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WAKITA MASAHIRO  脇田 将裕

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Wakita Masahiro  脇田 将裕

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Researcher Number 70794668
Other IDs
Affiliation (Current) 2025: 大阪大学, 微生物病研究所, 助教
Affiliation (based on the past Project Information) *help 2025: 大阪大学, 微生物病研究所, 助教
2020 – 2022: 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤)
2018 – 2019: 大阪大学, 微生物病研究所, 特任研究員(常勤)
Review Section/Research Field
Principal Investigator
Basic Section 49010:Pathological biochemistry-related / Basic Section 59040:Nutrition science and health science-related / Basic Section 50010:Tumor biology-related
Keywords
Principal Investigator
セノリティックドラッグ / 細胞老化 / 老化細胞 / セノリティック ドラッグ / 加齢 / がん / 炎症
  • Research Projects

    (4 results)
  • Research Products

    (11 results)
  • Co-Researchers

    (2 People)
  •  Establishment of methods for the removal of senescent cells with a reduced risk of side effectsPrincipal Investigator

    • Principal Investigator
      脇田 将裕
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      The University of Osaka
  •  加齢性疾患克服に向けた漸進型の老化細胞除去療法の確立Principal Investigator

    • Principal Investigator
      脇田 将裕
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Osaka University
  •  Understanding the interrelationship between senescent cells and age-related diseases and the elucidation of the mechanisms for the killing of senescent cells by senolytic drugsPrincipal Investigator

    • Principal Investigator
      Wakita Masahiro
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Osaka University
  •  Approach toward age-related diseases with the use of a new senolytic drugsPrincipal Investigator

    • Principal Investigator
      Wakita Masahiro
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Osaka University

All 2022 2021 2020 2019 2018

All Journal Article Presentation Book Patent

  • [Book] 実験医学2022

    • Author(s)
      脇田 将裕, 原 英二
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-20K16156
  • [Book] 炎症と免疫2021

    • Author(s)
      脇田 将裕, 原 英二
    • Publisher
      先端医学社
    • Data Source
      KAKENHI-PROJECT-20K16156
  • [Journal Article] A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells.2020

    • Author(s)
      Wakita M, Takahashi A, Sano O, Loo TM, Imai Y, Narukawa M, Iwata H, Matsudaira T, Kawamoto S, Ohtani N, Yoshimori T, Hara E.
    • Journal Title

      Nat Commun

      Volume: 1935 Issue: 1 Pages: 1935-1935

    • DOI

      10.1038/s41467-020-15719-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15188, KAKENHI-PROJECT-20K07446, KAKENHI-PROJECT-20K16163, KAKENHI-PROJECT-19K16612, KAKENHI-PROJECT-19H03507, KAKENHI-PROJECT-18K15065, KAKENHI-PROJECT-19K22571, KAKENHI-PROJECT-20K16156
  • [Journal Article] Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells2018

    • Author(s)
      Takahashi A, Loo TM, Okada R, Kamachi F, Watanabe Y, Wakita M, Watanabe S, Kawamoto S, Miyata K, Barber GN, Ohtani N, Hara E
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 1249-1249

    • DOI

      10.1038/s41467-018-03555-8

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19031, KAKENHI-PUBLICLY-17H05628, KAKENHI-PROJECT-16H04700, KAKENHI-PROJECT-17K19618, KAKENHI-PROJECT-18K15065, KAKENHI-PROJECT-16H04699
  • [Patent] BET阻害剤及びその作用機序を利用した老化細胞除去2019

    • Inventor(s)
      原英二、脇田将裕、高橋暁子
    • Industrial Property Rights Holder
      原英二、脇田将裕、高橋暁子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Data Source
      KAKENHI-PROJECT-18K15065
  • [Presentation] Senolytic drugによる老化細胞除去の影響とがん治療への可能性2022

    • Author(s)
      脇田将裕
    • Organizer
      第22回日本抗加齢医学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K07189
  • [Presentation] 新規Senotherapyがもたらすがん治療への可能性2022

    • Author(s)
      脇田将裕
    • Organizer
      第45回日本分子生物学大会
    • Data Source
      KAKENHI-PROJECT-22K07189
  • [Presentation] Impact of BET-family protein degrader in the killing of senescent cells and its potential for cancer treatment2021

    • Author(s)
      脇田将裕
    • Organizer
      第94回日本生化学大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K16156
  • [Presentation] Clearance of senescent cells by BET-family protein degrader and their potential for cancer therapy2021

    • Author(s)
      脇田将裕
    • Organizer
      第80回日本癌学会総会
    • Data Source
      KAKENHI-PROJECT-20K16156
  • [Presentation] 新規老化細胞除去薬によるがん治療への可能性2020

    • Author(s)
      脇田 将裕, 高橋 暁子, 大谷 直子, 原 英二
    • Organizer
      日本癌学会総会
    • Data Source
      KAKENHI-PROJECT-20K16156
  • [Presentation] High-throughput screening of senolysis drug uncovers cellular vulnerability of senescent cells2019

    • Author(s)
      脇田将裕
    • Organizer
      2019年度 先端モデル動物支援プラットフォーム 成果発表会
    • Data Source
      KAKENHI-PROJECT-18K15065
  • 1.  河本 新平
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 2.  蒲池 史卓
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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