DIRISALA ANJANEYULU ディリサラアンジャネユル

… Alternative Names

Dirisala Anjaneyulu ディリサラアンジャネユル

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Researcher Number	70794353
Other IDs	https://orcid.org/0000-0003-1566-7142
Affiliation (Current)	2024: 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 主任研究員
Affiliation (based on the past Project Information) *help	2023: 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 主任研究員 2018 – 2021: 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 90110:Biomedical engineering-related / Basic Section 90120:Biomaterials-related
Keywords	Principal Investigator Lipid nanoparticle / Messenger RNA / Interleukin-12 / Gene drugs / CRISPR/Cas9 / Genome editing / Hepatocytes / Gene delivery / Hepatocyte targeting / Liver stealth coating … More / PEG-oligo(amino acid) / Double arm PEG-OLys / Single arm PEG-OLys / Liver blockade / Two-arm-PEG-OligoLysine / Sinusoidal wall / Reticuloendothelium / Retargeting nanomedicine / Bile clearance / Two-arm-PEG-peptide / PEG coating to liver / RES blockade Less

Preferential on-tumor expression of sticky interleukin-12 for safe local and systemic cancer immunotherapyPrincipal Investigator
- Principal Investigator
  
  ディリサラアンジャネユル
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine
Ligand-free hepatocyte-targeting of nanomedicines by selective stealth coating of liver reticuloendothelial system scavenger cellsPrincipal Investigator
- Principal Investigator
  
  ディリサラアンジャネユル
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine
Reticuloendothelial system blockade by PEG-oligo(amino acid) block copolymers: A strategy for functional tuning of nanomedicine pharmacokineticsPrincipal Investigator
- Principal Investigator
  
  Dirisala Anjaneyulu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine

All 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Effective mRNA Protection by Poly(l-ornithine) Synergizes with Endosomal Escape Functionality of a Charge-Conversion Polymer toward Maximizing mRNA Introduction Efficiency2022
- Author(s)
  A. Dirisala, S. Uchida, J. Li, J.F.R. Van Guyse, K. Hayashi, S.V.C. Vummaleti, S. Kaur, Y. Mochida, S. Fukushima, K. Kataoka
- Journal Title
  
  Macromol. Rapid Commun.
  
  Volume: - Issue: 12 Pages: 2100754-2100754
- DOI
  10.1002/marc.202100754
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04962, KAKENHI-PROJECT-21K19923, KAKENHI-PROJECT-20K20209, KAKENHI-PROJECT-21K18062
[Journal Article] mRNA loading into ATP-responsive polyplex micelles with optimal density of phenylboronate ester crosslinking to balance robustness in the biological milieu and intracellular translational efficiency2021
- Author(s)
  Yoshinaga Naoto、Uchida Satoshi、Dirisala Anjaneyulu、Naito Mitsuru、Osada Kensuke、Cabral Horacio、Kataoka Kazunori
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 330 Pages: 317-328
- DOI
  10.1016/j.jconrel.2020.12.033
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0102, KAKENHI-PROJECT-18H03529, KAKENHI-PROJECT-17K20086, KAKENHI-PROJECT-18K18393
[Journal Article] Co-encapsulation of Cas9 mRNA and guide RNA in polyplex micelles enables genome editing in mouse brain2021
- Author(s)
  S. Abbasi, S. Uchida, K. Toh, T.A. Tockary, A. Dirisala, K. Hayashi, S. Fukushima, K. Kataoka
- Journal Title
  
  J. Control. Release
  
  Volume: 332 Pages: 260-268
- DOI
  10.1016/j.jconrel.2021.02.026
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03529, KAKENHI-PROJECT-19F19116, KAKENHI-PROJECT-17K20086, KAKENHI-PROJECT-18K18393
[Journal Article] Enzymatically Transformable Polymersome-Based Nanotherapeutics to Eliminate Minimal Relapsable Cancer2021
- Author(s)
  J. Li, Z. Ge, K. Toh, X. Liu, A. Dirisala, W. Ke, P. Wen, H. Zhou, Z. Wang, S. Xiao, J.F.R. Van Guyse, T.A. Tockary, J. Xie, D. Gonzalez-Carter, H. Kinoh, S. Uchida, Y. Anraku, K. Kataoka
- Journal Title
  
  Adv. Mater.
  
  Volume: 33 Issue: 49 Pages: 2105254-2105254
- DOI
  10.1002/adma.202105254
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04962, KAKENHI-PROJECT-21K19923, KAKENHI-PROJECT-20K20209, KAKENHI-PROJECT-21K18062
[Journal Article] Bridging mRNA and polycation using RNA oligonucleotide derivatives improves the robustness of polyplex micelle for efficient mRNA delivery.2021
- Author(s)
  N. Yoshinaga, S. Uchida, A. Dirisala, M. Naito, K. Koji, K. Osada, H. Cabral, K. Kataoka,
- Journal Title
  
  Advanced Healthcare Materials,
  
  Volume: - Issue: 9 Pages: 2102016-2102016
- DOI
  10.1002/adhm.202102016
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03178, KAKENHI-PROJECT-21H04962, KAKENHI-PROJECT-21K19014, KAKENHI-PROJECT-21K19923, KAKENHI-PROJECT-21K18062, KAKENHI-PROJECT-17KK0102, KAKENHI-PROJECT-23K21857
[Journal Article] Targeting nanoparticles to the brain by exploiting the blood-brain barrier impermeability to selectively label the brain endothelium2020
- Author(s)
  Daniel Gonzalez-Carter, Xueying Liu, Theofilus A Tockary, Anjaneyulu Dirisala , Kazuko Toh , Yasutaka Anraku , Kazunori Kataoka
- Journal Title
  
  Proc Natl Acad Sci U S A .
  
  Volume: 117 (32) Issue: 32 Pages: 19141-19150
- DOI
  10.1073/pnas.2002016117
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14100, KAKENHI-PROJECT-18K18393
[Journal Article] Dual-Sensitive Nanomicelles Enhancing Systemic Delivery of Therapeutically Active Antibodies Specifically into the Brain2020
- Author(s)
  Jinbing Xie, Daniel Gonzalez-Carter, Theofilus A. Tockary, Noriko Nakamura, Yonger Xue, Makoto Nakakido, Hiroki Akiba, Anjaneyulu Dirisala, Xueying Liu, Kazuko Toh, Tao Yang, Zengtao Wang, Shigeto Fukushima, Junjie Li, Sabina Quader, Kouhei Tsumoto, Takanori Yokota, Yasutaka Anraku*, and Kazunori Kataoka
- Journal Title
  
  ACS Nano
  
  Volume: - Issue: 6 Pages: 6729-6742
- DOI
  10.1021/acsnano.9b09991
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14100, KAKENHI-PROJECT-20H02531, KAKENHI-PROJECT-18K18393
[Journal Article] Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines2020
- Author(s)
  Dirisala Anjaneyulu、Uchida Satoshi、Toh Kazuko、Li Junjie、Osawa Shigehito、Tockary Theofilus A.、Liu Xueying、Abbasi Saed、Hayashi Kotaro、Mochida Yuki、Fukushima Shigeto、Kinoh Hiroaki、Osada Kensuke、Kataoka Kazunori
- Journal Title
  
  Science Advances
  
  Volume: 6 Issue: 26
- DOI
  10.1126/sciadv.abb8133
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0102, KAKENHI-PROJECT-18H03529, KAKENHI-PROJECT-19F19116, KAKENHI-PROJECT-17K20086, KAKENHI-PROJECT-18K18393
[Journal Article] Precise tuning of disulphide crosslinking in mRNA polyplex micelles for optimising extracellular and intracellular nuclease tolerability.2019
- Author(s)
  Dirisala A, Uchida S, Tockary TA, Yoshinaga N, Li J, Osawa S, Gorantla L, Fukushima S, Osada K, Kataoka K.
- Journal Title
  
  J Drug Target
  
  Volume: 27
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18393
[Journal Article] Single-stranded DNA-packaged polyplex micelle as adeno-associated-virus-inspired compact vector to systemically target stroma-rich pancreatic cancer.2019
- Author(s)
  T. A. Tockary, W. Foo, A. Dirisala, Q. Chen, S. Uchida, S. Osawa, Y. Mochida, X. Liu, H. Kinoh, H. Cabral, K. Osada, K. Kataoka
- Journal Title
  
  ACS Nano
  
  Volume: 13 Issue: 11 Pages: 12732-12742
- DOI
  10.1021/acsnano.9b04676
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20086, KAKENHI-PROJECT-18K18393, KAKENHI-PROJECT-17KK0102, KAKENHI-PROJECT-16H03178, KAKENHI-PROJECT-16H03179, KAKENHI-PROJECT-18H03529, KAKENHI-PROJECT-17K07234, KAKENHI-PROJECT-18K19901
[Journal Article] Precise tuning of disulfide crosslinking in mRNA polyplex micelles for optimizing extracellular and intracellular nuclease tolerability.2019
- Author(s)
  A. Dirisala, S. Uchida, T. A. Tockary, N. Yoshinaga, J. Li, S. Osawa, L. Gorantla, S. Fukushima, K. Osada, K. Kataoka
- Journal Title
  
  J. Drug Target.
  
  Volume: 印刷中 Issue: 5-6 Pages: 670-680
- DOI
  10.1080/1061186x.2018.1550646
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20086, KAKENHI-PROJECT-17KK0102, KAKENHI-PROJECT-16H03178, KAKENHI-PROJECT-18H03529, KAKENHI-PROJECT-18K18393
[Presentation] Liver sinusoidal blockade by poly(ethylene glycol)－oligo(amino acid) block copolymers for tuning pharmacokinetics of NanoMedicine2019
- Author(s)
  Anjaneyulu Dirisala, Satoshi Uchida, Kazuko Toh, Shigehito Osawa, Kotaro Hayashi, Kazunori Kataoka
- Organizer
  The 12th Annual Symposium on Nanotechnology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18393
[Presentation] Liver sinusoidal blockade by poly(ethylene glycol)-oligo(amino acid) block copolymers for tuning pharmacokinetics of NanoMedicine2019
- Author(s)
  Anjaneyulu Dirisala, Satoshi Uchida, Kazuko Toh, Shigehito Osawa, Kotaro Hayashi, Kazunori Kataoka
- Organizer
  2019 International Symposium on Nanotechnology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18393
[Presentation] Effect of poly(ethylene glycol) molecular weight for overcoming liver sinusoidal barrier towards prolonged circulation activity of polyplex micelles2018
- Author(s)
  Dirisala Anjaneyulu, Kensuke Osada, Kazuko Toh, Theofilus A. Tockary, Satoshi Uchida, Horacio Cabral, Kazunori Kataoka
- Organizer
  The 12th SPSJ International Polymer Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18393

1. OSADA Kensuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
2. 内田智士

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results

DIRISALA ANJANEYULU ディリサラ アンジャネユル

Dirisala Anjaneyulu ディリサラ アンジャネユル

Research Projects

Research Products

Co-Researchers

Preferential on-tumor expression of sticky interleukin-12 for safe local and systemic cancer immunotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Ligand-free hepatocyte-targeting of nanomedicines by selective stealth coating of liver reticuloendothelial system scavenger cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Reticuloendothelial system blockade by PEG-oligo(amino acid) block copolymers: A strategy for functional tuning of nanomedicine pharmacokineticsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Effective mRNA Protection by Poly(l-ornithine) Synergizes with Endosomal Escape Functionality of a Charge-Conversion Polymer toward Maximizing mRNA Introduction Efficiency2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] mRNA loading into ATP-responsive polyplex micelles with optimal density of phenylboronate ester crosslinking to balance robustness in the biological milieu and intracellular translational efficiency2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Co-encapsulation of Cas9 mRNA and guide RNA in polyplex micelles enables genome editing in mouse brain2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enzymatically Transformable Polymersome-Based Nanotherapeutics to Eliminate Minimal Relapsable Cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bridging mRNA and polycation using RNA oligonucleotide derivatives improves the robustness of polyplex micelle for efficient mRNA delivery.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting nanoparticles to the brain by exploiting the blood-brain barrier impermeability to selectively label the brain endothelium2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dual-Sensitive Nanomicelles Enhancing Systemic Delivery of Therapeutically Active Antibodies Specifically into the Brain2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Precise tuning of disulphide crosslinking in mRNA polyplex micelles for optimising extracellular and intracellular nuclease tolerability.2019

Author(s)

Journal Title

Data Source

[Journal Article] Single-stranded DNA-packaged polyplex micelle as adeno-associated-virus-inspired compact vector to systemically target stroma-rich pancreatic cancer.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Precise tuning of disulfide crosslinking in mRNA polyplex micelles for optimizing extracellular and intracellular nuclease tolerability.2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Liver sinusoidal blockade by poly(ethylene glycol)－oligo(amino acid) block copolymers for tuning pharmacokinetics of NanoMedicine2019

Author(s)

Organizer

DIRISALA ANJANEYULU ディリサラアンジャネユル

Dirisala Anjaneyulu ディリサラアンジャネユル