Kodama Michiko 小玉美智子

Researcher Number	70791391
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 大阪大学, 大学院医学系研究科, 講師 2022: 大阪大学, 大学院医学系研究科, 助教 2017 – 2021: 大阪大学, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology Except Principal Investigator Basic Section 56040:Obstetrics and gynecology-related
Keywords	Principal Investigator Sleeping beautyトランスポゾン / 子宮平滑筋肉腫 / ゲノム変異 / 胃型腺癌 / 子宮頸癌 / ステップワイズ / 分葉状頸管腺過形成 / 全エクソームシーケンス / 子宮頸部胃型腺癌 / 治療抵抗性 … More / 発生 / フォワードジェネティクス / 薬剤抵抗性 / 増悪 / 発症 / トランスポゾンスクリーニング / Sleeping beauty / ドライバー遺伝子 / フォワードジェネティックスクリーニング / スクリーニング / トランスポゾン … More Except Principal Investigator 卵巣がん / バイオマーカー / 高異型度漿液性腺癌 / 環状RNA / 卵巣癌 / 遺伝子改変モデルマウス / CRISPR-Cas9c / GWAS / CRISPR-Cas9 / GEMM / マウスモデル / HGSC / リキッドバイオプシー / PDXマウス / CDK1 / circERSP2 / 高異型度漿液性癌 / 婦人科希少がん保存バンク / 希少がん / Omipalisib / Trametinib / 中腎管様癌 / 化合物ライブラリー / オミックス解析 / PDXモデルマウス / 婦人科癌 / 希少癌 / MAVS / type-1 IFN / Aurora kinase / 漿液性卵巣癌 / PDX / 3次元培養 / ドラッグスクリーニング / ARID1A / 子宮体がん / 婦人科がん / 子宮内膜症関連癌 / 子宮内膜症悪性化 / 子宮内膜症癌化 / 上皮性卵巣癌 / ユビキチン・プロテアソームシステム / 順遺伝学手法 / 糖鎖 / レクチン / 子宮内膜症 / miR-1290 / miR-99a-5p / 腹膜播種 / DDS / エクソソーム / マイクロRNA Less

Aurora Kinase を標的とした、卵巣癌の免疫療法抵抗性解除の可能性の探索
- Principal Investigator
  
  中塚えりか
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Osaka University
卵巣高異型度漿液性腺癌における特異的に発現上昇する環状RNAの同定とその役割の解明
- Principal Investigator
  
  岡村綾子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Osaka University
CRISPR-Cas9によるスピーディかつ汎用性の高い卵巣がんモデルマウスの樹立
- Principal Investigator
  
  中村幸司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Osaka University
網羅的ゲノム解析・微小環境空間的解析による子宮頸部胃型腺癌の発症・治療戦略の樹立Principal Investigator
- Principal Investigator
  
  小玉美智子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Osaka University
網羅的解析を通じた卵巣癌特異的な環状RNAの同定とその役割の解明
- Principal Investigator
  
  澤田健二郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Osaka University
PDXとドラッグスクリーニングによるARID1A変異婦人科がんの個別化医療開発
- Principal Investigator
  
  木瀬康人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Osaka University
PDX モデルマウスとオミックス解析を用いた希少がん保存バンクの設立
- Principal Investigator
  
  木村正
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Osaka University
低酸素環境下におけるMDSCの癌幹細胞誘導作用の解明
- Principal Investigator
  
  松本有里
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Osaka University
Investigation of sarcomagenesis and progression mechanisms in uterine leiomyosarcoma by transposon screening methodPrincipal Investigator
- Principal Investigator
  
  Kodama Michiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Osaka University
The role of lectins in the development of endometriosis.
- Principal Investigator
  
  Hashimoto Kae
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Osaka University
Elucidation of the regulatory mechanism of ovarian cancer progression and endometriosis carcinogenesis by deubiquitinating enzymes using a forward genetics approach.
- Principal Investigator
  
  Kimura Tadashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Osaka University
The development of a novel microRNA replacement therapy for ovarian cancer - a potential of patient derived-exosomes as a carrier.
- Principal Investigator
  
  Sawada Kenjiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Osaka University
Sleeping Beauty Transposon mutagenesis screen for identifying driver genes in uterine leiomyosarcomaPrincipal Investigator
- Principal Investigator
  
  Kodama Michiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Ring Finger Protein 125 Is an Anti-Proliferative Tumor Suppressor in Hepatocellular Carcinoma2022
- Author(s)
  Kodama Takahiro、Kodama Michiko、Jenkins Nancy A.、Copeland Neal G.、Chen Huanhuan Joyce、Wei Zhubo
- Journal Title
  
  Cancers
  
  Volume: 14 Issue: 11 Pages: 2589-2589
- DOI
  10.3390/cancers14112589
- Data Source
  KAKENHI-PROJECT-20K09617
[Journal Article] Gastric-Type Adenocarcinoma of the Uterine Cervix Associated with Poor Response to Definitive Radiotherapy2022
- Author(s)
  Kuruma Airi、Kodama Michiko、Hori Yumiko、Sato Kazuaki、Fujii Makoto、Isohashi Fumiaki、Miyoshi Ai、Mabuchi Seiji、Setoguchi Akira、Shimura Hiroko、Goto Takeshi、Toda Aska、Nakagawa Satoshi、Kinose Yasuto、Takiuchi Tsuyoshi、Kobayashi Eiji、Hashimoto Kae、Ueda Yutaka、Sawada Kenjiro、Morii Eiichi、Kimura Tadashi
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 1 Pages: 170-170
- DOI
  10.3390/cancers15010170
- Data Source
  KAKENHI-PROJECT-20K09617
[Journal Article] Ubiquitin specific peptidase 32 acts as an oncogene in epithelial ovarian cancer by deubiquitylating farnesyl-diphosphate farnesyltransferase 12021
- Author(s)
  Nakae Aya、Kodama Michiko、Okamoto Toru、Tokunaga Makoto、Shimura Hiroko、Hashimoto Kae、Sawada Kenjiro、Kodama Takahiro、Copeland Neal G.、Jenkins Nancy A.、Kimura Tadashi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 552 Pages: 120-127
- DOI
  10.1016/j.bbrc.2021.03.049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03495, KAKENHI-PROJECT-20K22978, KAKENHI-PROJECT-19H03799
[Journal Article] Sleeping Beauty Transposon Mutagenesis Identifies Genes Driving the Initiation and Metastasis of Uterine Leiomyosarcoma2021
- Author(s)
  Kodama Michiko、Shimura Hiroko、Tien Jean C.、Newberg Justin Y.、Kodama Takahiro、Wei Zhubo、Rangel Roberto、Yoshihara Kosuke、Kuruma Airi、Nakae Aya、Hashimoto Kae、Sawada Kenjiro、Kimura Tadashi、Jenkins Nancy A.、Copeland Neal G.
- Journal Title
  
  Cancer Research
  
  Volume: 81 Issue: 21 Pages: 5413-5424
- DOI
  10.1158/0008-5472.can-21-0356
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-20K09617, KAKENHI-PROJECT-16H06279
[Journal Article] Exploring the potential of engineered exosomes as delivery systems for tumor-suppressor microRNA replacement therapy in ovarian cancer2020
- Author(s)
  Kobayashi Masaki、Sawada Kenjiro、Miyamoto Mayuko、Shimizu Aasa、Yamamoto Misa、Kinose Yasuto、Nakamura Koji、Kawano Mahiru、Kodama Michiko、Hashimoto Kae、Kimura Tadashi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 527 Issue: 1 Pages: 153-161
- DOI
  10.1016/j.bbrc.2020.04.076
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09227
[Journal Article] Exosomal miR-99a-5p is elevated in sera of ovarian cancer patients and promotes cancer cell invasion by increasing fibronectin and vitronectin expression in neighboring peritoneal mesothelial cells2018
- Author(s)
  Yoshimura Akihiko、Sawada Kenjiro、Nakamura Koji、Kinose Yasuto、Nakatsuka Erika、Kobayashi Masaki、Miyamoto Mayuko、Ishida Kyoso、Matsumoto Yuri、Kodama Michiko、Hashimoto Kae、Mabuchi Seiji、Kimura Tadashi
- Journal Title
  
  BMC Cancer
  
  Volume: 18 Issue: 1 Pages: 1065-1065
- DOI
  10.1186/s12885-018-4974-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09227
[Journal Article] Exosomal miR-1290 is a potential biomarker of high-grade serous ovarian carcinoma and can discriminate patients from those with malignancies of other histological types2018
- Author(s)
  Kobayashi Masaki、Sawada Kenjiro、Nakamura Koji、Yoshimura Akihiko、Miyamoto Mayuko、Shimizu Aasa、Ishida Kyoso、Nakatsuka Erika、Kodama Michiko、Hashimoto Kae、Mabuchi Seiji、Kimura Tadashi
- Journal Title
  
  Journal of Ovarian Research
  
  Volume: 11 Issue: 1 Pages: 81-81
- DOI
  10.1186/s13048-018-0458-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09227
[Presentation] CircESRP1 promotes cell proliferation of high-grade serous ovarian cancers（HGSOC）via miR-142-3p/HMGA2 pathway2024
- Author(s)
  Tadashi Oride, Kenjiro Sawada, Yukako Oi, Aska Toda, Koji Nakamura, Mahiru Kawano, Yasuto Kinose, Michiko Kodama, Kae Hashimoto, Tadashi Kimura
- Organizer
  第76回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-22K09641
[Presentation] CircESRP1 promotes cell proliferation of high-grade serous ovarian cancers（HGSOC）via miR-142-3p/HMGA2 pathway2024
- Author(s)
  Tadashi Oride, Kenjiro Sawada, Yukako Oi, Aska Toda, Koji Nakamura, Mahiru Kawano, Yasuto Kinose, Michiko Kodama, Kae Hashimoto, Tadashi Kimura
- Organizer
  第76回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-23K08822
[Presentation] Dual blockade of BRD4 and ATR/WEE1 pathways exploits ARID1A loss in clear cell ovarian via G1 cell cycle arrest, decreased homologous recombination, and increased DNA double strand breaks2024
- Author(s)
  Yasuto Kinose, Koji Nakamura, Aska Toda, Mahiru Kawano, Michiko Kodama, Kae Hashimoto, Kenjiro Sawada, Tadashi Kimura
- Organizer
  第76回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-23K24485
[Presentation] CircSOD2 is elevated in ovarian clear cell carcinoma than high grade serous carcinoma and its suppression inhibits ovarian cancer progression via miR-224-5p/SDC4 axis.2023
- Author(s)
  Oi Y, Sawada K, Oride T, Nakamura K, Kinose Y, Kodama M, Hashimoto K, Kimura T.
- Organizer
  第75回日本産科婦人科学会学術講演会 International Session-Work Shop-3-6
- Data Source
  KAKENHI-PROJECT-22K09641
[Presentation] 全エクソーム解析による分葉状頸管腺過形成発症と胃型腺癌への進展に関与する遺伝子変異の検討2023
- Author(s)
  來間愛里, 小玉美智子, 増田達郎, 甲村奈緒子, 橋本香映, 佐藤和明, 横井猛, 澤田健二郎, 森井英一, 木村正
- Organizer
  第65回日本婦人科腫瘍学会学術講演会
- Data Source
  KAKENHI-PROJECT-23K08887
[Presentation] Identification of circular RNAs which are elevated in ovarian cancer and elucidation of their roles2022
- Author(s)
  Yukako Oi, Kenjiro Sawada, Misa Yamamoto, Koji Nakamura, Yasuto Kinose, Michiko Kodama, Kae Hashimoto, Tadashi Kimura
- Organizer
  第74回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-22K09641
[Presentation] Establishment of a patient-derived xenograft（PDX）mouse model of rare gynecologic tumor for precision medicine. An example of mesonephric adenocarcinoma2022
- Author(s)
  Kasuya Kanako, Kinose Yasuto, Toda Aska, Nakamura Koji, Kodama Michiko, Hashimoto Kae, Sawada Kenjiro, Kimura Tadashi
- Organizer
  第74回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-23K24485
[Presentation] Excellent Usefulness of Engineered Exosomes as a Carrier for Tumor-suppressor microRNA Replacement Therapy of Ovarian Cancer2021
- Author(s)
  kobayashi, M. Sawada, K. Miyamoto, M. Shimizu, A. Yamamoto, M. Kawano, M. Kodama, M. Hashimoto, K. Kimura, T.
- Organizer
  第62回日本婦人科腫瘍学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K09227
[Presentation] Screening of cancer driver genes involved in sarcomagenesis and metastasis of uterine leiomyosarcoma using Sleeping Beauty transposon2020
- Author(s)
  Hiroko Shimura, Michiko Kodama, Kosuke Yoshihara, Aya Nakae, Kae Hashimoto, Kenjiro Sawada, Tadashi Kimura
- Organizer
  第72回日本産科婦人科学術講演会
- Data Source
  KAKENHI-PROJECT-20K09617
[Presentation] The potential of engineered exosomes as a carrier of tumor-suppressor microRNA replacement therapy for ovarian cancer2020
- Author(s)
  Kobayashi, M. Sawada, K. Miyamoto, M. Shimizu, A. Yamamoto, M. Kawano, M. Kodama, M. Hashimoto, K. Kimura, T.
- Organizer
  第72回日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-18K09227
[Presentation] Functional analysis of USP32, detected from in vivo shRNA library screen, as a therapeutic target of epithelial ovarian cancer2020
- Author(s)
  Aya Nakae, Michiko Kodama, Hiroko Shimura, Kae Hashimoto, Kenjiro Sawada, Tadashi Kimura
- Organizer
  第72回日本産科婦人科学術講演会
- Data Source
  KAKENHI-PROJECT-19H03799
[Presentation] Potential of patient-derived exosomes as a carrier of siRNA delivery for the treatment of ovarian cancer peritoneal dissemination2020
- Author(s)
  Shimizu, A. Sawada, K. Kobayashi, M. Miyamoto, M. Kinose, Y. Kodama, M. Hashimoto, K. Kimura, T.
- Organizer
  第72回日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-18K09227
[Presentation] In vivo pooled shRNA library screening identifies USP32 as a new drug target of epithelial ovarian cancer2019
- Author(s)
  Nakae, A. Kimura, T. Sawada, K. Kodama, M. Hashimoto, K. Nakatsuka, E.
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03799
[Presentation] Sleeping beauty transposon mutagenesis screen identified cancer genes driving sarcomagenesis and metastases of uterine leiomyosarcoma2019
- Author(s)
  小玉美智子. 中江　彩. 吉原弘祐. 橋本香映. 澤田健二郎. 木村　正.
- Organizer
  第61回日本婦人科腫瘍学会
- Data Source
  KAKENHI-PROJECT-19H03799
[Presentation] 平滑筋肉腫の新しい動物モデルを用いたゲノム解析2019
- Author(s)
  小玉美智子
- Organizer
  第4回日本肉腫学会
- Data Source
  KAKENHI-PROJECT-17K11277
[Presentation] Combination of in vivo shRNA library screening and cancer microarray database identifies USP32 as a new drug target of ovarian cancer2019
- Author(s)
  Nakae, A. Kodama, M. Nakatsuka, E. Kawano, M. Matsumoto, Y. Hashimoto, K. Mabuchi, S. Sawada, K. Kimura, T.
- Organizer
  第71回日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-19H03799
[Presentation] Sleeping beauty transposon mutagenesis screen identified cancer genes driving sarcomagenesis and metastases of uterine leiomyosarcoma2019
- Author(s)
  小玉美智子　中江彩　吉原弘祐　橋本香映　澤田健二郎　木村正
- Organizer
  第61回日本婦人科腫瘍学会
- Data Source
  KAKENHI-PROJECT-17K11277
[Presentation] Sleeping Beauty transposon insertional mutagenesis screen of uterine leiomyosarcoma identified cancer genes driving sarcomagenesis.2018
- Author(s)
  Michiko Kodama, Takahiro Kodama, Justin Y. Newberg, Jean C. Tien, Roberto Rangel, Aya Nakae, Tadashi Kimura, Neal G. Copeland, Nancy A. Jenkins.
- Organizer
  11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research: Biology to Precision Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11277
[Presentation] Sleeping beauty transposon insertional mutagenesis identified driver genes of uterine leiomyosarcoma.2018
- Author(s)
  Michiko Kodama, Hiroko Shimura, Aya Nakae, Kae Hashimoto, Seiji Mabuchi, Kenjiro Sawada, Tadashi Kimura.
- Organizer
  The 17th Biennial Meeting of the International Gynecologic Cancer Society (International Gynecologic Cancer Society)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11277
[Presentation] トランスポゾンを用いたマウス子宮平滑筋肉腫発症に関与するドライバー遺伝子のスクリーニング2018
- Author(s)
  小玉美智子　中江彩　志村寛子　橋本香映　馬淵誠士　澤田健二郎　木村正
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K11277
[Presentation] Sleeping Beauty transposon mutagenesis screen identifies cancer genes of uterine leiomyosarcoma driving sarcomagenesis and lung metastasis.2018
- Author(s)
  Michiko Kodama, Takahiro Kodama, Justin Y. Newberg, Jean C. Tien, Roberto Rangel, Aya Nakae, Kae Hashimoto, Seiji Mabuchi, Kenjiro Sawada, Tadashi Kimura, Nancy A. Jenkins, Neal G. Copeland.
- Organizer
  AACR Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11277

1. Sawada Kenjiro (00452392)

# of Collaborated Projects: 12 results

# of Collaborated Products: 23 results
2. Hashimoto Kae (90612078)

# of Collaborated Projects: 8 results

# of Collaborated Products: 12 results
3. 木瀬康人 (90778531)

# of Collaborated Projects: 7 results

# of Collaborated Products: 6 results
4. 中村幸司 (00900151)

# of Collaborated Projects: 6 results

# of Collaborated Products: 6 results
5. Kimura Tadashi (90240845)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
6. 馬淵誠士 (00452441)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
7. 松本有里 (90756488)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 上田豊 (10346215)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 遠藤誠之 (30644794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 瀧内剛 (40733358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 中塚えりか (00816514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 戸田有朱香 (00884610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 岡村綾子 (40910253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. OKAMOTO Toru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 小玉尚宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kodama Michiko 小玉 美智子

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網羅的ゲノム解析・微小環境空間的解析による子宮頸部胃型腺癌の発症・治療戦略の樹立Principal Investigator

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Investigation of sarcomagenesis and progression mechanisms in uterine leiomyosarcoma by transposon screening methodPrincipal Investigator

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Sleeping Beauty Transposon mutagenesis screen for identifying driver genes in uterine leiomyosarcomaPrincipal Investigator

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[Journal Article] Ring Finger Protein 125 Is an Anti-Proliferative Tumor Suppressor in Hepatocellular Carcinoma2022

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[Journal Article] Gastric-Type Adenocarcinoma of the Uterine Cervix Associated with Poor Response to Definitive Radiotherapy2022

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Kodama Michiko 小玉美智子