Watanabe Yuichi 渡邉雄一

Researcher Number	70792729
Other IDs
Affiliation (based on the past Project Information) *help	2021 – 2023: 昭和大学, 薬学部, 助教 2017 – 2020: 東京大学, 大学院農学生命科学研究科(農学部), 特任助教
Review Section/Research Field	Principal Investigator Basic Section 38050:Food sciences-related / Food science Except Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Keywords	Principal Investigator 酸化ステロール / 脂肪組織 / 生活習慣病 / 肥満 / oxysterol / 脂肪肝 / 線維化 / 炎症 / ステロール代謝酵素 / 代謝酵素 … More / CYP7B1 / 胆汁酸合成経路 / 酸化ステロール代謝 / NASH / 統合的ストレス応答 / 酸化コレステロール / 細胞死 / ATF4 / Insig … More Except Principal Investigator LC-MS/MS / 中間比重粒子 / PLIN2 / COPⅡ小胞 / Sar1 / 細胞内脂肪滴 Less

Novel approach to search for factors regulating intracellular lipid droplet formation based o Sar1b function.
- Principal Investigator
  
  板部洋之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Showa University
Molecular mechanism of oxysterol 7-alpha hydroxylase on NASH progressionPrincipal Investigator
- Principal Investigator
  
  Watanabe Yuichi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Showa University
  The University of Tokyo
The novel function of Insig; acting as a mediator for stress response by oxysterol.Principal Investigator
- Principal Investigator
  
  Watanabe Yuichi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Food science
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Behavior of intracellular lipid droplets during cell division in HuH7 hepatoma cells2023
- Author(s)
  Tomohiko Makiyama, Takashi Obama, Yuichi Watanabe, Masahiro Chatani, Yuki Azetsu, Kosuke Kawaguchi, Tsuneo Imanaka, Hiroyuki Itabe
- Journal Title
  
  Exp Cell Res.
  
  Volume: 433 Issue: 2 Pages: 113855-113855
- DOI
  10.1016/j.yexcr.2023.113855
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06255, KAKENHI-PROJECT-22K06617, KAKENHI-PROJECT-20K18465, KAKENHI-PROJECT-19KK0233
[Journal Article] Sar1 affects the localization of perilipin 2 to lipid droplets2022
- Author(s)
  Tomohiko Makiyama, Takashi Obama, Yuichi Watanabe, Hiroyuki Itabe
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 2 Issue: 12 Pages: 6366-6366
- DOI
  10.3390/ijms23126366
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06617
[Journal Article] Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK?eIF2α?ATF4 axis2021
- Author(s)
  Watanabe Yuichi、Sasaki Takashi、Miyoshi Shoko、Shimizu Makoto、Yamauchi Yoshio、Sato Ryuichiro
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 297 Issue: 2 Pages: 100989-100989
- DOI
  10.1016/j.jbc.2021.100989
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00408, KAKENHI-PROJECT-19H02906, KAKENHI-PROJECT-21K19066, KAKENHI-PROJECT-19K15764
[Presentation] 細胞分裂期における脂肪滴の挙動2023
- Author(s)
  牧山智彦、小濵孝士、渡邉雄一、板部洋之
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06617
[Presentation] 細胞分裂期の細胞内脂肪滴は、構成タンパク質が変動し他のオルガネラと異なる細胞内局在を示す2023
- Author(s)
  牧山　智彦, 小濵　孝士, 渡邉　雄一, 板部　洋之
- Organizer
  第64回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-22K06617
[Presentation] 細胞内脂肪滴は細胞分裂期において他のオルガネラと異なる局在を示す2023
- Author(s)
  牧山　智彦, 小濵　孝士, 渡邉　雄一, 茶谷　昌弘, 畔津　祐希, 川口　甲介, 今中　常雄, 板部　洋之
- Organizer
  第96回日本生化学会
- Data Source
  KAKENHI-PROJECT-22K06617
[Presentation] INSIGを介した酸化ステロールによる細胞死誘導機構2021
- Author(s)
  渡邉雄一、三吉翔子、清水誠、山内祥生、佐藤隆一郎
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-19K15764
[Presentation] 酸化ステロールはINSIGを介してPERK/ATF4経路活性化とそれに伴う細胞死を誘導する2021
- Author(s)
  渡邉雄一、佐々木崇、三吉翔子、清水誠、山内祥生、佐藤隆一郎
- Organizer
  第94回日本生化学会
- Data Source
  KAKENHI-PROJECT-19K15764
[Presentation] The novel signaling of Insig-oxysterol interaction2020
- Author(s)
  渡邉雄一、三吉翔子、清水誠、山内祥生、佐藤隆一郎
- Organizer
  日本農芸化学会2020年度大会
- Data Source
  KAKENHI-PROJECT-19K15764
[Presentation] CYP7B1 and its function on the progression of non-alcoholic steatohepatitis2020
- Author(s)
  Napatsorn DUMRONGKULCHART, Yuichi WATANABE, Makoto SHIMIZU, Yoshio YAMAUCHI, Ryuichiro SATO
- Organizer
  日本農芸化学会2020年度大会
- Data Source
  KAKENHI-PROJECT-19K15764
[Presentation] 脂質代謝制御因子Insig-酸化ステロール結合の新規応答2020
- Author(s)
  渡邉雄一、三吉翔子、清水誠、山内祥生、佐藤隆一郎
- Organizer
  日本農芸化学会2020年度大会
- Data Source
  KAKENHI-PROJECT-19K15764
[Presentation] 脂質代謝制御因子Insigを介した酸化ステロールによる新規応答2019
- Author(s)
  渡邉雄一、三吉翔子、清水誠、山内祥生、佐藤隆一郎
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K15764
[Presentation] 酸化ステロールはInsigを介して細胞死を誘発する2019
- Author(s)
  渡邉雄一、三吉翔子、清水誠、山内祥生、佐藤隆一郎
- Organizer
  日本農芸化学会2019年度大会
- Data Source
  KAKENHI-PROJECT-17K15266
[Presentation] 酸化コレステロール結合タンパク質Insig1/2によるATF4発現亢進機構の解明2018
- Author(s)
  渡邉雄一
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-17K15266
[Presentation] 酸化コレステロールはInsigを介してATF4発現を亢進する2018
- Author(s)
  渡邉雄一、三吉翔子、清水誠、井上順、佐藤隆一郎
- Organizer
  第60回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-17K15266
[Presentation] 酸化コレステロールはInsig2を介してATF4発現を誘導する2017
- Author(s)
  渡邉雄一
- Organizer
  2017年度生命科学系合同年次大会 (ConBio2017)
- Data Source
  KAKENHI-PROJECT-17K15266

1. 板部洋之 (30203079)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. 小濱孝士 (60395647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 牧山智彦 (60733102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. OBAMA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 佐藤隆一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 畔津佑季

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 茶谷昌宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Watanabe Yuichi 渡邉 雄一

Research Projects

Research Products

Co-Researchers

Novel approach to search for factors regulating intracellular lipid droplet formation based o Sar1b function.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of oxysterol 7-alpha hydroxylase on NASH progressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The novel function of Insig; acting as a mediator for stress response by oxysterol.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Behavior of intracellular lipid droplets during cell division in HuH7 hepatoma cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sar1 affects the localization of perilipin 2 to lipid droplets2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK?eIF2α?ATF4 axis2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] 細胞分裂期における脂肪滴の挙動2023

Author(s)

Organizer

Data Source

[Presentation] 細胞分裂期の細胞内脂肪滴は、構成タンパク質が変動し 他のオルガネラと異なる細胞内局在を示す2023

Author(s)

Organizer

Data Source

[Presentation] 細胞内脂肪滴は細胞分裂期において他のオルガネラと異なる局在を示す2023

Author(s)

Organizer

Data Source

[Presentation] INSIGを介した酸化ステロールによる細胞死誘導機構2021

Author(s)

Organizer

Data Source

[Presentation] 酸化ステロールはINSIGを介してPERK/ATF4経路活性化とそれに伴う細胞死を誘導する2021

Author(s)

Organizer

Data Source

[Presentation] The novel signaling of Insig-oxysterol interaction2020

Author(s)

Organizer

Data Source

[Presentation] CYP7B1 and its function on the progression of non-alcoholic steatohepatitis2020

Author(s)

Organizer

Data Source

[Presentation] 脂質代謝制御因子Insig-酸化ステロール結合の新規応答2020

Author(s)

Organizer

Data Source

[Presentation] 脂質代謝制御因子Insigを介した酸化ステロールによる新規応答2019

Author(s)

Organizer

Data Source

[Presentation] 酸化ステロールはInsigを介して細胞死を誘発する2019

Author(s)

Organizer

Data Source

[Presentation] 酸化コレステロール結合タンパク質Insig1/2によるATF4発現亢進機構の解明2018

Author(s)

Organizer

Watanabe Yuichi 渡邉雄一

[Presentation] 細胞分裂期の細胞内脂肪滴は、構成タンパク質が変動し他のオルガネラと異なる細胞内局在を示す2023