Tanaka Hiroo 田中啓雄

Researcher Number	70795905
Other IDs
Affiliation (based on the past Project Information) *help	2019 – 2024: 帝京大学, 医学部, 助教 2019 – 2020: 大阪大学, 生命機能研究科, 特任講師
Review Section/Research Field	Principal Investigator Basic Section 44010:Cell biology-related Except Principal Investigator Biological Sciences
Keywords	Principal Investigator 細胞間バリア / タイトジャンクション / クローディン / 生体バリア / 細胞間チャネル / グリア細胞 / 細胞間接着 / アストロサイト / 脳血管内皮細胞 / 生体恒常性 … More / 血液脳関門 / トランスポーター / チャネル / トランスポーター、チャネル / アピカル / 上皮バリア … More Except Principal Investigator TJ-MAPs / TJ-ストランド / アピカル細胞骨格 / TJ-アピカル複合体 / 細胞間バリア / TJストランド / クライオ電顕 / アピカル骨格 / TJMAP / 液-液相分離（LLPS） / アピカル膜 / クライオ電顕トモグラフィー / 細胞骨格 / 上皮細胞 / クローディン / タイトジャンクション / 上皮バリア Less

Fundamental principles underlying the functional diversity of tight junctionsPrincipal Investigator
- Principal Investigator
  
  田中啓雄
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Teikyo University
Astrocytes form tight junctions to organize blood brain barrierPrincipal Investigator
- Principal Investigator
  
  Tanaka Hiroo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Teikyo University
Tight junctions to organize apical membranes of epithelial cell sheets.Principal Investigator
- Principal Investigator
  
  Tanaka Hiroo
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Teikyo University
Novel approach focusing on the tight junction-based paracellular barrier combined with the apical barrier toward understanding and manipulating epithelial barriers
- Principal Investigator
  
  月田早智子
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Teikyo University
  Osaka University

All 2024 2023 2022 2021 2020 2019 Other

All Journal Article Presentation Book Other

[Book] 膜タンパク質工学ハンドブック　「クローディンを基盤とするタイトジャンクションと生体システム構築の多様性」2020
- Author(s)
  田中　啓雄、田村　淳、矢野　智樹、月田　早智子
- Total Pages
  10
- Publisher
  (株)エヌ・ティー・エス
- Data Source
  KAKENHI-PROJECT-19K16126
[Book] 膜タンパク質工学ハンドブック「クローディンを基盤とするタイトジャンクションと生体システム構築の多様性」2020
- Author(s)
  田中啓雄、田村淳、矢野智樹、月田早智子
- Total Pages
  10
- Publisher
  (株)エヌティーエス
- Data Source
  KAKENHI-PROJECT-19K16126
[Journal Article] Dual-color live imaging unveils stepwise organization of multiple basal body arrays by cytoskeletons2024
- Author(s)
  Shiratsuchi Gen、Konishi Satoshi、Yano Tomoki、Yanagihashi Yuichi、Nakayama Shogo、Katsuno Tatsuya、Kashihara Hiroka、Tanaka Hiroo、Tsukita Kazuto、Suzuki Koya、Herawati Elisa、Watanabe Hitomi、Hirai Toyohiro、Yagi Takeshi、Kondoh Gen、Gotoh Shimpei、Tamura Atsushi、Tsukita Sachiko
- Journal Title
  
  EMBO Reports
  
  Volume: 25 Issue: 3 Pages: 1176-1207
- DOI
  10.1038/s44319-024-00066-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09629, KAKENHI-PROJECT-19H05468, KAKENHI-PROJECT-18H04016
[Journal Article] Phase separation of an actin nucleator by junctional microtubules regulates epithelial function2023
- Author(s)
  Tsukita Kazuto、Kitamata Manabu、Kashihara Hiroka、Yano Tomoki、Fujiwara Ikuko、Day Timothy F.、Katsuno Tatsuya、Kim Jaewon、Takenaga Fumiko、Tanaka Hiroo、Park Sungsu、Miyata Makoto、Watanabe Hitomi、Kondoh Gen、Takahashi Ryosuke、Tamura Atsushi、Tsukita Sachiko
- Journal Title
  
  Science Advances
  
  Volume: 9 Issue: 7
- DOI
  10.1126/sciadv.adf6358
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03453, KAKENHI-PROJECT-21K09629, KAKENHI-PROJECT-21K15092, KAKENHI-PROJECT-19H05468
[Journal Article] The tight junction protein occludin modulates blood brain barrier integrity and neurological function after ischemic stroke in mice2023
- Author(s)
  Sugiyama Shintaro、Sasaki Tsutomu、Tanaka Hiroo、Yan Haomin、Ikegami Takeshi、Kanki Hideaki、Nishiyama Kumiko、Beck Goichi、Gon Yasufumi、Okazaki Shuhei、Todo Kenichi、Tamura Atsushi、Tsukita Sachiko、Mochizuki Hideki
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 2892-2892
- DOI
  10.1038/s41598-023-29894-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07414, KAKENHI-PROJECT-20K16497, KAKENHI-PROJECT-20K06910, KAKENHI-PROJECT-19H03453, KAKENHI-PROJECT-21K15092, KAKENHI-PROJECT-19H05468
[Journal Article] A microtubule‐LUZP1 association around tight junction promotes epithelial cell apical constriction2020
- Author(s)
  Yano Tomoki、Tsukita Kazuto、Kanoh Hatsuho、Nakayama Shogo、Kashihara Hiroka、Mizuno Tomoaki、Tanaka Hiroo、Matsui Takeshi、Goto Yuhei、Komatsubara Akira、Aoki Kazuhiro、Takahashi Ryosuke、Tamura Atsushi、Tsukita Sachiko
- Journal Title
  
  The EMBO Journal
  
  Volume: 40 Issue: 2
- DOI
  10.15252/embj.2020104712
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16050, KAKENHI-PLANNED-19H05798, KAKENHI-PROJECT-18H02444, KAKENHI-PROJECT-19H03453, KAKENHI-PROJECT-19K16126, KAKENHI-PROJECT-19H05468, KAKENHI-ORGANIZER-19H05794, KAKENHI-PROJECT-21K15092
[Journal Article] Cellular and Mathematical Analyses of LUBAC Involvement in T Cell Receptor-Mediated NF-κB Activation Pathway2020
- Author(s)
  D.Oikawa, N.Hatanaka, T.Suzuki, F.Tokunaga
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 11 Pages: 601926-601926
- DOI
  10.3389/fimmu.2020.601926
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06576, KAKENHI-PLANNED-16H06575, KAKENHI-PUBLICLY-20H05337, KAKENHI-PROJECT-18K06967, KAKENHI-PROJECT-19K22541, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19H05468, KAKENHI-PUBLICLY-19H05296
[Journal Article] Vinculin is critical for the robustness of the epithelial cell sheet paracellular barrier for ions.2019
- Author(s)
  Konishi S, Yano T, Tanaka H, Mizuno T, Kanoh H, Tsukita K, Namba T, Tamura A, Yonemura S, Gotoh S, Matsumoto H, Hirai T, Tsukita S.
- Journal Title
  
  Life Sci Alliance
  
  Volume: 2 Issue: 4 Pages: e201900414-e201900414
- DOI
  10.26508/lsa.201900414
- NAID
  120007144472
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08649, KAKENHI-PROJECT-19K16126, KAKENHI-PROJECT-18H03999, KAKENHI-PROJECT-18H02617, KAKENHI-PROJECT-18K14696, KAKENHI-PROJECT-16H05121, KAKENHI-PROJECT-19H05468, KAKENHI-PROJECT-19H03453
[Journal Article] The Claudins: From Tight Junctions to Biological Systems2019
- Author(s)
  Tsukita Sachiko、Tanaka Hiroo、Tamura Atsushi
- Journal Title
  
  Trends in Biochemical Sciences
  
  Volume: 44 Issue: 2 Pages: 141-152
- DOI
  10.1016/j.tibs.2018.09.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16126, KAKENHI-PROJECT-18H03999, KAKENHI-PROJECT-16H05121, KAKENHI-PROJECT-19H05468
[Journal Article] Deficiency of Stomach-Type Claudin-18 in Mice Induces Gastric Tumor Formation Independent of H. Pylori Infection.2019
- Author(s)
  Suzuki K, Sentani K, Tanaka H, Yano T, Suzuki K, Oshima M, Yasui W, Tamura A, Tsukita S.
- Journal Title
  
  Cell Mol Gastroenterol Hepatol.
  
  Volume: 印刷中 Issue: 1 Pages: 119-142
- DOI
  10.1016/j.jcmgh.2019.03.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08691, KAKENHI-PROJECT-19K07434, KAKENHI-PROJECT-19K16126, KAKENHI-PROJECT-19H03443, KAKENHI-PROJECT-18H03999, KAKENHI-PROJECT-16H05121
[Journal Article] Morphologic determinant of tight junctions revealed by claudin-3 structures2019
- Author(s)
  Nakamura Shun、Irie Katsumasa、Tanaka Hiroo、Nishikawa Kouki、Suzuki Hiroshi、Saitoh Yasunori、Tamura Atsushi、Tsukita Sachiko、Fujiyoshi Yoshinori
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 816-816
- DOI
  10.1038/s41467-019-08760-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K17795, KAKENHI-PROJECT-15H05775, KAKENHI-PROJECT-19K16126, KAKENHI-PROJECT-18H03999, KAKENHI-PROJECT-16H05121
[Presentation] TJMAP2は微小管依存的な相分離により細胞接着部位のアクチン重合を制御する2022
- Author(s)
  月田和人, 　矢野智樹、藤原、Day Timothy Francis, 勝野達也、柏原宏香、竹永富妙子、田中啓雄、田村淳、月田早智子
- Organizer
  第74回細胞生物学会
- Data Source
  KAKENHI-PROJECT-19H05468
[Presentation] TJMAP2は微小管依存的な相分離により細胞接着部位のアクチン重合を制御する2022
- Author(s)
  月田和人, 　矢野智樹、藤原、DayTimothyFrancisFrancis, 勝野達也、柏原宏香、竹永富妙子、田中啓雄、田村淳、月田早智子
- Organizer
  第74回細胞生物学会
- Data Source
  KAKENHI-PROJECT-19H05468
[Presentation] 上皮細胞間接着装置タイトジャンクションによる外分泌システムの構築と生体防御2021
- Author(s)
  田中啓雄、田村淳、月田早智子
- Organizer
  第92回　日本動物学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15092
[Presentation] StCldn18 deficiency activates signaling cascade towards gastric tumorigenesis in mice2021
- Author(s)
  Tamura, A. Suzuki, K., Tanaka, H., Yano, T., Hayashi, D., Sentani, K., Oshima, M., Yasui, W., and Tsukit, S.
- Organizer
  4th International Tight Junction Conference, Berlin (online conference)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05468
[Presentation] 上皮細胞間接着装置タイトジャンクションによる外分泌制御と生体防御2021
- Author(s)
  田中啓雄
- Organizer
  公益社団法人日本動物学会　第92回米子大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16126
[Presentation] 上皮細胞間接着装置タイトジャンクションによる外分泌システムの構築2021
- Author(s)
  田中啓雄
- Organizer
  第126回日本解剖学会総会・全国学術集会、第98回日本生理学会大会　合同大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16126
[Presentation] タイトジャンクションの変化はマウス胃腫瘍形成へのシグナルカスケードを活性化する2020
- Author(s)
  田村淳、鈴木浩也、田中啓雄、矢野智樹、仙谷和弘、大島正伸、安井弥、月田早智子
- Organizer
  第 79 回日本癌学会学術総会(Web 開催)
- Data Source
  KAKENHI-PROJECT-19H05468
[Presentation] 上皮細胞間接着装置タイトジャンクションによる外分泌システムの構築2020
- Author(s)
  田中啓雄
- Organizer
  第 126 回日本解剖学会総会・全国学術集会、第 98 回日本生理学会大会合同大会(Web 開催)
- Data Source
  KAKENHI-PROJECT-19H05468
[Presentation] Claudin-3の結晶構造が明らかにするタイトジャンクション形態の決定要素2019
- Author(s)
  中村駿, 入江克雅, 田中啓雄, 田村淳, 月田早智子, 藤吉好則
- Organizer
  第19回日本蛋白質科学会年会・第71回日本細胞生物学会大会合同年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H05468
[]

1. 月田早智子 (00188517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. Danev Radostin (50415931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 中村駿 (80882779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 後藤慎平 (50747219)

# of Collaborated Projects: 1 results

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5. 近藤玄 (40243258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 田村淳 (00362525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
7. 柏原宏香 (20966692)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 足澤悦子 (00446262)

# of Collaborated Projects: 1 results

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9. 足立誠 (30335244)

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10. 鈴木貴 (40114516)

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11. 矢野智樹 (20546121)

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# of Collaborated Products: 4 results
12. 入江克雅 (20415087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. SASAKI Tsutomu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. SENTANI Kazuhiro

# of Collaborated Projects: 0 results

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15. KATSUNO Tatsuya

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16. 松本久子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 後藤祐平

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# of Collaborated Products: 1 results

Tanaka Hiroo 田中 啓雄

Research Projects

Research Products

Co-Researchers

Fundamental principles underlying the functional diversity of tight junctionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Astrocytes form tight junctions to organize blood brain barrierPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Tight junctions to organize apical membranes of epithelial cell sheets.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel approach focusing on the tight junction-based paracellular barrier combined with the apical barrier toward understanding and manipulating epithelial barriers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 膜タンパク質工学ハンドブック 「クローディンを基盤とするタイトジャンクションと生体システム構築の多様性」2020

Author(s)

Total Pages

Publisher

Data Source

[Book] 膜タンパク質工学ハンドブック 「クローディンを基盤とするタイトジャンクションと生体システム構築 の多様性」2020

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Dual-color live imaging unveils stepwise organization of multiple basal body arrays by cytoskeletons2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phase separation of an actin nucleator by junctional microtubules regulates epithelial function2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The tight junction protein occludin modulates blood brain barrier integrity and neurological function after ischemic stroke in mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A microtubule‐LUZP1 association around tight junction promotes epithelial cell apical constriction2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cellular and Mathematical Analyses of LUBAC Involvement in T Cell Receptor-Mediated NF-κB Activation Pathway2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Vinculin is critical for the robustness of the epithelial cell sheet paracellular barrier for ions.2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] The Claudins: From Tight Junctions to Biological Systems2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deficiency of Stomach-Type Claudin-18 in Mice Induces Gastric Tumor Formation Independent of H. Pylori Infection.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Morphologic determinant of tight junctions revealed by claudin-3 structures2019

Tanaka Hiroo 田中啓雄

[Book] 膜タンパク質工学ハンドブック　「クローディンを基盤とするタイトジャンクションと生体システム構築の多様性」2020

[Book] 膜タンパク質工学ハンドブック「クローディンを基盤とするタイトジャンクションと生体システム構築の多様性」2020