KAWAGUCHI KOTOKU 川口高徳

… Alternative Names

川口高徳カワグチコウトク

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Researcher Number	70844281
Other IDs
Affiliation (Current)	2025: 明海大学, 歯学部, 助教
Affiliation (based on the past Project Information) *help	2025: 明海大学, 歯学部, 助教 2021 – 2023: 立命館大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 57080:Social dentistry-related / Basic Section 53030:Respiratory medicine-related Except Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Keywords	Principal Investigator 細胞骨格 / 感染防御 / 阻害剤 / リン酸化 / 膜タンパク質 / アドレナリン受容体 / 足場タンパク質 / ERMタンパク質 / 線毛 Except Principal Investigator 線毛 / 脳機能 / 上衣細胞 / 線毛運動

気道・脳室線毛の機能的および構造的違いに着目した粘液線毛クリアランス機構の解明Principal Investigator
- Principal Investigator
  
  川口高徳
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57080:Social dentistry-related
- Research Institution
  Meikai University
脳機能の改善を目指した脳室上衣線毛運動の活性化物質の探索と調節機構の解明
- Principal Investigator
  
  浅野真司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Ritsumeikan University
粘液線毛クリアランスにおける細胞骨格関連タンパク質の研究Principal Investigator
- Principal Investigator
  
  川口高徳
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Ritsumeikan University

All 2024 2023 2022 2021 Other

All Journal Article Presentation Other

[Journal Article] Inhibition of ezrin phosphorylation by NSC305787 attenuates procaterol-stimulated ciliary beating in airway cilia2024
- Author(s)
  Kawaguchi Kotoku、Yokoyama Sakura、Wang Haoting、Asano Shinji
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 703 Pages: 149685-149685
- DOI
  10.1016/j.bbrc.2024.149685
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16125, KAKENHI-PROJECT-23K06107
[Journal Article] Adenosine stimulates beating of neonatal brain-derived cilia through adenosine A2B receptor on the cilia and activation of protein kinase A pathway.2024
- Author(s)
  Kawaguchi K, Tsuji S, Hirao T, Liu Y, Boshi Z, Asano S.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06107
[Journal Article] Ambroxol-enhanced ciliary beating via voltage-gated Ca2+ channels in mouse airway ciliated cells2023
- Author(s)
  Saito Daichi、Suzuki Chihiro、Tanaka Saori、Hosogi Shigekuni、Kawaguchi Kotoku、Asano Shinji、Okamoto Shohta、Yasuda Makoto、Hirano Shigeru、Inui Toshio、Marunaka Yoshinori、Nakahari Takashi
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 941 Pages: 175496-175496
- DOI
  10.1016/j.ejphar.2023.175496
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16125, KAKENHI-PROJECT-23K21626
[Journal Article] Ambroxol-Enhanced Frequency and Amplitude of Beating Cilia Controlled by a Voltage-Gated Ca2+ Channel, Cav1.2, via pHi Increase and [Cl?]i Decrease in the Lung Airway Epithelial Cells of Mice2023
- Author(s)
  Nakahari Takashi、Suzuki Chihiro、Kawaguchi Kotoku、Hosogi Shigekuni、Tanaka Saori、Asano Shinji、Inui Toshio、Marunaka Yoshinori
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 23 Pages: 16976-16976
- DOI
  10.3390/ijms242316976
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16125, KAKENHI-PROJECT-23K21626
[Journal Article] Transforming Growth Factor-β1 and Bone Morphogenetic Protein-2 Inhibit Differentiation into Mature Ependymal Multiciliated Cells2023
- Author(s)
  Hirao Takuya、Kim Beak Gyu、Habuchi Hinako、Kawaguchi Kotoku、Nakahari Takashi、Marunaka Yoshinori、Asano Shinji
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 1 Pages: 111-122
- DOI
  10.1248/bpb.b22-00733
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-01-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16125, KAKENHI-PROJECT-23K21626
[Journal Article] Enhancement of airway ciliary beating mediated via voltage-gated Ca2+ channels/α7-nicotinic receptors in mice2022
- Author(s)
  Saitoh Daichi、Kawaguchi Kotoku、Asano Shinji、Inui Toshio、Marunaka Yoshinori、Nakahari Takashi
- Journal Title
  
  Pflugers Archiv - European Journal of Physiology
  
  Volume: 474 Issue: 10 Pages: 1091-1106
- DOI
  10.1007/s00424-022-02724-5
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16125, KAKENHI-PROJECT-23K21626
[Journal Article] Pathophysiological Roles of Actin-Binding Scaffold Protein, Ezrin.2022
- Author(s)
  Kawaguchi K, Asano S.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 6 Pages: 3246-3246
- DOI
  10.3390/ijms23063246
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16125
[Journal Article] Hochu-ekki-to enhanced airway ciliary beating by an [Ca2+]i increase via TRPV4 in mice2022
- Author(s)
  Ikeuchi-Yamamoto Yukiko、Kogiso Haruka、Saito Daichi、Kawaguchi Kotoku、Ikeda Riko、Asano Shinji、Inui Toshio、Marunaka Yoshinori、Nakahari Takashi
- Journal Title
  
  Phytomedicine Plus
  
  Volume: 2 Issue: 2 Pages: 100243-100243
- DOI
  10.1016/j.phyplu.2022.100243
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16125, KAKENHI-PROJECT-23K21626
[Journal Article] Ezrin knockdown reduces procaterol-stimulated ciliary beating without morphological changes in mouse airway cilia.2022
- Author(s)
  Kawaguchi K, Nakayama S, Saito D, Kogiso H, Yasuoka K, Marunaka Y, Nakahari T, Asano S.
- Journal Title
  
  Journal of Cell Science
  
  Volume: 135 Issue: 6
- DOI
  10.1242/jcs.259201
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16125, KAKENHI-PROJECT-23K21626
[Presentation] Inhibitory effect of cytoplasmic dynein inhibitors on axonemal dynein2024
- Author(s)
  Kotoku Kawaguchi, Shiori Morimoto, Boshi Zhao, Takashi Nakahari, Shinji Asano
- Organizer
  The Annual Meeting of The Physiological Society of Japan (101)
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] 脳室線毛運動を活性化する因子の探索：アデノシンは線毛運動を活性化する2024
- Author(s)
  浅野真司、辻涼香、平尾拓也、Zhao Boshi、Liu Yixin、川口高徳
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K06107
[Presentation] プロカテロールは脳室線毛運動を活性化する2024
- Author(s)
  川端美香、川口高徳、平尾拓也、才愛奈、浅野真司
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K06107
[Presentation] Roles of Ezrin in regulation of ciliary beating in lung multiciliated cell.2023
- Author(s)
  Kawaguchi K, Saito D, Yasuoka K, Asano S.
- Organizer
  Cold Spring Harbor Asia Conference (CSHA) on Cilia & Centrosome 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] 脳室線毛運動を活性化する因子の探索 ―アデノシンは脳室線毛運動を活性化する―2023
- Author(s)
  辻涼香、LIU Yixin、平尾拓也、川口高徳、浅野真司
- Organizer
  第73回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] 脳室線毛運動を活性化させる因子の探索2023
- Author(s)
  Liu Yixin、辻涼香、平尾拓也、川口高徳、浅野真司
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K06107
[Presentation] 細胞質ダイニン阻害剤による線毛運動阻害効果の検討2023
- Author(s)
  守本栞、Zhao Boshi、廣澤孝駿、川口高徳、浅野真司
- Organizer
  第73回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] 多線毛細胞における細胞質Dynein阻害剤の線毛運動への効果の検討2023
- Author(s)
  川口高徳、守本栞、廣澤孝駿、安岡加紗音、平尾拓也、浅野真司
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] 多線毛細胞における細胞質Dynein阻害剤の線毛運動への効果の検討2023
- Author(s)
  川口高徳
- Organizer
  第65回歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] 脳室上衣細胞の初代培養系を用いた線毛運動活性化因子の探索2023
- Author(s)
  辻涼香、平尾拓也、Liu Yixin、川口高徳、浅野真司
- Organizer
  第44回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-23K06107
[Presentation] 多線毛細胞における細胞質Dynein阻害剤の線毛運動への検討2023
- Author(s)
  川口高徳、守本栞、Zhao Boshi、廣澤孝駿、浅野真司
- Organizer
  第96回日本生化学会
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] 脳室線毛運動を活性化する因子の探索：アデノシンは脳室線毛運動を活性化する2023
- Author(s)
  辻涼香、Liu Yixin、平尾拓也、川口高徳、浅野真司
- Organizer
  第73回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-23K06107
[Presentation] 多線毛細胞での細胞質Dynein阻害剤の線毛運動阻害効果の検討2023
- Author(s)
  川口高徳、守本栞、Zhao Boshi、浅野真司
- Organizer
  第44回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] Ezrinリン酸化阻害剤NSC305787の線毛運動に対する効果の検討2023
- Author(s)
  横山さくら、Wang Haoting、川口高徳、浅野真司
- Organizer
  第73回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] Ｅzrinリン酸化阻害剤NSC305787の線毛運動に対する効果の検討2023
- Author(s)
  横山さくら、Wang Haoting、川口高徳、浅野真司
- Organizer
  第73回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-23K06107
[Presentation] Ezrinノックダウンマウスの肺他線毛上皮における線毛形成および線毛運動の解析2022
- Author(s)
  川口高徳、齋藤大地、安岡加紗音、浅野真司
- Organizer
  第68回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] Roles of ezrin on the morphogenesis and regulation of movement of airway cilia.2022
- Author(s)
  Kawaguchi K, Saito D, Yasuoka K, Asano S.
- Organizer
  稀少疾患シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] Roles of Ezrin in regulation of ciliary beating in airway ciliary cell.2022
- Author(s)
  川口高徳、齋藤大地、安岡加紗音、丸中良典、中張隆司、浅野真司
- Organizer
  第99回日本生理学会
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] 気道線毛の形態形成および運動調節におけるEzrinの役割の検討2022
- Author(s)
  川口高徳、齋藤大地、安岡加紗音、中張隆司、浅野真司
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] 気道線毛の形態形成および運動調節におけるEzrinの役割の検討2022
- Author(s)
  川口高徳、齋藤大地、安岡加紗音、中張隆司、浅野真司
- Organizer
  2022年度生理研研究会『上皮膜輸送と細胞極性形成機構の統合的理解を目指して』
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] Ezrinノックダウンマウスの肺他線毛上皮における線毛形成および線毛運動の解析2022
- Author(s)
  川口高徳、安岡加紗音、中張隆司、浅野真司
- Organizer
  第72回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] 気道線毛の形態形成および運動調節におけるEzrinの役割の検討2022
- Author(s)
  川口高徳、齋藤大地、安岡加紗音、中張隆司、浅野真司
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] 気道線毛の形態形成および運動調節におけるEzrinの役割の検討2021
- Author(s)
  川口高徳、齋藤大地、安岡加紗音、丸中良典、中張隆司、浅野真司
- Organizer
  日本生理学会第113回近畿生理学談話会
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] Roles of Ezrin in regulation of ciliary beating in airway ciliary cell.2021
- Author(s)
  Kawaguchi K, Saito D, Yasuoka K, Nakahari T, Asano S.
- Organizer
  The 51st NIPS International Symposium Frontiers in Epithelial Cell Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] 肺多線毛上皮での線毛運動調節におけるEzrinの役割の検討2021
- Author(s)
  川口高徳、斎藤大地、安岡加紗音、中張隆司、浅野真司
- Organizer
  第67回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] 気道線毛の形態形成および運動調節におけるEzrinの役割の検討2021
- Author(s)
  川口高徳、齋藤大地、安岡加紗音、中張隆司、浅野真司
- Organizer
  2021年度生理学研究所研究会「上皮膜輸送の多様性・調和機構を基盤とする異分野融合研究の創出」
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] Roles of Ezrin in regulation of ciliary beating in lung multiciliated cell2021
- Author(s)
  Kotoku Kawaguchi
- Organizer
  EXPERIMENTAL BIOLOGY 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] 気道線毛の線毛形成および運動調節におけるEzrinの役割の検討2021
- Author(s)
  川口高徳、齋藤大地、安岡加紗音、中張隆司、浅野真司
- Organizer
  第71回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] 肺多線毛上皮での線毛運動調節におけるEzrinの役割の検討2021
- Author(s)
  川口高徳、齋藤大地、安岡加紗音、中張隆司、浅野真司
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K16125
[Presentation] 気道線毛の形態形成および運動調節におけるEzrinの役割の検討2021
- Author(s)
  川口高徳、斎藤大地、安岡加紗音、中張隆司、浅野真司
- Organizer
  2021年度稀少疾患シンポジウム
- Data Source
  KAKENHI-PROJECT-21K16125
[]

1. 浅野真司 (90167891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results

KAWAGUCHI KOTOKU 川口 高徳

川口 高徳 カワグチ コウトク

Research Projects

Research Products

Co-Researchers

気道・脳室線毛の機能的および構造的違いに着目した粘液線毛クリアランス機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脳機能の改善を目指した脳室上衣線毛運動の活性化物質の探索と調節機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

粘液線毛クリアランスにおける細胞骨格関連タンパク質の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Inhibition of ezrin phosphorylation by NSC305787 attenuates procaterol-stimulated ciliary beating in airway cilia2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adenosine stimulates beating of neonatal brain-derived cilia through adenosine A2B receptor on the cilia and activation of protein kinase A pathway.2024

Author(s)

Journal Title

Data Source

[Journal Article] Ambroxol-enhanced ciliary beating via voltage-gated Ca2+ channels in mouse airway ciliated cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ambroxol-Enhanced Frequency and Amplitude of Beating Cilia Controlled by a Voltage-Gated Ca2+ Channel, Cav1.2, via pHi Increase and [Cl?]i Decrease in the Lung Airway Epithelial Cells of Mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transforming Growth Factor-β1 and Bone Morphogenetic Protein-2 Inhibit Differentiation into Mature Ependymal Multiciliated Cells2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Enhancement of airway ciliary beating mediated via voltage-gated Ca2+ channels/α7-nicotinic receptors in mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pathophysiological Roles of Actin-Binding Scaffold Protein, Ezrin.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hochu-ekki-to enhanced airway ciliary beating by an [Ca2+]i increase via TRPV4 in mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ezrin knockdown reduces procaterol-stimulated ciliary beating without morphological changes in mouse airway cilia.2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] Inhibitory effect of cytoplasmic dynein inhibitors on axonemal dynein2024

Author(s)

Organizer

Data Source

[Presentation] 脳室線毛運動を活性化する因子の探索：アデノシンは線毛運動を活性化する2024

Author(s)

Organizer

Data Source

[Presentation] プロカテロールは脳室線毛運動を活性化する2024

Author(s)

KAWAGUCHI KOTOKU 川口高徳

川口高徳カワグチコウトク