TOYODA MAKO 豊田真子

… Alternative Names

豊田真子トヨダマコ

Toyoda Mako 豊田真子

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Researcher Number	70771129
Other IDs
Affiliation (Current)	2025: 熊本大学, ヒトレトロウイルス学共同研究センター, 特別研究員(RPD)
Affiliation (based on the past Project Information) *help	2023: 熊本大学, ヒトレトロウイルス学共同研究センター, 特別研究員(RPD) 2022: 熊本大学, ヒトレトロウイルス学共同研究センター, 特別研究員 2019 – 2020: 熊本大学, ヒトレトロウイルス学共同研究センター, 特任助教 2018: 熊本大学, エイズ学研究センター, 特任助教 2016 – 2017: 熊本大学, エイズ学研究センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 49060:Virology-related / Virology
Keywords	Principal Investigator 感染症 / Nef / SERINC3/5 / HIV-1 / ウイルス / 感染 / 新型コロナウイルス / 変異株 / 細胞間感染 / SARS-CoV-2 … More / HIV / 細胞膜 / ウイルス蛋白質 / 宿主制限因子 / 感染者コホート / SERINC5 / ウィルス / HLA Less

新型コロナウイルス感染様式評価系の構築と関連分子の同定Principal Investigator
- Principal Investigator
  
  豊田真子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Kumamoto University
Elucidation of HIV-1 pathogenesis dictated by the interplay between viral factor and host factor on the cell membranePrincipal Investigator
- Principal Investigator
  
  Toyoda Mako
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Kumamoto University
Elucidation of HIV-1 pathogenesis dictated by the interplay between Nef and SERINC3/5Principal Investigator
- Principal Investigator
  
  Toyoda Mako
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Kumamoto University

All 2023 2022 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Evaluation of Neutralizing Activity against Omicron Subvariants in BA.5 Breakthrough Infection and Three-Dose Vaccination Using a Novel Chemiluminescence-Based, Virus-Mediated Cytopathic Assay2023
- Author(s)
  Toyoda Mako、Tan Toong Seng、Motozono Chihiro、Barabona Godfrey、Yonekawa Akiko、Shimono Nobuyuki、Minami Rumi、Nagasaki Yoji、Miyashita Yusuke、Oshiumi Hiroyuki、Nakamura Kimitoshi、Matsushita Shuzo、Kuwata Takeo、Ueno Takamasa
- Journal Title
  
  Microbiology Spectrum
  
  Volume: 11 Issue: 4 Pages: 00660-23
- DOI
  10.1128/spectrum.00660-23
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KJ1775, KAKENHI-PROJECT-22KK0277, KAKENHI-PROJECT-22K07089, KAKENHI-PROJECT-21K05989, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-23K24139, KAKENHI-PROJECT-23K24378, KAKENHI-PROJECT-23K27640
[Journal Article] Impaired ability of Nef to counteract SERINC5 is associated with reduced plasma viremia in HIV-infected individuals2020
- Author(s)
  Toyoda Mako、Kamori Doreen、Tan Toong Seng、Goebuchi Kageaki、Ohashi Jun、Carlson Jonathan、Kawana-Tachikawa Ai、Gatanaga Hiroyuki、Oka Shinichi、Pizzato Massimo、Ueno Takamasa
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1
- DOI
  10.1038/s41598-020-76375-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03703, KAKENHI-PROJECT-18K15170
[Journal Article] An HIV-1 Nef genotype that diminishes immune control mediated by protective human leucocyte antigen alleles2020
- Author(s)
  Mwimanzi Francis、Ngare Isaac、Toyoda Mako、Mori Masahiko、Mann Jaclyn、Ndung’u Thumbi、Goulder Phillip、Ueno Takamasa
- Journal Title
  
  AIDS
  
  Volume: 34 Issue: 9 Pages: 1325-1330
- DOI
  10.1097/qad.0000000000002559
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03703, KAKENHI-PROJECT-18K15170, KAKENHI-PROJECT-18KK0230
[Journal Article] Resistance of major histocompatibility complex class B (MHC-B) to Nef-mediated downregulation relative to that of MHC-A is conserved among primate lentiviruses and influences antiviral T cell responses in HIV-1-infected individuals.2018
- Author(s)
  F Mwimanzi, M Toyoda, M Mahiti, J Mann, J Martin, D Bangsberg, M Brockman, P Goulder, F Kirchhoff, Z Brumme, T Ndung’u, T Ueno
- Journal Title
  
  Journal of Virology
  
  Volume: 92 Issue: 1
- DOI
  10.1128/jvi.01409-17
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05822, KAKENHI-PROJECT-16K15284, KAKENHI-PROJECT-16K19141, KAKENHI-PROJECT-18K16178
[Presentation] In vitro priming of HLA-A*24:02-restricted variants-specific CD8+ T cells in SARS-COV-2 infection2023
- Author(s)
  Huanyu Li, Takeshi Nakama, Yoshihiko Goto, Yoshiki Aritsu, Mako Toyoda, Takamasa Ueno, Chihiro Motozono
- Organizer
  24th Kumamoto AIDS Seminar, Kumamoto, Japan. November 6-7, 2023.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07089
[Presentation] 優れた抗ウイルス活性を有するSARS-CoV-2特異的なHLA-C拘束性CD8＋T細胞応答2023
- Author(s)
  後藤由比古、豊田真子、Toong Seng Tan、浜名洋、仲摩健、Huanyu Li、有津由樹、北松瑞生、岸裕幸、冨田雄介、坂上拓郎、上野貴将、本園千尋
- Organizer
  第31回抗ウイルス療法学会学術集会・総会　9月14-16日、2023 横浜
- Data Source
  KAKENHI-PROJECT-22K07089
[Presentation] Analysis of virological and immunological characteristics of SARS-CoV-2 spike variants with mutations at position L4522023
- Author(s)
  Mako Toyoda, Toong Seng Tan, Hirotaka Ode, Chihiro Motozono, Yasumasa Iwatani, Takamasa Ueno.
- Organizer
  24th Kumamoto AIDS Seminar, Kumamoto, Japan. November 6-7, 2023.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07089
[Presentation] Cross-reactivity of HLA-A*24:02-restricted T-cell receptors towards SARS-CoV-2 mutations2023
- Author(s)
  Takeshi Nakama, Aaron Wall, Hiroshi Hamana, Huanyu Li, Yoshihiko Goto, Yoshiki Aritsu, Mako Toyoda, Toong Seng Tan, Mizuki Kitamatsu, Keiko Udaka, Pierre J Rizkallah, Hiroyuki Kishi, Andrew K. Sewell, Takamasa Ueno, Chihiro Motozono.
- Organizer
  24th Kumamoto AIDS Seminar, Kumamoto, Japan. November 6-7, 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07089
[Presentation] Characterization of Antigen-specific T Cell Responses in Third-Dose SARS-CoV-2 Vaccinated　Japanese with HIV-1 Infection.2023
- Author(s)
  Ndubi Mark, Mako Toyoda, Chihiro Motozono, Rumi Minami, Takamasa Ueno
- Organizer
  24th Kumamoto AIDS Seminar, Kumamoto, Japan. November 6-7, 2023.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07089
[Presentation] HLA-C-restricted CTLs specific for SARS-CoV-2 nucleocapsid display potent antiviral activity across viral variants and are maintained as a long-lived memory cells2023
- Author(s)
  Yoshihiko Goto, Mako Toyoda, Toong Seng Tan, Hiroshi Hamana, Takeshi Nakama, Hanyu Li, Yoshiki Aritsu, Mizuki Kitamatsu, Hiroyuki Kishi, Yusuke Tomita Takuro Sakagami, Takamasa Ueno, Chihiro Motozono
- Organizer
  24th Kumamoto AIDS Seminar, Kumamoto, Japan. November 6-7, 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07089
[Presentation] 新型コロナウイルススパイク蛋白質L452部位での変異獲得におけるウイルス学的、免疫学的特徴の解析2023
- Author(s)
  豊田真子、Tan Toong Seng、大出裕高、本園千尋、岩谷靖雅、上野貴将.
- Organizer
  第31回抗ウイルス療法学会学術集会・総会　9月14-16日、2023 横浜
- Data Source
  KAKENHI-PROJECT-22K07089
[Presentation] 新型コロナウイルスに対する中和抗体およびCTLの抗ウイルス機能評価2022
- Author(s)
  豊田真子、Tan Toong Seng、本園千尋、岡田誠治、中田浩智、松岡雅雄、上野貴将.
- Organizer
  第30回抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-22K07089
[Presentation] Novel authentic virus-based evaluation systems for humoral and cellular immune responses against SARS-CoV-2 variants.2022
- Author(s)
  Mako Toyoda, Toong Seng Tan, Chihiro Motozono, Takamasa Ueno.
- Organizer
  23th Kumamoto AIDS Seminar, Kumamoto, Japan
- Data Source
  KAKENHI-PROJECT-22K07089
[Presentation] Severe baseline immunosuppression is associated with higher levels of plasma inflammatory markers despite long term ART treatment in HIV infected Tanzanians2020
- Author(s)
  Godfrey Barabona, Macdonald Mahiti, Mako Toyoda, Doreen Kamori, Salim Masoud, George Peter Judicate Ndossi, Bruno Sunguya, Eligius Lyamuya, Takamasa Ueno
- Organizer
  The 2nd Joint MUHAS-KU Webinar
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15170
[Presentation] Naturally occurring non-subtype B envelope sequences show diverse range of sensitivity to SERINC5-mediated inhibition of HIV-1 infectivity2020
- Author(s)
  Emmanuel James Nkuwi, George Peter Judicate Ndossi, Toong seng Tan, Godfrey Barabona, Mako Toyoda, Takamasa Ueno
- Organizer
  The 2nd Joint MUHAS-KU Webinar
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15170
[Presentation] Severe baseline immunosuppression is associated with higher levels of plasma inflammatory markers despite long term ART treatment in HIV infected Tanzanians2020
- Author(s)
  Godfrey Barabona, Macdonald Mahiti, Mako Toyoda, Doreen Kamori, Salim Masoud, George Peter Judicate Ndossi, Bruno Sunguya, Eligius Lyamuya, Takamasa Ueno
- Organizer
  21st Kumamoto AIDS Seminar (ONLINE Seminar)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15170
[Presentation] Naturally occurring non-subtype B envelope sequences show diverse range of sensitivity to SERINC5-mediated inhibition of HIV-1 infectivity2020
- Author(s)
  Emmanuel James Nkuwi, George Peter Judicate Ndossi, Toong seng Tan, Godfrey Barabona, Mako Toyoda, Takamasa Ueno
- Organizer
  21st Kumamoto AIDS Seminar (ONLINE Seminar)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15170
[Presentation] A single amino acid change in SERINC5 abrogates the infectivity restriction function against retroviruses including HIV-12020
- Author(s)
  Toong seng Tan, Mako Toyoda, Massimo Pizzato, Kenzo Tokunaga, Takamasa Ueno
- Organizer
  21st Kumamoto AIDS Seminar (ONLINE Seminar)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15170
[Presentation] Naturally arising HIV-1 Nef mutations that affect counteraction of SERINC3/5 and virion infectivity.2019
- Author(s)
  Mako Toyoda, Doreen Kamori, Massimo Pizzato, Takamasa Ueno
- Organizer
  The 33rd Annual Meeting of the Japanese Society for AIDS Research, Kumamoto, Japan.
- Data Source
  KAKENHI-PROJECT-18K15170
[Presentation] A single amino acid change in an extracellular loop of SERINC5 attenuates the ability to restrict HIV-1.2019
- Author(s)
  Toong Seng Tan, Mako Toyoda, Takamasa Ueno.
- Organizer
  The 33rd Annual Meeting of the Japanese Society for AIDS Research, Kumamoto, Japan.
- Data Source
  KAKENHI-PROJECT-18K15170
[Presentation] Impaired Nef’s ability to counteract SERINC5 by immune-driven mutations.2019
- Author(s)
  Mako Toyoda, Doreen Kamori, Jonathan Carlson, Ai Kawana-Tachikawa, Hiroyuki Gatanaga, Shinichi Oka, Takamasa Ueno.
- Organizer
  The annual Conference on Retroviruses and Opportunistic Infections (CROI), Seattle, USA, March 4-7, 2019.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15170
[Presentation] Contribution of extracellular loop structures of SERINC5 in HIV-1 infectivity restriction.2018
- Author(s)
  Toong Seng Tan, Mako Toyoda, Takamasa Ueno.
- Organizer
  21st Summer Retrovirus Conference (SRC), Kobe, Japan. July 12-13, 2018.
- Data Source
  KAKENHI-PROJECT-18K15170
[Presentation] Contribution of extracellular loop structures of SERINC5 in HIV-1 infectivity restriction.2018
- Author(s)
  Toong Seng Tan, Mako Toyoda, Takamasa Ueno.
- Organizer
  19th Kumamoto AIDS Seminar, Kumamoto, Japan. Nov 6-7, 2018.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15170
[Presentation] Naturally arising HIV-1 Nef mutations that affect counteraction of SERINC3/5 and virion infectivity.2018
- Author(s)
  Mako Toyoda, Doreen Kamori, Massimo Pizzato, Takamasa Ueno.
- Organizer
  19th Kumamoto AIDS Seminar, Kumamoto, Japan. Nov 6-7, 2018.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15170
[Presentation] Differential ability to antagonize SERINC3/5 counteraction by naturally arising HIV-1 Nef variants associating with decreased plasma viremia.2017
- Author(s)
  豊田真子、 Kamori Doreen、Jonathan Carlson、潟永博之、立川（川名）愛、岡慎一、Massimo Pizzato、上野貴将.
- Organizer
  第65回日本ウイルス学会学術集会.
- Data Source
  KAKENHI-PROJECT-16K19141
[Presentation] Impaired Nef’s ability to counteract SERINC5 is associated with decreased plasma viremia.2017
- Author(s)
  Toyoda Mako, Kamori Doreen, Carlson Jonathan, Gatanaga Hiroyuki, Kawana-Tachikawa Ai, Oka Shinichi, Pizzato Massimo, Ueno Takamasa.
- Organizer
  9th IAS Conference on HIV Science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19141
[Presentation] Impaired Nef’s ability to counteract SERINC5 is associated with decreased plasma viremia.2017
- Author(s)
  Toyoda Mako, Kamori Doreen, Carlson Jonathan, Gatanaga Hiroyuki, Kawana-Tachikawa Ai, Oka Shinichi, Pizzato Massimo, Ueno Takamasa.
- Organizer
  Keystone Symposia Conference.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19141
[Presentation] Naturally arising HIV-1 Nef variants that impair Nef’s ability to counteract SERINC3/5 are associated with decreased plasma viremia.2017
- Author(s)
  Toyoda Mako, Kamori Doreen, Carlson Jonathan, Gatanaga Hiroyuki, Kawana-Tachikawa Ai, Oka Shinichi, Pizzato Massimo, Ueno Takamasa.
- Organizer
  18th Kumamoto AIDS Seminar.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19141
[Presentation] アクセサリー蛋白質に対する免疫淘汰圧がウイルス複製に与える影響2016
- Author(s)
  豊田真子、 Kamori Doreen、立川（川名）愛、潟永博之、岡慎一、上野貴将
- Organizer
  第30回日本エイズ学会学術集会・総会
- Place of Presentation
  鹿児島県民交流センター
- Year and Date
  2016-11-23
- Data Source
  KAKENHI-PROJECT-16K19141
[Presentation] Naturally occurring HLA-associated Nef polymorphisms that are associated with decreased plasma viral load and impaired Nef-mediated enhancement of virion infectivity.2016
- Author(s)
  Toyoda Mako, Kamori Doreen, Ueno Takamasa
- Organizer
  Cold Spring Harbor Laboratory Meeting: Retroviruses.
- Place of Presentation
  NY, USA. Cold Spring Harbor Laboratory
- Year and Date
  2016-05-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19141
[Presentation] Naturally occurring HIV-1 Nef variants that impair Nef’s ability to counteract SERINC5 and enhance virion infectivity.2016
- Author(s)
  Toyoda Mako, Kamori Doreen, Pizzato Massimo, Ueno Takamasa
- Organizer
  2nd Kumamoto IRCMS International Symposium and 17th Kumamoto AIDS Seminar.
- Place of Presentation
  Kumamoto Kenmin Koryu Kaikan-Parea
- Year and Date
  2016-10-31
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19141
[Presentation] Viral fitness cost imposed by naturally occurring HLA-associated polymorphisms across HIV-1 accessory proteins.2016
- Author(s)
  豊田真子、 Kamori Doreen、上野貴将
- Organizer
  第64回日本ウイルス学会学術集会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-16K19141

1. 上野貴将

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

TOYODA MAKO 豊田 真子

豊田 真子 トヨダ マコ

Toyoda Mako 豊田 真子

Research Projects

Research Products

Co-Researchers

新型コロナウイルス感染様式評価系の構築と関連分子の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of HIV-1 pathogenesis dictated by the interplay between viral factor and host factor on the cell membranePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of HIV-1 pathogenesis dictated by the interplay between Nef and SERINC3/5Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Evaluation of Neutralizing Activity against Omicron Subvariants in BA.5 Breakthrough Infection and Three-Dose Vaccination Using a Novel Chemiluminescence-Based, Virus-Mediated Cytopathic Assay2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impaired ability of Nef to counteract SERINC5 is associated with reduced plasma viremia in HIV-infected individuals2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An HIV-1 Nef genotype that diminishes immune control mediated by protective human leucocyte antigen alleles2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Resistance of major histocompatibility complex class B (MHC-B) to Nef-mediated downregulation relative to that of MHC-A is conserved among primate lentiviruses and influences antiviral T cell responses in HIV-1-infected individuals.2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] In vitro priming of HLA-A*24:02-restricted variants-specific CD8+ T cells in SARS-COV-2 infection2023

Author(s)

Organizer

Data Source

[Presentation] 優れた抗ウイルス活性を有するSARS-CoV-2特異的なHLA-C拘束性CD8＋T細胞応答2023

Author(s)

Organizer

Data Source

[Presentation] Analysis of virological and immunological characteristics of SARS-CoV-2 spike variants with mutations at position L4522023

Author(s)

Organizer

Data Source

[Presentation] Cross-reactivity of HLA-A*24:02-restricted T-cell receptors towards SARS-CoV-2 mutations2023

Author(s)

Organizer

Data Source

[Presentation] Characterization of Antigen-specific T Cell Responses in Third-Dose SARS-CoV-2 Vaccinated Japanese with HIV-1 Infection.2023

Author(s)

Organizer

Data Source

[Presentation] HLA-C-restricted CTLs specific for SARS-CoV-2 nucleocapsid display potent antiviral activity across viral variants and are maintained as a long-lived memory cells2023

Author(s)

Organizer

Data Source

[Presentation] 新型コロナウイルススパイク蛋白質L452部位での変異獲得におけるウイルス学的、免疫学的特徴の解析2023

Author(s)

Organizer

Data Source

[Presentation] 新型コロナウイルスに対する中和抗体およびCTLの抗ウイルス機能評価2022

Author(s)

Organizer

Data Source

[Presentation] Novel authentic virus-based evaluation systems for humoral and cellular immune responses against SARS-CoV-2 variants.2022

Author(s)

Organizer

Data Source

TOYODA MAKO 豊田真子

豊田真子トヨダマコ

Toyoda Mako 豊田真子

[Presentation] Characterization of Antigen-specific T Cell Responses in Third-Dose SARS-CoV-2 Vaccinated　Japanese with HIV-1 Infection.2023