Hirayama Satoru 平山悟

Researcher Number	70778555
Other IDs
Affiliation (Current)	2025: 新潟大学, 医歯学系, 助教
Affiliation (based on the past Project Information) *help	2020 – 2025: 新潟大学, 医歯学系, 助教 2018 – 2019: 国立感染症研究所, 細菌第一部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 57020:Oral pathobiological science-related / Basic Section 49050:Bacteriology-related Except Principal Investigator Medium-sized Section 57:Oral science and related fields / Medium-sized Section 58:Society medicine, nursing, and related fields / Basic Section 57020:Oral pathobiological science-related / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Basic Section 57030:Conservative dentistry-related
Keywords	Principal Investigator 細菌性肺炎 / 肺炎球菌 / グリシン / メンブレンベシクル / プロテオミクス / 誤嚥性肺炎 / ワクチン / 自己溶菌 / プラスミン / プラスミノーゲン … More / Streptococcus pneumoniae / 肺炎球菌性肺炎 / 歯周病 / 血液脳関門 / アルツハイマー病 / Porphyromonas gingivalis / 歯周病原細菌 / vesicle uptake / membrane vesicle / 形質転換 / 細胞間コミュニケーション … More Except Principal Investigator 肺炎球菌 / 肺炎 / 細菌由来膜小胞 / 外膜小胞 / 慢性炎症 / ワクチン / 天然化合物 / 唾液 / 加齢 / 誤嚥性肺炎 / 好中球 / 老化 / S. pneumoniae / 膵臓がん / 細菌由来外膜小胞 / 歯周病原細菌 / 細菌膜小胞 / 膜小胞 / Porphyromonas gingivalis / Outer membrane vesicles / ナノ粒子ワクチン / ワクチンの安全性評価 / 細菌 / メンブレンヴェシクル / Pg / Porphyromonus gingivalis / 歯周病 Less

感染部位依存的な肺炎球菌の病原性発現およびその制御因子の解析Principal Investigator
- Principal Investigator
  
  平山悟
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Niigata University
肺炎球菌性肺炎の統合的な検査/予防/治療に向けた開発研究
- Principal Investigator
  
  寺尾豊
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Niigata University
好中球老化マーカーの同定と抗加齢研究への挑戦
- Principal Investigator
  
  土門久哲
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Niigata University
iTRAQ-MS/MS解析を基盤とする新規肺炎球菌ワクチンの開発研究Principal Investigator
- Principal Investigator
  
  平山悟
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Niigata University
The development of high-snsitivity detection system of bacteria-derived membrane vesicle and detection of membrane vesicle in the chronic inflamatory vascular deseases
- Principal Investigator
  
  Miyazaki Hidetaka
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Aichi Medical University
  Oita University
Are membrane vesicles of periodontopathogenic bacteria a pathogenic factor in Alzheimer's disease?Principal Investigator
- Principal Investigator
  
  HIRAYAMA SATORU
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Niigata University
Periodontopathic bacterial outer membrane vesicles: Biogenesis and relation to development of chronic inflammation and carcinogenesis
- Principal Investigator
  
  Nakao Ryoma
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  National Institute of Infectious Diseases
Novel nano paticle vaccine | Biogenesis and medical application of outer membrane vesicles
- Principal Investigator
  
  Nakao Ryoma
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  National Institute of Infectious Diseases
Investigation of the mechanism of bacterial membrane vesicle uptakePrincipal Investigator
- Principal Investigator
  
  Hirayama Satoru
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  National Institute of Infectious Diseases

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Book

[Book] Methods in Molecular Biology: Glycine Induction Method: Effective Production of Immunoactive Bacterial Membrane Vesicles with Low Endotoxin Content2022
- Author(s)
  Hirayama S, Nakao R.
- Publisher
  Springer Nature
- Data Source
  KAKENHI-PROJECT-20H03861
[Book] Methods in Molecular Biology: Glycine Induction Method: Effective Production of Immunoactive Bacterial Membrane Vesicles with Low Endotoxin Content2022
- Author(s)
  Hirayama S, Nakao R.
- Total Pages
  10
- Publisher
  Springer Nature
- Data Source
  KAKENHI-PROJECT-19K22644
[Book] Methods in Molecular Biology: Intranasal vaccine study using Porphyromonas gingivalis membrane vesicles: isolation method and application to a mouse model2021
- Author(s)
  Hirayama S, Nakao R.
- Publisher
  Springer Nature
- Data Source
  KAKENHI-PROJECT-20H03861
[Book] Methods in Molecular Biology: Intranasal vaccine study using Porphyromonas gingivalis membrane vesicles: isolation method and application to a mouse model2021
- Author(s)
  Hirayama S, Nakao R.
- Total Pages
  10
- Publisher
  Springer Nature
- Data Source
  KAKENHI-PROJECT-19K22644
[Journal Article] Lipoprotein signal peptidase‐deficient Streptococcus pneumoniae exhibits impaired Toll‐like receptor 2‐stimulatory activity2024
- Author(s)
  Domon Hisanori、Hirayama Satoru、Isono Toshihito、Saito Rui、Yanagihara Katsunori、Terao Yutaka
- Journal Title
  
  Microbiology and Immunology
  
  Volume: － Issue: 4 Pages: 155-159
- DOI
  10.1111/1348-0421.13117
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18355, KAKENHI-PROJECT-22K09923, KAKENHI-PROJECT-22KJ1445
[Journal Article] Lipoprotein signal peptidase-deficient Streptococcus pneumoniae exhibits impaired Toll-like receptor 2-stimulatory activity.2024
- Author(s)
  Domon H, Hirayama S, Isono T, Saito R, Yanagihara K, Terao Y
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 68(4): Pages: 155-159
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23H00445
[Journal Article] Pneumococcus downregulates the molecular weight of the extracellular domain of the epidermal growth factor receptor of alveolar epithelial cells.2024
- Author(s)
  Isono T, Hirayama S, Domon H, Terao Y
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 68(1) Pages: 23-26
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23H00445
[Journal Article] Biofilm-derived membrane vesicles exhibit potent immunomodulatory activity in Pseudomonas aeruginosa PAO12024
- Author(s)
  Minato Takahara, Satoru Hirayama, Hiroyuki Futamata,Ryoma Nakao, Yosuke Tashiro
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03861
[Journal Article] Pneumococcal proteins ClpC and UvrC as novel host plasminogen binding factors2023
- Author(s)
  Satoru Hirayama, Yoshihito Yasui, Karin Sasagawa, Hisanori Domon, Yutaka Terao
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 67 Issue: 2 Pages: 99-104
- DOI
  10.1111/1348-0421.13040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K09923, KAKENHI-PROJECT-20K09903
[Journal Article] Pneumococcus downregulates the molecular weight of the extracellular domain of the epidermal growth factor receptor of alveolar epithelial cells2023
- Author(s)
  Isono Toshihito、Hirayama Satoru、Domon Hisanori、Terao Yutaka
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 68 Issue: 1 Pages: 23-26
- DOI
  10.1111/1348-0421.13103
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18355, KAKENHI-PROJECT-22K09923, KAKENHI-PROJECT-22KJ1445
[Journal Article] Macrolides Decrease the Proinflammatory Activity of Macrolide-Resistant Streptococcus pneumoniae2023
- Author(s)
  Domon Hisanori、Hirayama Satoru、Isono Toshihito、Sasagawa Karin、Takizawa Fumio、Maekawa Tomoki、Yanagihara Katsunori、Terao Yutaka
- Journal Title
  
  Microbiology Spectrum
  
  Volume: 11 Issue: 3
- DOI
  10.1128/spectrum.00148-23
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18355, KAKENHI-PROJECT-23KK0160, KAKENHI-PROJECT-22K09923, KAKENHI-PROJECT-22KJ1445, KAKENHI-PROJECT-23K24525
[Journal Article] Degradation of EGFR on lung epithelial cells by neutrophil elastase contributes to the aggravation of pneumococcal pneumonia2023
- Author(s)
  Isono Toshihito、Hirayama Satoru、Domon Hisanori、Maekawa Tomoki、Tamura Hikaru、Hiyoshi Takumi、Sirisereephap Kridtapat、Takenaka Shoji、Noiri Yuichiro、Terao Yutaka
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 6 Pages: 104760-104760
- DOI
  10.1016/j.jbc.2023.104760
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18355, KAKENHI-PROJECT-23KK0160, KAKENHI-PROJECT-22K09923, KAKENHI-PROJECT-22KJ1445, KAKENHI-PROJECT-23K24525
[Journal Article] C-Terminal Lysine Residue of Pneumococcal Triosephosphate Isomerase Contributes to Its Binding to Host Plasminogen2023
- Author(s)
  Hirayama Satoru、Hiyoshi Takumi、Yasui Yoshihito、Domon Hisanori、Terao Yutaka
- Journal Title
  
  Microorganisms
  
  Volume: 11 Issue: 5 Pages: 1198-1198
- DOI
  10.3390/microorganisms11051198
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18355, KAKENHI-PROJECT-22K09923
[Journal Article] Macrolides decrease the proinflammatory activity of macrolide-resistant Streptococcus pneumoniae.2023
- Author(s)
  Domon H, Hirayama S, Isono T, Sasagawa K, Takizawa F, Maekawa T, Yanagihara K, Terao Y
- Journal Title
  
  Microbiology Spectrum
  
  Volume: 11(3)
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23H00445
[Journal Article] The Pneumococcal Protein SufC Binds to Host Plasminogen and Promotes Its Conversion into Plasmin2023
- Author(s)
  Yasui Yoshihito、Hirayama Satoru、Hiyoshi Takumi、Isono Toshihito、Domon Hisanori、Maekawa Tomoki、Tabeta Koichi、Terao Yutaka
- Journal Title
  
  Microorganisms
  
  Volume: 11 Issue: 12 Pages: 2969-2969
- DOI
  10.3390/microorganisms11122969
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18355, KAKENHI-PROJECT-23KK0160, KAKENHI-PROJECT-22K09923, KAKENHI-PROJECT-22KJ1445, KAKENHI-PROJECT-23K24525
[Journal Article] Degradation of EGFR on lung epithelial cells by neutrophil elastase contributes to the aggravation of pneumococcal pneumonia.2023
- Author(s)
  Isono T, Hirayama S, Domon H, Maekawa T, Tamura H, Hiyoshi T, Sirisereephap K, Takenaka S, Noiri Y, Terao Y
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299(6) Pages: 104760-104760
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23H00445
[Journal Article] C-terminal lysine residue of pneumococcal triosephosphate isomerase contributes to its binding to host plasminogen.2023
- Author(s)
  Hirayama S, Hiyoshi T, Yasui Y, Domon H, Terao Y
- Journal Title
  
  Microorganisms
  
  Volume: 11(5) Pages: 1198-1198
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23H00445
[Journal Article] Scanning Electron Microscopy of Escherichia coli Encapsulated in a Spacerized Graphene Sandwich2022
- Author(s)
  Sasaki, Yuki; Hirayama, Satoru; Nakao, Ryoma
- Journal Title
  
  Microscopy
  
  Volume: in press Issue: 3 Pages: 175-180
- DOI
  10.1093/jmicro/dfac010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22644, KAKENHI-PROJECT-20H03861, KAKENHI-PROJECT-21K18284, KAKENHI-PROJECT-21KK0164, KAKENHI-PROJECT-19K15404
[Journal Article] Glycine Induction Method: Effective Production of Immunoactive Bacterial Membrane Vesicles with Low Endotoxin Content2021
- Author(s)
  Satoru Hirayama, Ryoma Nakao
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2414 Pages: 207-226
- DOI
  10.1007/978-1-0716-1900-1_13
- ISBN
  9781071618998, 9781071619001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K18492, KAKENHI-PROJECT-21K18284, KAKENHI-PROJECT-21KK0164
[Journal Article] Roles of membrane vesicles from Streptococcus mutans for the induction of antibodies to glucosyltransferase in mucosal immunity2020
- Author(s)
  Nakamura Tomoyo、Iwabuchi Yusuke、Hirayama Satoru、Narisawa Naoki、Takenaga Fumio、Nakao Ryoma、Senpuku Hidenobu
- Journal Title
  
  Microbial Pathogenesis
  
  Volume: 149 Pages: 104260-104260
- DOI
  10.1016/j.micpath.2020.104260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K10286, KAKENHI-PROJECT-19K22644
[Journal Article] Glycine significantly enhances bacterial membrane vesicle production: a powerful approach for isolation of LPS-reduced membrane vesicles of probiotic Escherichia coli2020
- Author(s)
  Satoru Hirayama and Ryoma Nakao
- Journal Title
  
  Microbial Biotechnology
  
  Volume: 13 Pages: 1162-1178
- DOI
  10.1007/978-1-0716-0939-2_15
- ISBN
  9781071609385, 9781071609392
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22644
[Journal Article] Glycine Significantly Enhances Bacterial Membrane Vesicle Production: A Powerful Approach for Isolation of LPS-reduced Membrane Vesicles of Probiotic Escherichia Coli2020
- Author(s)
  Satoru Hirayama, Ryoma Nakao
- Journal Title
  
  Microb Biotechnol
  
  Volume: 13 Issue: 4 Pages: 1162-1178
- DOI
  10.1111/1751-7915.13572
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22644, KAKENHI-PROJECT-18K15160
[Journal Article] 高速原子間力顕微鏡を用いた細菌の形態変化の観察 ―プロポリスが歯周病原細菌Porphyromonas gingivalisに及ぼす抗菌作用2019
- Author(s)
  平山悟、吉益由莉、中尾龍馬
- Journal Title
  
  顕微鏡/KENBIKYO
  
  Volume: 54 Pages: 72-76
- NAID
  130007704154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22644
[Journal Article] Effects of Complex DNA and MVs With GTF Extracted From Streptococcus mutans on the Oral Biofilm2019
- Author(s)
  Senpuku H, Nakamura T, Iwabuchi Y, Hirayama S, Nakao R, Ohnishi M
- Journal Title
  
  Molecules
  
  Volume: 24 Issue: 17 Pages: 1-1
- DOI
  10.3390/molecules24173131
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22644
[Presentation] マクロライド系薬はマクロライド耐性肺炎球菌の炎症誘導能を減弱させる2023
- Author(s)
  土門久哲，平山　悟，磯野俊仁，笹川花梨，滝澤史雄，前川知樹，寺尾　豊
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K18355
[Presentation] 肺炎球菌トリオースリン酸イソメラーゼの感染関連機能の解析2023
- Author(s)
  平山悟, 日吉巧, 安井惟人, 土門久哲, 寺尾豊
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-22K09923
[Presentation] 好中球エラスターゼによる上皮成長因子受容体の分解は，肺胞上皮の修復を阻害する2023
- Author(s)
  磯野俊仁, 平山悟, 土門久哲, 前川知樹, 寺尾豊
- Organizer
  第53回レンサ球菌研究会
- Data Source
  KAKENHI-PROJECT-22K09923
[Presentation] マクロライド系薬はマクロライド耐性肺炎球菌の炎症誘導能を減弱させる2023
- Author(s)
  土門久哲，平山　悟，磯野俊仁，笹川花梨，滝澤史雄，前川知樹，寺尾　豊
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23H00445
[Presentation] 分泌型白血球プロテアーゼインヒビターによる歯周組織破壊抑制作用の解析2023
- Author(s)
  笹川花梨, 土門久哲, 平山悟, 前川知樹, 磯野俊仁, 滝澤史雄, 斎藤瑠郁, 安井惟人, 寺尾豊
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-22K09923
[Presentation] 肺炎球菌トリオースリン酸イソメラーゼの感染関連機能の解析2023
- Author(s)
  平山　悟，日吉　巧，安井惟人，土門久哲，寺尾　豊
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23H00445
[Presentation] 感染時に発現する肺炎球菌タンパク質の感染関連機能の解析2023
- Author(s)
  平山悟, 日吉巧, 安井惟人, 土門久哲, 寺尾豊
- Organizer
  第53回レンサ球菌研究会
- Data Source
  KAKENHI-PROJECT-22K09923
[Presentation] 分泌型白血球プロテアーゼ阻害因子による歯周組織破壊抑制作用の解析2023
- Author(s)
  笹川花梨, 土門久哲, 平山悟, 前川知樹, 寺尾豊, 多部田康一
- Organizer
  第66回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-22K09923
[Presentation] 好中球エラスターゼは上皮成長因子受容体を分解し，肺組織の修復を阻害する2023
- Author(s)
  磯野俊仁，平山　悟，土門久哲，前川知樹，寺尾　豊
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23H00445
[Presentation] 口腔関連感染症の新たな予防・治療法の探索2023
- Author(s)
  笹川花梨，土門久哲，平山　悟，前川知樹，多部田康一，寺尾　豊
- Organizer
  令和5年度新潟歯学会第1回例会
- Data Source
  KAKENHI-PROJECT-23H00445
[Presentation] 肺炎球菌タンパクSufCは宿主プラスミノーゲンと結合しプラスミンへの変換を促進する2023
- Author(s)
  安井惟人，平山　悟，磯野俊仁，日吉　巧，土門久哲，寺尾　豊
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K18355
[Presentation] 好中球エラスターゼは上皮成長因子受容体を分解し，肺組織の修復を阻害する2023
- Author(s)
  磯野俊仁, 平山悟, 土門久哲, 前川知樹, 寺尾豊
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-22K09923
[Presentation] 分泌型白血球プロテアーゼ阻害因子による歯周組織破壊抑制作用の解析2023
- Author(s)
  笹川花梨，土門久哲，平山　悟，前川知樹，寺尾　豊，多部田康一
- Organizer
  第66回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-23K18355
[Presentation] 分泌型白血球プロテアーゼ阻害因子による歯周組織破壊抑制作用の解析2023
- Author(s)
  笹川花梨，土門久哲，平山　悟，前川知樹，寺尾　豊，多部田康一
- Organizer
  第66回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-23H00445
[Presentation] 肺炎球菌トリオースリン酸イソメラーゼの感染関連機能の解析2023
- Author(s)
  平山　悟，日吉　巧，安井惟人，土門久哲，寺尾　豊
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K18355
[Presentation] 分泌型白血球プロテアーゼインヒビターによる歯周組織破壊抑制作用の解析2023
- Author(s)
  笹川花梨，土門久哲，平山　悟，前川知樹，磯野俊仁，滝澤史雄，斎藤瑠郁，安井惟人，寺尾　豊
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K18355
[Presentation] マクロライド系薬はマクロライド耐性肺炎球菌の炎症誘導能を減弱させる2023
- Author(s)
  土門久哲, 平山悟, 磯野俊仁, 笹川花梨, 滝澤史雄, 前川知樹, 寺尾豊
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-22K09923
[Presentation] 仁，滝澤史雄，斎藤瑠郁，安井惟人，寺尾　豊：分泌型白血球プロテアーゼインヒビターによる歯周組織破壊抑制作用の解析2023
- Author(s)
  笹川花梨，土門久哲，平山　悟，前川知樹，磯野俊仁，滝澤史雄，斎藤瑠郁，安井惟人，寺尾　豊
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23H00445
[Presentation] 口腔関連感染症の新たな予防・治療法の探索2023
- Author(s)
  笹川花梨，土門久哲，平山　悟，前川知樹，多部田康一，寺尾　豊
- Organizer
  令和5年度新潟歯学会第1回例会
- Data Source
  KAKENHI-PROJECT-23K18355
[Presentation] 口腔関連感染症の新たな予防・治療法の探索2023
- Author(s)
  笹川花梨, 土門久哲, 平山悟, 前川知樹, 多部田康一, 寺尾豊
- Organizer
  令和5年度新潟歯学会第1回例会
- Data Source
  KAKENHI-PROJECT-22K09923
[Presentation] 肺炎球菌タンパクSufCは宿主プラスミノーゲンと結合しプラスミンへの変換を促進する2023
- Author(s)
  安井惟人, 平山悟, 磯野俊仁, 日吉巧, 土門久哲, 寺尾豊
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-22K09923
[Presentation] 肺炎球菌タンパクSufCは宿主プラスミノーゲンと結合しプラスミンへの変換を促進する2023
- Author(s)
  安井惟人，平山　悟，磯野俊仁，日吉　巧，土門久哲，寺尾　豊
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23H00445
[Presentation] 好中球エラスターゼは上皮成長因子受容体を分解し，肺組織の修復を阻害する2023
- Author(s)
  磯野俊仁，平山　悟，土門久哲，前川知樹，寺尾　豊
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K18355
[Presentation] 肺炎球菌性肺炎の新たな治療法と治療標的の探索研究2022
- Author(s)
  磯野俊仁, 平山悟, 土門久哲, 前川知樹, 田村光, 日吉巧, 竹中彰治, 野杁由一郎, 寺尾豊
- Organizer
  令和4年度新潟歯学会第2回例会
- Data Source
  KAKENHI-PROJECT-22K09923
[Presentation] グリシンにより誘導された細菌メンブレンベシクルの性質とアジュバント活性の解析2021
- Author(s)
  平山悟, 中尾龍馬
- Organizer
  第63回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-20K18492
[Presentation] Characterization of immunomodulatory membrane vesicles derived from Pseudomonas aeruginosa biofilm2021
- Author(s)
  Minato Takahara, Satoru Hirayama, Ryoma Nakao, Hiroyuki Futamata, Yosuke Tashiro
- Organizer
  EMBO Workshop: Bacterial Membrane Vesicles: Biogenesis, functions, and medical applications
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03861
[Presentation] グリシンにより誘導された細菌メンブレンベシクルの性質とアジュバント活性の解析2021
- Author(s)
  平山悟、中尾龍馬
- Organizer
  第63回歯科基礎医学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03861
[Presentation] グリシンにより誘導された細菌メンブレンベシクルの性質とアジュバント活性の解析2021
- Author(s)
  Hirayama S, Nakao R.
- Organizer
  第63回歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-20K09943
[Presentation] Intranasal vaccine development using probiotic E. coli-derived membrane vesicles carrying pneumococcal capsular polysaccharides2021
- Author(s)
  Nakao R, Iwabuchi Y, Kimura S, Hirayama S, Morino S, Suzuki M, Ohnishi M.
- Organizer
  15th Vaccine Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22644
[Presentation] Intranasal vaccine development using probiotic E. coli-derived membrane vesicles carrying pneumococcal capsular polysaccharides2021
- Author(s)
  Nakao R, Iwabuchi Y, Kimura S, Hirayama S, Morino S, Suzuki M, Ohnishi M.
- Organizer
  15th Vaccine Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03861
[Presentation] 外来性莢膜多糖を発現するプロバイオティクス大腸菌が作る膜小胞ワクチンの特性評価2021
- Author(s)
  Ryoma Nakao, Hiroaki Kobayashi, Yusuke Iwabuchi, Yusuke Sasaki, Madeleine Ramstedt, Satoru Hirayama, Makoto Ohnishi
- Organizer
  第15回日本ワクチン学会
- Data Source
  KAKENHI-PROJECT-20H03861
[Presentation] 外来性莢膜多糖を発現するプロバイオティクス大腸菌が作る膜小胞ワクチンの特性評価2021
- Author(s)
  Ryoma Nakao, Hiroaki Kobayashi, Yusuke Iwabuchi, Yusuke Sasaki, Madeleine Ramstedt, Satoru Hirayama, Makoto Ohnishi
- Organizer
  第15回日本ワクチン学会
- Data Source
  KAKENHI-PROJECT-19K22644
[Presentation] Probiotic Eshcherichia coli Membraned Vesicles Carrying Pneumococcal Capsular Polysaccharides: An In Vivo Study of intranasal Vaccines Using Safe and immunogenic Nanoparticles.2020
- Author(s)
  Ryoma Nakao, Satoru Hirayama, Iwabuchi Yusuke, Makoto Ohnishi
- Organizer
  12th International Symposium on Pneumococci & Pneumococcal Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22644
[Presentation] グリシンにより誘導された細菌メンブレンベシクルの特性解析―歯周病細菌ベシクルワクチンの粘膜アジュバント開発等に向けて―2020
- Author(s)
  平山悟、中尾龍馬
- Organizer
  第62回歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-19K22644
[Presentation] グリシンによる大腸菌メンブレンベシクル産生の誘導とその特性解析2020
- Author(s)
  平山悟, 中尾龍馬
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K15160
[Presentation] バイオフィルム由来膜小胞による免疫応答促進（学術奨励賞）2020
- Author(s)
  高原翠夏人、平山悟、中尾龍馬、二又裕之、田代陽介
- Organizer
  2020年度日本農芸化学会中部支部
- Data Source
  KAKENHI-PROJECT-19K22644
[Presentation] グリシンによる細菌メンブレンベシクル産生の誘導とその特性2020
- Author(s)
  平山悟, 中尾龍馬
- Organizer
  生物工学Webシンポジウム2020
- Invited
- Data Source
  KAKENHI-PROJECT-20K18492
[Presentation] グリシンにより誘導された細菌メンブレンベシクルの特性解析―歯周病原細菌ベシクルワクチンの粘膜アジュバント開発等に向けて―2020
- Author(s)
  平山悟, 中尾龍馬
- Organizer
  第62回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-20K18492
[Presentation] グリシンによる細菌メンブレンベシクル産生の誘導とその特性2020
- Author(s)
  平山悟、中尾龍馬
- Organizer
  生物工学会Webシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19K22644

1. 土門久哲 (00594350)

# of Collaborated Projects: 4 results

# of Collaborated Products: 36 results
2. Nakao Ryoma (10370959)

# of Collaborated Projects: 3 results

# of Collaborated Products: 21 results
3. 寺尾豊 (50397717)

# of Collaborated Projects: 3 results

# of Collaborated Products: 36 results
4. 前川知樹 (50625168)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
5. 泉福英信 (20250186)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. Miyazaki Hidetaka (70420271)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 工藤敏文 (50431911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 尾花望 (00722688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 川崎忠寛 (10372533)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 佐々木祐生 (80808668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 上野尚雄 (90450832)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 竹中彰治 (50313549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Hirayama Satoru 平山 悟

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感染部位依存的な肺炎球菌の病原性発現およびその制御因子の解析Principal Investigator

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肺炎球菌性肺炎の統合的な検査/予防/治療に向けた開発研究

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好中球老化マーカーの同定と抗加齢研究への挑戦

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iTRAQ-MS/MS解析を基盤とする新規肺炎球菌ワクチンの開発研究Principal Investigator

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The development of high-snsitivity detection system of bacteria-derived membrane vesicle and detection of membrane vesicle in the chronic inflamatory vascular deseases

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Are membrane vesicles of periodontopathogenic bacteria a pathogenic factor in Alzheimer's disease?Principal Investigator

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Periodontopathic bacterial outer membrane vesicles: Biogenesis and relation to development of chronic inflammation and carcinogenesis

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Novel nano paticle vaccine | Biogenesis and medical application of outer membrane vesicles

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Investigation of the mechanism of bacterial membrane vesicle uptakePrincipal Investigator

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[Book] Methods in Molecular Biology: Glycine Induction Method: Effective Production of Immunoactive Bacterial Membrane Vesicles with Low Endotoxin Content2022

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[Book] Methods in Molecular Biology: Glycine Induction Method: Effective Production of Immunoactive Bacterial Membrane Vesicles with Low Endotoxin Content2022

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[Book] Methods in Molecular Biology: Intranasal vaccine study using Porphyromonas gingivalis membrane vesicles: isolation method and application to a mouse model2021

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[Book] Methods in Molecular Biology: Intranasal vaccine study using Porphyromonas gingivalis membrane vesicles: isolation method and application to a mouse model2021

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[Journal Article] Lipoprotein signal peptidase‐deficient Streptococcus pneumoniae exhibits impaired Toll‐like receptor 2‐stimulatory activity2024

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Hirayama Satoru 平山悟