HORIGUCHI HARUKI 堀口晴紀

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Horiguchi Haruki 堀口晴紀

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Researcher Number	70755454
Other IDs
Affiliation (Current)	2025: 熊本大学, 大学院生命科学研究部(医), 客員講師
Affiliation (based on the past Project Information) *help	2021 – 2023: 熊本大学, 大学院生命科学研究部(医), 特任助教 2018 – 2019: 熊本大学, 生命資源研究・支援センター, 特任助教 2015 – 2016: 熊本大学, 生命資源研究・支援センター, 特定事業研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Pathological medical chemistry
Keywords	Principal Investigator がん免疫 / アンジオポエチン様因子2 / 免疫 / がん / 抗腫瘍免疫 / がん微小環境 / ANGPTL2 / 腫瘍免疫 / 腸管免疫 / 恒常性維持機構 / 大腸がん / アンジオポエチン様2 / 潰瘍性大腸炎

がん微小環境における細胞間相互作用が織りなすがん免疫制御機構の解明Principal Investigator
- Principal Investigator
  
  堀口晴紀
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kumamoto University
Regulatory mechanisms of cell-cell interactions mediated by ANGPTL2 in the tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  Horiguchi Haruki
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kumamoto University
The elucidation of the molecular mechanism underlying homeostasis against cancerPrincipal Investigator
- Principal Investigator
  
  Horiguchi Haruki
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kumamoto University
ANGPTL2 controls intestinal homeostasisPrincipal Investigator
- Principal Investigator
  
  Horiguchi Haruki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kumamoto University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article

[Journal Article] Tumor stroma-derived ANGPTL2 potentiates immune checkpoint inhibitor efficacy2024
- Author(s)
  Horiguchi Haruki、Kadomatsu Tsuyoshi、Yamashita Tomoya、Yumoto Shinsei、Horino Taichi、Sato Michio、Terada Kazutoyo、Miyata Keishi、Ichigozaki Yuki、Kimura Toshihiro、Fukushima Satoshi、Moroishi Toshiro、Oike Yuichi
- Journal Title
  
  Cancer Gene Therapy
  
  Volume: Online ahead of print Issue: 6 Pages: 0-0
- DOI
  10.1038/s41417-024-00757-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16285, KAKENHI-PROJECT-22K08187, KAKENHI-PROJECT-23K06638, KAKENHI-PROJECT-23K07511, KAKENHI-PROJECT-21K07101, KAKENHI-PROJECT-21H04825
[Journal Article] ANGPTL2 promotes immune checkpoint inhibitor-related murine autoimmune myocarditis2023
- Author(s)
  Horiguchi Haruki、Kadomatsu Tsuyoshi、Yamashita Tomoya、Yumoto Shinsei、Terada Kazutoyo、Sato Michio、Morinaga Jun、Miyata Keishi、Oike Yuichi
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 965-965
- DOI
  10.1038/s42003-023-05338-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08187, KAKENHI-PROJECT-23K06638, KAKENHI-PROJECT-23K07511, KAKENHI-PROJECT-21K07101, KAKENHI-PROJECT-22K19533, KAKENHI-PROJECT-21H04825
[Journal Article] ANGPTL2‐mediated epigenetic repression of MHC‐I in tumor cells accelerates tumor immune evasion2023
- Author(s)
  Kadomatsu Tsuyoshi、Hara Chiaki、Kurahashi Ryoma、Horiguchi Haruki、Morinaga Jun、Miyata Keishi、Kurano Sohtaro、Kanemaru Hisashi、Fukushima Satoshi、Araki Kimi、Baba Masaya、Linehan W. Marston、Kamba Tomomi、Oike Yuichi
- Journal Title
  
  Molecular Oncology
  
  Volume: 17 Issue: 12 Pages: 2637-2658
- DOI
  10.1002/1878-0261.13490
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08187, KAKENHI-PROJECT-23K06638, KAKENHI-PROJECT-21K07101, KAKENHI-PROJECT-21K08351, KAKENHI-PROJECT-21K19721, KAKENHI-PROJECT-22K19533, KAKENHI-PROJECT-20K16450, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H04825, KAKENHI-PROJECT-23K24474
[Journal Article] Tumor cell-derived ANGPTL2 promotes β-catenin-driven intestinal tumorigenesis.2022
- Author(s)
  1.Horiguchi H, Kadomatsu T, Yumoto S, Masuda T, Miyata K, Yamamura S, Sato M, Morinaga J, Ohtsuki S, Baba H, Moroishi T, and Oike Y
- Journal Title
  
  Oncogene
  
  Volume: 41 Issue: 33 Pages: 4208-4041
- DOI
  10.1038/s41388-022-02405-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07101, KAKENHI-PROJECT-22K08187, KAKENHI-PROJECT-22K19533, KAKENHI-PROJECT-21K15508, KAKENHI-PROJECT-21K16061
[Journal Article] Vaccine targeting ANGPTL3 ameliorates dyslipidemia and associated diseases in mouse models of obese dyslipidemia and familial hypercholesterolemia2021
- Author(s)
  Fukami Hirotaka、Morinaga Jun、Nakagami Hironori、Hayashi Hiroki、Okadome Yusuke、Matsunaga Eiji、Kadomatsu Tsuyoshi、Horiguchi Haruki、Sato Michio、Sugizaki Taichi、Kuwabara Takashige、Miyata Keishi、Mukoyama Masashi、Morishita Ryuichi、Oike Yuichi
- Journal Title
  
  Cell Reports Medicine
  
  Volume: 2 Issue: 11 Pages: 100446-100446
- DOI
  10.1016/j.xcrm.2021.100446
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08560, KAKENHI-PROJECT-19K08728, KAKENHI-PROJECT-20K17288, KAKENHI-PROJECT-21H04825, KAKENHI-PROJECT-20K08611, KAKENHI-PROJECT-21K07101, KAKENHI-PROJECT-21K15508, KAKENHI-PROJECT-21K16061, KAKENHI-PROJECT-21K20935
[Journal Article] The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis2021
- Author(s)
  Sato Michio, Kadomatsu Tsuyoshi, Miyata Keishi, Warren Junco S., Tian Zhe、Node Koichi、Araki Kimi、 Oike Yuichi et al
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 2529-2529
- DOI
  10.1038/s41467-021-22735-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08560, KAKENHI-PROJECT-21H04825, KAKENHI-PROJECT-21K05999, KAKENHI-PROJECT-21K07101, KAKENHI-PROJECT-21K15508, KAKENHI-PROJECT-21K16061, KAKENHI-PROJECT-16H06276, KAKENHI-PLANNED-21H05274
[Journal Article] Tumor cell-derived angiopoietin-like protein 2 establishes a preference for glycolytic metabolism in lung cancer cells.2020
- Author(s)
  Osumi H, Horiguchi H, Kadomatsu T, Tashiro K, Morinaga J, Takahashi T, Ikeda K, Ito T, Suzuki M, Endo M, Oike Y
- Journal Title
  
  Cancer Sci
  
  Volume: - Issue: 4 Pages: 1241-1253
- DOI
  10.1111/cas.14337
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08663, KAKENHI-PROJECT-18K15246, KAKENHI-PROJECT-20K08530, KAKENHI-PROJECT-16H02468, KAKENHI-PROJECT-18H02809, KAKENHI-PROJECT-18K07236
[Journal Article] Loss of Endogenous HMGB2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice2019
- Author(s)
  Sato M, Miyata K, Tian Z, Kadomatsu T, Ujihara Y, Morinaga J, Horiguchi H, Endo M, Zhao J, Zhu S, Sugizaki T, Igata K, Muramatsu M, Minami T, Ito T, Bianchi ME, Mohri S, Araki K, Node K, Oike Y
- Journal Title
  
  Circ J
  
  Volume: 83 Issue: 2 Pages: 368-378
- DOI
  10.1253/circj.CJ-18-0925
- NAID
  130007557092
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2019-01-25
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08663, KAKENHI-PROJECT-18K15246, KAKENHI-PUBLICLY-17H05652, KAKENHI-PROJECT-18H02809, KAKENHI-PROJECT-18H02904, KAKENHI-PROJECT-17H04740, KAKENHI-PROJECT-16K07093, KAKENHI-PROJECT-16K09504, KAKENHI-PROJECT-17K15622, KAKENHI-PROJECT-18KT0026, KAKENHI-PROJECT-19K17607, KAKENHI-PUBLICLY-19H04972, KAKENHI-PROJECT-17H03580, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18K19519
[Journal Article] Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity.2019
- Author(s)
  Horiguchi H, Kadomatsu T, Kurahashi R, Hara C, Miyata K, Baba M, Osumi H, Terada K, Araki K, Takai T, Kamba T, Linehan WM, Moroishi T, Oike Y.
- Journal Title
  
  Genes Dev
  
  Volume: 33 Issue: 23-24 Pages: 1641-1656
- DOI
  10.1101/gad.329417.119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07236, KAKENHI-PROJECT-19K08560, KAKENHI-PROJECT-18H02438, KAKENHI-PROJECT-18H02938, KAKENHI-PROJECT-18K19619, KAKENHI-PROJECT-18K15246
[Journal Article] Association of circulating ANGPTL 3, 4, and 8 levels with medical status in a population undergoing routine medical checkups: A cross-sectional study.2018
- Author(s)
  Morinaga J, Zhao J, Endo M, Kadomatsu T, Miyata K, Sugizaki T, Okadome Y, Tian Z, Horiguchi H, Miyashita K, Maruyama N, Mukoyama M, Oike Y.
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 3 Pages: e0193731-e0193731
- DOI
  10.1371/journal.pone.0193731
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08663, KAKENHI-PROJECT-17K09706, KAKENHI-PROJECT-18K15246, KAKENHI-PROJECT-15K06836
[Journal Article] ANGPTL2 expression in intestinal stem cell niche controls epithelial regeneration and homeostasis.2017
- Author(s)
  Horiguchi H, Endo M, Kawane K, Kadomatsu T, Terada K, Morinaga J, Araki K, Miyata K, Oike Y,
- Journal Title
  
  EMBO Journal
  
  Volume: 36 Issue: 4 Pages: 409-424
- DOI
  10.15252/embj.201695690
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01520, KAKENHI-PROJECT-15H06508, KAKENHI-PROJECT-26293190, KAKENHI-PROJECT-26713011, KAKENHI-PROJECT-16K07093, KAKENHI-PROJECT-15K06836
[Journal Article] ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism.2016
- Author(s)
  Tian Z, Miyata K, Kadomatsu T, Horiguchi H, Fukushima H, Tohyama S, Ujihara Y, Okumura T, Yamaguchi S, Zhao J, Endo M, Morinaga J, Sato M, Sugizaki T, Zhu S, Terada K, Sakaguchi H, Komohara Y, Takeya M, Takeda N, Araki K, Manabe I, Fukuda K, Otsu K, Wada J, Murohara T, Mohri S, Yamashita JK, Sano M, Oike Y.
- Journal Title
  
  Nature Communications
  
  Volume: 7 Issue: 1 Pages: 13016-13016
- DOI
  10.1038/ncomms13016
- NAID
  120006345014
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01520, KAKENHI-PROJECT-15H06508, KAKENHI-PROJECT-26282127, KAKENHI-PROJECT-26293190, KAKENHI-PROJECT-26293218, KAKENHI-PROJECT-16K09504, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-15K06836, KAKENHI-PROJECT-16K15445
[Journal Article] Interstitial pneumonia induced by bleomycin treatment is exacerbated in Angptl2-deficient mice2016
- Author(s)
  Motokawa I, Endo M, Terada K, Horiguchi H, Miyata K, Kadomatsu T, Morinaga J, Sugizaki T, Ito T, Araki K, Morioka MS, Manabe I, Samukawa T, Watanabe M, Inoue H, Oike Y.
- Journal Title
  
  American Journal of Physiology. Lung Cellular and Molecular Physiology
  
  Volume: 311 Issue: 4 Pages: 704-713
- DOI
  10.1152/ajplung.00005.2016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H06508, KAKENHI-PROJECT-15K09179, KAKENHI-PROJECT-15K09180
[Journal Article] Mice Deficient in Angiopoietin-like Protein 2 (Angptl2) Gene Show Increased Susceptibility to Bacterial Infection Due to Attenuated Macrophage Activity2016
- Author(s)
  Yugami M, Odagiri H, Endo M, Tsutsuki H, Fujii S, Kadomatsu T, Masuda T, Miyata K, Terada K, Tanoue H, Ito H, Morinaga J, Horiguchi H, Sugizaki T, Akaike T, Gotoh T, Takai T, Sawa T, Mizuta H, Oike Y
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 291 Issue: 36 Pages: 18843-18852
- DOI
  10.1074/jbc.m116.720870
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01159, KAKENHI-PUBLICLY-15H01520, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15H06508, KAKENHI-PROJECT-26293190, KAKENHI-PROJECT-15K20008, KAKENHI-PROJECT-15K08456, KAKENHI-PROJECT-16K15208

1. ENDO Motoyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. KADOMATSU Tsuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
3. 尾池雄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 宮田敬士

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
5. 木村俊寛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HORIGUCHI HARUKI 堀口 晴紀

Horiguchi Haruki 堀口 晴紀

Research Projects

Research Products

Co-Researchers

がん微小環境における細胞間相互作用が織りなすがん免疫制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulatory mechanisms of cell-cell interactions mediated by ANGPTL2 in the tumor microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The elucidation of the molecular mechanism underlying homeostasis against cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ANGPTL2 controls intestinal homeostasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Tumor stroma-derived ANGPTL2 potentiates immune checkpoint inhibitor efficacy2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ANGPTL2 promotes immune checkpoint inhibitor-related murine autoimmune myocarditis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ANGPTL2‐mediated epigenetic repression of MHC‐I in tumor cells accelerates tumor immune evasion2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor cell-derived ANGPTL2 promotes β-catenin-driven intestinal tumorigenesis.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Vaccine targeting ANGPTL3 ameliorates dyslipidemia and associated diseases in mouse models of obese dyslipidemia and familial hypercholesterolemia2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor cell-derived angiopoietin-like protein 2 establishes a preference for glycolytic metabolism in lung cancer cells.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss of Endogenous HMGB2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice2019

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of circulating ANGPTL 3, 4, and 8 levels with medical status in a population undergoing routine medical checkups: A cross-sectional study.2018

Author(s)

HORIGUCHI HARUKI 堀口晴紀

Horiguchi Haruki 堀口晴紀