Miyake Takahito 三宅崇仁

Researcher Number	70836866
Other IDs
Affiliation (Current)	2025: 関西学院大学, 生命環境学部, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 京都大学, 薬学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Basic Section 47040:Pharmacology-related
Keywords	Principal Investigator 翻訳 / 発現制御機構 / 体内時計 / 体温 / uORF / mRNA翻訳 / 発現制御 / 生物時計 / 炎症応答 / 膜タンパク質 / かゆみ

uORFー非翻訳領域の翻訳ーが支配する生命機能の解明Principal Investigator
- Principal Investigator
  
  三宅崇仁
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Kyoto University
Mechanisms of uORF-mediated biological clock phase entrainment by physiological body temperature rhythmsPrincipal Investigator
- Principal Investigator
  
  Miyake Takahito
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Kyoto University
Molecular mechanisms underlying circadian pruritic behavior for chronopharmacologyPrincipal Investigator
- Principal Investigator
  
  Miyake Takahito
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Kyoto University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Temperature-Dependent Upregulation of Per2 Protein Expression Is Mediated by eIF2α Kinases PERK and PKR through PI3K Activation2024
- Author(s)
  Shao Xinyan、Miyake Takahito、Inoue Yuichi、Hasegawa Emi、Doi Masao
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 47 Issue: 3 Pages: 600-605
- DOI
  10.1248/bpb.b23-00739
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2024-03-05
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15274, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-22H04987
[Journal Article] Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm2023
- Author(s)
  Miyake Takahito、Inoue Yuichi、Shao Xinyan、Seta Takehito、Aoki Yuto、Nguyen Pham Khanh Tien、Shichino Yuichi、Sasaki Junko、Sasaki Takehiko、Ikawa Masahito、Yamaguchi Yoshiaki、Okamura Hitoshi、Iwasaki Shintaro、Doi Masao
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 3 Pages: 112157-112157
- DOI
  10.1016/j.celrep.2023.112157
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06594, KAKENHI-PROJECT-22K18384, KAKENHI-PROJECT-22K15274, KAKENHI-ORGANIZER-20H05782, KAKENHI-PLANNED-20H05783, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-22H04987, KAKENHI-PROJECT-21H02680, KAKENHI-PROJECT-20K21426, KAKENHI-PROJECT-21K15023, KAKENHI-PROJECT-18H04015, KAKENHI-PROJECT-23K27319
[Journal Article] Minimal uORF-mediated mechanisms of mammalian clock adaptation to day/night physiological body temperature fluctuations2023
- Author(s)
  三宅崇仁、土居雅夫
- Journal Title
  
  生化学
  
  Volume: 95 Issue: 6 Pages: 837-841
- DOI
  10.14952/SEIKAGAKU.2023.950837
- ISSN
  0037-1017
- Year and Date
  2023-12-25
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-22K15274, KAKENHI-PROJECT-22H04987
[Journal Article] 特集温度を感じる脳と身体の科学体温の日内リズム制御における概日時計機構の役割2022
- Author(s)
  Takahito Miyake, Masao Doi
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 74 Issue: 2 Pages: 159-166
- DOI
  10.11477/mf.1416202001
- ISSN
  1344-8129, 1881-6096
- Year and Date
  2022-02-01
- Data Source
  KAKENHI-PROJECT-19K16371, KAKENHI-PLANNED-20H05783, KAKENHI-PROJECT-17H01524, KAKENHI-PROJECT-20K21426, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-22H04922
[Journal Article] Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction2022
- Author(s)
  Sasaki Lena、Hamada Yuki、Yarimizu Daisuke、Morinaga Hironobu、Nishimura Emi K.、Kudo Fujimi、Manabe Ichiro、Haraguchi Shogo、Sugiura Yuki、Suematsu Makoto、Kinoshita Shigeru、Machida Mamiko、Nakajima Takeshi、Kiyonari Hiroshi、Okamura Hitoshi、Yamaguchi Yoshiaki、Miyake Takahito、Doi Masao
- Journal Title
  
  Nature Aging
  
  Volume: 2 Issue: 2 Pages: 105-114
- DOI
  10.1038/s43587-021-00167-8
- NAID
  120007191374
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09033, KAKENHI-PROJECT-19K16371, KAKENHI-ORGANIZER-20H05782, KAKENHI-PLANNED-20H05783, KAKENHI-PROJECT-17H01524, KAKENHI-PROJECT-19H03110, KAKENHI-PROJECT-20K21426, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-22K09771, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-23K21623
[Journal Article] Gpr19 is a circadian clock-controlled orphan GPCR with a role in modulating free-running period and light resetting capacity of the circadian clock2021
- Author(s)
  Yoshiaki Yamaguchi, Iori Murai, Kaoru Goto, Shotaro Doi, Huihua Zhou, Genzui Setsu, Hiroyuki Shimatani, Hitoshi Okamura, Takahito Miyake, Masao Doi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 22406-22406
- DOI
  10.1038/s41598-021-01764-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16371, KAKENHI-ORGANIZER-20H05782, KAKENHI-PLANNED-20H05783, KAKENHI-PROJECT-17H01524, KAKENHI-PROJECT-20K21426, KAKENHI-PROJECT-16H06276
[Journal Article] Thermographic imaging of mouse across circadian time reveals body surface temperature elevation associated with non-locomotor body movements2021
- Author(s)
  Hiroyuki Shimatani, Yuichi Inoue, Yota Maekawa, Takahito Miyake, Yoshiaki Yamaguchi, Masao Doi
- Journal Title
  
  PLoS One
  
  Volume: 16 Issue: 5 Pages: e0252447-e0252447
- DOI
  10.1371/journal.pone.0252447
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16371, KAKENHI-ORGANIZER-20H05782, KAKENHI-PLANNED-20H05783, KAKENHI-PROJECT-17H01524, KAKENHI-PROJECT-20J15408, KAKENHI-PROJECT-20K21426, KAKENHI-PROJECT-16H06276
[Journal Article] Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr1762020
- Author(s)
  Tianyu Wang, Shumpei Nakagawa, Takahito Miyake, Genzui Setsu, Sumihiro Kunisue, Kaoru Goto, Akira Hirasawa, Hitoshi Okamura, Yoshiaki Yamaguchi, Masao Doi
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 4429-4429
- DOI
  10.1038/s41598-020-61370-y
- NAID
  120006822520
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16371, KAKENHI-PLANNED-15H05933, KAKENHI-PROJECT-17H01524, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18H04015
[Journal Article] Reconstitution of Organismal Liver Clock Function Requires Light.2019
- Author(s)
  Takahito Miyake, Masao Doi
- Journal Title
  
  Trends in endocrinology and metabolism
  
  Volume: 30 Issue: 9 Pages: 569-571
- DOI
  10.1016/j.tem.2019.07.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16371, KAKENHI-PLANNED-15H05933, KAKENHI-PROJECT-17H01524, KAKENHI-PROJECT-16H06276
[Presentation] The minimal upstream open reading frame of Per2 has a role in enhancing the integrity of the physiological circadian response2024
- Author(s)
  三宅崇仁、土居雅夫
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K15274
[Presentation] Temperature entrainment mechanism of peripheral clocks via circadian body temperature and its role in physiology2024
- Author(s)
  三宅崇仁、土居雅夫
- Organizer
  第101回日本生理学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15274
[Presentation] 体内時計を介した概日体温リズムによる生体恒常性維持機構2024
- Author(s)
  三宅崇仁、土居雅夫
- Organizer
  2024年度生理学研究会　臓器連関による生体恒常性維持機構と生体活動の統合的理解
- Data Source
  KAKENHI-PROJECT-22K15274
[Presentation] コア時計遺伝子Per2 の最小単位上流翻訳領域は生物時計の概日体温リズムへの同調に重要である2024
- Author(s)
  三宅崇仁、井ノ上雄一、土居雅夫
- Organizer
  2023年度文部科学省学術変革領域研究学術研究支援基盤形成　先端モデル動物支援プラットフォーム　成果発表会
- Data Source
  KAKENHI-PROJECT-22K15274
[Presentation] 生理的微小温度変化を感知するmRNA翻訳制御エレメントの発見とその生理的意義2024
- Author(s)
  三宅崇仁、土居雅夫
- Organizer
  第3回関西RNAクラブ
- Invited
- Data Source
  KAKENHI-PROJECT-22K15274
[Presentation] 生理的な微小温度変化がもたらすmRNA翻訳速度調節を介した概日時計制御機構2023
- Author(s)
  三宅崇仁、井ノ上雄一、土居雅夫
- Organizer
  第12回都医学研シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22K15274
[Presentation] 体温と翻訳を介した生物時計のしなやかな調律メカニズム2023
- Author(s)
  三宅崇仁
- Organizer
  大阪大学蛋白質研究所セミナー「生命のしなやかさに着目したタンパク質研究の現状と展望」
- Invited
- Data Source
  KAKENHI-PROJECT-22K15274
[Presentation] 非翻訳領域の翻訳を介した生理的微小温度変化による生物時計調律2023
- Author(s)
  三宅崇仁、井ノ上雄一、土居雅夫
- Organizer
  第5回量子生命科学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15274
[Presentation] 非翻訳領域に位置する最小翻訳フレームを介した概日時計温度制御機構2023
- Author(s)
  三宅崇仁、井ノ上雄一、土居雅夫
- Organizer
  日本睡眠学会第45回定期学術集会・第30回日本時間生物学会学術大会　合同大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15274
[Presentation] パラメトリックmRNA翻訳速度調節を介した体温による概日時計調律機構2023
- Author(s)
  三宅崇仁、土居雅夫
- Organizer
  第41回日本内分泌学会内分泌代謝学サマーセミナー YECシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22K15274
[Presentation] 微小な温度変化がもたらすmRNA翻訳速度調節と概日時計制御2022
- Author(s)
  三宅崇仁、井ノ上雄一、土居雅夫
- Organizer
  温熱生理学研究会2022
- Invited
- Data Source
  KAKENHI-PROJECT-22K15274
[Presentation] 翻訳速度制御を介した体内時計のパラメトリック制御2021
- Author(s)
  三宅崇仁、井ノ上雄一、土居雅夫
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16371
[Presentation] 生理的体温変化による体内時計のパラメトリック制御2021
- Author(s)
  三宅崇仁、井ノ上雄一、土居雅夫
- Organizer
  第59回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-19K16371
[Presentation] 微小な温度変化がもたらすmRNA翻訳速度調節と概日時計制御2021
- Author(s)
  三宅崇仁、井ノ上雄一、土居雅夫
- Organizer
  Biothermology Workshop - 2021's Annual Workshop
- Data Source
  KAKENHI-PROJECT-19K16371
[Presentation] A robust and sustained circadian rhythm of Per2::Luc expression in the mouse meibomian gland acinar cells2021
- Author(s)
  グエンファムカンティエン、三宅崇仁、土居雅夫
- Organizer
  第28回日本時間生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16371
[Presentation] Circadian PER2 protein oscillations do not persist when de novo translation is inhibited in cultured mouse embryonic fibroblasts2020
- Author(s)
  Xinyan Shao, Takahito Miyake, and Masao Doi
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16371
[Presentation] 体内時計の温度同調機構：生理的な範囲の温度変化が培養マウス繊維芽細胞の分子時計に与える影響について2020
- Author(s)
  井ノ上雄一、三宅崇仁、土居雅夫
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16371

1. YAMAGUCHI Yoshiaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 原口省吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Miyake Takahito 三宅 崇仁

Research Projects

Research Products

Co-Researchers

uORFー非翻訳領域の翻訳ーが支配する生命機能の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of uORF-mediated biological clock phase entrainment by physiological body temperature rhythmsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms underlying circadian pruritic behavior for chronopharmacologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Temperature-Dependent Upregulation of Per2 Protein Expression Is Mediated by eIF2α Kinases PERK and PKR through PI3K Activation2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Minimal uORF-mediated mechanisms of mammalian clock adaptation to day/night physiological body temperature fluctuations2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] 特集 温度を感じる脳と身体の科学 体温の日内リズム制御における概日時計機構の役割2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Data Source

[Journal Article] Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction2022

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Gpr19 is a circadian clock-controlled orphan GPCR with a role in modulating free-running period and light resetting capacity of the circadian clock2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Thermographic imaging of mouse across circadian time reveals body surface temperature elevation associated with non-locomotor body movements2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr1762020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Reconstitution of Organismal Liver Clock Function Requires Light.2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] The minimal upstream open reading frame of Per2 has a role in enhancing the integrity of the physiological circadian response2024

Author(s)

Organizer

Miyake Takahito 三宅崇仁

[Journal Article] 特集温度を感じる脳と身体の科学体温の日内リズム制御における概日時計機構の役割2022