Okazaki Keito 岡崎慶斗

Researcher Number	70826289
Other IDs
Affiliation (Current)	2025: 東北大学, 加齢医学研究所, 助教
Affiliation (based on the past Project Information) *help	2020 – 2024: 東北大学, 加齢医学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator Regnase-1 / NRF2 / 腫瘍幹細胞性 / NRF2-CEBPB連携 / NRF2活性化がん / 薬剤耐性遺伝子 / CEBPB / NOTCH3

難治性がんにおけるRegnase-1によるRNA分解調節機構の検証Principal Investigator
- Principal Investigator
  
  岡崎慶斗
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University
Mechanisms of cancer malignant transformation created by Regnase-1.Principal Investigator
- Principal Investigator
  
  Keito Okazaki
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University
Research for unveiled molecular mechanism underlying cancer malignancyPrincipal Investigator
- Principal Investigator
  
  Okazaki Keito
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University

All 2024 2023 2022 2021 2020

All Journal Article Presentation Book

[Book] がん微小環境と標的治療2020
- Author(s)
  岡崎慶斗、本橋ほづみ
- Total Pages
  7
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-20K16350
[Journal Article] CEBPB is required for NRF2-mediated drug resistance in NRF2-activated non-small cell lung cancer cells2022
- Author(s)
  Okazaki Keito、Anzawa Hayato、Katsuoka Fumiki、Kinoshita Kengo、Sekine Hiroki、Motohashi Hozumi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: - Issue: 5 Pages: 567-578
- DOI
  10.1093/jb/mvac013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16350, KAKENHI-PROJECT-20K07335, KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05264, KAKENHI-PROJECT-21H04799
[Journal Article] Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers2020
- Author(s)
  Okazaki Keito、Anzawa Hayato、Liu Zun、Ota Nao、Kitamura Hiroshi、Onodera Yoshiaki、Alam Md. Morshedul、Matsumaru Daisuke、et al.
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 5911-5911
- DOI
  10.1038/s41467-020-19593-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07361, KAKENHI-PROJECT-19K07379, KAKENHI-PROJECT-19K09065, KAKENHI-PROJECT-20K16350, KAKENHI-PUBLICLY-20H04832, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-17K08617
[Journal Article] Metabolic features of cancer cells in NRF2 addiction status2020
- Author(s)
  Okazaki K, Papagiannakopoulos T, Motohashi H
- Journal Title
  
  Biophysical Reviews
  
  Volume: in press Issue: 2 Pages: 435-441
- DOI
  10.1007/s12551-020-00659-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04794, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-20K16350
[Presentation] Regnase-1は非小細胞肺がんの腫瘍幹細胞性に貢献する2024
- Author(s)
  岡崎慶斗
- Organizer
  第83回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15504
[Presentation] NRF2活性化がんにおけるRNA分解酵素Regnase-1の機能解析2023
- Author(s)
  岡崎慶斗
- Organizer
  第96回日本生化学会大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15504
[Presentation] NRF2活性化状態におけるCEBPB依存的な転写制御とその意義.2021
- Author(s)
  岡崎慶斗、本橋ほづみ.
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K16350
[Presentation] 難治性がんにおけるエンハンサーリモリングがもたらす腫瘍幹細胞性の増強2021
- Author(s)
  岡崎慶斗
- Organizer
  生化学会東北支部第87回例会
- Data Source
  KAKENHI-PROJECT-20K16350
[Presentation] NRF2の持続的活性化によるエンハンサーリモデリングとNRF2活性化肺がんの悪性化機構の解明2021
- Author(s)
  岡崎慶斗
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K16350
[Presentation] NRF2活性化がんの悪性化をもたらすエンハンサー・リモデリング2020
- Author(s)
  岡崎慶斗、本橋ほづみ
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K16350

1. 松丸大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 本橋ほづみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okazaki Keito 岡崎 慶斗

Research Projects

Research Products

Co-Researchers

難治性がんにおけるRegnase-1によるRNA分解調節機構の検証Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of cancer malignant transformation created by Regnase-1.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research for unveiled molecular mechanism underlying cancer malignancyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] がん微小環境と標的治療2020

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Total Pages

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Data Source

[Journal Article] CEBPB is required for NRF2-mediated drug resistance in NRF2-activated non-small cell lung cancer cells2022

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Journal Title

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[Journal Article] Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers2020

Author(s)

Journal Title

DOI

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[Journal Article] Metabolic features of cancer cells in NRF2 addiction status2020

Author(s)

Journal Title

DOI

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[Presentation] Regnase-1は非小細胞肺がんの腫瘍幹細胞性に貢献する2024

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[Presentation] NRF2活性化がんにおけるRNA分解酵素Regnase-1の機能解析2023

Author(s)

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[Presentation] NRF2活性化状態におけるCEBPB依存的な転写制御とその意義.2021

Author(s)

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Data Source

[Presentation] 難治性がんにおけるエンハンサーリモリングがもたらす腫瘍幹細胞性の増強2021

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Data Source

[Presentation] NRF2の持続的活性化によるエンハンサーリモデリングとNRF2活性化肺がんの悪性化機構の解明2021

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Organizer

Data Source

[Presentation] NRF2活性化がんの悪性化をもたらすエンハンサー・リモデリング2020

Author(s)

Organizer

Data Source

Okazaki Keito 岡崎慶斗