Uehara Ryo 上原了

Researcher Number	70842590
Other IDs
Affiliation (Current)	2025: 立命館大学, 生命科学部, 助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 立命館大学, 生命科学部, 助教 2020 – 2022: 愛知県がんセンター(研究所), 腫瘍制御学分野, 研究員 2019: 立命館大学, 立命館グローバル・イノベーション研究機構, 助教
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Basic Section 43010:Molecular biology-related / 0701:Biology at molecular to cellular levels, and related fields Except Principal Investigator Basic Section 43040:Biophysics-related
Keywords	Principal Investigator RNase H2 / RAB27A / がん / 細胞外小胞 / 転写 / 自己免疫応答 / アーキア / RNase H / ゲノム不安定性 / 自己免疫疾患 … More / R-loop / X線結晶構造解析 / RNA/DNAハイブリッド / BRCA2 / DNA修復 … More Except Principal Investigator Divisome / 構造 / 細胞分裂 Less

Regulation mechanism of cell division promoted by a bacterial divisome
- Principal Investigator
  
  松村浩由
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Ritsumeikan University
Study on the regulation mechanism of RAB27A expression underlying excessive secretion of extracellular vesicles in cancerPrincipal Investigator
- Principal Investigator
  
  上原了
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Ritsumeikan University
Physiological function of RNase H resolving R-loop structures formed on chromsomePrincipal Investigator
- Principal Investigator
  
  Ryo Uehara
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Aichi Cancer Center Research Institute
Structural basis for DNA repair machinery including RNA/DNA heteroduplexPrincipal Investigator
- Principal Investigator
  
  Uehara Ryo
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0701:Biology at molecular to cellular levels, and related fields
- Research Institution
  Aichi Cancer Center Research Institute
  Ritsumeikan University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Patent

[Journal Article] MEK/ERK‐mediated oncogenic signals promote secretion of extracellular vesicles by controlling lysosome function2022
- Author(s)
  Hikita Tomoya、Uehara Ryo、Itoh Reina E.、Mitani Fumie、Miyata Mamiko、Yoshida Takuya、Yamaguchi Rui、Oneyama Chitose
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 4 Pages: 1264-1276
- DOI
  10.1111/cas.15288
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15721, KAKENHI-PROJECT-22K05434, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H03456
[Journal Article] Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function.2022
- Author(s)
  Mitani F, Lin J, Sakamoto T, Uehara R, Hikita T, Yoshida T, Setiawan A, Arai M, Oneyama C.
- Journal Title
  
  Sci Rep
  
  Volume: 12 Issue: 1 Pages: 6674-6674
- DOI
  10.1038/s41598-022-10692-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03456, KAKENHI-PROJECT-20K15721, KAKENHI-PROJECT-23K21156
[Journal Article] 超好熱性サチライシンをモデルにみるタンパク質フォールディングの高温環境適応戦略 Tk-subtilisinと3つの挿入配列2021
- Author(s)
  上原了、田中俊一
- Journal Title
  
  化学と生物
  
  Volume: 59 Pages: 272-274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15721
[Journal Article] Insertion loop‐mediated folding propagation governs efficient maturation of hyperthermophilic Tk‐subtilisin at high temperatures2020
- Author(s)
  Uehara R., Dan N., Amesaka H., Yoshizawa T., Koga Y.., Kanaya S., Takano K., Matsumura H., Tanaka SI.
- Journal Title
  
  FEBS letters
  
  Volume: 594 Issue: 4 Pages: 452-461
- DOI
  10.1002/1873-3468.14028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05827, KAKENHI-PROJECT-20K15721, KAKENHI-PUBLICLY-19H04735, KAKENHI-PUBLICLY-19H05401, KAKENHI-PUBLICLY-20H05516, KAKENHI-PROJECT-18K05445, KAKENHI-PROJECT-18K06094, KAKENHI-PROJECT-19K23733
[Journal Article] A threshold of ribonucleotide tolerance in chromosomal DNA2020
- Author(s)
  上原了
- Journal Title
  
  生化学
  
  Volume: 92 Issue: 5 Pages: 744-747
- DOI
  10.14952/SEIKAGAKU.2020.920744
- NAID
  40022394521
- ISSN
  0037-1017
- Year and Date
  2020-10-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15721, KAKENHI-PROJECT-19K23733
[Journal Article] Val143 of human ribonuclease H2 is not critical for, but plays a role in determining catalytic activity and substrate specificity2020
- Author(s)
  Baba Misato、Kojima Kenji、Nishimura Takuto、Sugiura Takuya、Takita Teisuke、Uehara Ryo、Crouch Robert J.、Yasukawa Kiyoshi
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 2 Pages: e0228774-e0228774
- DOI
  10.1371/journal.pone.0228774
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23733, KAKENHI-PROJECT-18J14339, KAKENHI-PROJECT-18KK0285, KAKENHI-PROJECT-18K19839
[Journal Article] Crystal structures of the cell-division protein FtsZ from Klebsiella pneumoniae and Escherichia coli2020
- Author(s)
  Yoshizawa Takuya、Fujita Junso、Terakado Haruna、Ozawa Mayuki、Kuroda Natsuko、Tanaka Shun-ichi、Uehara Ryo、Matsumura Hiroyoshi
- Journal Title
  
  Acta Crystallographica Section F Structural Biology Communications
  
  Volume: 76 Issue: 2 Pages: 86-93
- DOI
  10.1107/s2053230x2000076x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05445, KAKENHI-PROJECT-18K06094, KAKENHI-PROJECT-19K16060, KAKENHI-PROJECT-19K23733, KAKENHI-PUBLICLY-19H04735, KAKENHI-PUBLICLY-19H05401
[Journal Article] Crystal structure of a GH1 β‐glucosidase from Hamamotoa singularis2020
- Author(s)
  Uehara Ryo、Iwamoto Riki、Aoki Sayaka、Yoshizawa Takuya、Takano Kazufumi、Matsumura Hiroyoshi、Tanaka Shun‐ichi
- Journal Title
  
  Protein Science
  
  Volume: 29 Issue: 9 Pages: 2000-2008
- DOI
  10.1002/pro.3916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15721, KAKENHI-PUBLICLY-19H04735, KAKENHI-PUBLICLY-19H05401, KAKENHI-PROJECT-18K05445, KAKENHI-PROJECT-18K06094, KAKENHI-PROJECT-19K23733
[Journal Article] Aicardi-Goutieres syndrome gene Rnaseh2c is a metastasis susceptibility gene in breast cancer2019
- Author(s)
  Deasy Sarah K.、Uehara Ryo、Vodnala Suman K.、Yang Howard H.、Dass Randall A.、Hu Ying、Lee Maxwell P.、Crouch Robert J.、Hunter Kent W.
- Journal Title
  
  PLOS Genetics
  
  Volume: 15 Issue: 5 Pages: e1008020-e1008020
- DOI
  10.1371/journal.pgen.1008020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23733
[Journal Article] Unlike the Escherichia coli counterpart, archaeal RNase HII cannot process ribose monophosphate abasic sites and oxidized ribonucleotides embedded in DNA2019
- Author(s)
  Malfatti Matilde Clarissa、Henneke Ghislaine、Balachander Sathya、Koh Kyung Duk、Newnam Gary、Uehara Ryo、Crouch Robert J.、Storici Francesca、Tell Gianluca
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 35 Pages: 13061-13072
- DOI
  10.1074/jbc.ra119.009493
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23733
[Patent] ホスホエノールピルビン酸カルボキシラーゼを活性化することができるポリペプチド2023
- Inventor(s)
  松村浩由、上原了、田中俊一、戸谷吉博、清水浩、徳山健斗、他４名
- Industrial Property Rights Holder
  松村浩由、上原了、田中俊一、戸谷吉博、清水浩、徳山健斗、他４名
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-23K06418
[Presentation] 超好熱性サチライシン様プロテアーゼの大量生産系の開発2024
- Author(s)
  上原了、西崎柊登、雨坂心人、高野和文、松村浩由、田中俊一
- Organizer
  第100回日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-23K06418
[Presentation] ZapAによるFtsZフィラメント架橋構造の動態観察2024
- Author(s)
  神子島豪太、藤田純三、日比野滉大、上村菜月、加藤夕貴、上原了、松村浩由、内橋貴之
- Organizer
  生物物理学会中部支部会
- Data Source
  KAKENHI-PROJECT-23K06418
[Presentation] C4型光合成鍵タンパク質の複合体解析2023
- Author(s)
  佐野藤悟、上原了、松村浩由
- Organizer
  琵琶湖環境研究センター×生物資源研究センター×R-GIRO「気候変動に対応する生命圏科学の基盤創生」合同シンポジウム「地域資源 ×グリーンイノベーション」
- Data Source
  KAKENHI-PROJECT-23K06418
[Presentation] ALS関連変異型FUSタンパク質が形成する相分離液滴の状態解析2023
- Author(s)
  井手郁佳、吉澤拓也、笹原直哉、谷本峰成、上原了、松村浩由
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K06418
[Presentation] イネいもち病菌に対する農薬作用機序の解明に向けたMoICT1のX線構造解析2023
- Author(s)
  田中想、駒野俊紀、日比野滉太、上原了、松村浩由、竹田篤史
- Organizer
  琵琶湖環境研究センター×生物資源研究センター×R-GIRO「気候変動に対応する生命圏科学の基盤創生」合同シンポジウム「地域資源 ×グリーンイノベーション」
- Data Source
  KAKENHI-PROJECT-23K06418
[Presentation] 大腸菌由来ホスホエノールピルビン酸カルボキシラーゼ変異体の構造機能2023
- Author(s)
  三宅智哉、西村和樹、松田佳央理、藤田純三、難波啓一、徳山健斗、戸谷吉博、清水浩、栗栖源嗣、Gert-Jan Bekker、上原了、松村浩由
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K06418
[Presentation] Pro-Argポリジペプチドによる核輸送受容体Kapβ2の機能阻害機構2023
- Author(s)
  谷本峰成、吉澤拓也、笹原直哉、井手郁佳、上原了、松村浩由
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K06418
[Presentation] 大腸菌ホスホエノールピルビン酸カルボキシラーゼ変異体の構造解析2023
- Author(s)
  松田佳央理、三宅智哉、西村和樹、上原了、松村浩由
- Organizer
  琵琶湖環境研究センター×生物資源研究センター×R-GIRO「気候変動に対応する生命圏科学の基盤創生」合同シンポジウム「地域資源 ×グリーンイノベーション」
- Data Source
  KAKENHI-PROJECT-23K06418
[Presentation] RAB27A発現を制御する新規EV分泌阻害剤の同定2022
- Author(s)
  上原了、青木玲奈、小根山千歳
- Organizer
  第9回日本細胞外小胞学会
- Data Source
  KAKENHI-PROJECT-20K15721
[Presentation] がん細胞由来細胞外小胞を標的とした新規阻害剤の探索2022
- Author(s)
  上原了
- Organizer
  2022年度　先端モデル動物支援プラットフォーム　若手支援技術講習会
- Data Source
  KAKENHI-PROJECT-20K15721
[Presentation] Comparative study between Escherichia coli and Pyrococcus abyssi RNase HII activity and structure2022
- Author(s)
  Elena CABON, Lea VIALLE, Yuki ISHIZUKA, Shun-ichi TANAKA, Takuya YOSHIZAWA, Hiroyoshi MATSUMURA, Ryo UEHARA, Etienne HENRY, Ghislaine HENNEKE
- Organizer
  RBPGO9
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15721
[Presentation] A threshold of tolerance to ribonucleotides embedded in DNA during mouse embryogenesis2021
- Author(s)
  上原了
- Organizer
  第94回日本生化学大会
- Data Source
  KAKENHI-PROJECT-20K15721
[Presentation] RNA/DNAハイブリッドの蓄積によるゲノム不安定性2019
- Author(s)
  上原了、Emily Herm、Kiran Sakhuja、Susana M Cerritelli、Robert J Crouch
- Organizer
  日本農芸化学会関西支部　第508回講演会
- Data Source
  KAKENHI-PROJECT-19K23733
[Presentation] Separation of two RNase H2 activities in mammalian cells2019
- Author(s)
  Ryo Uehara, Emily Herm, Kiran Sakhuja, Susana M Cerritelli, Robert J Crouch
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19K23733
[Presentation] RNA/DNAハイブリッド加水分解酵素RNase H2の機能分割2019
- Author(s)
  上原了、Emily Herm、Naushaba Hasin、Kiran Sakhuja、Susana M Cerritelli、Robert J Crouch
- Organizer
  酵素・補酵素研究会2019
- Data Source
  KAKENHI-PROJECT-19K23733
[Presentation] A threshold of ribonucleotide tolerance in genomic DNA for embryonic development2019
- Author(s)
  Ryo Uehara, Naushaba Hasin, Sakhuja Kiran, Susana M Cerritelli, Robert J Crouch
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K23733

1. 松村浩由 (30324809)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
2. 田中俊一 (70591387)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 小根山千歳 (90373208)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. KOGA Yuuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 吉澤拓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Uehara Ryo 上原 了

Research Projects

Research Products

Co-Researchers

Regulation mechanism of cell division promoted by a bacterial divisome

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on the regulation mechanism of RAB27A expression underlying excessive secretion of extracellular vesicles in cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Physiological function of RNase H resolving R-loop structures formed on chromsomePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural basis for DNA repair machinery including RNA/DNA heteroduplexPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] MEK/ERK‐mediated oncogenic signals promote secretion of extracellular vesicles by controlling lysosome function2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 超好熱性サチライシンをモデルにみるタンパク質フォールディングの高温環境適応戦略 Tk-subtilisinと3つの挿入配列2021

Author(s)

Journal Title

Data Source

[Journal Article] Insertion loop‐mediated folding propagation governs efficient maturation of hyperthermophilic Tk‐subtilisin at high temperatures2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A threshold of ribonucleotide tolerance in chromosomal DNA2020

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Val143 of human ribonuclease H2 is not critical for, but plays a role in determining catalytic activity and substrate specificity2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crystal structures of the cell-division protein FtsZ from Klebsiella pneumoniae and Escherichia coli2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crystal structure of a GH1 β‐glucosidase from Hamamotoa singularis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aicardi-Goutieres syndrome gene Rnaseh2c is a metastasis susceptibility gene in breast cancer2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Unlike the Escherichia coli counterpart, archaeal RNase HII cannot process ribose monophosphate abasic sites and oxidized ribonucleotides embedded in DNA2019

Author(s)

Journal Title

DOI

Uehara Ryo 上原了