SHIRAISHI DAISUKE 白石大偉輔

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Shiraishi Daisuke 白石大偉輔

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Researcher Number	70769512
Other IDs
Affiliation (Current)	2025: 熊本大学, 大学院生命科学研究部(医), 特定研究員
Affiliation (based on the past Project Information) *help	2021 – 2023: 熊本大学, 大学院生命科学研究部(医), 特定研究員 2019 – 2020: 熊本大学, 病院, 非常勤診療医師 2018: 熊本大学, 医学部附属病院, 非常勤診療医師 2016 – 2017: 熊本大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Orthopaedic surgery Except Principal Investigator General internal medicine(including psychosomatic medicine)
Keywords	Principal Investigator 腫瘍関連マクロファージ / 腫瘍内微小環境 / 腫瘍 / CD163 / マクロファージ / 免疫微小環境 / 骨軟部肉腫 / スルフィド化合物 / 肉腫 / 骨肉腫 … More Except Principal Investigator … More スルフィド化合物 / ガン免疫 / 環状スルフィド化合物 / マクロファージ / 代替医療 / ガン / マクロファージクロファージ Less

肉腫の転移に関わる免疫微小環境を標的とした新規治療法の開発Principal Investigator
- Principal Investigator
  
  白石大偉輔
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kumamoto University
Elucidation of the function of CD163-positive macrophages in the tumor microenvironment.Principal Investigator
- Principal Investigator
  
  Shiraishi Daisuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kumamoto University
Novel anti-cancer therapy with cyclic sulfide compounds regulating macrophage activation
- Principal Investigator
  
  Fujiwara Yukio
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Kumamoto University
Studies on the function of CD163, a macrophage scavenger receptor, in tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  Shiraishi Daisuke
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kumamoto University

All 2023 2022 2021 2020 2018 2017 2016

All Journal Article Presentation

[Journal Article] リバース型人工肩関節置換術のscapular notchingの発生頻度2022
- Author(s)
  甲斐裕基、田村論史、小田勇一郎、白石大偉輔、松原秀太、高田紘平、菊川憲志
- Journal Title
  
  整形外科と災害外科
  
  Volume: 71 Pages: 406-409
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K09308
[Journal Article] 陳旧性胸鎖関節脱臼に対し胸鎖靭帯再建術を施行した1例2022
- Author(s)
  高田紘平、菊川憲志、小田勇一郎、白石大偉輔*、田村諭史、甲斐裕基、松原秀太
- Journal Title
  
  整形外科と災害外科
  
  Volume: 71 Pages: 799-801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K09308
[Journal Article] Cyclic sulfur compounds targeting macrophage polarization into M2/protumor phenotype and their anti-tumor effects2021
- Author(s)
  Pan Cheng、Fujiwara Yukio、Horlad Hasita、Iriki Toyohisa、Shiraishi Daisuke、Komohara Yoshihiro
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: - Issue: 6 Pages: 1331-1343
- DOI
  10.1007/s00262-021-03085-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08603, KAKENHI-PROJECT-19K09555, KAKENHI-PROJECT-22K09308
[Journal Article] CD163 deficiency facilitates lipopolysaccharide-induced inflammatory responses and endotoxin shock in mice2020
- Author(s)
  Fujiwara Y, Ohnishi K, Horlad H, Saito Y, Shiraishi D, Takeya H, Yoshii D, Kaieda S, Hoshino T, Komohara Y.
- Journal Title
  
  Clinical Translational Immunology
  
  Volume: 25 Issue: 9
- DOI
  10.1002/cti2.1162
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08898, KAKENHI-PROJECT-19K09555, KAKENHI-PROJECT-18J01441, KAKENHI-PROJECT-18K06991
[Journal Article] Flavonoid Compounds Contained in Epimedii Herba Inhibit Tumor Progression by Suppressing STAT3 Activation in the Tumor Microenvironment2020
- Author(s)
  Pan Cheng、Fujiwara Yukio、Horlad Hasita、Shiraishi Daisuke、Iriki Toyohisa、Tsuboki Jyunko、Ikeda Tsuyoshi、Komohara Yoshihiro
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 11 Pages: 00262-00262
- DOI
  10.3389/fphar.2020.00262
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08603, KAKENHI-PROJECT-19K09555, KAKENHI-PROJECT-17H04060, KAKENHI-PROJECT-17K08763, KAKENHI-PROJECT-20K07122
[Journal Article] CD163 is required for protumoral activation of macrophages in human and murine sarcoma.2018
- Author(s)
  Shiraishi D, Fujiwara Y, Horlad H, Saito Y, Iriki T, Tsuboki J, Cheng P, Nakagata N, Mizuta H, Bekki H, Nakashima Y, Oda Y, Takeya M, Komohara Y.
- Journal Title
  
  Cancer Res
  
  Volume: in press Issue: 12 Pages: 3255-3266
- DOI
  10.1158/0008-5472.can-17-2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08763, KAKENHI-PROJECT-17H04060, KAKENHI-PROJECT-18J01441, KAKENHI-PROJECT-16K09247, KAKENHI-PROJECT-16K10865, KAKENHI-PROJECT-16K15248
[Journal Article] 痛風結節を伴った膝関節内の限局型腱滑膜巨細胞腫の1例2017
- Author(s)
  甲斐裕基、岡元信和、佐藤広生、中村英一、山部聡一郎、舛田哲朗、白石大偉輔、水田博志
- Journal Title
  
  Orthopedics & Traumatology
  
  Volume: 66 Issue: 3 Pages: 529-533
- DOI
  10.5035/nishiseisai.66.529
- NAID
  130006252112
- ISSN
  0037-1033, 1349-4333
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10865
[Journal Article] Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages.2016
- Author(s)
  Tsuboki J, Fujiwara Y, Horlad H, Shiraishi D, Nohara T, Tayama S, Motohara T, Saito Y, Ikeda T, Takaishi K, Tashiro H, Yonemoto Y, Katabuchi H, Takeya M, Komohara Y.
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 29588-29588
- DOI
  10.1038/srep29588
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09247, KAKENHI-PROJECT-16K10865, KAKENHI-PROJECT-16K11145
[Journal Article] Onionin A, a sulfur-containing compound isolated from onions, impairs tumor development and lung metastasis by inhibiting the protumoral and immunosuppressive functions of myeloid cells2016
- Author(s)
  Fujiwara Yukio, Horlad Hasita, Shiraishi Daisuke, Tsuboki Junko, Kudo Rino, Ikeda Tsuyoshi, Nohara Toshihiro, Takeya Motohiro, Komohara Yoshihiro
- Journal Title
  
  Molecular Nutrition & Food Research
  
  Volume: 60(11) Issue: 11 Pages: 2467-2480
- DOI
  10.1002/mnfr.201500995
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460141, KAKENHI-PROJECT-16K09247, KAKENHI-PROJECT-16K10865
[Presentation] α1-酸性糖タンパク質のマクロファージ活性化を介した腫瘍細胞のp53発現制御による腫瘍促進作用2023
- Author(s)
  藤原章雄、田中隆聖、潘程、矢野浩夢、白石大偉輔、入来豊久、丸山徹、菰原義弘
- Organizer
  第113回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-22K09308
[Presentation] 当院におけるリバース型人工肩関節置換術後3年以上経過した症例の検討　-術後1年時との比較2023
- Author(s)
  高橋啓太、菊川憲志、田村諭史、白石大偉輔、福田雅俊、松原秀太、荒木崇士、中瀬啓太
- Organizer
  第146回西日本整形外科・災害外科学会
- Data Source
  KAKENHI-PROJECT-22K09308
[Presentation] a1-acid glycoprotein contributes to cancer cell malignancy via tumor-associated macrophages2023
- Author(s)
  Yukio Fujiwara, Ryusei Tanaka, Cheng Pan, Daisuke Shiraishi, Toru Maruyama, Yoshihiro Komohara
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K09308
[Presentation] 外旋機能不全を合併した腱板断裂性関節症に対してL‘Episcopo法を併用したリバース型人工肩関節置換術の治療成績2023
- Author(s)
  中瀬啓太、菊川憲志、田村諭史、白石大偉輔、福田雅俊、松原秀太、荒木崇士
- Organizer
  第146回西日本整形外科・災害外科学会
- Data Source
  KAKENHI-PROJECT-22K09308
[Presentation] マクロファージCD163の肉腫進展における機能解析2018
- Author(s)
  藤原章雄、白石大偉輔、西東洋一、潘程、小田義直、竹屋元裕、菰原義弘
- Organizer
  第58回日本リンパ網内系学会総会
- Data Source
  KAKENHI-PROJECT-16K09247
[Presentation] マクロファージCD163の肉腫進展における機能解析2018
- Author(s)
  藤原章雄、白石大偉輔、西東洋一、潘程、小田義直、竹屋元裕、菰原義弘
- Organizer
  第58回日本リンパ網内系学会総会
- Data Source
  KAKENHI-PROJECT-16K10865
[Presentation] 腫瘍進展におけるマクロファージスカベンジャー受容体CD163の機能解析2018
- Author(s)
  藤原章雄、白石大偉輔、潘　程、中川雄伸、宮川育子、竹屋元裕、菰原義弘
- Organizer
  日本薬学会第138回年会
- Data Source
  KAKENHI-PROJECT-16K10865
[Presentation] 肉腫の腫瘍微小環境におけるマクロファージスカベンジャー受容体 CD163の機能解析2018
- Author(s)
  藤原章雄、白石大偉輔、Hasita Horlad、菰原義弘
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09247
[Presentation] 腫瘍進展におけるマクロファージスカベンジャー受容体CD163の機能解析2018
- Author(s)
  藤原章雄、白石大偉輔、潘　程、中川雄伸、宮川育子、竹屋元裕、菰原義弘
- Organizer
  日本薬学会第138回年会
- Data Source
  KAKENHI-PROJECT-16K09247
[Presentation] 肉腫の腫瘍微小環境におけるマクロファージスカベンジャー受容体 CD163の機能解析2018
- Author(s)
  藤原章雄、白石大偉輔、Hasita Horlad、菰原義弘
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K10865
[Presentation] Hemicallotasis （HCO）における Medial Proximal Tibial Angle の術後変化について2017
- Author(s)
  白石大偉輔　中村英一　岡元信和　山部聡一郎　舛田哲朗　水田博志
- Organizer
  第90回日本整形外科学会学術総会
- Data Source
  KAKENHI-PROJECT-16K10865
[Presentation] Onionin A, a sulfur-containing compound isolated from onions, impairs tumor progression by inhibiting the protumoral functions of macrophages2017
- Author(s)
  Yukio Fujiwara, Junko Tsuboki, Hasita Horlad, Daisuke Shiraishi, Toshihiro Nohara, Yoshihiro Komohara, Motohiro Takeya
- Organizer
  Keystone Symposia, Mononuclear Phagocytes in Health, Immune Defense and Disease (D3)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09247
[Presentation] 変形性膝関節症に対する Hemicallotasis 術後の MPTA と歩行動態の変化について2017
- Author(s)
  白石大偉輔　中村英一　岡元信和　山部聡一郎　舛田哲朗　西佳子　嶋村梨紗　加治哲也　水田博志
- Organizer
  第6回日本 Knee Osteotomy 研究会
- Data Source
  KAKENHI-PROJECT-16K10865
[Presentation] 変形性膝関節症に対する Hemicallotasis 術後の MPTA と歩行動態の変化について2017
- Author(s)
  白石大偉輔　中村英一　岡元信和　山部聡一郎　舛田哲朗　西佳子　嶋村梨紗　加治哲也　水田博志
- Organizer
  第4回九州 Knee Osteotomy 研究会
- Data Source
  KAKENHI-PROJECT-16K10865
[Presentation] Onionin A, a sulfur-containing compound isolated from onions, impairs tumor progression by inhibiting the protumoral functions of macrophages2017
- Author(s)
  Yukio Fujiwara, Junko Tsuboki, Hasita Horlad, Daisuke Shiraishi, Toshihiro Nohara, Yoshihiro Komohara, Motohiro Takeya
- Organizer
  Keystone Symposia, Mononuclear Phagocytes in Health, Immune Defense and Disease (D3)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10865
[Presentation] CD163, a scavenger receptor for the hemoglobin-haptoglobin complex, relates to tumorgenesis in murine sarcoma model.2016
- Author(s)
  Yukio Fujiwara, Daisuke Shiraishi, Hasita Horlad, Hiroshi Mizuta, Yoshihiro Komohara, Motohiro Takeya
- Organizer
  The 24th International Symposium on Molecular Cell Biology of Macrophages
- Place of Presentation
  Tokyo Bay Maihama Hotel Club Resort, Urayasu, Chiba
- Year and Date
  2016-06-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09247
[Presentation] 肉腫移植マウスモデルを用いた腫瘍進展におけるマクロファージスカベンジャー受容体CD163の機能解析2016
- Author(s)
  白石大偉輔、藤原章雄、HORLAD Hasita、菰原義弘、大西紘二、竹屋元裕、水田博志
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡、福岡国際会議場
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K10865

1. 菰原義弘 (40449921)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
2. Fujiwara Yukio (70452886)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
3. 哈斯塔 (00644840)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Ohnishi Koji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. HORLAD Hasita

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
6. 海江田信二郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 星野友昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 入來豊久

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 池田剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIRAISHI DAISUKE 白石 大偉輔

Shiraishi Daisuke 白石 大偉輔

Research Projects

Research Products

Co-Researchers

肉腫の転移に関わる免疫微小環境を標的とした新規治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the function of CD163-positive macrophages in the tumor microenvironment.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel anti-cancer therapy with cyclic sulfide compounds regulating macrophage activation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the function of CD163, a macrophage scavenger receptor, in tumor microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] リバース型人工肩関節置換術のscapular notchingの発生頻度2022

Author(s)

Journal Title

Data Source

[Journal Article] 陳旧性胸鎖関節脱臼に対し胸鎖靭帯再建術を施行した1例2022

Author(s)

Journal Title

Data Source

[Journal Article] Cyclic sulfur compounds targeting macrophage polarization into M2/protumor phenotype and their anti-tumor effects2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD163 deficiency facilitates lipopolysaccharide-induced inflammatory responses and endotoxin shock in mice2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Flavonoid Compounds Contained in Epimedii Herba Inhibit Tumor Progression by Suppressing STAT3 Activation in the Tumor Microenvironment2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD163 is required for protumoral activation of macrophages in human and murine sarcoma.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 痛風結節を伴った膝関節内の限局型腱滑膜巨細胞腫の1例2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Onionin A, a sulfur-containing compound isolated from onions, impairs tumor development and lung metastasis by inhibiting the protumoral and immunosuppressive functions of myeloid cells2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] α1-酸性糖タンパク質のマクロファージ活性化を介した腫瘍細胞のp53発現制御による腫瘍促進作用2023

Author(s)

Organizer

Data Source

[Presentation] 当院におけるリバース型人工肩関節置換術後3年以上経過した症例の検討 -術後1年時との比較2023

SHIRAISHI DAISUKE 白石大偉輔

Shiraishi Daisuke 白石大偉輔

[Presentation] 当院におけるリバース型人工肩関節置換術後3年以上経過した症例の検討　-術後1年時との比較2023