shingai yasuhiro 新開泰宏

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Shingai Yasuhiro 新開泰宏

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Researcher Number	70791614
Other IDs
Affiliation (Current)	2025: 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 血液内科医長
Affiliation (based on the past Project Information) *help	2022 – 2023: 大阪大学, 大学院医学系研究科, 招へい教員 2021: 大阪大学, 医学系研究科, 招へい教員 2018 – 2020: 大阪大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator TGFβシグナル / 急性骨髄性白血病 / 不均一性 / ESAM / 白血病幹細胞 Except Principal Investigator 血管内皮関連抗原 / 白血病幹細胞 / 幹細胞 / 可塑性 / サイトカインシグナル … More / 腫瘍幹細胞 / 急性骨髄性白血病 / 免疫 / 造血 / リンパ球 / クロマチン構造調節蛋白 / クロマチン構造制御タンパク / リンパ球分化 / 老化 / 造血幹細胞 Less

Therapeutic Development Targeting Autonomous Cytokine Signaling Inducing Leukemia Stem Cell Heterogeneity
- Principal Investigator
  
  Takafumi Yokota
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Osaka University
Analysis of heterogeneity and fluctuation of leukemic stem cells and its application to leukemia therapyPrincipal Investigator
- Principal Investigator
  
  Shingai Yasuhiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Osaka University
Innovation of new methods rejuvenating lymphopoietic activity in aged hematopoietic stem cells
- Principal Investigator
  
  Yokota Takafumi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] A single‐institution pre-post comparison of subcutaneous immunoglobulin replacement therapy in allogeneic haematopoietic cell transplantation recipients2024
- Author(s)
  Suga Makiko、Fuji Shigeo、Tada Yuma、Tsutsumi Kazuhito、Kida Shuhei、Shibata Kumi、Nakata Ryo、Shingai Yasuhiro、Yuda Sayako、Yokota Takafumi、Ishikawa Jun
- Journal Title
  
  British Journal of Haematology
  
  Volume: 204 Issue: 1 Pages: 260-267
- DOI
  10.1111/bjh.19203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08415
[Journal Article] A treatment strategy to mitigate the adverse effect of pretransplant mogamulizumab on post‐transplant clinical outcome in patients with aggressive ATL2024
- Author(s)
  Fuji Shigeo、Yuda Sayako、Tada Yuma、Kano Mitsuki、Sanda Kazuhiro、Fujishita Keigo、Terakawa Takuya、Shingai Yasuhiro、Kasahara Hidenori、Yokota Takafumi、Ishikawa Jun
- Journal Title
  
  British Journal of Haematology
  
  Volume: 204 Issue: 2
- DOI
  10.1111/bjh.19231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08415
[Journal Article] Gilteritinib in peritransplant period for relapsed or refractory FLT3-mutated acute myeloid leukemia: A case report of three patients2023
- Author(s)
  Mima F, Fuji S, Shibata K, Kida S, Tsutsumi K, Tada Y, Shingai Y, Yuda S, Yokota T, Ishikawa J
- Journal Title
  
  BLOOD CELL THERAPY / The official journal of APBMT
  
  Volume: 6 Issue: 3 Pages: 77-79
- DOI
  10.31547/bct-2023-003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08415
[Journal Article] A case of severe oral mucosal GVHD induced by heterologous SARS-CoV-2 vaccination after cord blood transplantation2023
- Author(s)
  Sanda K, Fuji S, Satomi H, Kitamura M, Nishimura N, Tada Y, Shingai Y, Yuda S, Yokota T, Ishikawa J
- Journal Title
  
  BLOOD CELL THERAPY / The official journal of APBMT
  
  Volume: 6 Issue: 2 Pages: 49-53
- DOI
  10.31547/bct-2022-019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08415
[Journal Article] Special AT-Rich Sequence-Binding Protein 1 Supports Survival and Maturation of Naive B Cells Stimulated by B Cell Receptors2022
- Author(s)
  Ozawa Takayuki、Fujii Kentaro、Sudo Takao、Doi Yukiko、Nakai Ritsuko、Shingai Yasuhiro、Ueda Tomoaki、Baba Yoshihiro、Hosen Naoki、Yokota Takafumi
- Journal Title
  
  The Journal of Immunology
  
  Volume: 208 Issue: 8 Pages: 1937-1946
- DOI
  10.4049/jimmunol.2101097
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17378, KAKENHI-PROJECT-20K16356, KAKENHI-PROJECT-21K08415
[Journal Article] Autoimmune-mediated thrombocytopenia after allogeneic hematopoietic stem cell transplantation: significance of detecting reticulated platelets and glycoprotein-specific platelet autoantibodies2022
- Author(s)
  Akuta Keigo、Fukushima Kentaro、Nakata Keiichi、Hayashi Satoru、Toda Jun、Shingai Yasuhiro、Tsutsumi Kazuhito、Machida Tomohisa、Hino Akihisa、Kusakabe Shinsuke、Doi Yukiko、Fujita Jiro、Kato Hisashi、Maeda Tetsuo、Yokota Takafumi、Tomiyama Yoshiaki、Hosen Naoki、Kashiwagi Hirokazu
- Journal Title
  
  International Journal of Hematology
  
  Volume: 115 Issue: 3 Pages: 322-328
- DOI
  10.1007/s12185-021-03272-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08813, KAKENHI-PROJECT-21K08371, KAKENHI-PROJECT-21K08415, KAKENHI-PROJECT-22K08476
[Journal Article] Autonomous TGFβ signaling induces phenotypic variation in human acute myeloid leukemia2021
- Author(s)
  Yasuhiro Shingai , Takafumi Yokota，et al
- Journal Title
  
  Stem cells
  
  Volume: - Issue: 6 Pages: 723-736
- DOI
  10.1002/stem.3348
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16356, KAKENHI-PROJECT-18K08355, KAKENHI-PROJECT-19K17622, KAKENHI-PROJECT-19K08861, KAKENHI-PROJECT-19K08863, KAKENHI-PROJECT-20K17378, KAKENHI-PROJECT-21K08415
[Journal Article] Endothelial Cell-Selective Adhesion Molecule Contributes to the Development of Definitive Hematopoiesis in the Fetal Liver2019
- Author(s)
  Ueda Tomoaki、Yokota Takafumi、Okuzaki Daisuke、Uno Yoshihiro、Mashimo Tomoji、Kubota Yoshiaki、Sudo Takao、Ishibashi Tomohiko、Shingai Yasuhiro、Doi Yukiko、Ozawa Takayuki、Nakai Ritsuko、Tanimura Akira、Ichii Michiko、Ezoe Sachiko、Shibayama Hirohiko、Oritani Kenji、Kanakura Yuzuru
- Journal Title
  
  Stem Cell Reports
  
  Volume: 13 Issue: 6 Pages: 992-1005
- DOI
  10.1016/j.stemcr.2019.11.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08355, KAKENHI-PROJECT-19K08861, KAKENHI-PROJECT-19K08863, KAKENHI-PROJECT-19K17622, KAKENHI-PROJECT-18KK0307, KAKENHI-PROJECT-18H03974, KAKENHI-PROJECT-18K16114
[Journal Article] Variable SATB1 Levels Regulate Hematopoietic Stem Cell Heterogeneity with Distinct Lineage Fate2018
- Author(s)
  Yukiko Doi, Takafumi Yokota, Yusuke Satoh, Daisuke Okuzaki, Masahiro Tokunaga, Tomohiko Ishibashi, Takao Sudo, Tomoaki Ueda, Yasuhiro Shingai, Michiko Ichii, Akira Tanimura, Sachiko Ezoe, Hirohiko Shibayama, Terumi Kohwi-Shigematsu, Junji Takeda, Kenji Oritani, and Yuzuru Kanakura
- Journal Title
  
  Cell Reports
  
  Volume: 23 Issue: 11 Pages: 3223-3235
- DOI
  10.1016/j.celrep.2018.05.042
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09952, KAKENHI-PROJECT-18K08355, KAKENHI-PROJECT-16H05339, KAKENHI-PROJECT-16K09871, KAKENHI-PROJECT-16K09872, KAKENHI-PROJECT-16K09874, KAKENHI-PROJECT-18K19445, KAKENHI-PROJECT-17K16201
[Presentation] Mitochondrial complex-I dysfunction impairs the early stage of B-lymphoid differentiation in mice2021
- Author(s)
  Ritsuko Nakai, Takafumi Yokota, Takao Sudo, Daisuke Okuzaki, Yoshihiro Uno, Tomoaki Ueda, Yasuhiro Shingai, Takayuki Ozawa, Tomoaki Shinohara, Masashi Suganuma, Naoki Hosen
- Organizer
  日本免疫学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08415
[Presentation] Autonomous TGFβ signaling promotes phenotypic variations of human AML cells2020
- Author(s)
  Yasuhiro Shingai
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-20K16356
[Presentation] Autonomous TGFβ signaling induces phenotypic variation in human acute myeloid leukemia.2020
- Author(s)
  Yasuhiro Shingai, Takafumi Yokota, Daisuke Okuzaki, Takao Sudo, Tomohiko Ishibashi, Yukiko Doi, Tomoaki Ueda, Takayuki Ozawa, Ritsuko Nakai, Akira Tanimura, Michiko Ichii, Hirohiko Shibayama, Yuzuru Kanakura, Naoki Hosen
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-18K08355
[Presentation] Special AT-Rich Sequence Binding Protein 1 Is Involved in Function of B Cell’s Antigen Presentation2020
- Author(s)
  Takayuki Ozawa, Takafumi Yokota, Ritsuko Nakai, Yasuhiro Shingai, Tomoaki Ueda, Yukiko Doi, Hirohiko Shibayama, Naoki Hosen
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-18K08355
[Presentation] ESAM on the Cells of Endothelial Lineage Plays an Important Role in the Development of Definitive Hematopoiesis2018
- Author(s)
  Tomoaki Ueda, Takafumi Yokota, Yoshihiro Uno, Tomoji Mashimo, Takao Sudo, Tomohiko Ishibashi, Yukiko Doi1, Yasuhiro Shingai, Akira Tanimura, Michiko Ichii, Sachiko Ezoe, Hirohiko Shibayama, Kenji Oritani, Yuzuru Kanakura
- Organizer
  The American Society of Hematology 60th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08355
[Presentation] クロマチン構造制御蛋白SATB1はリンパ球分化における造血幹細胞の機能的ゆらぎに関与する2018
- Author(s)
  土居由貴子, 横田貴史, 佐藤友亮, 石橋知彦, 数藤孝雄, 上田智朗, 新開泰宏, 小澤孝幸, 一井倫子, 谷村朗, 江副幸子, 柴山浩彦, Terumi Kohwi-Shigematsu, 織谷健司, 金倉譲
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08355
[Presentation] B細胞免疫寛容におけるSATB1蛋白の機能的意義について2018
- Author(s)
  小澤孝幸, 横田貴史, 新開泰宏, 上田智朗, 土居由貴子, 柴山浩彦, 金倉譲
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08355
[Presentation] Monitoring ESAM Expression Levels Reveals Autonomous Fluctuation of Leukemia Stem Cells By Autocrine/Paracrine Cytokine Signaling2018
- Author(s)
  Yasuhiro Shingai, Takafumi Yokota, Takayuki Ozawa, Tomoaki Ueda, Yukiko Doi, Tomohiko Ishibashi, Akira Tanimura, Michiko Ichii, Hirohiko Shibayama, Yuzuru Kanakura
- Organizer
  The American Society of Hematology 60th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08355

1. Yokota Takafumi (60403200)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
2. 上田智朗 (60747517)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
3. 金倉譲 (20177489)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. 土居由貴子 (60722288)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. 小澤孝幸 (90815474)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. KASHIWAGI Hirokazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 数藤孝雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 加藤恒

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 冨山佳昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

shingai yasuhiro 新開 泰宏

Shingai Yasuhiro 新開 泰宏

Research Projects

Research Products

Co-Researchers

Therapeutic Development Targeting Autonomous Cytokine Signaling Inducing Leukemia Stem Cell Heterogeneity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of heterogeneity and fluctuation of leukemic stem cells and its application to leukemia therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Innovation of new methods rejuvenating lymphopoietic activity in aged hematopoietic stem cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] A single‐institution pre-post comparison of subcutaneous immunoglobulin replacement therapy in allogeneic haematopoietic cell transplantation recipients2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A treatment strategy to mitigate the adverse effect of pretransplant mogamulizumab on post‐transplant clinical outcome in patients with aggressive ATL2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gilteritinib in peritransplant period for relapsed or refractory FLT3-mutated acute myeloid leukemia: A case report of three patients2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A case of severe oral mucosal GVHD induced by heterologous SARS-CoV-2 vaccination after cord blood transplantation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Special AT-Rich Sequence-Binding Protein 1 Supports Survival and Maturation of Naive B Cells Stimulated by B Cell Receptors2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Autoimmune-mediated thrombocytopenia after allogeneic hematopoietic stem cell transplantation: significance of detecting reticulated platelets and glycoprotein-specific platelet autoantibodies2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Autonomous TGFβ signaling induces phenotypic variation in human acute myeloid leukemia2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endothelial Cell-Selective Adhesion Molecule Contributes to the Development of Definitive Hematopoiesis in the Fetal Liver2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Variable SATB1 Levels Regulate Hematopoietic Stem Cell Heterogeneity with Distinct Lineage Fate2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] Mitochondrial complex-I dysfunction impairs the early stage of B-lymphoid differentiation in mice2021

Author(s)

Organizer

Data Source

[Presentation] Autonomous TGFβ signaling promotes phenotypic variations of human AML cells2020

Author(s)

Organizer

Data Source

[Presentation] Autonomous TGFβ signaling induces phenotypic variation in human acute myeloid leukemia.2020

Author(s)

Organizer

Data Source

shingai yasuhiro 新開泰宏

Shingai Yasuhiro 新開泰宏