Kise Yoshiaki 木瀬孔明

Researcher Number	70769611
Affiliation (Current)	2025: 東京大学, 大学院理学系研究科(理学部), 特任准教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 東京大学, 大学院理学系研究科(理学部), 特任准教授 2016 – 2020: 東京大学, 大学院理学系研究科(理学部), 特任助教
Review Section/Research Field	Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 43020:Structural biochemistry-related / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Basic Section 44010:Cell biology-related / Cell biology Except Principal Investigator Developmental biology
Keywords	Principal Investigator イオンチャネル / シグナル伝達 / 軸索 / リポソーム / 自己交叉忌避 / 樹状突起 / 分枝 / 軸索分枝 Except Principal Investigator リン酸化酵素 / 維持 … More / 自己組織化 / 老化 / 神経回路 / 時空間制御 / 受容体 / 細胞内シグナル伝達 / シナプス / 空間配置 / 軸索 / 感覚ニューロン / タイリング / 受容領域 / 樹状突起 / ショウジョウバエ Less

骨形成シグナルを選択的に活性化する革新的骨粗しょう症経口薬の開発Principal Investigator
- Principal Investigator
  
  木瀬孔明
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
新規リポソーム再構成法による膜電位、膜張力依存的イオンチャネルの作動機構の解明Principal Investigator
- Principal Investigator
  
  木瀬孔明
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo
イオンチャネル巨大複合体のモジュレーション機構Principal Investigator
- Principal Investigator
  
  木瀬孔明
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  The University of Tokyo
Molecular mechanisms of neurite self-avoidancePrincipal Investigator
- Principal Investigator
  
  Kise Yoshiaki
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  The University of Tokyo
Mechanisms of axon collateral formation by cell-intrinsic Dscam1-Dscam1 interactionsPrincipal Investigator
- Principal Investigator
  
  Kise Yoshiaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  The University of Tokyo
Molecular and cellular basis for dendritic development and maintenance
- Principal Investigator
  
  Emoto Kazuo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Developmental biology
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2019 2018 2016

All Journal Article Presentation Book

[Book] クライオ電子顕微鏡ハンドブック　Kv4電位依存性カリウムチャネル複合体におけるゲート開閉制御機構2023
- Author(s)
  木瀬孔明　濡木理
- Total Pages
  427
- Publisher
  エヌ・ティー・エス出版
- ISBN
  4860438043
- Data Source
  KAKENHI-PROJECT-22K19263
[Book] クライオ電子顕微鏡ハンドブック“Kv4電位依存性カリウムチャネル複合体におけるゲート開閉制御機構”2023
- Author(s)
  木瀬孔明、濡木理
- Total Pages
  427
- Publisher
  エヌ・ティー・エス
- Data Source
  KAKENHI-PROJECT-22K19263
[Book] クライオ電子顕微鏡ハンドブック　Kv4電位依存性カリウムチャネル複合体におけるゲート開閉制御機構2023
- Author(s)
  木瀬孔明　濡木理
- Total Pages
  427
- Publisher
  エヌ・ティー・エス出版
- ISBN
  4860438043
- Data Source
  KAKENHI-PROJECT-23K23819
[Journal Article] Structural basis for lysophosphatidylserine recognition by GPR342024
- Author(s)
  Izume Tamaki、Kawahara Ryo、Uwamizu Akiharu、Chen Luying、Yaginuma Shun、Omi Jumpei、Kawana Hiroki、Hou Fengjue、Sano Fumiya K.、Tanaka Tatsuki、Kobayashi Kazuhiro、Okamoto Hiroyuki H.、Kise Yoshiaki、Ohwada Tomohiko、Aoki Junken、Shihoya Wataru、Nureki Osamu
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 902-902
- DOI
  10.1038/s41467-024-45046-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19263, KAKENHI-PROJECT-22K19371, KAKENHI-PROJECT-22K15273, KAKENHI-PROJECT-22KJ0530, KAKENHI-PROJECT-22KJ0577, KAKENHI-PROJECT-22KJ0604, KAKENHI-PROJECT-21H05037, KAKENHI-PROJECT-23K23819, KAKENHI-PLANNED-19H05777
[Journal Article] Structure of full-length ERGIC-53 in complex with MCFD2 for cargo transport2024
- Author(s)
  Watanabe Satoshi、Kise Yoshiaki、Yonezawa Kento、Inoue Mariko、Shimizu Nobutaka、Nureki Osamu、Inaba Kenji
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 2404-2404
- DOI
  10.1038/s41467-024-46747-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19263, KAKENHI-PROJECT-23K18193, KAKENHI-PROJECT-23K23819, KAKENHI-PLANNED-19H05781, KAKENHI-PLANNED-21H05253, KAKENHI-PROJECT-21H04758
[Journal Article] Mechanistic and evolutionary insights into a type V-M CRISPR?Cas effector enzyme2023
- Author(s)
  Omura Satoshi N.、Nakagawa Ryoya、S?dfeld Christian、Villegas Warren Ricardo、Wu Wen Y.、Hirano Hisato、Laffeber Charlie、Kusakizako Tsukasa、Kise Yoshiaki、Lebbink Joyce H. G.、Itoh Yuzuru、van der Oost John、Nureki Osamu
- Journal Title
  
  Nature Structural and Molecular Biology
  
  Volume: 30 Issue: 8 Pages: 1172-1182
- DOI
  10.1038/s41594-023-01042-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19263, KAKENHI-PROJECT-22K15072, KAKENHI-PROJECT-23K23819
[Journal Article] Dual allosteric modulation of voltage and calcium sensitivities of the Slo1-LRRC channel complex2023
- Author(s)
  Yamanouchi Daichi、Kasuya Go、Nakajo Koichi、Kise Yoshiaki、Nureki Osamu
- Journal Title
  
  Molecular Cell
  
  Volume: 83 Issue: 24 Pages: 4555-4569.e4
- DOI
  10.1016/j.molcel.2023.11.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19263, KAKENHI-PROJECT-21K06786, KAKENHI-PROJECT-23K23819
[Journal Article] An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis2023
- Author(s)
  Hino Tomohiro、Omura Satoshi N.、Nakagawa Ryoya、Togashi Tomoki、Takeda Satoru N.、Hiramoto Takafumi、Tasaka Satoshi、Hirano Hisato、Tokuyama Takeshi、Uosaki Hideki、Ishiguro Soh、Kagieva Madina、Yamano Hiroyuki、Ozaki Yuki、Motooka Daisuke、Mori Hideto、Kirita Yuhei、Kise Yoshiaki et al.
- Journal Title
  
  Cell
  
  Volume: 186 Issue: 22 Pages: 4920-4935
- DOI
  10.1016/j.cell.2023.08.031
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19263, KAKENHI-PROJECT-19KK0219, KAKENHI-PROJECT-22K15397, KAKENHI-PROJECT-22KJ0608, KAKENHI-PROJECT-23K23819, KAKENHI-PROJECT-23K24332
[Journal Article] Cryo-EM structure of the transposon-associated TnpB enzyme2023
- Author(s)
  Nakagawa Ryoya、Hirano Hisato、Omura Satoshi N.、Nety Suchita、Kannan Soumya、Altae-Tran Han、Yao Xiao、Sakaguchi Yuriko、Ohira Takayuki、Wu Wen Y.、Nakayama Hiroshi、Shuto Yutaro、Tanaka Tatsuki、Sano Fumiya K.、Kusakizako Tsukasa、Kise Yoshiaki et al.
- Journal Title
  
  Nature
  
  Volume: 616 Issue: 7956 Pages: 390-397
- DOI
  10.1038/s41586-023-05933-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19263, KAKENHI-PROJECT-22K15072, KAKENHI-PROJECT-22KJ0577, KAKENHI-PROJECT-22KJ0608, KAKENHI-PROJECT-18H05272, KAKENHI-PROJECT-23K23819
[Journal Article] Structural basis of gating modulation of Kv4 channel complexes.2021
- Author(s)
  Kise Y, Kasuya G, Okamoto HH, Yamanouchi D, Kobayashi K, Kusakizako T, Nishizawa T, Nakajo K, Nureki O.
- Journal Title
  
  Nature
  
  Volume: 599 Issue: 7883 Pages: 158-164
- DOI
  10.1038/s41586-021-03935-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06207, KAKENHI-PROJECT-16H06294, KAKENHI-PROJECT-20H03216, KAKENHI-PROJECT-21K06786, KAKENHI-PROJECT-20K15754, KAKENHI-PROJECT-22KJ0604, KAKENHI-PROJECT-21H05037, KAKENHI-PROJECT-20H03200
[Journal Article] Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed2021
- Author(s)
  Izadifar A, Courchet J, Virga DM, Verreet T, Hamilton S, Ayaz D, Misbaer A, Vandenbogaerde S, Monteiro L, Petrovic M, Sachse S, Yan B, Erfurth ML, Dascenco D, Kise Y, Yan J, Edwards-Faret G, Lewis T, Polleux F, Schmucker D.
- Journal Title
  
  Neuron
  
  Volume: 109 Issue: 18 Pages: 2864-2883
- DOI
  10.1016/j.neuron.2021.07.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06207
[Journal Article] Nuclear import of the DSCAM-cytoplasmic domain drives signaling capable of inhibiting synapse formation.2019
- Author(s)
  Sachse SM, Lievens S, Ribeiro LF, Dascenco D, Masschaele D, Horre K, Misbaer A, Vanderroost N, De Smet AS, Salta E, Erfurth ML, Kise Y, Nebel S, Van Delm W, Plaisance S, Tavernier J, De Strooper B, De Wit J, Schmucker D.
- Journal Title
  
  EMBO J
  
  Volume: 38 Issue: 6
- DOI
  10.15252/embj.201899669
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06207, KAKENHI-PROJECT-16K18536
[Presentation] クライオ電子顕微鏡を用いたイオンチャネル複合体の作動機構解明と創薬への試み2023
- Author(s)
  木瀬　孔明
- Organizer
  INGEM ＆ ToMMoセミナーシリーズ第28回
- Invited
- Data Source
  KAKENHI-PROJECT-22K19263
[Presentation] Structural study of SARS-CoV2 RdRp- aptamer complex2023
- Author(s)
  Shin Mukai, Chieko Harada, Kazuhiro Sawada, Yoshiaki Kise, Osamu Nureki
- Organizer
  Structure, Function, and Dynamics Conference, 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23819
[Presentation] Dual allosteric modulation of voltage and calcium sensitivities of the Slo1-LRRC channel complex2023
- Author(s)
  Yamanouchi D, Kasuya G, Nakajo K, Kise Y, Nureki O
- Organizer
  Structure, Function, and Dynamics Conference, 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23819
[Presentation] クライオ電子顕微鏡によるイオンチャネル複合体の作動機構の理解と創薬への試み2023
- Author(s)
  木瀬　孔明
- Organizer
  2023年度　日本薬理学会西南部会
- Invited
- Data Source
  KAKENHI-PROJECT-23K23819
[Presentation] クライオ電子顕微鏡によるイオンチャネル複合体の作動機構の理解と創薬への試み2023
- Author(s)
  木瀬　孔明
- Organizer
  2023年度　日本薬理学会西南部会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19263
[Presentation] Structural study of SARS-CoV2 RdRp- aptamer complex2023
- Author(s)
  Shin Mukai, Chieko Harada, Kazuhiro Sawada, Yoshiaki Kise, Osamu Nureki
- Organizer
  Structure, Function, and Dynamics Conference, 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19263
[Presentation] クライオ電子顕微鏡を用いたイオンチャネル複合体の作動機構解明と創薬への試み2023
- Author(s)
  木瀬　孔明
- Organizer
  INGEM ＆ ToMMoセミナーシリーズ第28回
- Invited
- Data Source
  KAKENHI-PROJECT-23K23819
[Presentation] Dual allosteric modulation of voltage and calcium sensitivities of the Slo1-LRRC channel complex2023
- Author(s)
  Yamanouchi D, Kasuya G, Nakajo K, Kise Y, Nureki O
- Organizer
  Structure, Function, and Dynamics Conference, 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19263
[Presentation] Structural basis for dual allosteric gating modulation of subunit complex2022
- Author(s)
  Yamanouchi D, Kasuya G, Nakajo K, Kise Y, Nureki O
- Organizer
  Ion Channels Gordon Research Conferences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19263
[Presentation] Structural basis for dual allosteric gating modulation of subunit complex2022
- Author(s)
  Yamanouchi D, Kasuya G, Nakajo K, Kise Y, Nureki O
- Organizer
  Ion Channels Gordon Research Conferences, 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23819
[Presentation] Structural basis of modulation of Kv4 channel complexes2022
- Author(s)
  Kise Y, Kasuya G, Okamoto H, Yamanouchi D, Kobayashi K, Kusakizako T, Nishizawa T, Nureki O
- Organizer
  Ion Channels Gordon Research Conferences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19263
[Presentation] 電位依存性カリウムチャネル複合体の制御機構2022
- Author(s)
  木瀬　孔明
- Organizer
  2022年度BINDSユニット連携講習会
- Invited
- Data Source
  KAKENHI-PROJECT-23K23819
[Presentation] Structural basis of modulation of Kv4 channel complexes2022
- Author(s)
  Kise Y, Kasuya G, Okamoto H, Yamanouchi D, Kobayashi K, Kusakizako T, Nishizawa T, Nureki O
- Organizer
  Ion Channels Gordon Research Conferences, 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23819
[Presentation] Structural basis of gating modulation of the Kv4 macromolecular channel complex2021
- Author(s)
  Yoshiaki Kise
- Organizer
  生理研研究会「構造情報を基盤とした膜機能分子の生理機能理解に向けて」
- Invited
- Data Source
  KAKENHI-PROJECT-18K06207
[Presentation] Molecular signaling pathways regulating axon branching via Dscam12019
- Author(s)
  Kise Y, Izadifar A, Schmucker D, Emoto K
- Organizer
  The 41st Annual Meeting of the Japan Neuroscience Society in 2018 at Kobe
- Data Source
  KAKENHI-PROJECT-18K06207
[Presentation] Wnk regulates Nmnat and Axundead during axon morphogenesis and maintenance2019
- Author(s)
  Izadifar A., Courchet J., Verreet T., Ayaz D., Petrovic M., Sachse S. Misbaer A., Vandenbogaerde S., Yan B., Erfurth ML, Dascenco D., Kise Y., Yan J., Lewis T., Polleux F., Schmucker D.
- Organizer
  3rd Axon Meeting "Circuits Development & Axon Regeneration" at Spain
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06207
[Presentation] Molecular signaling pathways regulating axon branching via Dscam12018
- Author(s)
  Kise Y, Izadifar A, Schmucker D, Emoto K
- Organizer
  The 41st Annual Meeting of the Japan Neuroscience Society in 2018 at Kobe
- Data Source
  KAKENHI-PROJECT-16K18536
[Presentation] Studying diversity and functions of clustered protocadherins in Xenopus tropicalis2016
- Author(s)
  Zengjin Huang, Yoshiaki Kise, Changsheng Chen, Sun Wei, Emre Etlioglu, Maximilian Ulbrich, Wei Chen, Dietmar Schmucker
- Organizer
  Cold Spring Harbor Laboratory Meeting on Axon guidance, Synapse formation & Regeneration
- Place of Presentation
  Cold Spring Harbor (the USA)
- Year and Date
  2016-09-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18536

1. Emoto Kazuo (80300953)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 冨樫和也 (40450613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 古泉博之 (10334335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Dietmar Schmucker

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Kise Yoshiaki 木瀬 孔明

Research Projects

Research Products

Co-Researchers

骨形成シグナルを選択的に活性化する革新的骨粗しょう症経口薬の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規リポソーム再構成法による膜電位、膜張力依存的イオンチャネルの作動機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

イオンチャネル巨大複合体のモジュレーション機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms of neurite self-avoidancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of axon collateral formation by cell-intrinsic Dscam1-Dscam1 interactionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular and cellular basis for dendritic development and maintenance

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] クライオ電子顕微鏡ハンドブック Kv4電位依存性カリウムチャネル複合体におけるゲート開閉制御機構2023

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] クライオ電子顕微鏡ハンドブック“Kv4電位依存性カリウムチャネル複合体におけるゲート開閉制御機構”2023

Author(s)

Total Pages

Publisher

Data Source

[Book] クライオ電子顕微鏡ハンドブック Kv4電位依存性カリウムチャネル複合体におけるゲート開閉制御機構2023

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Structural basis for lysophosphatidylserine recognition by GPR342024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure of full-length ERGIC-53 in complex with MCFD2 for cargo transport2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mechanistic and evolutionary insights into a type V-M CRISPR?Cas effector enzyme2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dual allosteric modulation of voltage and calcium sensitivities of the Slo1-LRRC channel complex2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis2023

Author(s)

Journal Title

Kise Yoshiaki 木瀬孔明

[Book] クライオ電子顕微鏡ハンドブック　Kv4電位依存性カリウムチャネル複合体におけるゲート開閉制御機構2023

[Book] クライオ電子顕微鏡ハンドブック　Kv4電位依存性カリウムチャネル複合体におけるゲート開閉制御機構2023