , Masanobu Kitagawa
- Organizer
  日本癌学会総会
- Data Source
  KAKENHI-PROJECT-19K16582
[Presentation] 脱細胞化骨組織を用いたヒト骨髄微小環境の構築2020
- Author(s)
  大西威一郎、倉田盛人、山本浩平、北川昌伸
- Organizer
  日本病理学会総会
- Data Source
  KAKENHI-PROJECT-19K16582
[Presentation] 骨髄異形成症候群におけるオートファゴソームの解析2019
- Author(s)
  Iichiroh Onishi
- Organizer
  第108会　日本病理学会総会
- Data Source
  KAKENHI-PROJECT-19K16582

1. KURATA Morito

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 中村卓郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 山本浩平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 佐藤信吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Onishi Iichiroh 大西 威一郎

Research Projects

Research Products

Co-Researchers

CRISPR screeningデータベースを用いた、BRCA変異乳癌の新たな 合成致死因子同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of human bone-marrow microenvironment model using Decellularized bonePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of autophagosome formation in myelodysplastic syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Indirect CRISPR screening with photoconversion revealed key factors of drug resistance with cell?cell interactions2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of NRAS Downstream Genes with CRISPR Activation Screening2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of the Factor That Leads Human Mesenchymal Stem Cell Lines into Decellularized Bone2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficient Identification of the MYC Regulator with the Use of the CRISPR Library and Context-Matched Database Screenings2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] C/EBPβ induces B‐cell acute lymphoblastic leukemia and cooperates with <i>BLNK</i> mutations2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] To Discover the Efficient and Novel Drug Targets in Human Cancers Using CRISPR/Cas Screening and Databases2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CRISPR screening identifies M1AP as a new MYC regulator with a promoter-reporter system2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SECISBP2 is a novel prognostic predictor that regulates selenoproteins in diffuse large B-cell lymphoma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bone marrow niches in myeloid neoplasms2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] データベースを用いた、 遺伝性乳がんの新たな合成致死因子の探索2023

Author(s)

Organizer

Data Source

[Presentation] Identification of a new synthetic lethal factor for BRCA- mutated breast cancer using CRISPR screening database2023

Author(s)

Organizer

Data Source

[Presentation] CRISPR activation libraryを用いたMYCの発現調節因子の探求2022

Author(s)

Organizer

Data Source

[Presentation] CRISPR activation libraryより同定された脱細胞化骨への間葉系幹細胞の進展因子SHC4の解析2022

Onishi Iichiroh 大西威一郎

CRISPR screeningデータベースを用いた、BRCA変異乳癌の新たな合成致死因子同定Principal Investigator

[Presentation] データベースを用いた、遺伝性乳がんの新たな合成致死因子の探索2023

[Presentation] 骨髄の病理:基礎から病理診断まで　骨髄の病理診断2021