Shichino Shigeyuki 七野成之

Researcher Number	70822435
Other IDs
Affiliation (Current)	2022: 東京理科大学, 研究推進機構生命医科学研究所, 助教
Affiliation (based on the past Project Information) *help	2022: 東京理科大学, 付置研究所, 助教 2018 – 2022: 東京理科大学, 研究推進機構生命医科学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / Transformative Research Areas, Section (III) Except Principal Investigator Complex systems / Immunology / Basic Section 49030:Experimental pathology-related / Basic Section 53030:Respiratory medicine-related
Keywords	Principal Investigator T細胞応答 / TCRレパトワ解析 / single-cell TCR-seq / single-cell RNA-seq / シングルセルTCR-seq / がん免疫 / 1細胞トランスクリプトーム / T細胞 / T細胞受容体 / バイオインフォマティクス … More Except Principal Investigator … More

間葉系細胞-間質性細胞相互作用の肺-骨髄間クロストークの意義の解明Principal Investigator
- Principal Investigator
  
  七野成之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Tokyo University of Science
増殖の臓器指向性と一細胞遺伝子発現解析に基づく治療最適抗腫瘍T細胞クローンの同定
- Principal Investigator
  
  上羽悟史
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Tokyo University of Science
新規シングルセル解析法を用いたじん肺発症-進展における包括的基盤研究
- Principal Investigator
  
  山野荘太郎
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Japan Organization of Occupational Health and Safety Japan Bioassay Research Center
Investigation of the immune response of the tumor-infilteating T cells by novel scTCR-seq methodsPrincipal Investigator
- Principal Investigator
  
  Shichino Shigeyuki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Tokyo University of Science
Inflammation cellular society in pulmonary fibrosis
- Principal Investigator
  
  Matsushima Kouji
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tokyo University of Science
  The University of Tokyo
Mechanisms of transcriptional regulation of fibroblast activation in pulmonary fibrosis
- Principal Investigator
  
  Matsushima Kouji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Tokyo University of Science
  The University of Tokyo

All 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Patent

[Journal Article] Transient Depletion of CD4+ Cells Induces Remodeling of the TCR Repertoire in Gastrointestinal Cancer.2021
- Author(s)
  Aoki H, Ueha S, Shichino S, Ogiwara H, Shitara K, Shimomura M, Suzuki T, Nakatsura T, Yamashita M, Kitano S, Kuroda S, Wakabayashi M, Kurachi M, Ito S, Doi T, Matsushima K.
- Journal Title
  
  Cancer Immunol Res
  
  Volume: 0 Pages: 0-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16620
[Journal Article] Transient Depletion of CD4 + Cells Induces Remodeling of the TCR Repertoire in Gastrointestinal Cancer2021
- Author(s)
  Aoki H, Ueha S, Shichino S, Ogiwara H, Shitara K, Shimomura M, Suzuki T, Nakatsura T, Yamashita M, Kitano S, Kuroda S, Wakabayashi M, Kurachi M, Ito S, Doi T, Matsushima K.
- Journal Title
  
  Cancer Immunol Res.
  
  Volume: -
- DOI
  10.1158/2326-6066.cir-20-0989
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06392, KAKENHI-PROJECT-17K07207
[Journal Article] Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer2021
- Author(s)
  Nishina T, Deguchi Y, Ohshima D, Takeda W, Ohtsuka M, Shichino S, Ueha S, Yamazaki S, Kawauchi M, Nakamura E, Nishiyama C, Kojima Y, Adachi-Akahane S, Hasegawa M, Nakayama M, Oshima M, Yagita H, Shibuya K, Mikami T, Inohara N, Matsushima K, Tada N, Nakano H.
- Journal Title
  
  Nat Commun
  
  Volume: 12 Pages: 0-0
- DOI
  10.1038/s41467-021-22450-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06859, KAKENHI-PROJECT-20H02939, KAKENHI-PROJECT-20H03475, KAKENHI-PROJECT-19K16620
[Journal Article] The Increased Frequency of Methicillin-Resistant Staphylococcus Aureus With Low MIC of Beta-Lactam Antibiotics Isolated From Hospitalized Patients2020
- Author(s)
  Iwata Y、Sakai N、Yoneda I、Satou K、Furuichi K、Senda Y、Sakai-Takemori Y、Wada T、Fujita S、Ogura H、Sato K、Minami T、Yamaguchi K、Kitajima S、Toyama T、Yamamura Y、Miyagawa T、Hara A、Shimizu M、Sakai Y、Ikeo K、Shichino S、Ueha S、Nakajima T、Matsushima K、Wada T
- Journal Title
  
  J Infect Chemother
  
  Volume: 26 Pages: 604-610
- DOI
  10.1016/j.jiac.2020.01.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06392, KAKENHI-PLANNED-17H06399, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06394
[Journal Article] Transcriptome network analysis identifies protective role of the LXR/SREBP-1c axis in murine pulmonary fibrosis2019
- Author(s)
  Shichino S, Ueha S, Hashimoto S, Otsuji M, Abe J, Tsukui T, Deshimaru S, Nakajima T, Kosugi-Kanaya M, Shand FH, Inagaki Y, Shimano H, Matsushima K.
- Journal Title
  
  JCI Insight
  
  Volume: 4(1) Pages: 122163-122163
- DOI
  10.1172/jci.insight.122163
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-16H05203, KAKENHI-PROJECT-17H04166, KAKENHI-PROJECT-16K08730, KAKENHI-PROJECT-17K19546, KAKENHI-ORGANIZER-17H06391
[Journal Article] Mesenchymal-Epithelial Interactome Analysis Reveals Essential Factors Required for Fibroblast-Free Alveolosphere Formation.2019
- Author(s)
  Shiraishi Kazushige、Shichino Shigeyuki、Ueha Satoshi、Nakajima Takuya、Hashimoto Shinichi、Yamazaki Satoshi、Matsushima Kouji
- Journal Title
  
  iScience.
  
  Volume: 11 Pages: 318-333
- DOI
  10.1016/j.isci.2018.12.022
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05095, KAKENHI-PROJECT-16H05203, KAKENHI-PROJECT-17H05086, KAKENHI-PROJECT-16K08730
[Journal Article] In vitro expansion of endogenous human alveolar epithelial type II cells in fibroblast-free spheroid culture2019
- Author(s)
  Shiraishi Kazushige、Nakajima Takuya、Shichino Shigeyuki、Deshimaru Shungo、Matsushima Kouji、Ueha Satoshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 515 Pages: 579-585
- DOI
  10.1016/j.bbrc.2019.05.187
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06392
[Journal Article] Engraftment and proliferation potential of embryonic lung tissue cells in irradiated mice with emphysema.2019
- Author(s)
  Shiraishi Kazushige、Shichino Shigeyuki、Tsukui Tatsuya、Hashimoto Shinichi、Ueha Satoshi、Matsushima Kouji
- Journal Title
  
  Sci Rep.
  
  Volume: 9 Pages: 1-12
- DOI
  10.1038/s41598-019-40237-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05203, KAKENHI-PROJECT-16K08730, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H01540
[Journal Article] First-in-human phase 1 study of IT1208, a defucosylated humanized anti-CD4 depleting antibody, in patients with advanced solid tumors2019
- Author(s)
  Shitara K、Ueha S、Shichino S、Aoki H、Ogiwara H、Nakatsura T、Suzuki T、Shimomura M、Yoshikawa T、Shoda K、Kitano S、Yamashita M、Nakayama T、Sato A、Kuroda Sakiko、Wakabayashi Masashi、Nomura Shogo、Yokochi Shoji、Ito Satoru、Matsushima Kouji、Doi Toshihiko
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 7 Pages: 195-195
- DOI
  10.1186/s40425-019-0677-y
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06392
[Journal Article] Gli signaling pathway modulates fibroblast activation and facilitates scar formation in pulmonary fibrosis.2019
- Author(s)
  Tsukui Tatsuya、Ueha Satoshi、Shichino Shigeyuki、Hashimoto Shinichi、Nakajima Takuya、Shiraishi Kazushige、Kihara Miho、Kiyonari Hiroshi、Inagaki Yutaka、Matsushima Kouji
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 514 Pages: 30879-4
- DOI
  10.1016/j.bbrc.2019.05.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22627, KAKENHI-PLANNED-17H06392, KAKENHI-PROJECT-17H04166, KAKENHI-PROJECT-17H01540
[Journal Article] Reduction of proliferating olfactory cells and low expression of extracellular matrix genes are hallmarks of the aged olfactory mucosa2018
- Author(s)
  Ueha R, Shichino S, Ueha S, Kondo K, Kikuta S, Nishijima H, Matsushima K, Yamasoba T.
- Journal Title
  
  Frontiers in Aging Neuroscience
  
  Volume: 10 Pages: 1-13
- DOI
  10.3389/fnagi.2018.00086
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08730, KAKENHI-PROJECT-17K19546, KAKENHI-PROJECT-16K20231, KAKENHI-PLANNED-17H06392, KAKENHI-PROJECT-16H05203, KAKENHI-PROJECT-15F15113, KAKENHI-PROJECT-17K11353, KAKENHI-PROJECT-18K09341, KAKENHI-PROJECT-18KK0448, KAKENHI-PROJECT-15K20185, KAKENHI-PROJECT-18K16832
[Journal Article] Lung fibroblasts express a miR-19a-19b-20a sub-cluster to suppress TGF-β-associated fibroblast activation in murine pulmonary fibrosis2018
- Author(s)
  Souma Kunihiko、Shichino Shigeyuki、Hashimoto Shinichi、Ueha Satoshi、Tsukui Tatsuya、Nakajima Takuya、Suzuki Hiroshi I.、Shand Francis H. W.、Inagaki Yutaka、Nagase Takahide、Matsushima Kouji
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 1-14
- DOI
  10.1038/s41598-018-34839-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-16H05203, KAKENHI-PROJECT-17H04166, KAKENHI-PROJECT-16K08730, KAKENHI-PROJECT-17K19546
[Journal Article] Long-lasting graft-Derived Donor T cells contribute to the Pathogenesis of chronic graft-versus-host Disease in Mice.2017
- Author(s)
  Kosugi-Kanaya M, Ueha S, Abe J, Shichino S, Shand FHW, Morikawa T, Kurachi M, Shono Y, Sudo N, Yamashita A, Suenaga F, Yokoyama A, Yong W, Imamura M, Teshima T, Matsushima K.
- Journal Title
  
  Front Immunol
  
  Volume: 8 Pages: 1842-1842
- DOI
  10.3389/fimmu.2017.01842
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08730, KAKENHI-PROJECT-17K19546, KAKENHI-PROJECT-17K19641, KAKENHI-PLANNED-17H06392, KAKENHI-PROJECT-16H05203, KAKENHI-PROJECT-17H04206, KAKENHI-PROJECT-15F15113
[Journal Article] Simian Immunodeficiency Virus Targeting of CXCR3+CD4+T Cells in Secondary Lymphoid Organs Is Associated with Robust CXCL10 Expression in Monocyte/Macrophage Subsets2017
- Author(s)
  Fujino, M., H. Sato, T. Okamura, A. Uda, S. Takeda, N. Ahmed, S. Shichino, T. Shiino, Y. Saito, S. Watanabe, C. Sugimoto, M. Kuroda, M. Ato, Y. Nagai, S. Izumo, K. Matsushima, M. Miyazawa, A. Ansari, F. Villinger, and K. Mori
- Journal Title
  
  J Virol
  
  Volume: 印刷中
- DOI
  10.1128/jvi.00439-17
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01268, KAKENHI-PROJECT-15K10043, KAKENHI-PROJECT-17K19546, KAKENHI-PLANNED-17H06392, KAKENHI-PROJECT-16H05199, KAKENHI-PROJECT-16H05203
[Patent] ビーズ担体を用いたcDNA増幅方法2019
- Inventor(s)
  松島　綱治, 七野　成之、青木　寛泰、伊藤　哲、上羽　悟史
- Industrial Property Rights Holder
  松島　綱治, 七野　成之、青木　寛泰、伊藤　哲、上羽　悟史
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-129017
- Filing Date
  2019
- Data Source
  KAKENHI-PLANNED-17H06392
[Presentation] 肺線維症のsingle cell transcriptome解析に基づく治療標的候補分子探索2021
- Author(s)
  七野成之
- Organizer
  ゲノム創薬・創発フォーラム第5回シンポジウム
- Data Source
  KAKENHI-PLANNED-17H06392
[Presentation] 肺線維症のsingle cell transcriptome解析に基づく治療標的候補分子探索2021
- Author(s)
  七野　成之
- Organizer
  ゲノム創薬・創発フォーラム第5回シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19K16620
[Presentation] シングルセルトランスクリプトーム解析の現状と、それに基づく肺線維症治療標的候補分子探索2021
- Author(s)
  七野成之
- Organizer
  第20回分子予防環境医学研究会
- Data Source
  KAKENHI-PLANNED-17H06392
[Presentation] シングルセルトランスクリプトーム解析の現状と、それに基づく肺線維症治療標的候補分子探索2021
- Author(s)
  七野　成之
- Organizer
  第２０回分子予防環境医学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16620
[Presentation] 1細胞遺伝子発現解析から観る腫瘍浸潤樹状細胞の多様性2020
- Author(s)
  上羽悟史, 七野成之, 小川達郎, 荻原春, 松島綱治
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PLANNED-17H06392
[Presentation] 新規single-cell RNA-seq解析法TAS-Seqを用いた肺線維症における細胞間相互作用ネットワークにおけるハブ因子の同定2020
- Author(s)
  七野　成之
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16620
[Presentation] 新規single-cell RNA-seq解析を用いた肺線維症における脂質代謝関連遺伝子変動とその役割の解析2020
- Author(s)
  七野　成之
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16620
[Presentation] 新規single-cell RNA-seq解析法TAS-Seqを用いた肺線維症における細胞間相互作用ネットワークにおけるハブ因子の同定2020
- Author(s)
  七野成之
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-17H06392
[Presentation] 新規single-cell RNA-seq解析を用いた肺線維症における脂質代謝関連遺伝子変動とその役割の解析2020
- Author(s)
  七野成之
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PLANNED-17H06392
[Presentation] 末梢血-腫瘍間で重複するTCRレパトアは、消化器癌患者に対するPD-1阻害療法の有効性を予測しうる2020
- Author(s)
  青木寛泰, 上羽悟史, 中村能章, 七野成之, 中島裕理, 下村真菜美, 中面哲也, 吉野孝之, 松島綱治
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PLANNED-17H06392
[Presentation] Anti CD4 Monoclonal Antibody Immunotherapy Exerts an Antitumor Effect by Replacing the T Cell Receptor Repertoire in Patients with Gastrointestinal Cancer.2019
- Author(s)
  Aoki H, Shitara K、Ueha S、Shichino S、Ogiwara H、Nakatsura T、Suzuki T、Shimomura M、Yoshikawa T、Shoda K、Kitano S、Yamashita M、Nakayama T、Sato A、Kuroda Sakiko、Wakabayashi Masashi、Nomura Shogo、Yokochi Shoji、Ito Satoru、Matsushima Kouji、Doi Toshihiko
- Organizer
  AACR Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06392
[Presentation] 担がん患者における抗CD4抗体投与後のTCRレパトア変動2019
- Author(s)
  青木寛泰, 上羽悟史, 七野成之, 荻原春, 設樂紘平, 中面哲也, 鈴木利宙, 下村真菜美, 北野滋久, 山下万貴子, 伊藤哲, 土井俊彦, 松島綱治
- Organizer
  第28回日本癌病態治療研究会
- Data Source
  KAKENHI-PLANNED-17H06392
[Presentation] ブレオマイシン誘導マウス肺線維症モデルにおける経時的１細胞トランスクリプトーム解析.2019
- Author(s)
  七野成之, 橋本真一, 上羽悟史, 松島綱治.
- Organizer
  第18回分子予防環境医学研究会大会
- Data Source
  KAKENHI-PROJECT-16H05203
[Presentation] 肺におけるデコリン陽性線維芽細胞の局在と線維化に対する予防効果2019
- Author(s)
  中島拓弥, 七野成之, 上羽悟史, 松島綱治
- Organizer
  第40回日本炎症・再生医学会
- Data Source
  KAKENHI-PLANNED-17H06392
[Presentation] 新規高感度包括的1細胞トランスクリプトーム法の開発と線維化肺における解析2019
- Author(s)
  七野成之, 橋本真一, 上羽悟史, 北畠正大, 伊藤利洋, 松島綱治
- Organizer
  第5回骨免疫学会
- Data Source
  KAKENHI-PLANNED-17H06392
[Presentation] Mesenchymal-epithelial interactome analysis during alveologenesis revealed essential factors required for fibroblast-free mouse alveolosphere formation and human alveolar type 2 cell monoculture2019
- Author(s)
  Kazushige Shiraishi, Shigeyuki Shichino, Takuya Nakajima, Satoshi Ueha, Shinichi Hashimoto, Satoshi Yamazaki, Kouji Matsushima
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06392
[Presentation] マウス肺線維症モデルへの移入ルートおよびドナーによる移入効率と治療効果の解析2019
- Author(s)
  中島拓弥・七野成之・上羽悟史・松島綱治
- Organizer
  第18回分子予防環境医学研究会大会
- Data Source
  KAKENHI-PROJECT-16H05203
[Presentation] TCR sequencing reveals the generation and expansion of tumor-specific CD8+T cell clones after anti-CD4 antibody treatment in tumor-bearing mice2018
- Author(s)
  Satoshi Ueha, Aoki Hiroyasu, Shigeyuki Shichino, Ogiwara Haru, Shinichi Hashimoto, Kazuhiro Kakimi, Kouji Matsushima
- Organizer
  Keystone Symposia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05203
[Presentation] Single-cell transcriptome identifies cytokine/chemokine expression signatures of lung cell subsets in murine pulmonary fibrosis2018
- Author(s)
  Shigeyuki Shichino, Shin-ichi Hashimoto, Satoshi Ueha, Kouji Matsushima.
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05203
[Presentation] マウス肺線維症モデルへの間葉系幹細胞の移入ルートおよびドナーによる移入効率と治療効果の解析2018
- Author(s)
  中島拓弥・七野成之・上羽悟史・松島綱治
- Organizer
  第39回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-16H05203
[Presentation] Single-cell transcriptomeによるマウス線維化肺のサイトカイン・ケモカイン発現プロファイルの解明2018
- Author(s)
  七野成之, 橋本真一, 上羽悟史, 松島綱治
- Organizer
  第83回日本インターフェロン・サイトカイン学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05203
[Presentation] TCR sequencing reveals the generation and expansion of tumor-specific CD8+T cell clones after anti-CD4 antibody treatment in tumor-bearing mice2018
- Author(s)
  Satoshi Ueha, Aoki Hiroyasu, Shigeyuki Shichino, Ogiwara Haru, Shinichi Hashimoto, Kazuhiro Kakimi, Kouji Matsushima
- Organizer
  Keystone Symposia
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06392
[Presentation] 担がんマウスにおけるCD8+ T細胞レパトアの臓器別解析2018
- Author(s)
  七野　成之, 青木　寛泰, 橋本　真一, 荻原　春, 上羽　悟史, 松島　綱治
- Organizer
  第17回分子予防環境医学研究会大会
- Data Source
  KAKENHI-PROJECT-16H05203
[Presentation] 細胞と分子の動きから観る臓器線維化2018
- Author(s)
  七野　成之, 津久井　達也, 橋本　真一, 大辻　幹哉, 上羽　悟史, 稲垣　豊, 島野　仁, 松島　綱治
- Organizer
  「炎症の慢性化機構の解明と制御に向けた基盤技術の創出」研究開発領域公開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16H05203
[Presentation] An organ-wide transcriptome of stromal cells identifies the core signature of steady-state murine fibroblasts2017
- Author(s)
  Shigeyuki SHICHINO, Satoshi UEHA, Shin-ichi HASHIMOTO, Inagaki YUTAKA, Kouji MATSUSHIMA
- Organizer
  4th Lymphoid tissue meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05203
[Presentation] TCR sequencing reveals the generation and expansion of tumor-specific CD8+ T cell clones after anti-CD4 antibody treatment in tumor-bearing mice2017
- Author(s)
  Satoshi Ueha, Yasuhiro Aoki, Shigeyuki Shichino, Haru Ogiwara, Shinichi Hashimoto, Kazuhiro Kakimi, Satoru Ito, Kouji Matsushima
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-17H06392
[Presentation] TCR sequencing reveals the generation and expansion of tumor-specific CD8+T cell clones after anti-CD4 antibody treatment in tumor-bearing mice2017
- Author(s)
  Satoshi Ueha, Aoki Hiroyasu, Shigeyuki Shichino, Ogiwara Haru, Shinichi Hashimoto, Kazuhiro Kakimi, Kouji Matsushima
- Organizer
  The 46th Japanese Society for Immunology
- Data Source
  KAKENHI-PLANNED-17H06392
[Presentation] 担がんマウスにおけるCD8+ T細胞レパトアの臓器別解析2017
- Author(s)
  青木　寛泰、七野　成之、橋本　真一、上羽　悟史、松島　綱治
- Organizer
  第3回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-16H05203
[Presentation] TCR sequencing reveals the generation and expansion of tumor-specific CD8+ T cell clones after anti-CD4 antibody treatment in tumor-bearing mice2017
- Author(s)
  Satoshi Ueha, Yasuhiro Aoki, Shigeyuki Shichino, Haru Ogiwara, Shinichi Hashimoto, Kazuhiro Kakimi, Satoru Ito, Kouji Matsushima
- Organizer
  第21回日本がん免疫学会総会
- Data Source
  KAKENHI-PLANNED-17H06392
[Presentation] Transcriptome analysis reveals PDGF signaling-dependent regulation of myelofibrosis in murine chronic graft-versus-host diseases2017
- Author(s)
  Shigeyuki Shichino, Satoshi Ueha, Naoto Sudo, Mizuha Kosugi-Kanaya, Francis HW Shand, Teppei Morikawa, Shin-ichi Hashimoto, Takanori Teshima, Kouji Matsushima
- Organizer
  5th Annual Meeting of the International Cytokine and Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05203
[Presentation] 担がんマウスにおけるCD8+ T細胞レパトアの臓器別解析2017
- Author(s)
  青木　寛泰、七野　成之、橋本　真一、上羽　悟史、松島　綱治
- Organizer
  第3回日本骨免疫学会
- Data Source
  KAKENHI-PLANNED-17H06392
[Presentation] Identification of a functional and transcriptional signature for tumor-infiltrating dendritic cells in mouse2017
- Author(s)
  Satoshi Ueha, Haru Ogiwara, Shigeyuki Shichino, Jun Abe, Francis Shand, Shinichi Hashimoto, Kouji Matsushima
- Organizer
  5th Annual Meeting of the International Cytokine and Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05203
[Presentation] Transcriptome network analysis reveals lipid-related transcription factors as hubs for fibroblast activation in murine pulmonary fibrosis2017
- Author(s)
  Shigeyuki Shichino, Satoshi Ueha, Inagaki Yutaka, Shin-ichi Hashimoto, Hitoshi Shimano, and Kouji Matsushima
- Organizer
  The 19th Takeda Science Foundation Symposium on Bioscience : Chronic Inflammation - initiation, Progression and Resolution
- Place of Presentation
  武田薬品研修所（大阪府吹田市）
- Year and Date
  2017-01-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05203
[Presentation] TCR sequencing reveals the generation and expansion of tumor-specific CD8+ T cell clones after anti-CD4 antibody treatment in tumor-bearing mice2017
- Author(s)
  Satoshi Ueha, Yasuhiro Aoki, Shigeyuki Shichino, Haru Ogiwara, Shinichi Hashimoto, Kazuhiro Kakimi, Satoru Ito, Kouji Matsushima
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05203
[Presentation] 肺線維症における活性化線維芽細胞の起源とその活性化制御機構2017
- Author(s)
  七野　成之, 上羽　悟史, 橋本　真一, 松島　綱治
- Organizer
  第38回日本炎症・再生医学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05203
[Presentation] Identification of a functional and transcriptional signature for tumor-infiltrating dendritic cells in mouse2017
- Author(s)
  Satoshi Ueha, Haru Ogiwara, Shigeyuki Shichino, Jun Abe, Francis Shand, Shinichi Hashimoto, Kouji Matsushima
- Organizer
  5th Annual Meeting of the International Cytokine and Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06392
[Presentation] TCR sequencing reveals the generation and expansion of tumor-specific CD8+ T cell clones after anti-CD4 antibody treatment in tumor-bearing mice2017
- Author(s)
  Satoshi Ueha, Yasuhiro Aoki, Shigeyuki Shichino, Haru Ogiwara, Shinichi Hashimoto, Kazuhiro Kakimi, Satoru Ito, Kouji Matsushima
- Organizer
  第21回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-16H05203
[Presentation] 慢性GVHDにおける骨髄線維化の分子メカニズムの検討2017
- Author(s)
  七野　成之, 上羽　悟史, 須藤　直人、小杉　瑞葉, 松島　綱治
- Organizer
  第3回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-16H05203
[Presentation] TCR sequencing reveals the generation and expansion of tumor-specific CD8+T cell clones after anti-CD4 antibody treatment in tumor-bearing mice2017
- Author(s)
  Satoshi Ueha, Aoki Hiroyasu, Shigeyuki Shichino, Ogiwara Haru, Shinichi Hashimoto, Kazuhiro Kakimi, Kouji Matsushima
- Organizer
  The 46th Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-16H05203
[Presentation] 肺線維症における細胞動態2016
- Author(s)
  上羽悟史、津久井達哉、七野成之、松島綱治
- Organizer
  第40回日本リンパ学会総会
- Place of Presentation
  東京大学伊藤国際学術研究センター（東京都文京区）
- Invited
- Data Source
  KAKENHI-PROJECT-16H05203
[Presentation] 多臓器間網羅的トランスクリプトーム解析による線維芽細胞 core transcriptomic signatureの同定2016
- Author(s)
  七野成之, 上羽悟史, 橋本真一, 松島綱治
- Organizer
  第2回日本骨免疫学会
- Place of Presentation
  ホテルモントレ沖縄スパ＆リゾート（沖縄県国頭郡）
- Year and Date
  2016-07-06
- Data Source
  KAKENHI-PROJECT-16H05203
[Presentation] Intravascular staining identifies tissue compartment of myeloid cell subsets in fibrotic and cancer-bearing murine lungs2016
- Author(s)
  Shigeyuki Shichino, Francis HW Shand, Satoshi Ueha, and Kouji Matsushima
- Organizer
  第24回マクロファージ分子細胞生物学国際シンポジウム
- Place of Presentation
  御茶ノ水ソラシティカンファレンスセンター（東京都千代田区）
- Year and Date
  2016-06-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05203
[Presentation] Macrophage regulation of inflammation and tissue remodeling in pulmonary fibrosis2016
- Author(s)
  Satoshi Ueha, Shigeyuki Shichino, Kouji Matsushima
- Organizer
  第89回生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-25
- Invited
- Data Source
  KAKENHI-PROJECT-16H05203
[Presentation] An organ-wide transcriptome of collagen-producing cells identifies the core signature of steady-state murine fibroblasts2016
- Author(s)
  "Shigeyuki SHICHINO, Satoshi UEHA, Shin-ichi HASHIMOTO, Inagaki YUTAKA and Kouji MATSUSHIMA"
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16H05203

1. 上羽悟史 (00447385)

# of Collaborated Projects: 3 results

# of Collaborated Products: 48 results
2. Matsushima Kouji (50222427)

# of Collaborated Projects: 2 results

# of Collaborated Products: 54 results
3. 橋本真一 (00313099)

# of Collaborated Projects: 2 results

# of Collaborated Products: 32 results
4. 伊藤利洋 (00595712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. 島岡猛士 (90422279)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 山野荘太郎 (80614528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 杉原英志 (50464996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Nakajima Takuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
9. Aoki Hiroyasu

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
10. INAGAKI Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
11. YAMASHITA Makiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. OGURA Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. IWATA Yasunori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. FURUICHI Kengo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. WADA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. FUJINO Masayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 島野仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 韓松伊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 山崎聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 上羽瑠美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 近藤健二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 菊田周

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 西嶌大宣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 豊嶋崇徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. SHAND FRANCIS

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
26. 池尾一穂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 坂井宣彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 宮澤正顕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 梨井康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 森一泰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 赤羽悟美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 西山千春

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 中野裕康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shichino Shigeyuki 七野 成之

Research Projects

Research Products

Co-Researchers

間葉系細胞-間質性細胞相互作用の肺-骨髄間クロストークの意義の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

増殖の臓器指向性と一細胞遺伝子発現解析に基づく治療最適抗腫瘍T細胞クローンの同定

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規シングルセル解析法を用いたじん肺発症-進展における包括的基盤研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the immune response of the tumor-infilteating T cells by novel scTCR-seq methodsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Inflammation cellular society in pulmonary fibrosis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of transcriptional regulation of fibroblast activation in pulmonary fibrosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Transient Depletion of CD4+ Cells Induces Remodeling of the TCR Repertoire in Gastrointestinal Cancer.2021

Author(s)

Journal Title

Data Source

[Journal Article] Transient Depletion of CD4 + Cells Induces Remodeling of the TCR Repertoire in Gastrointestinal Cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Increased Frequency of Methicillin-Resistant Staphylococcus Aureus With Low MIC of Beta-Lactam Antibiotics Isolated From Hospitalized Patients2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcriptome network analysis identifies protective role of the LXR/SREBP-1c axis in murine pulmonary fibrosis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mesenchymal-Epithelial Interactome Analysis Reveals Essential Factors Required for Fibroblast-Free Alveolosphere Formation.2019

Author(s)

Journal Title

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[Journal Article] In vitro expansion of endogenous human alveolar epithelial type II cells in fibroblast-free spheroid culture2019

Author(s)

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[Journal Article] Engraftment and proliferation potential of embryonic lung tissue cells in irradiated mice with emphysema.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] First-in-human phase 1 study of IT1208, a defucosylated humanized anti-CD4 depleting antibody, in patients with advanced solid tumors2019

Shichino Shigeyuki 七野成之