Okanishi Hiroki 岡西広樹

… Alternative Names

Hiroki Okanishi 岡西広樹

Less

Researcher Number	70792589
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 助教
Affiliation (based on the past Project Information) *help	2022 – 2025: 大阪大学, 大学院医学系研究科, 助教 2018 – 2021: 大阪大学, 医学系研究科, 助教 2018: 熊本大学, 大学院生命科学研究部(医), 産学官連携研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related Except Principal Investigator Basic Section 48030:Pharmacology-related / Medium-sized Section 48:Biomedical structure and function and related fields / Basic Section 48040:Medical biochemistry-related
Keywords	Principal Investigator リン酸化プロテオミクス / プロテオミクス / トランスポーター / アミノ酸 / チロシンリン酸化 / アミノ酸トランスポーター / シグナル伝達 Except Principal Investigator アミノ酸 / シグナル情報伝達 / トランスポーター … More / 輸送体 / 受容体 / アミノ酸トランスポーター / 細胞休眠化 / 細胞周期 / アミノ酸トランスポータ / シグナル伝達 / がん / 細胞代謝制御 / 細胞内代謝制御 / 抗腫瘍薬 / 寿命 Less

がん特異的LAT1アミノ酸シグナルにおけるIGF-1R活性調節機構の解明Principal Investigator
- Principal Investigator
  
  岡西広樹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  The University of Osaka
Elucidation of the transmembrane signal mechanism responsible for metabolic control by amino acid availability
- Principal Investigator
  
  Kanai Yoshikatsu
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  Osaka University
アミノ酸輸送体LAT1依存的リン酸化シグナルにおけるチロシンリン酸化制御機構解明Principal Investigator
- Principal Investigator
  
  岡西広樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Osaka University
がん細胞アミノ酸輸送体阻害薬の強力な細胞周期制御の機序と細胞休眠化機構の解明
- Principal Investigator
  
  金井好克
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Osaka University
Identification and mechanistic analysis of intracellular amino acid sensors and their potential as drug targets
- Principal Investigator
  
  Okuda Suguru
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  The University of Tokyo
  Osaka University
Revealing of phosphorylation signaling in the downstream of LAT1 in cancer cellsPrincipal Investigator
- Principal Investigator
  
  Hiroki Okanishi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Osaka University
Study on the amino acid signaling via transporters and receptors for the pharmacologic control of cellular metabolism
- Principal Investigator
  
  Kanai Yoshikatsu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Osaka University
アセチル化プロテオミクスによるグリオーマ幹細胞の治療標的解明Principal Investigator
- Principal Investigator
  
  岡西広樹
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kumamoto University
Study on the effects of amino acid availability on life span and the underlying molecular mechanisms
- Principal Investigator
  
  Kanai Yoshikatsu
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Identification of tumor-suppressive miRNAs that target amino acid transporter LAT1 and exhibit anti-proliferative effects on cholangiocarcinoma cells2024
- Author(s)
  Liu Xingming、Nishikubo Kou、Ohgaki Ryuichi、Okanishi Hiroki、Okuda Suguru、Xu Minhui、Kanai Yoshikatsu
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: － Issue: 4 Pages: 301-311
- DOI
  10.1016/j.jphs.2024.02.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06856, KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-21K20742, KAKENHI-PROJECT-22KJ2171, KAKENHI-PROJECT-23K24071
[Journal Article] Structure activity characteristics of phenylalanine analogs selectively transported by L-type amino acid transporter 1 (LAT1)2024
- Author(s)
  Chen Sihui、Jin Chunhuan、Ohgaki Ryuichi、Xu Minhui、Okanishi Hiroki、Kanai Yoshikatsu
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41598-024-55252-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K19451, KAKENHI-PROJECT-22K06856, KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-21K20742, KAKENHI-PROJECT-23K24071
[Journal Article] Upregulation of ATF4 mediates the cellular adaptation to pharmacologic inhibition of amino acid transporter LAT1 in pancreatic ductal adenocarcinoma cells2024
- Author(s)
  Ma Yu、Okuda Suguru、Okanishi Hiroki、Xu Minhui、Jin Chunhuan、Endou Hitoshi、Ohgaki Ryuichi、Kanai Yoshikatsu
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 155 Issue: 1 Pages: 14-20
- DOI
  10.1016/j.jphs.2024.03.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K19451, KAKENHI-PROJECT-22K06856, KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-21K20742, KAKENHI-PROJECT-23K24071
[Journal Article] Inhibition of amino acid transporter LAT1 in cancer cells suppresses G0/G1-S transition by downregulating cyclin D1 via p38 MAPK activation2024
- Author(s)
  Zhou Xinyu、Ohgaki Ryuichi、Jin Chunhuan、Xu Minhui、Okanishi Hiroki、Endou Hitoshi、Kanai Yoshikatsu
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 154 Issue: 3 Pages: 182-191
- DOI
  10.1016/j.jphs.2024.01.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K19451, KAKENHI-PROJECT-22K06856, KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-21K20742, KAKENHI-PROJECT-23K24071
[Journal Article] Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells2023
- Author(s)
  Nishikubo Kou、Ohgaki Ryuichi、Liu Xingming、Okanishi Hiroki、Xu Minhui、Endou Hitoshi、Kanai Yoshikatsu
- Journal Title
  
  Cancer Cell International
  
  Volume: 23 Issue: 1 Pages: 116-116
- DOI
  10.1186/s12935-023-02957-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06856, KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-21K20742, KAKENHI-PROJECT-22KJ2171, KAKENHI-PROJECT-23K24071
[Journal Article] The Clinical Potential of FBPA-PET/CT Imaging for Colorectal Cancer and its Liver Metastases Expressing LAT12023
- Author(s)
  MINOJI TAKAYUKI、TAKAHASHI HIDEKAZU、WATABE TADASHI、ISHIKAWA SATOSHI、KATO HIROKI、OHGAKI RYUICHI、KANAI YOSHIKATSU、SEKIDO YUKI、HATA TSUYOSHI、HAMABE ATSUSHI、OGINO TAKAYUKI、MIYOSHI NORIKATSU、UEMURA MAMORU、YAMAMOTO HIROFUMI、DOKI YUICHIRO、EGUCHI HIDETOSHI
- Journal Title
  
  Anticancer Research
  
  Volume: 43 Issue: 9 Pages: 3913-3921
- DOI
  10.21873/anticanres.16579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06856, KAKENHI-PROJECT-23K08128, KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-23K24071
[Journal Article] Inhibition of cancer-type amino acid transporter LAT1 suppresses B16-F10 melanoma metastasis in mouse models2023
- Author(s)
  Shi Zitong、Kaneda-Nakashima Kazuko、Ohgaki Ryuichi、Xu Minhui、Okanishi Hiroki、Endou Hitoshi、Nagamori Shushi、Kanai Yoshikatsu
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 13943-13943
- DOI
  10.1038/s41598-023-41096-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06856, KAKENHI-PROJECT-21K07619, KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-21K20742, KAKENHI-PROJECT-21H03365, KAKENHI-PROJECT-23K24071
[Journal Article] Evaluation of LAT1 Expression in Patients With Lung Cancer and Mediastinal Tumors2023
- Author(s)
  Watabe Tadashi、Ose Naoko、Naka Sadahiro、Fukui Eriko、Kimura Toru、Kanou Takashi、Funaki Soichiro、Sasaki Hidetaka、Kamiya Takashi、Kurimoto Kenta、Isohashi Kayako、Tatsumi Mitsuaki、Shimosegawa Eku、Kato Hiroki、Ohgaki Ryuichi、Kanai Yoshikatsu、Shintani Yasushi
- Journal Title
  
  Clinical Nuclear Medicine
  
  Volume: 48 Issue: 10 Pages: 853-860
- DOI
  10.1097/rlu.0000000000004816
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06856, KAKENHI-PROJECT-22K07706, KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-23K24071
[Journal Article] Crystal structure of a nucleotide-binding domain of fatty acid kinase FakA from Thermus thermophilus HB82022
- Author(s)
  Nakatani Maya、Nakahara Shun-ya、Fukui Kenji、Urano Momoka、Fujii Yuki、Murakawa Takeshi、Baba Seiki、Kumasaka Takashi、Okanishi Hiroki、Kanai Yoshikatsu、Yano Takato、Masui Ryoji
- Journal Title
  
  Journal of Structural Biology
  
  Volume: 214 Issue: 4 Pages: 107904-107904
- DOI
  10.1016/j.jsb.2022.107904
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-23K24071
[Journal Article] Functional coupling of organic anion transporter OAT10 (SLC22A13) and monocarboxylate transporter MCT1 (SLC16A1) influencing the transport function of OAT102022
- Author(s)
  Ohtsu Naoko、Ohgaki Ryuichi、Jin Chunhuan、Xu Minhui、Okanishi Hiroki、Takahashi Ryo、Matsui Akiko、Kishimoto Wataru、Ishiguro Naoki、Kanai Yoshikatsu
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 150 Issue: 1 Pages: 41-48
- DOI
  10.1016/j.jphs.2022.06.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-21K20742, KAKENHI-PROJECT-23K24071
[Journal Article] Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of l-type amino acid transporter 12022
- Author(s)
  Okanishi Hiroki、Ohgaki Ryuichi、Xu Minhui、Endou Hitoshi、Kanai Yoshikatsu
- Journal Title
  
  Cancer & Metabolism
  
  Volume: 10 Issue: 1 Pages: 18-18
- DOI
  10.1186/s40170-022-00295-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06856, KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-21K20742, KAKENHI-PROJECT-23K24071
[Journal Article] Pharmacologic inhibition of LAT1 predominantly suppresses transport of large neutral amino acids and downregulates global translation in cancer cells2022
- Author(s)
  Nishikubo Kou、Ohgaki Ryuichi、Okanishi Hiroki、Okuda Suguru、Xu Minhui、Endou Hitoshi、Kanai Yoshikatsu
- Journal Title
  
  Journal of Cellular and Molecular Medicine
  
  Volume: 26 Issue: 20 Pages: 5246-5256
- DOI
  10.1111/jcmm.17553
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06856, KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-21K20742, KAKENHI-PROJECT-22KJ2171, KAKENHI-PROJECT-20K07327, KAKENHI-PROJECT-23K24071
[Journal Article] Interaction of Halogenated Tyrosine/Phenylalanine Derivatives with Organic Anion Transporter 1 in the Renal Handling of Tumor Imaging Probes2020
- Author(s)
  Jin Chunhuan、Wei Ling、Ohgaki Ryuichi、Tominaga Hideyuki、Xu Minhui、Okuda Suguru、Okanishi Hiroki、Kawamoto Yasuharu、He Xin、Nagamori Shushi、Kanai Yoshikatsu
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics
  
  Volume: 375 Issue: 3 Pages: 451-462
- DOI
  10.1124/jpet.120.000235
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07327, KAKENHI-PROJECT-19H03407, KAKENHI-PROJECT-18K06931, KAKENHI-PROJECT-19H05648
[Journal Article] Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation2020
- Author(s)
  Quan Lili、Ohgaki Ryuichi、Hara Saori、Okuda Suguru、Wei Ling、Okanishi Hiroki、Nagamori Shushi、Endou Hitoshi、Kanai Yoshikatsu
- Journal Title
  
  Journal of Experimental & Clinical Cancer Research
  
  Volume: 39 Issue: 1 Pages: 266-266
- DOI
  10.1186/s13046-020-01762-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07327, KAKENHI-PROJECT-19H03407, KAKENHI-PROJECT-18K06931, KAKENHI-PROJECT-19H05648
[Journal Article] Proteomics and phosphoproteomics reveal key regulators associated with cytostatic effect of amino acid transporter LAT1 inhibitor2020
- Author(s)
  Okanishi Hiroki、Ohgaki Ryuichi、Okuda Suguru、Endou Hitoshi、Kanai Yoshikatsu
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 2 Pages: 871-883
- DOI
  10.1111/cas.14756
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07327, KAKENHI-PROJECT-19H03407, KAKENHI-PROJECT-18K06931, KAKENHI-PROJECT-19K16743
[Presentation] がん細胞におけるアミノ酸トランスポーター LAT1 の阻害は p38 MAPK 活性化を介したサイクリン D1 の下方制御により G0/G1 期から S 期への移行を抑制する2024
- Author(s)
  Zhou Xinyu、大垣隆一、Jin Chunhuan、Xu Minhui、岡西広樹、遠藤仁、金井好克
- Organizer
  第144回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-23K24071
[Presentation] がん細胞におけるアミノ酸トランスポーター LAT1 の阻害は p38 MAPK 活性化を介したサイクリン D1 の下方制御により G0/G1 期から S 期への移行を抑制する2024
- Author(s)
  Zhou Xinyu、大垣隆一、Jin Chunhuan、Xu Minhui、岡西広樹、遠藤仁、金井好克
- Organizer
  第144回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-22K19404
[Presentation] 個々のアミノ酸の細胞内濃度の経時変化と機能に着目したLAT1阻害薬のがん細胞増殖抑制のメカニズムの解明2023
- Author(s)
  西窪航、大垣隆一、岡西広樹、徐旻恵;、遠藤仁、金井好克
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K24071
[Presentation] 内在性モノカルボン酸トランスポーター MCT1 との機能共役はHEK293 細胞において発現させた有機アニオントランスポーター OAT10 の輸送機能に影響する2023
- Author(s)
  大津尚子、大垣隆一、金春奐、徐旻恵、岡西広樹、髙橋亮、松井明子、佐藤正延、岸本航、石黒直樹、金井好克
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K24071
[Presentation] 膵臓がん及び胆管がん細胞に対するアミノ酸トランスポーターLAT1阻害薬nanvuranlatと細胞障害性抗がん薬の併用効果の検討2023
- Author(s)
  西窪航、大垣隆一、劉星明、岡西広樹、徐旻恵;、遠藤仁、金井好克
- Organizer
  第143回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-23K24071
[Presentation] 内在性モノカルボン酸トランスポーター MCT1 との機能共役はHEK293 細胞において発現させた有機アニオントランスポーター OAT10 の輸送機能に影響する2023
- Author(s)
  大津尚子、大垣隆一、金春奐、徐旻恵、岡西広樹、髙橋亮、松井明子、佐藤正延、岸本航、石黒直樹、金井好克
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K19404
[Presentation] アミノ酸トランスポーターLAT1阻害薬のT細胞活性化によるPD-1阻害薬抗腫瘍効果の増進2023
- Author(s)
  徐旻恵, 周新宇, 金春奐, 岡西広樹, 大垣隆一, 遠藤仁, 金井好克
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K19404
[Presentation] 低酸素誘導因子の蓄積が大腸がん細胞におけるアミノ酸トランスポーターLAT1の発現に与える影響2023
- Author(s)
  大垣隆一、平瀬悠真、岡西広樹、徐旻恵、金井好克
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K19404
[Presentation] 個々のアミノ酸の細胞内濃度の経時変化と機能に着目したLAT1阻害薬のがん細胞増殖抑制のメカニズムの解明2023
- Author(s)
  西窪航、大垣隆一、岡西広樹、徐旻恵、遠藤仁、金井好克
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K19404
[Presentation] 膵臓がん及び胆管がん細胞に対するアミノ酸トランスポーターLAT1阻害薬nanvuranlatと細胞障害性抗がん薬の併用効果の検討2023
- Author(s)
  西窪航、大垣隆一、劉星明、岡西広樹、徐旻恵、遠藤仁、金井好克
- Organizer
  第143回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-22K19404
[Presentation] 低酸素誘導因子の蓄積が大腸がん細胞におけるアミノ酸トランスポーターLAT1の発現に与える影響2023
- Author(s)
  大垣隆一、平瀬悠真、岡西広樹、徐旻恵;、金井好克
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K24071
[Presentation] アミノ酸トランスポーターLAT1阻害薬のT細胞活性化によるPD-1阻害薬抗腫瘍効果の増進2023
- Author(s)
  徐旻恵, 周新宇, 金春奐, 岡西広樹, 大垣隆一, 遠藤仁, 金井好克
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24071
[Presentation] アミノ酸トランスポーターLAT1阻害薬が腫瘍細胞の大型中性アミノ酸輸送とタンパク質合成に与える影響2022
- Author(s)
  西窪航、大垣隆一、岡西広樹、奥田傑、徐旻恵、遠藤仁、金井好克
- Organizer
  第141回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-20K07327
[Presentation] がん特異的アミノ酸トランスポーターLAT1阻害薬JPH203による胆道がん細胞内アミノ酸プールの破綻に伴うリン酸化プロテオーム解析2022
- Author(s)
  岡西広樹, 大垣隆一, Xu Minhui, 遠藤仁, 金井好克
- Organizer
  第142回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-22K19404
[Presentation] がん特異的アミノ酸トランスポーターLAT1 阻害薬JPH203 による胆道がん細胞内アミノ酸プールの破綻に伴うリン酸化プロテオーム解析2022
- Author(s)
  岡西広樹, 大垣隆一, Xu Minhui, 遠藤仁, 金井好克
- Organizer
  第142回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-23K24071
[Presentation] がん細胞由来エクソソーム上におけるアミノ酸トランスポーターLAT1（SLC7A5）の発現：予後および診断バイオマーカーとしての潜在的価値2022
- Author(s)
  大垣隆一, Liu Yumiao, Xu Minhui, 岡西広樹, 金井好克
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K19404
[Presentation] Inhibition of amino acid transporter LAT1 drastically suppresses the transport of large neutral amino acids and induces the downregulation of global translation in cancer cells2022
- Author(s)
  西窪航、大垣隆一、岡西広樹、奥田傑、徐旻恵、遠藤仁、金井好克
- Organizer
  第96回　日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07327
[Presentation] アミノ酸トランスポーターLAT1の阻害はがん細胞における大型中性アミノ酸輸送を顕著に低下させグローバルな翻訳抑制を誘導する2022
- Author(s)
  西窪航, 大垣隆一, 岡西広樹, 奥田傑, Xu Minhui, 遠藤仁, 金井好克
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K24071
[Presentation] アミノ酸トランスポーターLAT1阻害薬が腫瘍細胞の大型中性アミノ酸輸送とタンパク質合成に与える影響2022
- Author(s)
  西窪航, 大垣隆一, 岡西広樹, 奥田傑, Xu Minhui, 遠藤仁, 金井好克
- Organizer
  第141回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-23K24071
[Presentation] がん細胞由来エクソソーム上におけるアミノ酸トランスポーターLAT1（SLC7A5）の発現：予後および診断バイオマーカーとしての潜在的価値2022
- Author(s)
  大垣隆一, Liu Yumiao, Xu Minhui, 岡西広樹, 金井好克
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K24071
[Presentation] アミノ酸トランスポーターLAT1の阻害はがん細胞における大型中性アミノ酸輸送を顕著に低下させグローバルな翻訳抑制を誘導する2022
- Author(s)
  西窪航, 大垣隆一, 岡西広樹, 奥田傑, Xu Minhui, 遠藤仁, 金井好克
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K19404
[Presentation] がん細胞におけるLAT1のアミノ酸の取込みへの寄与とLAT1阻害薬によるタンパク質合成抑制効果2022
- Author(s)
  西窪航、大垣隆一、岡西広樹、奥田傑、徐旻恵、遠藤仁、金井好克
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07327
[Presentation] アミノ酸トランスポーターLAT1阻害薬が腫瘍細胞の大型中性アミノ酸輸送とタンパク質合成に与える影響2022
- Author(s)
  西窪航, 大垣隆一, 岡西広樹, 奥田傑, Xu Minhui, 遠藤仁, 金井好克
- Organizer
  第141回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-22K19404
[Presentation] アミノ酸トランスポーターLAT1阻害薬JPH203による胆道がん細胞増殖抑制機構に関わるプロテオミクスおよびリン酸化プロテオミクス解析2021
- Author(s)
  岡西広樹、大垣隆一、奥田傑、遠藤仁、金井好克
- Organizer
  第94回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H03407
[Presentation] Amino acid transporter LAT1 is upregulated in tumor-associated vascular endothelial cells and plays essential roles in tumor angiogenesis by promoting proliferation and regulating VEGF-A-dependent pro-angiogenic mTORC1 activation2021
- Author(s)
  Ryuichi Ohgaki、Lili Quan、Suguru Okuda、Hiroki Okanishi、Shushi Nagamori、Hitoshi Endou、Yoshikatsu Kanai
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19H03407
[Presentation] アミノ酸トランスポーターLAT1阻害薬JPH203による胆道がん細胞増殖抑制機構に関わるプロテオミクスおよびリン酸化プロテオミクス解析2021
- Author(s)
  岡西広樹、大垣隆一、奥田傑、遠藤仁、金井好克
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07327
[Presentation] がん細胞におけるLAT1のアミノ酸の取込みへの寄与とLAT1阻害薬によるタンパク質合成抑制効果2021
- Author(s)
  西窪航、大垣隆一、岡西広樹、奥田傑、徐旻ケイ、遠藤仁、金井好克
- Organizer
  第95回　日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19H03407
[Presentation] Suppression of proliferation of cholangiocarcinoma cells by miRNAs targeting L type amino acid transporter 1 downregulated in cholangiocarcinomas2021
- Author(s)
  劉星明、大垣隆一、岡西広樹、奥田傑、徐旻ケイ、金井好克
- Organizer
  第139回　日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-19H03407
[Presentation] 胆道がん細胞株におけるアミノ酸トランスポーターLAT1阻害薬が示す増殖抑制作用のタンパク質発現・リン酸化変動の網羅的解析による検討2021
- Author(s)
  岡西広樹、大垣隆一、奥田傑、遠藤仁、金井好克
- Organizer
  第140回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-20K07327
[Presentation] アミノ酸トランスポーターLAT1阻害薬JPH203による胆道がん細胞増殖抑制機構に関わるプロテオミクスおよびリン酸化プロテオミクス解析2021
- Author(s)
  岡西広樹，大垣隆一，奥田傑，遠藤仁，金井好克
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K16743
[Presentation] 胆道がん細胞株におけるアミノ酸トランスポーターLAT1阻害薬が示す増殖抑制作用のタンパク質発現・リン酸化変動の網羅的解析による検討2021
- Author(s)
  岡西広樹，大垣隆一，奥田傑，遠藤仁，金井好克
- Organizer
  第140回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-19K16743
[Presentation] 胆道がん細胞株におけるアミノ酸トランスポーターLAT1阻害薬が示す増殖抑制作用のタンパク質発現・リン酸化変動の網羅的解析による検討2021
- Author(s)
  岡西広樹、大垣隆一、奥田傑、遠藤仁、金井好克
- Organizer
  第140回　日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-19H03407
[Presentation] 腫瘍間質の血管内皮細胞に高発現するアミノ酸トランスポーターLAT1は細胞増殖の促進と血管新生促進因子VEGF-AによるmTORC1活性化の制御を介して腫瘍血管新生に寄与する2021
- Author(s)
  大垣隆一、全麗麗、奥田傑、岡西広樹、永森收志、遠藤仁、金井好克
- Organizer
  第9４回　日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07327
[Presentation] Suppression of proliferation of cholangiocarcinoma cells by miRNAs targeting L-type amino acid transporter 1 downregulated in cholangiocarcinomas2021
- Author(s)
  劉星明、大垣隆一、岡西広樹、奥田傑、徐旻恵、金井好克
- Organizer
  第139回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-20K07327
[Presentation] Development of tumor-specific compounds avoiding renal uptake for PET imaging and targeted α-therapy2020
- Author(s)
  Chunhuan Jin、Ling Wei、Ryuichi Ohgaki、Suguru Okuda、Minhui Xu、Hiroki Okanishi、Shushi Nagamori、Yoshikatsu Kanai
- Organizer
  第138回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-19H03407
[Presentation] Development of tumor-specific compounds avoiding renal uptake for PET imaging and targeted a-therapy2020
- Author(s)
  Chunhuan Jin, Ling Wei, Ryuichi Ohgaki, Suguru Okuda, Minhui Xu, Hiroki Okanishi, Shushi Nagamori, Yoshikatsu Kanai
- Organizer
  第138回　日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-20K07327
[Presentation] Time-course analysis of the changes in intracellular amino acid concentrations and amino acid-related signaling pathways in cancer cells induced by the inhibition of cancer-type amino acid transporter LAT12020
- Author(s)
  西窪航, 大垣隆一, 岡西広樹, 奥田傑, 金井好克
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19H03407
[Presentation] 遊離アミノ酸量の定量的経時変化解析によるアミノ酸トランスポーター阻害効果の検討2020
- Author(s)
  西窪航、大垣隆一、岡西広樹、奥田傑、金井好克
- Organizer
  第137回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-19H03407
[Presentation] Time-course analysis of the changes in intracellular amino acid concentrations and amino acid-related signaling pathways in cancer cells induced by the inhibition of cancer-type amino acid transporter LAT12020
- Author(s)
  西窪航, 大垣隆一, 岡西広樹, 奥田傑, 金井好克
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K19429
[Presentation] 遊離アミノ酸量の定量的経時変化解析によるアミノ酸トランスポーター阻害効果の検討2020
- Author(s)
  西窪航，大垣隆一，岡西広樹，奥田傑，金井好克
- Organizer
  第137回　日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-20K07327
[Presentation] アミノ酸アベイラビリティが細胞内遊離アミノ酸濃度に与える影響2019
- Author(s)
  西窪航、大垣隆一、岡西広樹、奥田傑、金井好克
- Organizer
  第92回　日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K19429
[Presentation] Identification of miRNA regulating the expression of cancer-type amino acid transporter LAT1: its potential as an antionco-miRNA2019
- Author(s)
  劉星明, 大垣隆一, 岡西広樹, 奥田傑, 金井好克
- Organizer
  第136回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-18K19429
[Presentation] Identification of miRNA regulating the expression of cancer-type amino acid transporter LAT1: its potential as an antionco-miRNA2019
- Author(s)
  劉星明, 大垣隆一, 岡西広樹, 奥田傑, 金井好克
- Organizer
  第136回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-19H03407

1. Kanai Yoshikatsu (60204533)

# of Collaborated Projects: 4 results

# of Collaborated Products: 34 results
2. 大垣隆一 (20467525)

# of Collaborated Projects: 4 results

# of Collaborated Products: 40 results
3. Okuda Suguru (50511846)

# of Collaborated Projects: 3 results

# of Collaborated Products: 24 results
4. 徐旻恵 (20910201)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
5. 金春奐

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Okanishi Hiroki 岡西 広樹

Hiroki Okanishi 岡西 広樹

Research Projects

Research Products

Co-Researchers

がん特異的LAT1アミノ酸シグナルにおけるIGF-1R活性調節機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the transmembrane signal mechanism responsible for metabolic control by amino acid availability

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アミノ酸輸送体LAT1依存的リン酸化シグナルにおけるチロシンリン酸化制御機構解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

がん細胞アミノ酸輸送体阻害薬の強力な細胞周期制御の機序と細胞休眠化機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification and mechanistic analysis of intracellular amino acid sensors and their potential as drug targets

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Revealing of phosphorylation signaling in the downstream of LAT1 in cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on the amino acid signaling via transporters and receptors for the pharmacologic control of cellular metabolism

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アセチル化プロテオミクスによるグリオーマ幹細胞の治療標的解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on the effects of amino acid availability on life span and the underlying molecular mechanisms

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Identification of tumor-suppressive miRNAs that target amino acid transporter LAT1 and exhibit anti-proliferative effects on cholangiocarcinoma cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure activity characteristics of phenylalanine analogs selectively transported by L-type amino acid transporter 1 (LAT1)2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Upregulation of ATF4 mediates the cellular adaptation to pharmacologic inhibition of amino acid transporter LAT1 in pancreatic ductal adenocarcinoma cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of amino acid transporter LAT1 in cancer cells suppresses G0/G1-S transition by downregulating cyclin D1 via p38 MAPK activation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells2023

Okanishi Hiroki 岡西広樹

Hiroki Okanishi 岡西広樹