Ninoyu Yuzuru 二之湯弦

Researcher Number	70814573
Other IDs
Affiliation (Current)	2025: 京都府立医科大学, 医学(系)研究科(研究院), 特任講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 京都府立医科大学, 医学(系)研究科(研究院), 特任講師 2019 – 2020: 京都府立医科大学, 医学(系)研究科(研究院), 助教 2018: 京都府立医科大学, 医学部附属病院, 専攻医
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related
Keywords	Principal Investigator 内耳免疫 / マクロファージ / 多重免疫染色 / 光ー電子相関顕微鏡法 / 内耳 / イメージサイトメトリー / 内耳組織マクロファージ / 難聴 / シスプラチン / 蝸牛マクロファージ … More / DIAPH1 / リボンシナプス / 聴毛 / 頂側面結合 / 新規DFNA1変異 / 遺伝性難聴 / DFNA1 / 感音難聴 Less

Investigating Cochlear Immune Dynamics in Cisplatin-Induced Hearing Loss Through Correlated Multiplex Immunohistochemistry and Electron MicroscopyPrincipal Investigator
- Principal Investigator
  
  二之湯弦
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Analysis of Inner Ear Tissue Macrophages Using Multiplex Immunostaining and Image CytometryPrincipal Investigator
- Principal Investigator
  
  Ninoyu Yuzuru
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Analysis of physiological function of DIAPH1 in cochlea and development of novel therapeutic drag for DFNA1Principal Investigator
- Principal Investigator
  
  Ninoyu Yuzuru
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kyoto Prefectural University of Medicine

All 2024 2020 2019

All Journal Article Presentation

[Journal Article] The genetic landscape of age-related hearing loss2024
- Author(s)
  Ninoyu Yuzuru、Friedman Rick A.
- Journal Title
  
  Trends in Genetics
  
  Volume: 40 Issue: 3 Pages: 228-237
- DOI
  10.1016/j.tig.2023.12.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18321
[Journal Article] 【生体センシング研究の最前線】蝸牛有毛細胞における聴覚メカノセンシング機構とその分子基盤2020
- Author(s)
  二之湯弦、中村高志
- Journal Title
  
  京都府立医科大学雑誌
  
  Volume: 129 Pages: 687-697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16851
[Journal Article] The integrity of cochlear hair cells is established and maintained through the localization of Dia1 at apical junctional complexes and stereocilia2020
- Author(s)
  Ninoyu Yuzuru、Sakaguchi Hirofumi、Lin Chen、Suzuki Toshiaki、Hirano Shigeru、Hisa Yasuo、Saito Naoaki、Ueyama Takehiko
- Journal Title
  
  Cell Death & Disease
  
  Volume: 11 Issue: 7 Pages: 1-15
- DOI
  10.1038/s41419-020-02743-z
- NAID
  120006877483
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22472, KAKENHI-PROJECT-18K09383, KAKENHI-PROJECT-18K16851
[Presentation] 活性型変異体DIA1によるDFNA1難聴発症メカニズムの解明2020
- Author(s)
  二之湯弦
- Organizer
  第138回薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-18K16851
[Presentation] Constitutive activation of Dia1 induces hair cell vulnerability via attenuated integrity of apical junctional complexes and stereocilia2020
- Author(s)
  Ninoyu Y, Sakaguchi H, Chen L, Mohri H, Saito N, Ueyama T
- Organizer
  43rd ARO Annual MidWinter Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16851
[Presentation] Constitutive activation of Dia1 induces hair cell vulnerability via attenuated integrity of apical junctional complexes and stereocilia2020
- Author(s)
  Yuzuru Ninoyu
- Organizer
  43th Mid Winter Meeting Association for Research in Otolaryngology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16851
[Presentation] DFNA1疾患マウスモデルを用いたDIA1分子の局在と病態メカニズムの解明2019
- Author(s)
  二之湯弦, 坂口博史, 陳林, 毛利宏明, 斎藤尚亮, 上山健彦
- Organizer
  第60回日本組織細胞化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K16851
[Presentation] DFNA1疾患マウスモデルを用いたDIA1分子の局在と病態メカニズムの解明2019
- Author(s)
  二之湯弦
- Organizer
  第29回日本耳科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-18K16851

1. SAKAGUCHI Hirofumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 上山健彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ninoyu Yuzuru 二之湯 弦

Research Projects

Research Products

Co-Researchers

Investigating Cochlear Immune Dynamics in Cisplatin-Induced Hearing Loss Through Correlated Multiplex Immunohistochemistry and Electron MicroscopyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of Inner Ear Tissue Macrophages Using Multiplex Immunostaining and Image CytometryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of physiological function of DIAPH1 in cochlea and development of novel therapeutic drag for DFNA1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] The genetic landscape of age-related hearing loss2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 【生体センシング研究の最前線】蝸牛有毛細胞における聴覚メカノセンシング機構とその分子基盤2020

Author(s)

Journal Title

Data Source

[Journal Article] The integrity of cochlear hair cells is established and maintained through the localization of Dia1 at apical junctional complexes and stereocilia2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] 活性型変異体DIA1によるDFNA1難聴発症メカニズムの解明2020

Author(s)

Organizer

Data Source

[Presentation] Constitutive activation of Dia1 induces hair cell vulnerability via attenuated integrity of apical junctional complexes and stereocilia2020

Author(s)

Organizer

Data Source

[Presentation] Constitutive activation of Dia1 induces hair cell vulnerability via attenuated integrity of apical junctional complexes and stereocilia2020

Author(s)

Organizer

Data Source

[Presentation] DFNA1疾患マウスモデルを用いたDIA1分子の局在と病態メカニズムの解明2019

Author(s)

Organizer

Data Source

[Presentation] DFNA1疾患マウスモデルを用いたDIA1分子の局在と病態メカニズムの解明2019

Author(s)

Organizer

Data Source

Ninoyu Yuzuru 二之湯弦