Tokushige Akihiro 徳重明央

Researcher Number	70780287
Other IDs
Affiliation (Current)	2025: 琉球大学, 医学(系)研究科(研究院), 准教授
Affiliation (based on the past Project Information) *help	2022 – 2025: 琉球大学, 医学(系)研究科(研究院), 准教授 2020 – 2022: 鹿児島大学, 医歯学総合研究科, 特任講師 2021: 鹿児島大学, 医歯学域医学系, 助教
Review Section/Research Field	Principal Investigator Basic Section 55050:Anesthesiology-related / Basic Section 52010:General internal medicine-related Except Principal Investigator Basic Section 52010:General internal medicine-related
Keywords	Principal Investigator ミトコンドリアダイナミクス / 血管内皮機能 / 心機能 / 抗がん剤 / がん / 腫瘍循環器 Except Principal Investigator マイトファジー / 老化 / サルコペニア / ミトコンドリア … More / NAD / オートファジー / 閉経女性 / 拡張性心不全 / 骨格筋 / 心筋 / 抗がん剤 / 抗癌剤 / 骨格筋萎縮 / 心不全 / アンジオテンシン / 酸化ストレス / ミトコンドリア機能 Less

術前に検出された無症候性下腿深部静脈血栓症の管理・治療の均てん化への挑戦Principal Investigator
- Principal Investigator
  
  徳重明央
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  University of the Ryukyus
閉経後高齢女性が発症リスクの拡張性心不全に対する分子機序解明及び治療法開発
- Principal Investigator
  
  池田義之
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Kagoshima University
Novel mitochondria-mediated therapy for anticancer drug-induced cardiac and skeletal muscle damage
- Principal Investigator
  
  Akasaki Yuichi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Kagoshima University
がん患者におけるミトコンドリア関連miRNAを介した心血管機能への影響の解明Principal Investigator
- Principal Investigator
  
  徳重明央
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  University of the Ryukyus
  Kagoshima University

All 2024 2023 2022

All Journal Article Presentation

[Journal Article] Association between weight gain following smoking cessation and development of hypertension in the future2024
- Author(s)
  Ninomiya Yuichi、Kawasoe Shin、Kubozono Takuro、Tokushige Akihiro、Ichiki Hitoshi、Salim Anwar Ahmed、Ikeda Yoshiyuki、Miyahara Hironori、Tokushige Koichi、Ohishi Mitsuru
- Journal Title
  
  Hypertension Research
  
  Volume: - Issue: 5 Pages: 1-1
- DOI
  10.1038/s41440-023-01549-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07535, KAKENHI-PROJECT-23K27509
[Journal Article] J-shaped Association between Serum Uric Acid Levels and the Prevalence of a Reduced Kidney Function: A Cross-sectional Study Using Japanese Health Examination Data2024
- Author(s)
  Kawasoe Shin、Kubozono Takuro、Salim Anwar Ahmed、Ojima Satoko、Yamaguchi Satoshi、Ikeda Yoshiyuki、Miyahara Hironori、Tokushige Koichi、Ohishi Mitsuru
- Journal Title
  
  Intern. Med.
  
  Volume: 63 Issue: 11 Pages: 1539-1548
- DOI
  10.2169/internalmedicine.2474-23
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2024-06-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27509
[Journal Article] The Kagoshima-DVT Score Is a Useful Predictive Model for Cancer-Associated Thrombosis in Patients With Gastrointestinal Cancer2023
- Author(s)
  Shibata Keisuke、Tokushige Akihiro、Hamamoto Yuki、Higuchi Koji、Imamura Masakazu、Ikeda Yoshiyuki、Ohishi Mitsuru
- Journal Title
  
  Circulation Reports
  
  Volume: 5 Issue: 2 Pages: 19-26
- DOI
  10.1253/circrep.CR-22-0112
- ISSN
  2434-0790
- Year and Date
  2023-02-10
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16528, KAKENHI-PROJECT-19K07891
[Journal Article] Living alone predicts poor prognosis among patients with acute myocardial infarction2023
- Author(s)
  Fukumoto Daichi、Kanda Daisuke、Takumi Takuro、Ikeda Yoshiyuki、Tokushige Akihiro、Ohmure Kenta、Sonoda Takeshi、Arikawa Ryo、Anzaki Kazuhiro、Ohishi Mitsuru
- Journal Title
  
  Coronary Artery Disease
  
  Volume: 34 Issue: 8 Pages: 580-588
- DOI
  10.1097/mca.0000000000001286
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27509
[Journal Article] Clinical significance of atherosclerotic risk factors differs in early and advanced stages of plaque formation: A longitudinal study in the general population2023
- Author(s)
  Ojima Satoko、Kubozono Takuro、Kawasoe Shin、Kawabata Takeko、Salim Anwar Ahmed、Ikeda Yoshiyuki、Miyata Masaaki、Miyahara Hironori、Tokushige Koichi、Ohishi Mitsuru
- Journal Title
  
  International Journal of Cardiology
  
  Volume: 379 Pages: 111-117
- DOI
  10.1016/j.ijcard.2023.02.037
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07471, KAKENHI-PROJECT-20K08477, KAKENHI-PROJECT-23K27509
[Journal Article] Development of predictive equation and score for 5-year metabolic syndrome incidence in Japanese adults2023
- Author(s)
  Salim Anwar Ahmed、Kawasoe Shin、Kubozono Takuro、Ojima Satoko、Kawabata Takeko、Hashiguchi Hiroshi、Ikeda Yoshiyuki、Miyata Masaaki、Miyahara Hironori、Tokushige Koichi、Nishio Yoshihiko、Ohishi Mitsuru
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 4 Pages: 0284139-0284139
- DOI
  10.1371/journal.pone.0284139
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07471, KAKENHI-PROJECT-20K08477, KAKENHI-PROJECT-21K07372, KAKENHI-PROJECT-23K27509
[Journal Article] Different effects of medications for hypertension on renal function between patients with and without diabetes mellitus undergoing percutaneous coronary intervention: a retrospective single-center cohort study2023
- Author(s)
  Kanda Daisuke、Takumi Takuro、Tokushige Akihiro、Ikeda Yoshiyuki、Ohishi Mitsuru
- Journal Title
  
  BMC Cardiovascular Disorders
  
  Volume: 23 Issue: 1 Pages: 509-509
- DOI
  10.1186/s12872-023-03547-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27509
[Journal Article] Sex-specific associations between serum uric acid levels and risk of hypertension for different diagnostic reference values of high blood pressure2023
- Author(s)
  Salim Anwar Ahmed、Kawasoe Shin、Kubozono Takuro、Ojima Satoko、Kawabata Takeko、Ikeda Yoshiyuki、Miyahara Hironori、Tokushige Koichi、Ohishi Mitsuru
- Journal Title
  
  Hypertension Research
  
  Volume: Online ahead of print Issue: 5 Pages: 1-1
- DOI
  10.1038/s41440-023-01535-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27509
[Journal Article] A new pre-test probability score for diagnosis of deep vein thrombosis in patients before surgery2022
- Author(s)
  Hamamoto Yuki、Tokushige Akihiro、Toshinori Yuasa、Ikeda Yoshiyuki、Horizoe Yoshihisa、Yasuda Hisayo、Kubozono Takuro、Ohishi Mitsuru
- Journal Title
  
  Journal of Cardiology
  
  Volume: 79 Issue: 5 Pages: 664-670
- DOI
  10.1016/j.jjcc.2021.11.025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16528
[Presentation] 低尿酸血症と慢性腎臓病の関連：大規模健診データを用いた研究.2023
- Author(s)
  川添　晋, 窪薗琢郎, 小島聡子, 川畑孟子, 池田義之, 宮原広典, 徳重浩一, 大石　充.
- Organizer
  日本循環器病予防学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27509
[Presentation] 血清尿酸値と5年後の高血圧症リスクの性差に関する検討.2023
- Author(s)
  Anwar Ahmed Salim, 川添　晋, 窪薗琢郎, 小島聡子, 川畑孟子, 池田義之, 宮原広典, 徳重浩一, 大石　充.
- Organizer
  日本循環器病予防学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27509
[Presentation] 機械学習手法を用いた健診データによる5年後の高血圧発症予測.2023
- Author(s)
  川添　晋, 窪薗琢郎, 小島聡子, 山口　聡, 池田義之, 宮原広典, 徳重浩一, 大石　充.
- Organizer
  第71回日本心臓病学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27509
[Presentation] 慢性腎臓病発症に関わるトリグリセリド-グルコース(TyG)インデックスの性差・年代差2023
- Author(s)
  迫田　隆, 赤﨑雄一, 内門義博, 佐々木雄一, 川添　晋, 徳重明央, 窪薗琢郎, 池田義之, 宮原広典,　徳重浩一, 大石　充.
- Organizer
  第71回　日本心臓病学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07851
[Presentation] 乳腺動脈石灰化と冠動脈石灰化の関連の検討.2023
- Author(s)
  柴田啓佑, 徳重明央, 内山奈美, 赤﨑雄一, 窪薗琢郎, 権藤なおみ, 相良安昭, 池田義之, 大石　充.
- Organizer
  第71回日本心臓病学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27509
[Presentation] J-shaped association between serum uric acid levels and chronic kidney disease: a cross-sectional study using large health examination data.2023
- Author(s)
  Kawasoe S, Kubozono T, Salim AA, Ojima S, Kawabata T, Ikeda Y, Miyahara H, Tokushige K, Ohishi M.
- Organizer
  ESC Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27509
[Presentation] 禁煙後の体重増加と将来の高血圧発症との関連性.2023
- Author(s)
  二宮雄一, 川添　晋, 窪薗琢郎, 德重明央, 市來仁志, Anwar Ahmed Salim, 池田義之, 宮原広典, 徳重浩一, 大石　充.
- Organizer
  日本循環器病予防学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27509
[Presentation] Sex specific associations between serum uric acid levels and risk of hypertension for different reference values of high blood pressure.2023
- Author(s)
  Salim AA, Kawasoe S, Kubozono T, Ojima S, Kawabata T, Ikeda Y, Miyahara H, Tokushige K, Ohishi M.
- Organizer
  ESC Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27509
[Presentation] 血清尿酸値と慢性腎臓病有病率のJ字型の関連.2023
- Author(s)
  川添　晋, 窪薗琢郎, 小島聡子, 山口　聡, 池田義之, 宮原広典, 徳重浩一, 大石　充.
- Organizer
  第71回日本心臓病学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27509
[Presentation] 禁煙後の体重増加は将来の血圧上昇と関連するのか？2023
- Author(s)
  二宮雄一, 川添　晋, 窪薗琢郎, 德重明央, 市來仁志, Ahmed Salim Anwar, 池田義之, 宮原広典, 徳重浩一, 大石　充.
- Organizer
  第45回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-23K27509
[Presentation] 上腕-足首脈波伝播速度とトリグリセリド-グルコースインデックスとの関連2023
- Author(s)
  迫田　隆, 赤﨑雄一, 佐々木雄一, 川添　晋, 徳重明央, 窪薗琢郎, 池田義之, 宮原広典,　徳重浩一, 大石　充.
- Organizer
  第65回　日本老年医学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07851
[Presentation] 性別ごとにみた高齢者における炎症所見と血管機能との関連.2023
- Author(s)
  窪薗琢郎, 川添　晋, 小島聡子, 川畑孟子, Anwar Ahmed Salim, 池田義之, 宮原広典, 徳重浩一, 大石　充.
- Organizer
  第65回日本老年医学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27509
[Presentation] QT Prolongation and QT Variability Predict New-Onset Atrial Fibrillation in the General Japanese Population.2023
- Author(s)
  Ninomiya Y, Kawasoe S, Kubozono T, Tokushige A, Enokizono K, Kamada H, Yoshimoto I, Ikeda Y, Miyahara H, Tokushige K, Ohishi M.
- Organizer
  AHA Scientific Sessions 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27509
[Presentation] 頸動脈プラークの進行に関連する動脈硬化の危険因子の検討：一般住民を対象とした縦断研究.2023
- Author(s)
  小島聡子, 窪薗琢郎, 川添　晋, 川畑孟子, Anwar Ahmed Salim, 池田義之, 宮田昌明, 宮原広典, 徳重浩一, 大石　充.
- Organizer
  日本循環器病予防学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27509
[Presentation] トリグリセリド-グルコース(TyG)インデックスと、将来の慢性腎臓病発症との関連2023
- Author(s)
  迫田　隆, 赤﨑雄一, 内門義博, 佐々木雄一, 川添　晋, 徳重明央, 窪薗琢郎, 池田義之, 宮原広典,　徳重浩一, 大石　充.
- Organizer
  第59回　日本循環器病予防学会
- Data Source
  KAKENHI-PROJECT-20K07851
[Presentation] Relationship between corrected QT prolongation and new-onset atrial fibrillation in the general Japanese population.2023
- Author(s)
  Ninomiya Y, Kawasoe S, Kubozono T, Tokushige A, Ichiki H, Kamada H, Yoshimoto I, Ikeda Y, Miyahara H, Tokushige K, Ohishi M.
- Organizer
  ESC Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27509
[Presentation] 上腕-足首脈波伝播速度とトリグリセリド-グルコースインデックスとの関連.2023
- Author(s)
  迫田　隆, 赤﨑雄一, 佐々木雄一, 川添　晋, 德重明央, 窪薗琢郎, 池田義之, 宮原広典, 徳重浩一, 大石　充.
- Organizer
  第65回日本老年医学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27509
[Presentation] トリグリセリド-グルコース（TyG）インデックスと, 将来の慢性腎臓病発症との関連.2023
- Author(s)
  迫田　隆, 赤﨑雄一, 内門義博, 佐々木雄一, 川添　晋, 德重明央, 窪薗琢郎, 池田義之, 宮原広典, 徳重浩一, 大石　充.
- Organizer
  日本循環器病予防学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27509
[Presentation] 慢性腎臓病発症に関わるトリグリセリド-グルコース(TyG)インデックスの性差・年代差.2023
- Author(s)
  迫田　隆, 赤﨑雄一, 内門義博, 佐々木雄一, 川添　晋, 徳重明央, 窪薗琢郎, 池田義之, 宮原広典, 徳重浩一, 大石充.
- Organizer
  第71回日本心臓病学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27509
[Presentation] THE ONE-TWO PUNCH: Complication of coronary arterycalcification and malnutrition worsen prognosis of patients with stablecoronary artery disease.2023
- Author(s)
  Kanda D, Ikeda Y, Ohmure K, Anzaki K, Sonoda T, Tokushige A, Ohishi M.
- Organizer
  72th Annual Scientific Session of the American College of Cardiology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27509
[Presentation] 孤立性拡張期高血圧患者においてTyGインデックスは将来のCKD発症を予測する.2023
- Author(s)
  迫田　隆, 赤﨑雄一, 内門義博, 佐々木雄一, 川添　晋, 德重明央, 窪薗琢郎, 池田義之, 宮原広典, 徳重浩一, 大石充.
- Organizer
  第45回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-23K27509
[Presentation] Factors for new-onset isolated diastolic hypertension and progression to systolic hypertension in Japan.2022
- Author(s)
  Sakoda T, Akasaki Y, Kawasoe S, Kubozono T, Sasaki Y, Ikeda Y, Ohishi M, Miyahara H, Tokushige K.
- Organizer
  The 29th Scientific Meeting of the International Society of Hypertension
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07851
[Presentation] Hypertension due to Lenvatinib induction.2022
- Author(s)
  Shibata K, Tokushige A, Nitta M, Akasaki Y, Higuchi K, Ikeda Y, Ohishi M.
- Organizer
  The 29th Scientific Meeting of the International Society of Hypertension
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07851
[Presentation] トリグリセリド-グルコースインデックスは動脈硬化発症の予測因子となりうる.2022
- Author(s)
  迫田　隆, 赤﨑雄一, 德重明央, 内門義博, 上坊翔太, 佐々木雄一, 川添　晋, 窪薗琢郎, 池田義之, 宮原広典, 徳重浩一, 大石　充.
- Organizer
  第70回日本心臓病学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07851
[Presentation] Differences in risk factors for developing hypertension when hypertension reference values are changed.2022
- Author(s)
  Sakoda T, Akasaki Y, Kawasoe S, Kubozono T, Sasaki Y, Ikeda Y, Ohishi M, Miyahara H, Tokushige K.
- Organizer
  The 29th Scientific Meeting of the International Society of Hypertension
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07851

1. Akasaki Yuichi (00631920)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. 池田義之 (00573023)

# of Collaborated Projects: 2 results

# of Collaborated Products: 31 results
3. 窪薗琢郎 (00598013)

# of Collaborated Projects: 2 results

# of Collaborated Products: 26 results
4. 大石充 (50335345)

# of Collaborated Projects: 2 results

# of Collaborated Products: 31 results
5. 二宮雄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 市来仁志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tokushige Akihiro 徳重 明央

Research Projects

Research Products

Co-Researchers

術前に検出された無症候性下腿深部静脈血栓症の管理・治療の均てん化への挑戦Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

閉経後高齢女性が発症リスクの拡張性心不全に対する分子機序解明及び治療法開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel mitochondria-mediated therapy for anticancer drug-induced cardiac and skeletal muscle damage

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

がん患者におけるミトコンドリア関連miRNAを介した心血管機能への影響の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Association between weight gain following smoking cessation and development of hypertension in the future2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] J-shaped Association between Serum Uric Acid Levels and the Prevalence of a Reduced Kidney Function: A Cross-sectional Study Using Japanese Health Examination Data2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] The Kagoshima-DVT Score Is a Useful Predictive Model for Cancer-Associated Thrombosis in Patients With Gastrointestinal Cancer2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Living alone predicts poor prognosis among patients with acute myocardial infarction2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical significance of atherosclerotic risk factors differs in early and advanced stages of plaque formation: A longitudinal study in the general population2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of predictive equation and score for 5-year metabolic syndrome incidence in Japanese adults2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Different effects of medications for hypertension on renal function between patients with and without diabetes mellitus undergoing percutaneous coronary intervention: a retrospective single-center cohort study2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sex-specific associations between serum uric acid levels and risk of hypertension for different diagnostic reference values of high blood pressure2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A new pre-test probability score for diagnosis of deep vein thrombosis in patients before surgery2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] 低尿酸血症と慢性腎臓病の関連：大規模健診データを用いた研究.2023

Tokushige Akihiro 徳重明央