KIHARA YOSHIHIKO 木原慶彦

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Kihara Yoshihiko 木原慶彦

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Researcher Number	70812999
Other IDs
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 非常勤助教
Affiliation (based on the past Project Information) *help	2018 – 2023: 順天堂大学, 医学部, 博士研究員
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator 蛋白質の切断 / 細胞内蓄積 / calreticulin / 骨髄増殖性腫瘍 / 造血器腫瘍 / thrombopoietin receptor / プロテアーゼ / 分子シャペロン / トロンボポエチン受容体 / カルレティキュリン … More / 抗体医薬 / 抗体医療 / 蛋白質分泌経路 / 蛋白質分解経路 Less

Suppression of myeloproliferative neoplasm development by cleavage of mutant CALRPrincipal Investigator
- Principal Investigator
  
  Kihara Yoshihiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
Mechanisms governing intracellular accumulation of mutant CALR proteinsPrincipal Investigator
- Principal Investigator
  
  Yoshihiko Kihara
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University

All 2022 2021 2020 2019 2018

All Journal Article Presentation Patent

[Journal Article] Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia2021
- Author(s)
  Inano Tadaaki、Araki Marito、Morishita Soji、Imai Misa、Kihara Yoshihiko、Okuda Maho、Yang Yinjie、Ito Masafumi、Osaga Satoshi、Mano Hiroyuki、Edahiro Yoko、Ochiai Tomonori、Misawa Kyohei、Fukuda Yasutaka、Ando Jun、Komatsu Norio
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 17702-17702
- DOI
  10.1038/s41598-021-97106-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08848, KAKENHI-PROJECT-19K17871, KAKENHI-PROJECT-21K08376, KAKENHI-PROJECT-21K16250, KAKENHI-PROJECT-21K16275
[Journal Article] Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface2019
- Author(s)
  Masubuchi Nami、Araki Marito、Yang Yinjie、Hayashi Erina、Imai Misa、Edahiro Yoko、Hironaka Yumi、Mizukami Yoshihisa、Kihara Yoshihiko、Takei Hiraku、Nudejima Mai、Koike Masato、Ohsaka Akimichi、Komatsu Norio
- Journal Title
  
  Leukemia
  
  Volume: 34 Issue: 2 Pages: 499-509
- DOI
  10.1038/s41375-019-0564-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-18K08372, KAKENHI-PROJECT-19K08848, KAKENHI-PROJECT-18K16098, KAKENHI-PROJECT-18K16127, KAKENHI-PROJECT-19K17871, KAKENHI-PROJECT-17H04211, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-17K16195, KAKENHI-PROJECT-18K16126
[Journal Article] Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors.,2019
- Author(s)
  Tomomasa Yokomizo, Naoki Watanabe, Terumasa Umemoto, Junichi Matsuo, Ryota Harai, Yoshihiko Kihara, Eri Nakamura, Norihiro Tada, Tomohiko Sato, Tomoiku Takaku, Akihiko Shimono, Hitoshi Takizawa, Naomi Nakagata, Seiichi Mori, Mineo Kurokawa, Daniel Tenen, Motomi Osato, Toshio Suda, and Norio Komatsu.
- Journal Title
  
  J Exp Med
  
  Volume: 216 Issue: 7 Pages: 1599-1614
- DOI
  10.1084/jem.20181399
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05691, KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-19K22641, KAKENHI-PROJECT-18K16127, KAKENHI-PROJECT-18H05284, KAKENHI-PROJECT-18H04052, KAKENHI-PROJECT-19H03688, KAKENHI-PROJECT-17K09958
[Journal Article] Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation2018
- Author(s)
  Araki Marito、Yang Yinjie、Imai Misa、Mizukami Yoshihisa、Kihara Yoshihiko、Sunami Yoshitaka、Masubuchi Nami、Edahiro Yoko、Hironaka Yumi、Osaga Satoshi、Ohsaka Akimichi、Komatsu Norio
- Journal Title
  
  Leukemia
  
  Volume: 33 Issue: 1 Pages: 122-131
- DOI
  10.1038/s41375-018-0181-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-18K08372, KAKENHI-PROJECT-17K16195, KAKENHI-PROJECT-18K16098, KAKENHI-PROJECT-18K16100, KAKENHI-PROJECT-18K16126, KAKENHI-PROJECT-18K16127, KAKENHI-PROJECT-17H04211, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K09859
[Patent] 抗切断型変異CALR-CD3二重特異性抗体及び医薬組成物2020
- Inventor(s)
  小松則夫、荒木真理人、木原慶彦ら、計7名
- Industrial Property Rights Holder
  順天堂大学
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-18K16127
[Patent] 切断型の変異型Ｃａｌｒｅｔｉｃｕｌｉｎに結合する抗体、及び骨髄増殖性腫瘍の診断、予防又は治療薬2020
- Inventor(s)
  荒木真理人、小松則夫、木原慶彦
- Industrial Property Rights Holder
  順天堂大学
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-18K16127
[Patent] 非公開2019
- Inventor(s)
  荒木真理人、小松則夫、木原慶彦
- Industrial Property Rights Holder
  荒木真理人、小松則夫、木原慶彦
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18K16127
[Presentation] Elucidation of the molecular mechanism for the cleavage of mutant calreticulin2022
- Author(s)
  吉川隼平, 荒木真理人, 木原慶彦, 増渕菜弥, 楊印杰, 森下総司, 今井美沙, 枝廣陽子, 安藤美樹, 小松則夫
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K16250
[Presentation] Quantitative measurement of mutant calreticulin in specimens of myeloproliferative neoplasm patients2021
- Author(s)
  Satoko Ogata, Marito Araki, Yoshihiko Kihara, Maho Okuda, Soji Morishita, Misa Imai, Nami Masubuchi, Yousuke Mori, Yinjie Yang, Syunpei Yoshikawa, Tomonori Ochiai, Shuichi Shirane, Yoko Edahiro, Jun Ando, Norio Komatsu
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K16250
[Presentation] 典型的なドライバー遺伝子変異の見いだされない本態性血小板血症の特徴2020
- Author(s)
  荒木真理人, 稲野資明, 森下総司, 木原慶彦, 奥田真帆, 楊印杰, 今井美沙, 枝廣陽子, 伊藤雅文, 大佐賀智, 落合友則, 三澤恭平, 大坂顯通, 小松則夫
- Organizer
  第30回日本サイトメトリー学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16127
[Presentation] Concomitant occurrence of polyclonal hematopoiesis and cell-autonomous megakaryopoiesis in triple-negative essential thrombocythemia2020
- Author(s)
  Inano T, Araki M, Morishita S, Imai M, Kihara Y, Okuda M, Ito M, Osaga S, Yang Y, Edahiro Y, Ochiai T, Misawa K, Fukuda Y, Ohsaka A, Komatsu N
- Organizer
  62nd Annual Meeting & Exposition of American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16127
[Presentation] Therapeutic potential of myeloproliferative neoplasms by antibody targeting mutant calreticulin2020
- Author(s)
  Yoshihiko Kihara, Marito Araki, Misa Imai, Yasutaka Fukuda, Yosuke Mori, Teppei Taguchi, Nami Masubuchi, Yo Mabuchi, Yinjie Yang, Yoshihisa Mizukami, Soji Morishita, Chihiro Akazawa, Akimichi Ohsaka, Norio Komatsu
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16127
[Presentation] Therapeutic potential of an antibody targeting the cleaved form of mutant calreticulin in myeloproliferative neoplasms2020
- Author(s)
  Yoshihiko Kihara, Marito Araki, Misa Imai, Yosuke Mori, Mei Horino, Satoko Ogata, Syunpei Yoshikawa, Teppei Taguchi, Nami Masubuchi, Yo Mabuchi, Yinjie Yang, Yasutaka Fukuda, Soji Morishita, Takehiro Suzuki, Naoshi Domae, Motoyuki Shimonaka, Chihiro Akazawa, Akimichi Ohsaka, Norio Komatsu
- Organizer
  62nd ASH Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16127
[Presentation] calreticulin変異による骨髄増殖性腫瘍発症の分子メカニズム2019
- Author(s)
  荒木真理人，楊印杰，増渕菜弥，林英里奈，水上喜久，木原慶彦，今井美沙，弘中由美，橳島麻衣，枝廣陽子，大坂顯通，小松則夫
- Organizer
  第29回日本サイトメトリー学会学術集会，東京
- Data Source
  KAKENHI-PROJECT-18K16127
[Presentation] 変異型calreticulin特異的配列によるゴルジ体への局在2019
- Author(s)
  水上喜久，荒木真理人，今井美沙，林英里奈，増渕菜弥，楊印杰，木原慶彦，弘中由美，大坂顯通，小松則夫
- Organizer
  第81回日本血液学会学術集会，東京
- Data Source
  KAKENHI-PROJECT-18K16127
[Presentation] 変異型特異的配列による変異型CALRの細胞内局在の規定2019
- Author(s)
  水上喜久，荒木真理人，今井美沙，林英里奈，増渕菜弥，楊印杰，木原慶彦，弘中由美，大坂顯通，小松則夫
- Organizer
  第29回日本サイトメトリー学会学術集会，東京
- Data Source
  KAKENHI-PROJECT-18K16127
[Presentation] 抗TfR1抗体による真性多血症内因性赤芽球コロニーの形成阻害2019
- Author(s)
  木原慶彦，増渕菜弥，張黎臨，荒木真理人，小松則夫
- Organizer
  第81回日本血液学会学術集会，東京
- Data Source
  KAKENHI-PROJECT-18K16127
[Presentation] 分泌経路における変異型分子シャペロンとサイトカイン受容体の会合による細胞の腫瘍化2019
- Author(s)
  増渕菜弥，荒木真理人，木原慶彦，楊印杰，今井美沙，水上喜久，林英里奈，弘中由美，竹井拓，枝廣陽子，大坂顯通，小松則夫
- Organizer
  第29回日本サイトメトリー学会学術集会，東京
- Data Source
  KAKENHI-PROJECT-18K16127
[Presentation] 変異型CALRはMPLと分泌経路で相互作用し細胞表面で活性化を引き起こす2019
- Author(s)
  増渕菜弥，荒木真理人，楊印杰，林英里奈，今井美沙，枝廣陽子，弘中由美，水上喜久，木原慶彦，小池正人，大坂顯通，小松則夫
- Organizer
  第81回日本血液学会学術集会，東京
- Data Source
  KAKENHI-PROJECT-18K16127
[Presentation] Boarding on the secretary pathway is required for the oncogenic property of mutant calreticulin2018
- Author(s)
  Araki M, Masubuchi N, Hayashi E, Yang Y, Imai M, Kihara Y, Mizukami Y, Hironaka Y, Edahiro Y, Ohsaka A, Komatsu N
- Organizer
  23rd Congress of European Hematology Association, Stockholm, Sweden
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16127
[Presentation] Secreted Mutant Calreticulins As Rogue Cytokines Trigger Thrombopoietin Receptor Activation Specifically in CALR Mutated Cells: Perspectives for MPN Therapy2018
- Author(s)
  C Pecquet, T Balligand, I Chachoua, A Roy, G Vertenoeil, D Colau, E Fertig, C Marty, H Nivarthi, JP Defour, E Xu, E Hug, H Gisslinger, B Gisslinger, M Schalling, I Carola Casetti, E Rumi, D Pietra, C Cavalloni, L Arcaini, M Cazzola, N Komatsu, Y Kihara, et. al.
- Organizer
  60th ASH Annual Meeting, San Diego, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16127

1. ARAKI Marito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 小松則夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
3. 多田昇弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KIHARA YOSHIHIKO 木原 慶彦

Kihara Yoshihiko 木原 慶彦

Research Projects

Research Products

Co-Researchers

Suppression of myeloproliferative neoplasm development by cleavage of mutant CALRPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms governing intracellular accumulation of mutant CALR proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors.,2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation2018

Author(s)

Journal Title

DOI

Data Source

[Patent] 抗切断型変異CALR-CD3二重特異性抗体及び医薬組成物2020

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 切断型の変異型Ｃａｌｒｅｔｉｃｕｌｉｎに結合する抗体、及び骨髄増殖性腫瘍の診断、予防又は治療薬2020

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 非公開2019

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Presentation] Elucidation of the molecular mechanism for the cleavage of mutant calreticulin2022

Author(s)

Organizer

Data Source

[Presentation] Quantitative measurement of mutant calreticulin in specimens of myeloproliferative neoplasm patients2021

Author(s)

Organizer

Data Source

[Presentation] 典型的なドライバー遺伝子変異の見いだされない本態性血小板血症の特徴2020

Author(s)

Organizer

Data Source

[Presentation] Concomitant occurrence of polyclonal hematopoiesis and cell-autonomous megakaryopoiesis in triple-negative essential thrombocythemia2020

Author(s)

Organizer

Data Source

[Presentation] Therapeutic potential of myeloproliferative neoplasms by antibody targeting mutant calreticulin2020

Author(s)

Organizer

Data Source

[Presentation] Therapeutic potential of an antibody targeting the cleaved form of mutant calreticulin in myeloproliferative neoplasms2020

Author(s)

Organizer

Data Source

[Presentation] calreticulin変異による骨髄増殖性腫瘍発症の分子メカニズム2019

KIHARA YOSHIHIKO 木原慶彦

Kihara Yoshihiko 木原慶彦