Kambayashi Ryuichi 神林隆一

Researcher Number	70837492
Other IDs
Affiliation (Current)	2025: 東邦大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2025: 東邦大学, 医学部, 助教 2020 – 2022: 東邦大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 48040:Medical biochemistry-related / Basic Section 48030:Pharmacology-related
Keywords	Principal Investigator 病態モデル / 心房細動 / 抗不整脈薬 / 心不全 / SGLT2阻害薬 / 心血管 / 心室再分極 / 心房有効不応期 / 心室不整脈 / QT延長 / 重水素化

Research Projects
(2 results)
Research Products
(22 results)

心不全合併心房細動モデルを活用したSGLT2阻害薬の心房細動治療効果の解明Principal Investigator
- Principal Investigator
  
  神林隆一
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Toho University
Effects of deuterium modification on the electropharmacological profile of anti-atrial fibrillatory drugPrincipal Investigator
- Principal Investigator
  
  Kambayashi Ryuichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Toho University

All 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Characterization of electropharmacological profile of an anti-atrial fibrillatory drug vernakalant along with potential risk toward torsade de pointes: Translational studies using isoflurane-anesthetized dogs and isolated rat aortic preparations.2023
- Author(s)
  Goto Ai, Kambayashi Ryuichi, Izumi-Nakaseko Hiroko, Shinozaki Makoto, Takei Yoshinori, Sugiyama Atsushi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: － Issue: 4 Pages: 201-209
- DOI
  10.1016/j.jphs.2023.05.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16136, KAKENHI-PROJECT-23K15143, KAKENHI-PROJECT-23K08430
[Journal Article] Both osmolality-dependent and independent mechanisms are associated with acute hyperglycemia-induced cardiovascular adverse reactions: Analysis of the mutual interactions leading to cardiovascular phenotypes in dogs2023
- Author(s)
  Kambayashi Ryuichi, Izumi-Nakaseko Hiroko, Goto Ai, Takei Yoshinori, Matsumoto Akio, Lorch Ulrike, Taubel Jorg, Sugiyama Atsushi
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 48 Issue: 3 Pages: 169-178
- DOI
  10.2131/jts.48.169
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16136
[Journal Article] Imatinib induces diastolic dysfunction and ventricular early-repolarization delay in the halothane-anesthetized dogs: Class effects of tyrosine kinase inhibitors.2022
- Author(s)
  Chiba Koki, Kambayashi Ryuichi, Onozato Mayu, Goto Ai, Izumi-Nakaseko Hiroko, Takei Yoshinori, Matsumoto Akio, Tanaka Koichiro, Kanda Yasunari, Fukushima Takeshi, Sugiyama Atsushi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 150 Issue: 3 Pages: 154-162
- DOI
  10.1016/j.jphs.2022.07.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16136
[Journal Article] Analysis of clinically-reported, memantine-induced cardiovascular adverse responses using the halothane-anesthetized dogs: Reverse translational study2022
- Author(s)
  Kambayashi Ryuichi、Goto Ai、Hagiwara-Nagasawa Mihoko、Izumi-Nakaseko Hiroko、Shinozaki Makoto、Kawai Shinichi、Matsumoto Akio、Takei Yoshinori、Sugiyama Atsushi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 148 Issue: 4 Pages: 343-350
- DOI
  10.1016/j.jphs.2022.01.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16136
[Journal Article] Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts2022
- Author(s)
  Karkhanis Aneesh V.、Venkatesan Gopalakrishnan、Kambayashi Ryuichi、Leow Jacqueline Wen Hui、Han Marcus Qingrui、Izumi-Nakaseko Hiroko、Goto Ai、Pang Jeremy Kah Sheng、Soh Boon Seng、Kojodjojo Pipin、Sugiyama Atsushi、Chan Eric Chun Yong
- Journal Title
  
  Acta Pharmaceutica Sinica B
  
  Volume: － Issue: 10 Pages: 3905-3923
- DOI
  10.1016/j.apsb.2022.03.008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16136
[Journal Article] Roles of IK,ACh for perpetuating atrial fibrillation: effects of atrial-selective K+ channel inhibitor AVE0118 and class I drugs on the persistent atrial fibrillation canine model2022
- Author(s)
  Kambayashi Ryuichi、Goto Ai、Izumi-Nakaseko Hiroko、Takei Yoshinori、Matsumoto Akio、Kawai Shinichi、Sugiyama Atsushi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: － Issue: 4 Pages: 175-178
- DOI
  10.1016/j.jphs.2022.05.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16136
[Journal Article] Simultaneous analyses of hemodynamic and electrophysiological effects of oseltamivir along with its pharmacokinetic profile using the canine paroxysmal atrial fibrillation model2022
- Author(s)
  Kambayashi Ryuichi、Goto Ai、Onozato Mayu、Izumi-Nakaseko Hiroko、Takei Yoshinori、Matsumoto Akio、Kawai Shinichi、Fukushima Takeshi、Sugiyama Atsushi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 148 Issue: 1 Pages: 179-186
- DOI
  10.1016/j.jphs.2021.11.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16136
[Journal Article] Translational studies on anti-atrial fibrillatory action of oseltamivir by its in vivo and in vitro electropharmacological analyses2021
- Author(s)
  Ryuichi Kambayashi, Hiroko Izumi-Nakaseko, Ai Goto, Kazuya Tsurudome, Hironori Ohshiro, Taku Izumi, Mihoko Hagiwara-Nagasawa, Koki Chiba, Ryota Nishiyama, Satomi Oyama, Yoshio Nunoi, Yoshinori Takei, Akio Matsumoto, Atsushi Sugiyama
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 12
- DOI
  10.3389/fphar.2021.593021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16505, KAKENHI-PROJECT-20K16136
[Journal Article] An exploratory analysis of effects of poyendarone, a deuterated analogue of dronedarone, on the canine model of paroxysmal atrial fibrillation2021
- Author(s)
  Ryuichi Kambayashi, Ai Goto, Yoshio Nunoi, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Gopalakrishnan Venkatesan, Yoshinori Takei, Akio Matsumoto, Eric Chun Yong Chan, Atsushi Sugiyama
- Journal Title
  
  Naunyn-Schmiedeberg's archives of pharmacology
  
  Volume: - Issue: 6 Pages: 1103-1112
- DOI
  10.1007/s00210-020-02047-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16505, KAKENHI-PROJECT-20K16136
[Journal Article] In vivo characterization of anti-atrial fibrillatory potential and pharmacological safety profile of INa,L plus IKr inhibitor ranolazine using the halothane-anesthetized dogs2021
- Author(s)
  Yoshio Nunoi, Ryuichi Kambayashi, Ai Goto, Mihoko Hagiwara-Nagasawa, Koki Chiba, Hiroko Izumi-Nakaseko, Shinichi Kawai, Yoshinori Takei, Akio Matsumoto, Yoshinori Watanabe, Atsushi Sugiyama
- Journal Title
  
  Heart and Vessels
  
  Volume: - Issue: 7 Pages: 1088-1097
- DOI
  10.1007/s00380-021-01830-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16505, KAKENHI-PROJECT-20K16136
[Journal Article] Cardiohemodynamic and arrhythmogenic effects of the anti-atrial fibrillatory compound vanoxerine in halothane-anesthetized dogs2021
- Author(s)
  Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akio Matsumoto, Atsushi Sugiyama
- Journal Title
  
  Cardiovascular Toxicology
  
  Volume: 21 Issue: 3 Pages: 206-215
- DOI
  10.1007/s12012-020-09612-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16505, KAKENHI-PROJECT-20K16136
[Journal Article] Analysis of electropharmacological and proarrhythmic effects of donepezil using the halothane-anesthetized intact dogs and the conscious chronic atrioventricular block ones2021
- Author(s)
  Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Koki Chiba, Takeshi Wada, Yoshinori Takei, Akio Matsumoto, Atsushi Sugiyama
- Journal Title
  
  Naunyn-Schmiedeberg's archives of pharmacology
  
  Volume: 394 Issue: 4 Pages: 581-589
- DOI
  10.1007/s00210-020-01997-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16505, KAKENHI-PROJECT-20K16136
[Journal Article] Reverse translational analysis of clinically reported, lamotrigine-induced cardiovascular adverse events using the halothane-anesthetized dogs2021
- Author(s)
  Ai Goto, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Shinichi Kawai, Yoshinori Takei, Akio Matsumoto, Atsushi Sugiyama
- Journal Title
  
  Heart and Vessels
  
  Volume: 36 Issue: 3 Pages: 424-429
- DOI
  10.1007/s00380-020-01716-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16505, KAKENHI-PROJECT-20K16136
[Presentation] Onset Mechanisms of Imatinib-Induced Heart Failure and QT-Interval Prolongation in the Halothane-Anesthetized Dogs2023
- Author(s)
  Kambayashi Ryuichi, Matsumoto Akio, Sugiyama Atsushi
- Organizer
  第87回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16136
[Presentation] Analysis of electropharmacological effects of TASK-1 inhibitor doxapram along with anti-atrial fibrillatory action using the intact and chronic atrioventricular block dogs2022
- Author(s)
  Kambayashi Ryuichi、Goto Ai、Izumi-Nakaseko Hiroko、Takei Yoshinori、Matsumoto Akio、Kawai Shinichi、Sugiyama Atsushi
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K16136
[Presentation] 早期（J-Tpeak）および後期（Tpeak-Tend）再分極時間の延長様式が引き続き発生する torsade de pointes 発作の開始様式と自然停止確率を予測する2022
- Author(s)
  神林隆一, 後藤愛, 中瀬古（泉）寛子, 武井義則, 松本明郎, 杉山篤
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K16136
[Presentation] 心房細動の停止に有効なイオンチャネル遮断特性:発作性および持続性心房細動モデル犬を用いたoseltamivirの薬効評価2022
- Author(s)
  神林隆一, 後藤愛, 中瀬古(泉) 寛子, 武井義則, 松本明郎, 杉山篤
- Organizer
  第146回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-20K16136
[Presentation] TASK-1阻害薬doxapramのイソフルラン麻酔犬における電気薬理学的作用評価：抗心房細動薬としての可能性の検討2021
- Author(s)
  神林隆一、後藤愛、中瀨古（泉）寛子、武井義則、松本明郎、川合眞一、杉山篤
- Organizer
  第31回日本循環薬理学会
- Data Source
  KAKENHI-PROJECT-20K16136
[Presentation] Anti-atrial fibrillatory action of oseltamivir and its electrophysiological analysis using the paroxysmal and persistent atrial fibrillation models of dogs.2021
- Author(s)
  Kambayashi Ryuichi、Izumi-Nakaseko Hiroko、Goto Ai、Hagiwara-Nagasawa Mihoko、Nunoi Yoshio、Takei Yoshinori、Matsumoto Akio、Kawai Shinichi、Sugiyama Atsushi
- Organizer
  第67回日本不整脈心電学会学術大会
- Data Source
  KAKENHI-PROJECT-20K16136
[Presentation] Electrophysiological analysis of the anti-atrial fibrillatory action of oseltamivir using the paroxysmal atrial fibrillation canine model2021
- Author(s)
  Ryuichi Kambayashi, Yoshio Nunoi, Ai Goto, Yoshiki Hirokawa, Hiroko Izumi-Nakaseko, Mihoko Hagiwara-Nagasawa, Yoshinori Takei, Akio Matsumoto, Shinichi Kawai, Atsushi Sugiyama
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K16136
[Presentation] 先行する早期（J-Tpeak）および後期（Tpeak-Tend）再分極時間の変化がtorsade de pointesの病態形成を担う2021
- Author(s)
  神林隆一、後藤愛、布井啓雄、中瀬古（泉）寛子、松本明郎、杉山篤
- Organizer
  心電学関連春季大会2021
- Data Source
  KAKENHI-PROJECT-20K16136
[Presentation] How the Deuteration of Dronedarone Can Modify its Cardiovascular Profile: a New Strategy for Optimizing Efficacy and Adverse Effects2020
- Author(s)
  Ryuichi Kambayashi, Mihoko Hagiwara-Nagasawa, Akio Matsumoto, Atsushi Sugiyama
- Organizer
  第84回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16136

Kambayashi Ryuichi 神林 隆一

Research Projects

Research Products

心不全合併心房細動モデルを活用したSGLT2阻害薬の心房細動治療効果の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effects of deuterium modification on the electropharmacological profile of anti-atrial fibrillatory drugPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Characterization of electropharmacological profile of an anti-atrial fibrillatory drug vernakalant along with potential risk toward torsade de pointes: Translational studies using isoflurane-anesthetized dogs and isolated rat aortic preparations.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Both osmolality-dependent and independent mechanisms are associated with acute hyperglycemia-induced cardiovascular adverse reactions: Analysis of the mutual interactions leading to cardiovascular phenotypes in dogs2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Imatinib induces diastolic dysfunction and ventricular early-repolarization delay in the halothane-anesthetized dogs: Class effects of tyrosine kinase inhibitors.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of clinically-reported, memantine-induced cardiovascular adverse responses using the halothane-anesthetized dogs: Reverse translational study2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Roles of IK,ACh for perpetuating atrial fibrillation: effects of atrial-selective K+ channel inhibitor AVE0118 and class I drugs on the persistent atrial fibrillation canine model2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Simultaneous analyses of hemodynamic and electrophysiological effects of oseltamivir along with its pharmacokinetic profile using the canine paroxysmal atrial fibrillation model2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Translational studies on anti-atrial fibrillatory action of oseltamivir by its in vivo and in vitro electropharmacological analyses2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An exploratory analysis of effects of poyendarone, a deuterated analogue of dronedarone, on the canine model of paroxysmal atrial fibrillation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vivo characterization of anti-atrial fibrillatory potential and pharmacological safety profile of INa,L plus IKr inhibitor ranolazine using the halothane-anesthetized dogs2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cardiohemodynamic and arrhythmogenic effects of the anti-atrial fibrillatory compound vanoxerine in halothane-anesthetized dogs2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of electropharmacological and proarrhythmic effects of donepezil using the halothane-anesthetized intact dogs and the conscious chronic atrioventricular block ones2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reverse translational analysis of clinically reported, lamotrigine-induced cardiovascular adverse events using the halothane-anesthetized dogs2021

Author(s)

Journal Title

Kambayashi Ryuichi 神林隆一