Asamitsu Sefan 朝光世煌

Researcher Number	70849091
Other IDs	https://orcid.org/0000-0003-4003-8815
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 研究員
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 研究員 2023: 国立研究開発法人理化学研究所, 生命医科学研究センター, 研究員 2021 – 2022: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 訪問研究員 2020: 熊本大学, 発生医学研究所, 特別研究員(SPD・PD・RPD) 2019: 熊本大学, 発生医学研究所, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 37030:Chemical biology-related / Basic Section 37010:Bio-related chemistry / 0801:Pharmaceutical sciences and related fields
Keywords	Principal Investigator 核酸高次構造 / ノンコーディングRNA / RNA修飾 / 中枢神経系 / RNA化学修飾 / RNAターゲティング / G4RNAプローブ / グアニン四重鎖（G4） / グアニン四重鎖 / 中枢神経 … More / マウス脳 / 分子プローブ / 神経細胞 / RNA高次構造 / iPS神経細胞 / 疾患モデルマウス / 疾患ゲノム標的型薬剤 / 神経変性 / CTGリピート / 筋強直ジストロフィー1型 Less

分子プローブを自在に発現できるマウスを用いたクロマチン核酸構造の個体機能解析Principal Investigator
- Principal Investigator
  
  朝光世煌
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Institute of Physical and Chemical Research
RNA化学修飾操作技術を用いた脳エピトランスクリプトミクス制御の解明Principal Investigator
- Principal Investigator
  
  朝光世煌
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Institute of Physical and Chemical Research
Visualization of specific RNA secondary structures in vivoPrincipal Investigator
- Principal Investigator
  
  Asamitsu Sefan
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Institute of Physical and Chemical Research
  Kumamoto University
筋強直性ジストロフィーの病態解明と症状改善薬の開発Principal Investigator
- Principal Investigator
  
  朝光世煌
- Project Period (FY)
  2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  Kumamoto University

All 2023 2022 2021 2020 2019

All Journal Article Presentation Book Patent

[Book] Development of Selective DNA-Interacting Ligands2020
- Author(s)
  Sefan Asamitsu
- Total Pages
  111
- Publisher
  Springer
- ISBN
  9789811577161
- Data Source
  KAKENHI-PROJECT-20K15417
[Book] Quadruplex Nucleic Acids As Targets For Medicinal Chemistry- Chapter Three - Telomeric quadruplexes as therapeutic targets2020
- Author(s)
  Sefan Asamitsu, Norifumi Shioda, Hiroshi Sugiyama
- Total Pages
  546
- Publisher
  ELSEVIER
- ISBN
  9780128210178
- Data Source
  KAKENHI-PROJECT-20K15417
[Book] 日本薬理学雑誌2019
- Author(s)
  塩田倫史, 矢吹悌, 朝光世煌
- Total Pages
  361
- Publisher
  日本薬理学会
- Data Source
  KAKENHI-PROJECT-19K23801
[Journal Article] Structural polymorphism of the nucleic acids in pentanucleotide repeats associated with CANVAS2023
- Author(s)
  Kudo Kenta、Hori Karin、Asamitsu Sefan、Maeda Kohei、Aida Yukari、Hokimoto Mei、Matsuo Kazuya、Yabuki Yasushi、Shioda Norifumi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 300 Pages: 107138-107138
- DOI
  10.1101/2023.08.17.553768
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K13857
[Journal Article] RNA G-quadruplex organizes stress granule assembly through DNAPTP6 in neurons2023
- Author(s)
  Asamitsu Sefan、Yabuki Yasushi、Matsuo Kazuya、Kawasaki Moe、Hirose Yuki、Kashiwazaki Gengo、Chandran Anandhakumar、Bando Toshikazu、Wang Dan Ohtan、Sugiyama Hiroshi、Shioda Norifumi
- Journal Title
  
  Science Advances
  
  Volume: 9 Issue: 8
- DOI
  10.1126/sciadv.ade2035
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06579, KAKENHI-PROJECT-22K05353, KAKENHI-PROJECT-22K19297, KAKENHI-PROJECT-20H03393, KAKENHI-PROJECT-20J00520, KAKENHI-PROJECT-22KJ1695, KAKENHI-PROJECT-22KJ2516, KAKENHI-PROJECT-20K15417, KAKENHI-PUBLICLY-21H00207, KAKENHI-PLANNED-20H05936, KAKENHI-PROJECT-21H04705, KAKENHI-PROJECT-21H02580
[Journal Article] A cyclic pyrrole-imidazole polyamide reduces pathogenic RNA in CAG/CTG triplet repeat neurological disease models2023
- Author(s)
  Ikenoshita Susumu、Matsuo Kazuya、Yabuki Yasushi、Kawakubo Kosuke、Asamitsu Sefan、Hori Karin、Usuki Shingo、Hirose Yuki、Bando Toshikazu、Araki Kimi、Ueda Mitsuharu、Sugiyama Hiroshi、Shioda Norifumi
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 133 Issue: 22
- DOI
  10.1172/jci164792
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K13857, KAKENHI-PROJECT-22KJ2516, KAKENHI-PROJECT-22K05353, KAKENHI-PROJECT-21K06579, KAKENHI-PROJECT-22K19297, KAKENHI-PROJECT-22KJ1695, KAKENHI-PLANNED-23H03851, KAKENHI-PROJECT-21H04705, KAKENHI-PROJECT-23H00373, KAKENHI-PROJECT-23K24245
[Journal Article] Small molecule-based detection of non-canonical RNA G-quadruplex structures that modulate protein translation2022
- Author(s)
  Yousuke Katsuda, Shin-ichi Sato, Maimi Inoue, Hisashi Tsugawa, Takuto Kamura, Tomoki Kida, Rio Matsumoto, Sefan Asamitsu, Norifumi Shioda, Shuhei Shiroto, Yoshiki Oosawatsu, Kenji Yatsuzuka, Yusuke Kitamura, Masaki Hagihara, Toshihiro Ihara and Motonari Uesugi
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 50 Issue: 14 Pages: 8143-8153
- DOI
  10.1093/nar/gkac580
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K05326, KAKENHI-PROJECT-21K18214, KAKENHI-PROJECT-22K19297, KAKENHI-PROJECT-20H02769, KAKENHI-PROJECT-20H02859, KAKENHI-PROJECT-20H03393, KAKENHI-PROJECT-20J00520, KAKENHI-PROJECT-21J11197, KAKENHI-PROJECT-20K15417, KAKENHI-PUBLICLY-21H00207
[Journal Article] Potential roles of G-quadruplex structures in RNA granules for physiological and pathological phase separation2021
- Author(s)
  Asamitsu Sefan、Shioda Norifumi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: mvab018 Issue: 5 Pages: 527-533
- DOI
  10.1093/jb/mvab018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15417, KAKENHI-PUBLICLY-19H05221, KAKENHI-PROJECT-20J00520, KAKENHI-PROJECT-20K21400, KAKENHI-PUBLICLY-21H00207, KAKENHI-PROJECT-20H03393
[Journal Article] Strong and Specific Recognition of CAG/CTG Repeat DNA (5’‐dWGCWGCW‐3’) by a Cyclic Pyrrole‐Imidazole Polyamide2021
- Author(s)
  Hirose Yuki、Ohno Tomo、Asamitsu Sefan、Hashiya Kaori、Bando Toshikazu、Sugiyama Hiroshi
- Journal Title
  
  ChemBioChem
  
  Volume: 23 Issue: 2
- DOI
  10.1002/cbic.202100533
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J00520, KAKENHI-PROJECT-20K15417, KAKENHI-PROJECT-22KJ1695, KAKENHI-PROJECT-21H04705, KAKENHI-PLANNED-20H05936
[Journal Article] CGG repeat RNA G-quadruplexes interact with FMRpolyG to cause neuronal dysfunction in fragile X-related tremor/ataxia syndrome2021
- Author(s)
  Asamitsu Sefan、Yabuki Yasushi、Ikenoshita Susumu、Kawakubo Kosuke、Kawasaki Moe、Usuki Shingo、Nakayama Yuji、Adachi Kaori、Kugoh Hiroyuki、Ishii Kazuhiro、Matsuura Tohru、Nanba Eiji、Sugiyama Hiroshi、Fukunaga Kohji、Shioda Norifumi
- Journal Title
  
  Science Advances
  
  Volume: 7 Issue: 3
- DOI
  10.1126/sciadv.abd9440
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06183, KAKENHI-PROJECT-20K21400, KAKENHI-PROJECT-20K15417, KAKENHI-PUBLICLY-19H05221, KAKENHI-PROJECT-20H03393, KAKENHI-PROJECT-20J00520, KAKENHI-PROJECT-20K07740
[Journal Article] Identification and immunohistochemical characterization of G-quadruplexes in mouse brain.2020
- Author(s)
  Asamitsu S, Imai Y, Yabuki Y, Ikenoshita S, Takeuchi M, Kashiwagi H, Tanoue Y, Fukuda T, Shioda N.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: in press Issue: 1 Pages: 67-74
- DOI
  10.1016/j.bbrc.2020.01.145
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-19H05221, KAKENHI-PROJECT-19K23801, KAKENHI-PROJECT-20K21400, KAKENHI-PROJECT-20H03393
[Journal Article] A synthetic transcription factor pair mimic for precise recruitment of an epigenetic modifier to the targeted DNA locus2020
- Author(s)
  Yu Zutao、Ai Mengting、Samanta Soumen K.、Hashiya Fumitaka、Taniguchi Junichi、Asamitsu Sefan、Ikeda Shuji、Hashiya Kaori、Bando Toshikazu、Pandian Ganesh N.、Isaacs Lyle、Sugiyama Hiroshi
- Journal Title
  
  Chemical Communications
  
  Volume: 56 Issue: 15 Pages: 2296-2299
- DOI
  10.1039/c9cc09608f
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03349, KAKENHI-PROJECT-19K23801
[Journal Article] Pharmacological prospects of G-quadruplexes for neurological diseases using porphyrins.2020
- Author(s)
  Asamitsu S, Yabuki Y, Ikenoshita S, Wada T, Shioda N.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: - Issue: 1 Pages: 51-55
- DOI
  10.1016/j.bbrc.2020.01.054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07819, KAKENHI-PUBLICLY-19H05221, KAKENHI-PROJECT-19K23801, KAKENHI-PROJECT-20K21400, KAKENHI-PROJECT-20H03393
[Journal Article] Perspectives for Applying G-Quadruplex Structures in Neurobiology and Neuropharmacology.2019
- Author(s)
  Asamitsu S., Takeuchi M., Ikenoshita S., Imai Y., Kashiwagi H. and Shioda N.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 20 Issue: 12 Pages: 2884-2884
- DOI
  10.3390/ijms20122884
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H05221, KAKENHI-PROJECT-19K23801
[Journal Article] Switching Off Cancer-Causing Telomerase Using Small Molecules.2019
- Author(s)
  Asamitsu S., Shioda N, Sugiyama H.
- Journal Title
  
  Cell Chem Biol.
  
  Volume: 26 Issue: 8 Pages: 1045-1047
- DOI
  10.1016/j.chembiol.2019.08.001
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-19H05221, KAKENHI-PROJECT-19K23801, KAKENHI-PROJECT-16H06356
[Journal Article] Control of Forward/Reverse Orientation Preference of Cyclic Pyrrole/Imidazole Polyamides2019
- Author(s)
  Hirose Yuki、Asamitsu Sefan、Bando Toshikazu、Sugiyama Hiroshi
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 141 Issue: 33 Pages: 13165-13170
- DOI
  10.1021/jacs.9b05516
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K23801, KAKENHI-PROJECT-16H06356
[Patent] リピート結合剤2020
- Inventor(s)
  塩田倫史, 矢吹悌, 朝光世煌, 杉山弘, 板東俊和, 池田修司
- Industrial Property Rights Holder
  塩田倫史, 矢吹悌, 朝光世煌, 杉山弘, 板東俊和, 池田修司
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Acquisition Date
  2020
- Data Source
  KAKENHI-PROJECT-20K15417
[Presentation] RNA G-quadruplex regulates neuronal function through the functional formation of stress granules2023
- Author(s)
  Sefan Asamitsu
- Organizer
  FIBER Webinar Universe in Nucleic Acids Chemistry ☆Rising Stars
- Invited
- Data Source
  KAKENHI-PROJECT-23K13857
[Presentation] Elucidating the role of genomic G-quadruplex structure in neurons2023
- Author(s)
  Sefan Asamitsu, Kohei Maeda, Shingo Usuki, Norifumi Shioda
- Organizer
  The 46th Annual Meeting of the Molecular Biology Society of Japan
- Data Source
  KAKENHI-PROJECT-23K13857
[Presentation] Toward elucidating roles for RNA G-quadruplexes in neurons2022
- Author(s)
  Sefan Asamitsu
- Organizer
  8th International Meeting on Quadruplex Nucleic Acids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15417
[Presentation] RNA G-quadruplex organizes stress granule assembly through DNAPTP6 in neurons2022
- Author(s)
  Sefan Asamitsu
- Organizer
  Functional Genomics in Future
- Data Source
  KAKENHI-PROJECT-20K15417
[Presentation] 神経細胞におけるグアニン四重鎖の役割2022
- Author(s)
  朝光世煌
- Organizer
  FIBER 核酸化学ユニバースRising Stars
- Invited
- Data Source
  KAKENHI-PROJECT-20K15417
[Presentation] 神経細胞におけるグアニン四重鎖RNA構造の相分離現象に与える影響2022
- Author(s)
  朝光世煌、川嵜萌、廣瀬優希、矢吹悌、柏﨑玄伍、Anandhakumar Chandran、板東俊和、杉山弘、塩田倫史
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-20K15417
[Presentation] 神経細胞におけるRNAグアニン四重鎖構造の役割の解明2021
- Author(s)
  朝光世煌、川嵜萌、柏﨑玄伍、Anandhakumar Chandran、杉山弘、矢吹悌、塩田倫史
- Organizer
  日本ケミカルバイオロジー学会第15回年会
- Data Source
  KAKENHI-PROJECT-20K15417
[Presentation] 神経細胞におけるグアニン四重鎖RNA構造の相分離現象への寄与2021
- Author(s)
  朝光世煌、川嵜萌、廣瀬優希、矢吹悌、柏﨑玄伍、Anandhakumar Chandran、板東俊和、杉山弘、塩田倫史
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K15417
[Presentation] G-quadruplex-binding metabolites rescue decreased cognitive deficits seen in FXTAS model mice2019
- Author(s)
  Sefan Asamitsu, Yasushi Yabuki, Yuji Nakayama, Kaori Adachi, Hiroyuki Kugoh, Hiroshi Sugiyama, Eiji Nanba, Kohji Fukuanga, Norifumi Shioda
- Organizer
  19th International Workshop on Fragile X and other Neurodevelopmental Disorders
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23801
[Presentation] ゲノム上の指定したグアニン四重鎖DNA を認識可能なハイブリッド分子の開発2019
- Author(s)
  朝光世煌、小幡俊介、塩田倫史、板東俊和、杉山弘
- Organizer
  日本核酸医薬学会
- Data Source
  KAKENHI-PROJECT-19K23801
[Presentation] 特定のグアニン四重鎖DNAを標的とした合成リガンドの開発2019
- Author(s)
  朝光世煌、小幡俊介、塩田倫史、板東俊和、杉山弘
- Organizer
  日本ケミカルバイオロジー学会
- Data Source
  KAKENHI-PROJECT-19K23801

1. WADA Takahito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 塩田倫史

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
3. 杉山弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 矢吹悌

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 中山祐二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 萩原正規

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Asamitsu Sefan 朝光 世煌

Research Projects

Research Products

Co-Researchers

分子プローブを自在に発現できるマウスを用いたクロマチン核酸構造の個体機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

RNA化学修飾操作技術を用いた脳エピトランスクリプトミクス制御の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Visualization of specific RNA secondary structures in vivoPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

筋強直性ジストロフィーの病態解明と症状改善薬の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] Development of Selective DNA-Interacting Ligands2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] Quadruplex Nucleic Acids As Targets For Medicinal Chemistry- Chapter Three - Telomeric quadruplexes as therapeutic targets2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 日本薬理学雑誌2019

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Structural polymorphism of the nucleic acids in pentanucleotide repeats associated with CANVAS2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RNA G-quadruplex organizes stress granule assembly through DNAPTP6 in neurons2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A cyclic pyrrole-imidazole polyamide reduces pathogenic RNA in CAG/CTG triplet repeat neurological disease models2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Small molecule-based detection of non-canonical RNA G-quadruplex structures that modulate protein translation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Potential roles of G-quadruplex structures in RNA granules for physiological and pathological phase separation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Strong and Specific Recognition of CAG/CTG Repeat DNA (5’‐dWGCWGCW‐3’) by a Cyclic Pyrrole‐Imidazole Polyamide2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CGG repeat RNA G-quadruplexes interact with FMRpolyG to cause neuronal dysfunction in fragile X-related tremor/ataxia syndrome2021

Author(s)

Journal Title

DOI

Data Source

Asamitsu Sefan 朝光世煌