Sunada Shigeaki 砂田成章

Researcher Number	70807677
Other IDs	https://orcid.org/0000-0002-9446-8522
Affiliation (Current)	2025: 順天堂大学, 健康総合科学先端研究機構, 特任助教
Affiliation (based on the past Project Information) *help	2021 – 2022: 順天堂大学, 健康総合科学先端研究機構, 特任助教 2018 – 2021: 東京医科歯科大学, 難治疾患研究所, 助教 2017: 東京医科歯科大学, 難治疾患研究所, プロジェクト助教
Review Section/Research Field	Principal Investigator Basic Section 63020:Radiation influence-related / Risk sciences of radiation and chemicals Except Principal Investigator Basic Section 50010:Tumor biology-related / Medium-sized Section 50:Oncology and related fields
Keywords	Principal Investigator DNA二本鎖切断 / 遺伝性乳がん・卵巣がん / 細胞周期 / DNA修復 / 放射線感受性 / 相同組換え修復 / 既存薬再開発 / 多剤併用 / 化学療法抵抗性 / 合成致死 … More / 転写制御 / 相乗効果 / エトポシド / DNA損傷修復 / Tioxolone / PARP阻害剤 / ステロイド / トポイソメラーゼII阻害剤 / 相乗的抗腫瘍効果 / 化合物併用 / 化合物スクリーニング / 遺伝性乳がん / S/G2期 / G2/M期細胞周期アレスト / CDK1阻害剤 / G2/M細胞周期アレスト … More Except Principal Investigator 乳がん / BRCA1, BRCA2 / DNA相同組換え修復機能 / 合成致死 / BRCA1, 2 / BRCA2遺伝子 / BRCA1遺伝子 / DNA相同組換え修復 / 合成致死療法 / 耐性克服療法 / PARP阻害剤 / 相同組み換え修復 / 合成致死量法 / オートファジー / BRCA1/2 / Mfn / マイトファジー / ミトコンドリア Less

Development of novel cancer treatment to overcome acquired resistance mechanisms in synthetic lethal therapy targeting DNA repairPrincipal Investigator
- Principal Investigator
  
  Sunada Shigeaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Juntendo University
  Tokyo Medical and Dental University
Development of a Novel Synthetic Lethal Therapy for Breast Cancer by Targeting DNA Homologous Recombination Repair.
- Principal Investigator
  
  Miki Yoshio
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tokyo Medical and Dental University
Study on novel mechanism of breast cancer development by modulation of mitochondrial control
- Principal Investigator
  
  Miki Yoshio
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Tokyo Medical and Dental University
Development of radiation sensitization for cancer cells based on cell cycle-dependent DNA repair systemPrincipal Investigator
- Principal Investigator
  
  Sunada Shigeaki
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Tokyo Medical and Dental University
S/G2期における放射線感受性を高める因子の同定とがん治療開発へ向けた研究Principal Investigator
- Principal Investigator
  
  砂田成章
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Tokyo Medical and Dental University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Patent

[Journal Article] Discovery of novel DNA-damaging agents through phenotypic screening for DNA double-strand break2023
- Author(s)
  Zhang Doudou, Takashi Shimokawa, Qianqian Guo, Shingo Dan, Yoshio Miki, Shigeaki Sunada
- Journal Title
  
  Cancer Science
  
  Volume: 113(4) Issue: 3 Pages: 1108-1117
- DOI
  10.1111/cas.15659
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H04333
[Journal Article] CDK1 inhibitor controls G2/M phase transition and reverses DNA damage sensitivity.2021
- Author(s)
  Sunada S, Saito H, Zhang D, Xu Z, Miki Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 550 Pages: 56-61
- DOI
  10.1016/j.bbrc.2021.02.117
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03497, KAKENHI-PROJECT-20H04333
[Journal Article] PARP Inhibitors: Mechanism of Action2021
- Author(s)
  Sunada Shigeaki、Miki Yoshio
- Journal Title
  
  Hereditary Breast and Ovarian Cancer
  
  Volume: 1 Pages: 281-292
- DOI
  10.1007/978-981-16-4521-1_18
- ISBN
  9789811645204, 9789811645211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H04333
[Journal Article] Radiobiological Characterization of Canine Malignant Melanoma Cell Lines with Different Types of Ionizing Radiation and Efficacy Evaluation with Cytotoxic Agents2019
- Author(s)
  Yoshikawa Hiroto、Sunada Shigeaki、Hirakawa Hirokazu、Fujimori Akira、Elmegerhi Suad、Leary Del、Kato Takamitsu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 4 Pages: 841-841
- DOI
  10.3390/ijms20040841
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18192, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-PLANNED-15H05944, KAKENHI-ORGANIZER-15H05935
[Journal Article] Sister Chromatid Exchange as a Genotoxic Stress Marker2019
- Author(s)
  Sunada Shigeaki, Haskins Jeremy S., Kato Takamitsu A.
- Journal Title
  
  Methods in molecular biology (Clifton, N.J.)
  
  Volume: - Pages: 61-68
- DOI
  10.1007/978-1-4939-9432-8_7
- ISBN
  9781493994304, 9781493994328
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18192
[Journal Article] DNA Repair Deficient Chinese Hamster Ovary Cells Exhibiting Differential Sensitivity to Charged Particle Radiation under Aerobic and Hypoxic Conditions2018
- Author(s)
  Cartwright Ian M.、Su Cathy、Haskins Jeremy S.、Salinas Victoria A.、Sunada Shigeaki、Yu Hao、Uesaka Mitsuru、Hirakawa Hirokazu、Chen David J.、Fujimori Akira、Kato Takamitsu A.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 8 Pages: 2228-2228
- DOI
  10.3390/ijms19082228
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18192, KAKENHI-PLANNED-15H05944, KAKENHI-PROJECT-17H01071, KAKENHI-ORGANIZER-15H05935
[Journal Article] Crosstalk of DNA double-strand break repair pathways in poly(ADP-ribose) polymerase inhibitor treatment of breast cancer susceptibility gene 1/2-mutated cancer.2018
- Author(s)
  Sunada S, Nakanishi A, Miki Y.
- Journal Title
  
  Cancer Sci.
  
  Volume: 109 Issue: 4 Pages: 893-899
- DOI
  10.1111/cas.13530
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19473, KAKENHI-PUBLICLY-18H04898, KAKENHI-PROJECT-16H04693, KAKENHI-PROJECT-17H06651
[Patent] 悪性腫瘍治療剤2022
- Inventor(s)
  砂田成章, 三木義男
- Industrial Property Rights Holder
  砂田成章, 三木義男
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-144405
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-20H04333
[Presentation] ステロイドはTop2毒を促進することでトポイソメラーゼ2阻害剤による細胞感受性を増強する(Steroids sensitize Top2 inhibitor treated tumor cells by potentiating Top2 poisons)2022
- Author(s)
  砂田成章, 趙ニン, 張抖抖, 三木義男
- Organizer
  日本放射線影響学会第65回大会
- Data Source
  KAKENHI-PROJECT-20H04333
[Presentation] 臨床的意義不明なBRCA1/2バリアントの相同組み換え活性(Homologous Recombination Activity of BRCA1/2 VUSs)2022
- Author(s)
  郭倩倩, 姫しゅうてい, 斉藤広子, 三木義男, 砂田成章
- Organizer
  第81回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-20H04333
[Presentation] 臨床的意義不明なBRCA2バリアントの相同組換え活性2021
- Author(s)
  郭倩倩, 徐澤宇, 斉藤広子, 砂田成章, 三木義男
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03497
[Presentation] Tioxoloneによる新たな合成致死療法の開発2020
- Author(s)
  張抖抖, 砂田成章, 三木義男
- Organizer
  第79回癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H04333
[Presentation] ステロイドホルモンはトポイソメラーゼ2機能不全に伴う毒性を増強する2020
- Author(s)
  趙ニン, 砂田成章, 三木義男
- Organizer
  第79回癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H04333
[Presentation] 遺伝子修復を標的とする新しい治療法の開発2020
- Author(s)
  三木義男, 砂田成章, 中西啓
- Organizer
  第79回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03497
[Presentation] 臨床的意義不明なBRCA2バリアントの相同組換え活性2020
- Author(s)
  郭倩倩, 徐澤宇, 斉藤広子, 砂田成章, 三木義男
- Organizer
  第79回癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H04333
[Presentation] 遺伝性乳がん卵巣がんの原因遺伝子のVUSに対する相同組み換え活性に関する研究2019
- Author(s)
  Xu Zeyu, Guo Qianqian, 斉藤広子, 砂田成章, 三木義男
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K18192
[Presentation] 遺伝性乳がんにおけるPARP阻害剤耐性機構の獲得を克服する新たな合成致死療法の開発2019
- Author(s)
  Zhang Doudou, Zhao Ying, 砂田成章, 三木義男
- Organizer
  日本放射線影響学会第62回大会
- Data Source
  KAKENHI-PROJECT-18K18192
[Presentation] 細胞周期依存的なDNA修復機構を利用したがん特異的な放射線増感法の開発2019
- Author(s)
  砂田成章, 斉藤広子, 三木義男
- Organizer
  日本放射線影響学会第61回大会
- Data Source
  KAKENHI-PROJECT-18K19473
[Presentation] 細胞周期依存的なDNA修復機構を利用したがん特異的な放射線増感法の開発2018
- Author(s)
  砂田成章、斉藤広子、三木義男
- Organizer
  日本放射線影響学会　第61回大会
- Data Source
  KAKENHI-PROJECT-18K18192

1. Miki Yoshio (10281594)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
2. 下川卓志 (20608137)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 旦慎吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sunada Shigeaki 砂田 成章

Research Projects

Research Products

Co-Researchers

Development of novel cancer treatment to overcome acquired resistance mechanisms in synthetic lethal therapy targeting DNA repairPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a Novel Synthetic Lethal Therapy for Breast Cancer by Targeting DNA Homologous Recombination Repair.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on novel mechanism of breast cancer development by modulation of mitochondrial control

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of radiation sensitization for cancer cells based on cell cycle-dependent DNA repair systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

S/G2期における放射線感受性を高める因子の同定とがん治療開発へ向けた研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Discovery of novel DNA-damaging agents through phenotypic screening for DNA double-strand break2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CDK1 inhibitor controls G2/M phase transition and reverses DNA damage sensitivity.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PARP Inhibitors: Mechanism of Action2021

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Radiobiological Characterization of Canine Malignant Melanoma Cell Lines with Different Types of Ionizing Radiation and Efficacy Evaluation with Cytotoxic Agents2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sister Chromatid Exchange as a Genotoxic Stress Marker2019

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] DNA Repair Deficient Chinese Hamster Ovary Cells Exhibiting Differential Sensitivity to Charged Particle Radiation under Aerobic and Hypoxic Conditions2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crosstalk of DNA double-strand break repair pathways in poly(ADP-ribose) polymerase inhibitor treatment of breast cancer susceptibility gene 1/2-mutated cancer.2018

Author(s)

Journal Title

DOI

Data Source

[Patent] 悪性腫瘍治療剤2022

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] ステロイドはTop2毒を促進することでトポイソメラーゼ2阻害剤による細胞感受性を増強する(Steroids sensitize Top2 inhibitor treated tumor cells by potentiating Top2 poisons)2022

Author(s)

Sunada Shigeaki 砂田成章