SAKAGUCHI Takashi 坂口大

Researcher Number	70779008
Affiliation (Current)	2025: 鹿児島大学, 医歯学域医学系, 助教
Affiliation (based on the past Project Information) *help	2022 – 2023: 鹿児島大学, 鹿児島大学病院, 医員 2021 – 2023: 鹿児島大学, 医歯学域医学系, 助教 2020: 鹿児島大学, 鹿児島大学病院, 医員 2019: 鹿児島大学, 医歯学総合研究科, 客員研究員
Review Section/Research Field	Principal Investigator Basic Section 56030:Urology-related Except Principal Investigator Basic Section 56030:Urology-related
Keywords	Principal Investigator 腎癌 / スニチニブ耐性 / 腎細胞癌 / SLCA5 / エクソソーム / マイクロRNA / 治療抵抗性腎癌 / JQ1 / ブロモドメイン / 進行性腎癌 / BRD4 / ブロモドメイン蛋白 … More Except Principal Investigator … More マイクロRNA / 腎癌 / MYO15A / microRNA-1 / 腎細胞癌 / エクソソーム / 膀胱癌 / 腫瘍マーカー / 尿路上皮癌 Less

エクソソーム解析による治療抵抗性腎癌の新規治療戦略と治療効果予測マーカーの開発
- Principal Investigator
  
  鑪野秀一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kagoshima University
治療抵抗性腎癌に対するエクソソームを起点とした新規治療戦略の探索Principal Investigator
- Principal Investigator
  
  坂口大
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kagoshima University
Development of a new diagnostic method for urothelial carcinoma by detecting urinary microRNA using cell sorting system
- Principal Investigator
  
  ENOKIDA Hideki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kagoshima University
Elucidating anti-tumor effect of Bromodomain protein in refractory renal cell carcinomaPrincipal Investigator
- Principal Investigator
  
  SAKAGUCHI Takashi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kagoshima University

All 2023 2022 2021

All Journal Article Presentation

[Journal Article] Potential therapeutic target secretogranin II might cooperate with hypoxia‐inducible factor 1α in sunitinib‐resistant renal cell carcinoma2023
- Author(s)
  Fukumoto Wataru、Yoshino Hirofumi、Horike Shin‐Ichi、Kawakami Issei、Tamai Motoki、Arima Junya、Kawahara Ichiro、Mitsuke Akihiko、Sakaguchi Takashi、Inoguchi Satoru、Meguro‐Horike Makiko、Tatarano Shuichi、Enokida Hideki
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 10 Pages: 3946-3956
- DOI
  10.1111/cas.15914
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16820, KAKENHI-PROJECT-22K06896, KAKENHI-PROJECT-22K09452, KAKENHI-PROJECT-22K09507, KAKENHI-PROJECT-21K09430, KAKENHI-PROJECT-22K16792, KAKENHI-PROJECT-22K16805
[Journal Article] Characterization and treatment of gemcitabine‐ and cisplatin‐resistant bladder cancer cells with a pan‐RAS inhibitor2023
- Author(s)
  Yoshino Hirofumi、Yokoyama Seiya、Tamai Motoki、Okamura Shunsuke、Iizasa Sayaka、Sakaguchi Takashi、Osako Yoichi、Inoguchi Satoru、Matsushita Ryosuke、Yamada Yasutoshi、Nakagawa Masayuki、Tatarano Shuichi、Tanimoto Akihide、Enokida Hideki
- Journal Title
  
  FEBS Open Bio
  
  Volume: 13 Issue: 6 Pages: 1056-1066
- DOI
  10.1002/2211-5463.13616
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09452, KAKENHI-PROJECT-22K09478, KAKENHI-PROJECT-21K09404, KAKENHI-PROJECT-21K09430, KAKENHI-PROJECT-22K16792, KAKENHI-PROJECT-22K16805
[Journal Article] microRNA-99a-5p induces cellular senescence in gemcitabine-resistant bladder cancer by targeting SMARCD1.2022
- Author(s)
  Motoki Tamai, Shuichi Tatarano, Shunsuke Okamura, Wataru Fukumoto, Issei Kawakami, Yoichi Osako, Takashi Sakaguchi, Satoshi Sugita, Masaya Yonemori, Yasutoshi Yamada, Masayuki Nakagawa, Hideki Enokida, Hirofumi Yoshino.
- Journal Title
  
  Molecular Oncology
  
  Volume: 16 Issue: 6 Pages: 1329-1346
- DOI
  10.1002/1878-0261.13192
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09715, KAKENHI-PROJECT-20K18146, KAKENHI-PROJECT-21K09404, KAKENHI-PROJECT-22K09452, KAKENHI-PROJECT-22K09478
[Journal Article] microRNA-99a-5p induces cellular senescence in gemcitabine-resistant bladder cancer by targeting SMARCD12022
- Author(s)
  Motoki Tamai, Shuichi Tatarano, Shunsuke Okamura, Wataru Fukumoto, Issei Kawakami, Yoichi Osako, Takashi Sakaguchi, Satoshi Sugita, Masaya Yonemori, Yasutoshi Yamada, Masayuki Nakagawa, Hideki Enokida, Hirofumi Yoshino.
- Journal Title
  
  Molecular Oncology
  
  Volume: 16 Pages: 1329-1346
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09404
[Journal Article] Exosomal microRNA-1 and MYO15A as a target for therapy and diagnosis in renal cell carcinoma2022
- Author(s)
  Yoshino Hirofumi、Tatarano Shuichi、Tamai Motoki、Tsuruda Masafumi、Iizasa Sayaka、Arima Junya、Kawakami Issei、Fukumoto Wataru、Kawahara Ichiro、Li Gang、Sakaguchi Takashi、Inoguchi Satoru、Yamada Yasutoshi、Enokida Hideki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 630 Pages: 71-76
- DOI
  10.1016/j.bbrc.2022.09.056
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09430, KAKENHI-PROJECT-22K09452, KAKENHI-PROJECT-22K09507, KAKENHI-PROJECT-22K16792
[Journal Article] Targeting of the glutamine transporter SLC1A5 induces cellular senescence in clear cell renal cell carcinoma2022
- Author(s)
  Issei Kawakami, Hirofumi Yoshino, Wataru Fukumoto, Motoki Tamai, Shunsuke Okamura, Yoichi Osako, Takashi Sakaguchi, Satoru Inoguchi, Ryosuke Matsushita, Yasutoshi Yamada, Shuichi Tatarano, Masayuki Nakagawa, Hideki Enokida.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: - Pages: 99-106
- DOI
  10.1016/j.bbrc.2022.04.068
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07736, KAKENHI-PROJECT-21K09430, KAKENHI-PROJECT-22K09452, KAKENHI-PROJECT-22K16792, KAKENHI-PROJECT-22K16805, KAKENHI-PROJECT-22K16820
[Presentation] microRNA-99a-5pは、膀胱癌におけるゲムシタビン耐性を克服するための重要な分子である.2021
- Author(s)
  玉井元規, 吉野裕史, 坂口大, 榎田英樹.
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K09404

1. ENOKIDA Hideki (80347103)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. 吉野裕史 (90642611)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. 鑪野秀一 (30624655)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. NAKAGAWA Masayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 大迫洋一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 山田保俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAKAGUCHI Takashi 坂口 大

Research Projects

Research Products

Co-Researchers

エクソソーム解析による治療抵抗性腎癌の新規治療戦略と治療効果予測マーカーの開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

治療抵抗性腎癌に対するエクソソームを起点とした新規治療戦略の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a new diagnostic method for urothelial carcinoma by detecting urinary microRNA using cell sorting system

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating anti-tumor effect of Bromodomain protein in refractory renal cell carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Potential therapeutic target secretogranin II might cooperate with hypoxia‐inducible factor 1α in sunitinib‐resistant renal cell carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization and treatment of gemcitabine‐ and cisplatin‐resistant bladder cancer cells with a pan‐RAS inhibitor2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] microRNA-99a-5p induces cellular senescence in gemcitabine-resistant bladder cancer by targeting SMARCD1.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] microRNA-99a-5p induces cellular senescence in gemcitabine-resistant bladder cancer by targeting SMARCD12022

Author(s)

Journal Title

Data Source

[Journal Article] Exosomal microRNA-1 and MYO15A as a target for therapy and diagnosis in renal cell carcinoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting of the glutamine transporter SLC1A5 induces cellular senescence in clear cell renal cell carcinoma2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] microRNA-99a-5pは、膀胱癌におけるゲムシタビン耐性を克服するための重要な分子である.2021

Author(s)

Organizer

Data Source

SAKAGUCHI Takashi 坂口大