Kurosawa Mie 黒澤実愛

Researcher Number	70815802
Other IDs
Affiliation (Current)	2025: 富山大学, 学術研究部医学系, 助教
Affiliation (based on the past Project Information) *help	2021 – 2023: 昭和大学, 歯学部, 助教 2019 – 2020: 国立研究開発法人国立長寿医療研究センター, 口腔疾患研究部, 研究員 2018: 国立研究開発法人国立長寿医療研究センター, 口腔疾患研究部, 流動研究員
Review Section/Research Field	Principal Investigator Basic Section 57020:Oral pathobiological science-related
Keywords	Principal Investigator 唾液腺 / 加齢 / 免疫老化 / 細胞老化 / IgA / 口腔内細菌叢 / 口腔乾燥症 / T細胞 / 老化 / 女性ホルモン / エストロゲン欠乏 / シェーグレン症候群

口腔内細菌に対する唾液腺のB細胞恒常性維持メカニズムの解明Principal Investigator
- Principal Investigator
  
  黒澤実愛
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Showa University
Analysis of the mechanism of senescence-associated T cell accumulation in the salivary gland with aging.Principal Investigator
- Principal Investigator
  
  Kurosawa Mie
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Showa University
  National Center for Geriatrics and Gerontology
analysis of autoimmune disease caused by aging and sex hormones in a mouse model of sjogrens syndromePrincipal Investigator
- Principal Investigator
  
  Kurosawa Mie
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  National Center for Geriatrics and Gerontology

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Oral commensal bacterial flora is responsible for peripheral differentiation of neutrophils in the oral mucosa in the steady state2023
- Author(s)
  Trtic Natasa、Mori Mina、Matsui Shohei、Nakamura Natsuno、Fukamachi Haruka、Kurosawa Mie、Morisaki Hirobumi、Maruoka Yasubumi、Mayers Mie、Okahashi Nobuo、Kuwata Hirotaka、Itsumi Momoe
- Journal Title
  
  Journal of Oral Biosciences
  
  Volume: 65 Issue: 1 Pages: 119-125
- DOI
  10.1016/j.job.2022.11.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K18494
[Journal Article] Severity of acute lung injury in aspiration pneumonia model mice transplanted with human oral microflora2023
- Author(s)
  Hayashi Manami、Mori Mina、Itsumi Momoe、Nakamura Natsuno、Takaki Takashi、Onoyama Kaoru、Fukamachi Haruka、Kurosawa Mie、Morisaki Hirobumi、Funatsu Takahiro、Myers Mie、Iijima Takehiko、Kuwata Hirotaka
- Journal Title
  
  Oral Science International
  
  Volume: 21 Issue: 1 Pages: 121-130
- DOI
  10.1002/osi2.1198
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K09144
[Journal Article] Novel antibody assessment method for microbial compositional alteration in the oral cavity2022
- Author(s)
  Hoashi-Takiguchi Sumire、Morisaki Hirobumi、Itsumi Momoe、Kikuchi Mariko、Fukamachi Haruka、Kurosawa Mie、Yamada Michi、Suzuki Noriyuki、Kuwata Hirotaka
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 30 Pages: 101269-101269
- DOI
  10.1016/j.bbrep.2022.101269
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18494, KAKENHI-PROJECT-20K18542, KAKENHI-PROJECT-18K09558
[Journal Article] Analysis of senescence in gingival tissues and gingival fibroblast cultures2022
- Author(s)
  Furukawa, M., Matsuda ,K. et al.
- Journal Title
  
  Clinical and Experimental Dental Research
  
  Volume: 8 Issue: 4 Pages: 1-11
- DOI
  10.1002/cre2.581
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10256, KAKENHI-PROJECT-20K18494, KAKENHI-PROJECT-22K10112, KAKENHI-PROJECT-21H03115, KAKENHI-PROJECT-22KJ3207
[Journal Article] Molar loss induces hypothalamic and hippocampal astrogliosis in aged mice2022
- Author(s)
  Furukawa, M., Tada, H., Wang, J. et al.
- Journal Title
  
  Sci Rep
  
  Volume: 12 Issue: 1 Pages: 6409-6409
- DOI
  10.1038/s41598-022-10321-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10256, KAKENHI-PROJECT-22KJ3207, KAKENHI-PROJECT-20K18494, KAKENHI-PROJECT-21H03115, KAKENHI-PROJECT-20K21779, KAKENHI-PROJECT-23K24805
[Journal Article] Melatonin suppresses the antiviral immune response to EMCV infection through intracellular ATP deprivation caused by mitochondrial fragmentation2022
- Author(s)
  Kikuchi Mariko、Kadena Miki、Fukamachi Haruka、Takaki Takashi、Matsui Shohei、Hoashi-Takiguchi Sumire、Morisaki Hirobumi、Trtic Natasa、Mori Mina、Kurosawa Mie、Itsumi Momoe、Funatsu Takahiro、Sakurai Atsuo、Shintani Seikou、Kato Hiroki、Fujita Takashi、Maruoka Yasubumi、Kuwata Hirotaka
- Journal Title
  
  Heliyon
  
  Volume: 8 Issue: 10 Pages: e11149-e11149
- DOI
  10.1016/j.heliyon.2022.e11149
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09867, KAKENHI-PROJECT-20K18494, KAKENHI-PROJECT-21K21097, KAKENHI-PROJECT-19K07423, KAKENHI-PROJECT-18K17264
[Journal Article] The Priming Potential of Interferon Lambda-1 for Antiviral Defense in the Oral Mucosa2022
- Author(s)
  Shikama Yosuke、Kurosawa Mie、Furukawa Masae、Kudo Yasusei、Ishimaru Naozumi、Matsushita Kenji
- Journal Title
  
  Inflammation
  
  Volume: - Issue: 3 Pages: 1-14
- DOI
  10.1007/s10753-022-01624-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09548, KAKENHI-PROJECT-19K10256, KAKENHI-PROJECT-19H01070, KAKENHI-PROJECT-20H03904, KAKENHI-PROJECT-21K19605, KAKENHI-PROJECT-20K18494, KAKENHI-PROJECT-22KJ3207, KAKENHI-PROJECT-21H03115
[Journal Article] Chemokines Up-Regulated in Epithelial Cells Control Senescence-Associated T Cell Accumulation in Salivary Glands of Aged and Sj?gren’s Syndrome Model Mice2021
- Author(s)
  Kurosawa Mie、Shikama Yosuke、Furukawa Masae、Arakaki Rieko、Ishimaru Naozumi、Matsushita Kenji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 5 Pages: 2302-2302
- DOI
  10.3390/ijms22052302
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09548, KAKENHI-PROJECT-19K10256, KAKENHI-PROJECT-20K18494, KAKENHI-PROJECT-19H01070, KAKENHI-PROJECT-21K09859, KAKENHI-PROJECT-20H03904
[Journal Article] Effect of green propolis extracts on experimental aged gingival irritation in vivo and in vitro2021
- Author(s)
  Furukawa Masae、Wang Jingshu、Kurosawa Mie、Ogiso Noboru、Shikama Yosuke、Kanekura Takuro、Matsushita Kenji
- Journal Title
  
  Journal of Oral Biosciences
  
  Volume: 63 Issue: 1 Pages: 58-65
- DOI
  10.1016/j.job.2020.12.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09548, KAKENHI-PROJECT-19K10256, KAKENHI-PROJECT-20K18494, KAKENHI-PROJECT-20H03904
[Journal Article] Periodontal Disease and Periodontal Disease-Related Bacteria Involved in the Pathogenesis of Alzheimer’s Disease2020
- Author(s)
  Matsushita Kenji、Yamada-Furukawa Masae、Kurosawa Mie、Shikama Yosuke
- Journal Title
  
  Journal of Inflammation Research
  
  Volume: Volume 13 Pages: 275-283
- DOI
  10.2147/jir.s255309
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09548, KAKENHI-PROJECT-19K10256, KAKENHI-PROJECT-20K18494
[Journal Article] High concentration of glucose induces filaggrin-1 expression through AP-1 in skin keratinocytes2020
- Author(s)
  Masae Furukawa, Kiyoko Yamada, Mie Kurosawa, Yosuke Shikama, Takuro Kanekura and Kenji Matsushita
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: - Issue: 2 Pages: 137-140
- DOI
  10.1016/j.jdermsci.2020.04.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10256, KAKENHI-PROJECT-18K09548, KAKENHI-PROJECT-20K18494, KAKENHI-PROJECT-20H03904
[Journal Article] Involvement of adiponectin in age-related increases in tear production in mice2019
- Author(s)
  Shikama Yosuke、Kurosawa Mie、Furukawa Masae、Ishimaru Naozumi、Matsushita Kenji
- Journal Title
  
  Aging
  
  Volume: 11 Issue: 19 Pages: 8329-8346
- DOI
  10.18632/aging.102322
- NAID
  120007146099
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09548, KAKENHI-PROJECT-19H01070, KAKENHI-PROJECT-18K19648, KAKENHI-PROJECT-18K17037
[Presentation] Klebsiellaのマンノースホスホトランスフェラーゼシステムは腸管定着関連因子である2023
- Author(s)
  三木　優、深町　はるか、逸見　百江、森崎　弘史、黒澤　実愛、桑田　啓貴
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K09144
[Presentation] 口腔粘膜好中球の分化誘導における常在菌叢の役割2023
- Author(s)
  森美菜、林真奈美、中村夏野、逸見百江、黒澤実愛、深町はるか、森崎弘史、桑田啓貴
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-20K18494
[Presentation] ヒト口腔細菌移植マウスの急性肺障害誘導による誤嚥性肺炎マウスモデルの作製2023
- Author(s)
  林真奈美、森美菜、逸見百江、黒澤実愛、深町はるか、森崎弘史、桑田啓貴
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-20K18494
[Presentation] 口腔内細菌叢は口腔粘膜での好中球の末梢分化に関与している2023
- Author(s)
  逸見　百江、Natasa Trtic、森　美菜、松井　庄平、中村　夏野、深町　はるか、黒澤　実愛、森崎　弘史、桑田　啓貴
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K09144
[Presentation] 老化関連T細胞および唾液腺上皮の細胞老化が口腔乾燥症の病態形成に関与する可能性2020
- Author(s)
  黒澤実愛、古川匡恵、松下健二、四釜洋介
- Organizer
  第62回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-20K18494
[Presentation] 加齢による口腔乾燥症の病態形成における老化関連T細胞の関与2020
- Author(s)
  黒澤実愛、古川匡恵、松下健二
- Organizer
  第20回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-20K18494
[Presentation] 唾液腺上皮の細胞老化及び免疫老化が唾液腺機能に与える影響:老齢マウスおよびモデルマウスを用いた解析2019
- Author(s)
  黒澤実愛、古川匡恵、松下健二、四釜洋介
- Organizer
  第28回日本シェーグレン症候群学会学術集会
- Data Source
  KAKENHI-PROJECT-18K17037
[Presentation] Senescence-associated T-lymphocytes Accumulate in the Submandibular Glands of Aged Mice2019
- Author(s)
  M. Kurosawa, M. Furukawa, K. Matsushita, Y. Shikama.
- Organizer
  97th General Session of the IADR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17037
[Presentation] 加齢およびエストロゲンシグナル欠乏は唾液腺における老化関連T細胞集積を促進する2019
- Author(s)
  黒澤実愛、古川匡恵、松下健二、四釜洋介
- Organizer
  第61回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K17037
[Presentation] 免疫老化及び細胞老化による唾液腺へのSA-T細胞集積メカニズムの解析2019
- Author(s)
  黒澤実愛、古川匡恵、松下健二、四釜洋介
- Organizer
  第38回分子病理学研究会
- Data Source
  KAKENHI-PROJECT-18K17037
[Presentation] 口腔粘膜におけるIL-29の抗真菌および抗ウイルス作用：臨床応用の可能性.2018
- Author(s)
  四釜洋介、黒澤実愛、山田（古川）匡恵、松下健二
- Organizer
  第61回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-18K17037
[Presentation] IL-29は口腔粘膜上皮細胞においてRIG-I発現誘導を介し抗ウイルス活性を増強する.2018
- Author(s)
  四釜洋介、黒澤実愛、松下健二
- Organizer
  第24回日本エンドトキシン・自然免疫研究会
- Data Source
  KAKENHI-PROJECT-18K17037

1. 森崎弘史 (30317581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 桑田啓貴 (60380523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. SAKURAI Atsuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 四釜洋介

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
5. 古川匡恵

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
6. 松下健二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 新谷誠康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kurosawa Mie 黒澤 実愛

Research Projects

Research Products

Co-Researchers

口腔内細菌に対する唾液腺のB細胞恒常性維持メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the mechanism of senescence-associated T cell accumulation in the salivary gland with aging.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

analysis of autoimmune disease caused by aging and sex hormones in a mouse model of sjogrens syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Oral commensal bacterial flora is responsible for peripheral differentiation of neutrophils in the oral mucosa in the steady state2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Severity of acute lung injury in aspiration pneumonia model mice transplanted with human oral microflora2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel antibody assessment method for microbial compositional alteration in the oral cavity2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of senescence in gingival tissues and gingival fibroblast cultures2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molar loss induces hypothalamic and hippocampal astrogliosis in aged mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Melatonin suppresses the antiviral immune response to EMCV infection through intracellular ATP deprivation caused by mitochondrial fragmentation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Priming Potential of Interferon Lambda-1 for Antiviral Defense in the Oral Mucosa2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chemokines Up-Regulated in Epithelial Cells Control Senescence-Associated T Cell Accumulation in Salivary Glands of Aged and Sj?gren’s Syndrome Model Mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of green propolis extracts on experimental aged gingival irritation in vivo and in vitro2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Periodontal Disease and Periodontal Disease-Related Bacteria Involved in the Pathogenesis of Alzheimer’s Disease2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High concentration of glucose induces filaggrin-1 expression through AP-1 in skin keratinocytes2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Involvement of adiponectin in age-related increases in tear production in mice2019

Author(s)

Journal Title

Kurosawa Mie 黒澤実愛