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TOYODA MAKO  豊田 真子

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豊田 真子  トヨダ マコ

Toyoda Mako  豊田 真子

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Researcher Number 70771129
Other IDs
Affiliation (Current) 2025: 熊本大学, ヒトレトロウイルス学共同研究センター, 特別研究員(RPD)
Affiliation (based on the past Project Information) *help 2023: 熊本大学, ヒトレトロウイルス学共同研究センター, 特別研究員(RPD)
2022: 熊本大学, ヒトレトロウイルス学共同研究センター, 特別研究員
2019 – 2020: 熊本大学, ヒトレトロウイルス学共同研究センター, 特任助教
2018: 熊本大学, エイズ学研究センター, 特任助教
2016 – 2017: 熊本大学, エイズ学研究センター, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 49060:Virology-related / Virology
Keywords
Principal Investigator
感染症 / Nef / SERINC3/5 / HIV-1 / ウイルス / 感染 / 新型コロナウイルス / 変異株 / 細胞間感染 / SARS-CoV-2 … More / HIV / 細胞膜 / ウイルス蛋白質 / 宿主制限因子 / 感染者コホート / SERINC5 / ウィルス / HLA Less
  • Research Projects

    (3 results)
  • Research Products

    (32 results)
  • Co-Researchers

    (1 People)
  •  新型コロナウイルス感染様式評価系の構築と関連分子の同定Principal Investigator

    • Principal Investigator
      豊田 真子
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      Kumamoto University
  •  Elucidation of HIV-1 pathogenesis dictated by the interplay between viral factor and host factor on the cell membranePrincipal Investigator

    • Principal Investigator
      Toyoda Mako
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      Kumamoto University
  •  Elucidation of HIV-1 pathogenesis dictated by the interplay between Nef and SERINC3/5Principal Investigator

    • Principal Investigator
      Toyoda Mako
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Virology
    • Research Institution
      Kumamoto University

All 2023 2022 2020 2019 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] Evaluation of Neutralizing Activity against Omicron Subvariants in BA.5 Breakthrough Infection and Three-Dose Vaccination Using a Novel Chemiluminescence-Based, Virus-Mediated Cytopathic Assay2023

    • Author(s)
      Toyoda Mako、Tan Toong Seng、Motozono Chihiro、Barabona Godfrey、Yonekawa Akiko、Shimono Nobuyuki、Minami Rumi、Nagasaki Yoji、Miyashita Yusuke、Oshiumi Hiroyuki、Nakamura Kimitoshi、Matsushita Shuzo、Kuwata Takeo、Ueno Takamasa
    • Journal Title

      Microbiology Spectrum

      Volume: 11 Issue: 4 Pages: 00660-23

    • DOI

      10.1128/spectrum.00660-23

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23KJ1775, KAKENHI-PROJECT-22KK0277, KAKENHI-PROJECT-22K07089, KAKENHI-PROJECT-21K05989, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-23K24139, KAKENHI-PROJECT-23K24378, KAKENHI-PROJECT-23K27640
  • [Journal Article] Impaired ability of Nef to counteract SERINC5 is associated with reduced plasma viremia in HIV-infected individuals2020

    • Author(s)
      Toyoda Mako、Kamori Doreen、Tan Toong Seng、Goebuchi Kageaki、Ohashi Jun、Carlson Jonathan、Kawana-Tachikawa Ai、Gatanaga Hiroyuki、Oka Shinichi、Pizzato Massimo、Ueno Takamasa
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1

    • DOI

      10.1038/s41598-020-76375-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03703, KAKENHI-PROJECT-18K15170
  • [Journal Article] An HIV-1 Nef genotype that diminishes immune control mediated by protective human leucocyte antigen alleles2020

    • Author(s)
      Mwimanzi Francis、Ngare Isaac、Toyoda Mako、Mori Masahiko、Mann Jaclyn、Ndung’u Thumbi、Goulder Phillip、Ueno Takamasa
    • Journal Title

      AIDS

      Volume: 34 Issue: 9 Pages: 1325-1330

    • DOI

      10.1097/qad.0000000000002559

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03703, KAKENHI-PROJECT-18K15170, KAKENHI-PROJECT-18KK0230
  • [Journal Article] Resistance of major histocompatibility complex class B (MHC-B) to Nef-mediated downregulation relative to that of MHC-A is conserved among primate lentiviruses and influences antiviral T cell responses in HIV-1-infected individuals.2018

    • Author(s)
      F Mwimanzi, M Toyoda, M Mahiti, J Mann, J Martin, D Bangsberg, M Brockman, P Goulder, F Kirchhoff, Z Brumme, T Ndung’u, T Ueno
    • Journal Title

      Journal of Virology

      Volume: 92 Issue: 1

    • DOI

      10.1128/jvi.01409-17

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05822, KAKENHI-PROJECT-16K15284, KAKENHI-PROJECT-16K19141, KAKENHI-PROJECT-18K16178
  • [Presentation] In vitro priming of HLA-A*24:02-restricted variants-specific CD8+ T cells in SARS-COV-2 infection2023

    • Author(s)
      Huanyu Li, Takeshi Nakama, Yoshihiko Goto, Yoshiki Aritsu, Mako Toyoda, Takamasa Ueno, Chihiro Motozono
    • Organizer
      24th Kumamoto AIDS Seminar, Kumamoto, Japan. November 6-7, 2023.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07089
  • [Presentation] 優れた抗ウイルス活性を有するSARS-CoV-2特異的なHLA-C拘束性CD8+T細胞応答2023

    • Author(s)
      後藤由比古、豊田真子、Toong Seng Tan、浜名洋、仲摩健、Huanyu Li、有津由樹、北松瑞生、岸裕幸、冨田雄介、坂上拓郎、上野貴将、本園千尋
    • Organizer
      第31回抗ウイルス療法学会学術集会・総会 9月14-16日、2023 横浜
    • Data Source
      KAKENHI-PROJECT-22K07089
  • [Presentation] Analysis of virological and immunological characteristics of SARS-CoV-2 spike variants with mutations at position L4522023

    • Author(s)
      Mako Toyoda, Toong Seng Tan, Hirotaka Ode, Chihiro Motozono, Yasumasa Iwatani, Takamasa Ueno.
    • Organizer
      24th Kumamoto AIDS Seminar, Kumamoto, Japan. November 6-7, 2023.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07089
  • [Presentation] Cross-reactivity of HLA-A*24:02-restricted T-cell receptors towards SARS-CoV-2 mutations2023

    • Author(s)
      Takeshi Nakama, Aaron Wall, Hiroshi Hamana, Huanyu Li, Yoshihiko Goto, Yoshiki Aritsu, Mako Toyoda, Toong Seng Tan, Mizuki Kitamatsu, Keiko Udaka, Pierre J Rizkallah, Hiroyuki Kishi, Andrew K. Sewell, Takamasa Ueno, Chihiro Motozono.
    • Organizer
      24th Kumamoto AIDS Seminar, Kumamoto, Japan. November 6-7, 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07089
  • [Presentation] Characterization of Antigen-specific T Cell Responses in Third-Dose SARS-CoV-2 Vaccinated Japanese with HIV-1 Infection.2023

    • Author(s)
      Ndubi Mark, Mako Toyoda, Chihiro Motozono, Rumi Minami, Takamasa Ueno
    • Organizer
      24th Kumamoto AIDS Seminar, Kumamoto, Japan. November 6-7, 2023.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07089
  • [Presentation] HLA-C-restricted CTLs specific for SARS-CoV-2 nucleocapsid display potent antiviral activity across viral variants and are maintained as a long-lived memory cells2023

    • Author(s)
      Yoshihiko Goto, Mako Toyoda, Toong Seng Tan, Hiroshi Hamana, Takeshi Nakama, Hanyu Li, Yoshiki Aritsu, Mizuki Kitamatsu, Hiroyuki Kishi, Yusuke Tomita Takuro Sakagami, Takamasa Ueno, Chihiro Motozono
    • Organizer
      24th Kumamoto AIDS Seminar, Kumamoto, Japan. November 6-7, 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07089
  • [Presentation] 新型コロナウイルススパイク蛋白質L452部位での変異獲得におけるウイルス学的、免疫学的特徴の解析2023

    • Author(s)
      豊田真子、Tan Toong Seng、大出裕高、本園千尋、岩谷靖雅、上野貴将.
    • Organizer
      第31回抗ウイルス療法学会学術集会・総会 9月14-16日、2023 横浜
    • Data Source
      KAKENHI-PROJECT-22K07089
  • [Presentation] 新型コロナウイルスに対する中和抗体およびCTLの抗ウイルス機能評価2022

    • Author(s)
      豊田真子、Tan Toong Seng、本園千尋、岡田誠治、中田浩智、松岡雅雄、上野貴将.
    • Organizer
      第30回抗ウイルス療法学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-22K07089
  • [Presentation] Novel authentic virus-based evaluation systems for humoral and cellular immune responses against SARS-CoV-2 variants.2022

    • Author(s)
      Mako Toyoda, Toong Seng Tan, Chihiro Motozono, Takamasa Ueno.
    • Organizer
      23th Kumamoto AIDS Seminar, Kumamoto, Japan
    • Data Source
      KAKENHI-PROJECT-22K07089
  • [Presentation] Severe baseline immunosuppression is associated with higher levels of plasma inflammatory markers despite long term ART treatment in HIV infected Tanzanians2020

    • Author(s)
      Godfrey Barabona, Macdonald Mahiti, Mako Toyoda, Doreen Kamori, Salim Masoud, George Peter Judicate Ndossi, Bruno Sunguya, Eligius Lyamuya, Takamasa Ueno
    • Organizer
      The 2nd Joint MUHAS-KU Webinar
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15170
  • [Presentation] Naturally occurring non-subtype B envelope sequences show diverse range of sensitivity to SERINC5-mediated inhibition of HIV-1 infectivity2020

    • Author(s)
      Emmanuel James Nkuwi, George Peter Judicate Ndossi, Toong seng Tan, Godfrey Barabona, Mako Toyoda, Takamasa Ueno
    • Organizer
      The 2nd Joint MUHAS-KU Webinar
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15170
  • [Presentation] Severe baseline immunosuppression is associated with higher levels of plasma inflammatory markers despite long term ART treatment in HIV infected Tanzanians2020

    • Author(s)
      Godfrey Barabona, Macdonald Mahiti, Mako Toyoda, Doreen Kamori, Salim Masoud, George Peter Judicate Ndossi, Bruno Sunguya, Eligius Lyamuya, Takamasa Ueno
    • Organizer
      21st Kumamoto AIDS Seminar (ONLINE Seminar)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15170
  • [Presentation] Naturally occurring non-subtype B envelope sequences show diverse range of sensitivity to SERINC5-mediated inhibition of HIV-1 infectivity2020

    • Author(s)
      Emmanuel James Nkuwi, George Peter Judicate Ndossi, Toong seng Tan, Godfrey Barabona, Mako Toyoda, Takamasa Ueno
    • Organizer
      21st Kumamoto AIDS Seminar (ONLINE Seminar)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15170
  • [Presentation] A single amino acid change in SERINC5 abrogates the infectivity restriction function against retroviruses including HIV-12020

    • Author(s)
      Toong seng Tan, Mako Toyoda, Massimo Pizzato, Kenzo Tokunaga, Takamasa Ueno
    • Organizer
      21st Kumamoto AIDS Seminar (ONLINE Seminar)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15170
  • [Presentation] Naturally arising HIV-1 Nef mutations that affect counteraction of SERINC3/5 and virion infectivity.2019

    • Author(s)
      Mako Toyoda, Doreen Kamori, Massimo Pizzato, Takamasa Ueno
    • Organizer
      The 33rd Annual Meeting of the Japanese Society for AIDS Research, Kumamoto, Japan.
    • Data Source
      KAKENHI-PROJECT-18K15170
  • [Presentation] A single amino acid change in an extracellular loop of SERINC5 attenuates the ability to restrict HIV-1.2019

    • Author(s)
      Toong Seng Tan, Mako Toyoda, Takamasa Ueno.
    • Organizer
      The 33rd Annual Meeting of the Japanese Society for AIDS Research, Kumamoto, Japan.
    • Data Source
      KAKENHI-PROJECT-18K15170
  • [Presentation] Impaired Nef’s ability to counteract SERINC5 by immune-driven mutations.2019

    • Author(s)
      Mako Toyoda, Doreen Kamori, Jonathan Carlson, Ai Kawana-Tachikawa, Hiroyuki Gatanaga, Shinichi Oka, Takamasa Ueno.
    • Organizer
      The annual Conference on Retroviruses and Opportunistic Infections (CROI), Seattle, USA, March 4-7, 2019.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15170
  • [Presentation] Contribution of extracellular loop structures of SERINC5 in HIV-1 infectivity restriction.2018

    • Author(s)
      Toong Seng Tan, Mako Toyoda, Takamasa Ueno.
    • Organizer
      21st Summer Retrovirus Conference (SRC), Kobe, Japan. July 12-13, 2018.
    • Data Source
      KAKENHI-PROJECT-18K15170
  • [Presentation] Contribution of extracellular loop structures of SERINC5 in HIV-1 infectivity restriction.2018

    • Author(s)
      Toong Seng Tan, Mako Toyoda, Takamasa Ueno.
    • Organizer
      19th Kumamoto AIDS Seminar, Kumamoto, Japan. Nov 6-7, 2018.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15170
  • [Presentation] Naturally arising HIV-1 Nef mutations that affect counteraction of SERINC3/5 and virion infectivity.2018

    • Author(s)
      Mako Toyoda, Doreen Kamori, Massimo Pizzato, Takamasa Ueno.
    • Organizer
      19th Kumamoto AIDS Seminar, Kumamoto, Japan. Nov 6-7, 2018.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15170
  • [Presentation] Differential ability to antagonize SERINC3/5 counteraction by naturally arising HIV-1 Nef variants associating with decreased plasma viremia.2017

    • Author(s)
      豊田真子、 Kamori Doreen、Jonathan Carlson、潟永博之、立川(川名)愛、岡慎一、Massimo Pizzato、上野貴将.
    • Organizer
      第65回日本ウイルス学会学術集会.
    • Data Source
      KAKENHI-PROJECT-16K19141
  • [Presentation] Impaired Nef’s ability to counteract SERINC5 is associated with decreased plasma viremia.2017

    • Author(s)
      Toyoda Mako, Kamori Doreen, Carlson Jonathan, Gatanaga Hiroyuki, Kawana-Tachikawa Ai, Oka Shinichi, Pizzato Massimo, Ueno Takamasa.
    • Organizer
      9th IAS Conference on HIV Science
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19141
  • [Presentation] Impaired Nef’s ability to counteract SERINC5 is associated with decreased plasma viremia.2017

    • Author(s)
      Toyoda Mako, Kamori Doreen, Carlson Jonathan, Gatanaga Hiroyuki, Kawana-Tachikawa Ai, Oka Shinichi, Pizzato Massimo, Ueno Takamasa.
    • Organizer
      Keystone Symposia Conference.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19141
  • [Presentation] Naturally arising HIV-1 Nef variants that impair Nef’s ability to counteract SERINC3/5 are associated with decreased plasma viremia.2017

    • Author(s)
      Toyoda Mako, Kamori Doreen, Carlson Jonathan, Gatanaga Hiroyuki, Kawana-Tachikawa Ai, Oka Shinichi, Pizzato Massimo, Ueno Takamasa.
    • Organizer
      18th Kumamoto AIDS Seminar.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19141
  • [Presentation] アクセサリー蛋白質に対する免疫淘汰圧がウイルス複製に与える影響2016

    • Author(s)
      豊田真子、 Kamori Doreen、立川(川名)愛、潟永博之、岡慎一、上野貴将
    • Organizer
      第30回日本エイズ学会学術集会・総会
    • Place of Presentation
      鹿児島県民交流センター
    • Year and Date
      2016-11-23
    • Data Source
      KAKENHI-PROJECT-16K19141
  • [Presentation] Naturally occurring HLA-associated Nef polymorphisms that are associated with decreased plasma viral load and impaired Nef-mediated enhancement of virion infectivity.2016

    • Author(s)
      Toyoda Mako, Kamori Doreen, Ueno Takamasa
    • Organizer
      Cold Spring Harbor Laboratory Meeting: Retroviruses.
    • Place of Presentation
      NY, USA. Cold Spring Harbor Laboratory
    • Year and Date
      2016-05-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19141
  • [Presentation] Naturally occurring HIV-1 Nef variants that impair Nef’s ability to counteract SERINC5 and enhance virion infectivity.2016

    • Author(s)
      Toyoda Mako, Kamori Doreen, Pizzato Massimo, Ueno Takamasa
    • Organizer
      2nd Kumamoto IRCMS International Symposium and 17th Kumamoto AIDS Seminar.
    • Place of Presentation
      Kumamoto Kenmin Koryu Kaikan-Parea
    • Year and Date
      2016-10-31
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19141
  • [Presentation] Viral fitness cost imposed by naturally occurring HLA-associated polymorphisms across HIV-1 accessory proteins.2016

    • Author(s)
      豊田真子、 Kamori Doreen、上野貴将
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-16K19141
  • 1.  上野 貴将
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results

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