Kuniishi Mari 國石茉里 (彦坂)

… Alternative Names

彦坂

彦坂茉里ヒコサカマリ

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Researcher Number	70804326
Other IDs
Affiliation (Current)	2025: 富山大学, 学術研究部薬学・和漢系, 助教
Affiliation (based on the past Project Information) *help	2025: 富山大学, 学術研究部薬学・和漢系, 助教 2022 – 2023: 富山大学, 学術研究部薬学・和漢系, 助教 2017 – 2021: 三重大学, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / Experimental pathology
Keywords	Principal Investigator IgE / B cell / IgA / allergy / FDC / 抗原抗体複合体 / I型アレルギー / リンパ組織 / 支持細胞 / stromal cell … More / リンパ節 / Ab production / isolation / Antibody / 形質細胞 / 抗体産生 / 細胞凝集 / Fc gamma receptors / 凝集 / I型アレルギー疾患 Less

大腸粘膜固有層のT細胞非依存的IgA産生誘導におけるTRAF5の制御機構の解明Principal Investigator
- Principal Investigator
  
  國石茉里 (彦坂)
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  University of Toyama
I型アレルギー疾患の制御にむけたFDCによるIgA抗体の産生制御機構の基礎的研究Principal Investigator
- Principal Investigator
  
  國石茉里
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  University of Toyama
the regulation of IgE production by follicular dendritic cellsPrincipal Investigator
- Principal Investigator
  
  Kuniishi Mari
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  University of Toyama
  Mie University
The mechanisms about the cell aggregation of IgE-producing cellsPrincipal Investigator
- Principal Investigator
  
  Kuniishi Mari
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Experimental pathology
- Research Institution
  Mie University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Depletion of Neural Crest?Derived Cells Leads to Plasma Noradrenaline Decrease and Alters T Cell Development2023
- Author(s)
  Tsunokuma Naoki、Tetteh Doris Narki、Isono Kana、Kuniishi-Hikosaka Mari、Tsuneto Motokazu、Ishii Kenichiro、Yamazaki Hidetoshi
- Journal Title
  
  The Journal of Immunology
  
  Volume: 211 Issue: 10 Pages: 1494-1505
- DOI
  10.4049/jimmunol.2300045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15441, KAKENHI-PROJECT-22K09444, KAKENHI-PROJECT-22K09901
[Journal Article] Role of tumor necrosis factor receptor-associated factor 5 in B- and T-lymphocytes2023
- Author(s)
  Hikosaka Kuniishi Mari、Ishii Naoto、So Takanori
- Journal Title
  
  Exploration of Immunology
  
  Volume: 3 Pages: 40-55
- DOI
  10.37349/ei.2023.00088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15441, KAKENHI-PROJECT-19K16608
[Journal Article] Fundamental Characterization of Antibody Fusion-Single-Chain TNF Recombinant Proteins Directed against Costimulatory TNF Receptors Expressed by T-Lymphocytes2023
- Author(s)
  Nagai Hodaka、Azuma Mitsuki、Sato Ayaka、Shibui Nagito、Ogawara Sayaka、Tsutsui Yuta、Suzuki Ayano、Wakaizumi Tomomi、Ito Aya、Matsuyama Shimpei、Morita Masashi、Hikosaka Kuniishi Mari、Ishii Naoto、So Takanori
- Journal Title
  
  Cells
  
  Volume: 12 Issue: 12 Pages: 1596-1596
- DOI
  10.3390/cells12121596
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15441
[Journal Article] Multiple cell populations generate macrophage progenitors in the early yolk sac2022
- Author(s)
  Ito C, Hikosaka-Kuniishi M, Yamazaki H, Yamane T
- Journal Title
  
  Cellular and Molecular Life Sciences
  
  Volume: 79 Issue: 3 Pages: 159-159
- DOI
  10.1007/s00018-022-04203-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09950, KAKENHI-PROJECT-19K10041, KAKENHI-PROJECT-20K08752, KAKENHI-PROJECT-19K16608, KAKENHI-PROJECT-22K09901
[Journal Article] Isolation of CD35+ follicular dendritic cells and its role in the differentiation from B cells to IgA+GL7+ cells2022
- Author(s)
  Hikosaka-Kuniishi M, Yamane T, Isono K, Tetteh DN, Yamazaki H
- Journal Title
  
  Immunology Letters
  
  Volume: 243 Pages: 53-60
- DOI
  10.1016/j.imlet.2022.02.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09950, KAKENHI-PROJECT-19K10041, KAKENHI-PROJECT-20K08752, KAKENHI-PROJECT-19K16608, KAKENHI-PROJECT-22K09901
[Journal Article] Simultaneous Fluorescent Identification of Odontoblasts and Ameloblasts2021
- Author(s)
  Isono K, Takahashi E, Miyoshi I, Tsuneto M, Hikosaka-Kuniishi M, Yamane T, Yamazaki H
- Journal Title
  
  J. Dent. Res.
  
  Volume: 100 Issue: 5 Pages: 532-541
- DOI
  10.1177/0022034520974576
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09950, KAKENHI-PROJECT-19K10041, KAKENHI-PROJECT-20K08752, KAKENHI-PROJECT-19K16608
[Presentation] T細胞に発現するTNF受容体ファミリー分子OX40の機能を制御するOX40リガンドタンパク質の構造と機能評価.2024
- Author(s)
  佐藤綾香, 東充輝, 永井穂高, 鈴木綾乃, 伊藤文, 守田雅志, 國石（彦坂）茉里, 宗孝紀.
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K15441
[Presentation] Is the regulatory activity of TRAF5 for IL-6 receptor signaling important for the differentiation of follicular helper T cells?2024
- Author(s)
  Mari Hikosaka-Kuniishi, Sayaka Ogawara, Chieri Iwata, Tomomi Wakaizumi, Hodaka Nagai, Mitsuki Azuma, Masashi Morita, Naoto Ishii, Takanori So.
- Organizer
  The 52nd Annual Meeting of the Japanese Society for Immunology.
- Data Source
  KAKENHI-PROJECT-22K15441
[Presentation] Functional characterization of antibody fusion-single-chain TNF proteins that agonize costimulatory TNFR expressed by T cells.2024
- Author(s)
  Hodaka Nagai, Mitsuki Azuma, Ayaka Sato, Sayaka Ogawara, Yuta Tsutsui, Ayano Suzuki, Shimpei Matsuyama, Tomomi Wakaizumi, Masashi Morita, Mari Hikosaka-Kuniishi, Naoto Ishii, Takanori So,
- Organizer
  The 52nd Annual Meeting of the Japanese Society for Immunology.
- Data Source
  KAKENHI-PROJECT-22K15441
[Presentation] Structural and functional characterization of recombinant OX40 ligand fusion proteins.2024
- Author(s)
  Ayaka Sato, Mitsuki Azuma, Hodaka Nagai, Aya Ito, Masashi Morita, Mari Hikosaka-Kuniishi, Naoto Ishii, Takanori So.
- Organizer
  The 52nd Annual Meeting of the Japanese Society for Immunology.
- Data Source
  KAKENHI-PROJECT-22K15441
[Presentation] Basic characterization of TNF ligand-based agonists targeting OX40, 4-1BB, CD27, and GITR expressed by T cells.2024
- Author(s)
  Takanori So, Hodaka Nagai, Mitsuki Azuma, Ayaka Sato, Ayano Suzuki, Aya Ito, Masashi Morita, Mari Hikosaka-Kuniishi, Naoto Ishii.
- Organizer
  The 52nd Annual Meeting of the Japanese Society for Immunology.
- Data Source
  KAKENHI-PROJECT-22K15441
[Presentation] B細胞におけるTRAF5の高発現はTLRシグナルを介した IgM 抗体産生能の抑制に重要か？2024
- Author(s)
  東充輝, 斉藤弘晃, 若泉知美, 岩谷航洋, 小澤勇介, 守田雅志, 國石（彦坂）茉里, 宗孝紀.
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K15441
[Presentation] The expression level of TRAF5 negatively impacts the TLR signaling.2024
- Author(s)
  Mitsuki Azuma, Hiroaki Saito, Tomomi Wakaizumi, Koyo Iwatani, Yusuke Ozawa, Masashi Morita, Mari Kuniishi-Hikosaka, Naoto Ishii, Takanori So.
- Organizer
  The 52nd Annual Meeting of the Japanese Society for Immunology.
- Data Source
  KAKENHI-PROJECT-22K15441
[Presentation] ABCD1欠損ヒトアストロサイトーマU87細胞株のNLRP3インフラマソーム活性化機構の解析.2024
- Author(s)
  守田雅志, 松沢紗良, 國石（彦坂）茉里, 宗孝紀.
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K15441
[Presentation] マウス粘膜組織におけるIgA産生へのTraf5の役割の検討.2024
- Author(s)
  國石(彦坂)茉里, 筒井雄太, 小林奏一朗, 東充輝, 真柄弘汰, 小河原さやか, 岩田千恵梨, 若泉知美, 守田雅志, 宗孝紀.
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K15441
[Presentation] Structural requirement of soluble OX40 ligand protein for efficient induction of co-stimulatory signaling mediated by OX40.2023
- Author(s)
  Ayaka Sato, Mitsuki Azuma, Hodaka Nagai, Nagito Shibui, Sayaka Ogawara, Yuta Tsustui, Ayano Suzuki, Aya Ito, Tomomi Wakaizumi, Shimpei Matsuyama, Masashi Morita, Mari Hikosaka-Kuniishi, Takanori So.
- Organizer
  7th Toyama-Basel Joint Symposium 2023.
- Data Source
  KAKENHI-PROJECT-22K15441
[Presentation] ABCD1欠損アストロサイトのNLRP3インフラマソーム活性化2023
- Author(s)
  松沢紗良, 守田雅志, 國石茉里, 宗孝紀.
- Organizer
  日本薬学会北陸支部第135回例会
- Data Source
  KAKENHI-PROJECT-22K15441
[Presentation] Traf5欠損マウスの腸管粘膜固有層におけるIgA産生機構の解析2023
- Author(s)
  筒井雄太, 國石茉里, 小林奏一朗, 東充輝, 真柄弘汰, 小河原さやか, 岩田千恵梨, 若泉知美, 守田雅志, 宗孝紀.
- Organizer
  日本薬学会北陸支部第135回例会.
- Data Source
  KAKENHI-PROJECT-22K15441
[Presentation] TRAF5の欠損がマウスのリンパ組織におけるTfh細胞とGC B細胞の産生に及ぼす影響.2023
- Author(s)
  小河原さやか, 國石茉里, 岩田千恵梨, 若泉知美, 永井穂高, 東充輝, 真柄弘汰, 守田雅志, 宗孝紀.
- Organizer
  日本薬学会北陸支部第135回例会.
- Data Source
  KAKENHI-PROJECT-22K15441
[Presentation] Neural crest-derived mesenchymal cells support thymic reconstitution after lethal irradiation.2023
- Author(s)
  Doris Narki Tetteh, Mari Hikosaka-Kuniishi, Hidetoshi Yamazaki
- Organizer
  IMMUNOLOGY2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15441
[Presentation] Elucidation of the relationship between the expression level of TRAF5 and the negative regulatory function of TRAF5 for TLR signaling.2023
- Author(s)
  Mitsuki Azuma, Hiroaki Saito, Koyo Iwatani, Tomomi Wakaizumi, Wakana Imai, Sayaka Ogawara, Masashi Morita, Mari Hikosaka-Kuniishi, Takanori So.
- Organizer
  7th Toyama-Basel Joint Symposium 2023.
- Data Source
  KAKENHI-PROJECT-22K15441
[Presentation] Functional evaluation of single-chain TNF ligand-Fc fusion proteins for activation of co-stimulatory TNF receptors expressed by T-lymphocytes.2023
- Author(s)
  Hodaka Nagai, Mitsuki Azuma, Ayaka Sato, Nagito Shibui, Sayaka Ogawara, Yuta Tsutsui, Ayano Suzuki, Tomomi Wakaizumi, Aya Ito, Shimpei Matsuyama, Masashi Morita, Mari Hikosaka-Kuniishi, Takanori So.
- Organizer
  7th Toyama-Basel Joint Symposium 2023.
- Data Source
  KAKENHI-PROJECT-22K15441
[Presentation] Enhanced Th1 response mediated by LXR activation in ABCD1-deficient CD4+ T cells.2023
- Author(s)
  Masashi Morita, Reina Maeda, Mayu Oishi, Ryutaro Nagamori, Mari Kuniishi, Takanori So.
- Organizer
  第64回日本先天代謝異常学会学術集会.
- Data Source
  KAKENHI-PROJECT-22K15441
[Presentation] TRAF5欠損B細胞のTLRシグナル応答の解析.2023
- Author(s)
  若泉知美, 東充輝, 斉藤弘晃, 小澤勇介, 岩谷航洋, 守田雅志, 國石茉里, 宗孝紀.
- Organizer
  日本薬学会北陸支部第135回例会.
- Data Source
  KAKENHI-PROJECT-22K15441
[Presentation] The role of isolated CD35+ follicular dendritic cells in the differentiation from B cells to IgA+ GL7+ cells2022
- Author(s)
  Mari Hikosaka-Kuniishi, Toshiyuki Yamane, Doris Narki Tetteh, Hidetoshi Yamazaki
- Organizer
  The 51st Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-22K15441
[Presentation] Neural crest-derived mesenchymal cells support thymic regeneration after lethal irradiation2022
- Author(s)
  Doris Narki Tetteh, Hidetoshi Yamazaki, Mari Hikosaka-Kuniishi
- Organizer
  The 51st Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-22K15441
[Presentation] The role of isolated CD35+ follicular dendritic cells in the differentiation from B cells to IgA+ GL7+ cells2022
- Author(s)
  Mari Hikosaka-Kuniishi, Toshiyuki Yamane, Doris Narki Tetteh, Hidetoshi Yamazaki
- Organizer
  The 51st Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-19K16608
[Presentation] Neural crest-derived mesenchymal cells support thymic regeneration after lethal irradiation2022
- Author(s)
  Doris Narki Tetteh, Hidetoshi Yamazaki, Mari Hikosaka-Kuniishi
- Organizer
  The 51st Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-19K16608
[Presentation] リンパ節ストローマ細胞Follicular dendritic cellによるレチノイン酸を介したIgA抗体制御機序の解明への試み2021
- Author(s)
  國石(彦坂) 茉里、磯野加奈、山崎英俊
- Organizer
  第2回 Winter Dental Meeting in Tsu（ウインターデンタルミーティングin津）
- Data Source
  KAKENHI-PROJECT-19K16608
[Presentation] エナメル質形成不全マウス（Amelx♂）及び象牙質形成不全マウス（DsppGFP/GFP）を用いたエナメル質及び象牙質の構造解析の試み2021
- Author(s)
  磯野加奈、國石(彦坂) 茉里、山崎英俊
- Organizer
  第2回 Winter Dental Meeting in Tsu（ウインターデンタルミーティングin津）
- Data Source
  KAKENHI-PROJECT-19K16608
[Presentation] Follicular dendritic cell-mediated enhancement of the differentiation into IgA+GL7+ cells2021
- Author(s)
  Mari Hikosaka-Kuniishi, Toshiyuki Yamane, Hidetoshi Yamazaki
- Organizer
  the 50th annual meeting of the japanese society for immunology
- Data Source
  KAKENHI-PROJECT-19K16608
[Presentation] Amelx欠損及びDspp遺伝子欠損マウスの歯のCT解析2020
- Author(s)
  磯野加奈、國石（彦坂）茉里、山崎英俊
- Organizer
  第1回Winter Dental meeting in 津（第48回三重歯科・口腔外科学会）
- Data Source
  KAKENHI-PROJECT-19K16608
[Presentation] リンパ組織支持細胞Follicular dendritic cellによる粘膜免疫に関わるIgA抗体制御機構解明の試み2020
- Author(s)
  國石（彦坂）茉里、磯野加奈、山崎英俊
- Organizer
  第1回Winter Dental meeting in 津（第48回三重歯科・口腔外科学会）
- Data Source
  KAKENHI-PROJECT-19K16608
[Presentation] The role of Neural crest-derived cells in thymic regeneration2019
- Author(s)
  Doris Narki Tetteh, Mari Hikosaka-Kuniishi, Toshiyuki Yamane, Hidetoshi Yamazaki
- Organizer
  The 48th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-19K16608
[Presentation] Involvement of follicular dendritic cells in each LNs with IgAproduction2019
- Author(s)
  Mari Hikosaka-Kuniishi, Toshiyuki Yamane, Hidetoshi Yamazaki
- Organizer
  The 48th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-19K16608
[Presentation] The role of Neural crest-derived cells in thymic regeneration2019
- Author(s)
  Doris Narki Tetteh, Mari Hikosaka-Kuniishi, Toshiyuki Yamane, Hidetoshi Yamazaki
- Organizer
  The 48th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-17H06765
[Presentation] 粘膜免疫に関与するリンパ節支持細胞 follicular dendritic cellの検出の試み2019
- Author(s)
  國石（彦坂）茉里，磯野加奈，山崎英俊
- Organizer
  第47回　三重歯科・口腔外科学会
- Data Source
  KAKENHI-PROJECT-17H06765
[Presentation] 粘膜免疫に関与するリンパ節支持細胞 follicular dendritic cellの検出の試み2019
- Author(s)
  國石（彦坂）茉里, 磯野加奈, 山崎英俊
- Organizer
  第47回　三重歯科・口腔外科学会
- Data Source
  KAKENHI-PROJECT-19K16608
[Presentation] Multiple cell populations generate macrophage progenitors in the early yolk sac2019
- Author(s)
  Toshiyuki Yamane, Mari Hikosaka-Kuniishi, Hidetoshi Yamazaki
- Organizer
  The 48th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-19K16608
[Presentation] Multiple cell populations generate macrophage progenitors in the early yolk sac2019
- Author(s)
  Toshiyuki Yamane, Mari Hikosaka-Kuniishi, Hidetoshi Yamazaki
- Organizer
  The 48th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-17H06765
[Presentation] Involvement of follicular dendritic cells in each LNs with IgA production2019
- Author(s)
  Mari Hikosaka-Kuniishi, Toshiyuki Yamane, Hidetoshi Yamazaki
- Organizer
  The 48th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-17H06765

1. YAMANE Toshiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
2. 山崎英俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Kuniishi Mari 國石 茉里 (彦坂)

彦坂

彦坂 茉里 ヒコサカ マリ

Research Projects

Research Products

Co-Researchers

大腸粘膜固有層のT細胞非依存的IgA産生誘導におけるTRAF5の制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

I型アレルギー疾患の制御にむけたFDCによるIgA抗体の産生制御機構の基礎的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

the regulation of IgE production by follicular dendritic cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The mechanisms about the cell aggregation of IgE-producing cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Depletion of Neural Crest?Derived Cells Leads to Plasma Noradrenaline Decrease and Alters T Cell Development2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of tumor necrosis factor receptor-associated factor 5 in B- and T-lymphocytes2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fundamental Characterization of Antibody Fusion-Single-Chain TNF Recombinant Proteins Directed against Costimulatory TNF Receptors Expressed by T-Lymphocytes2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multiple cell populations generate macrophage progenitors in the early yolk sac2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isolation of CD35+ follicular dendritic cells and its role in the differentiation from B cells to IgA+GL7+ cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Simultaneous Fluorescent Identification of Odontoblasts and Ameloblasts2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] T細胞に発現するTNF受容体ファミリー分子OX40の機能を制御するOX40リガンドタンパク質の構造と機能評価.2024

Author(s)

Organizer

Data Source

[Presentation] Is the regulatory activity of TRAF5 for IL-6 receptor signaling important for the differentiation of follicular helper T cells?2024

Author(s)

Organizer

Data Source

[Presentation] Functional characterization of antibody fusion-single-chain TNF proteins that agonize costimulatory TNFR expressed by T cells.2024

Author(s)

Organizer

Data Source

[Presentation] Structural and functional characterization of recombinant OX40 ligand fusion proteins.2024

Author(s)

Organizer

Data Source

[Presentation] Basic characterization of TNF ligand-based agonists targeting OX40, 4-1BB, CD27, and GITR expressed by T cells.2024

Author(s)

Organizer

Data Source

Kuniishi Mari 國石茉里 (彦坂)

彦坂茉里ヒコサカマリ