Tsuchiya Takaho 土屋貴穂

Researcher Number	70853167
Other IDs	https://orcid.org/0000-0001-7540-5115
Affiliation (Current)	2025: 筑波大学, 医学医療系, 助教
Affiliation (based on the past Project Information) *help	2025: 筑波大学, 医学医療系, 助教 2019 – 2023: 筑波大学, 医学医療系, 助教
Review Section/Research Field	Principal Investigator Basic Section 62010:Life, health and medical informatics-related / 1002:Human informatics, applied informatics and related fields Except Principal Investigator Biological Sciences
Keywords	Principal Investigator 空間トランスクリプトーム / 細胞間相互作用 / バイオインフォマティクス / 1細胞空間トランスクリプトーム / 解析ツール開発 / 数理モデリング / １細胞空間トランスクプリプトーム / システムバイオロジー / 回帰モデル / シングルセル … More / PLS回帰モデル / Highly variable genes / ゲノム編集 / 遺伝子治療 / 創薬 / 集団ゲノム解析 / 一塩基多型 / 細胞型 / 転写因子認識配列 / データベース / エピジェネティクス … More Except Principal Investigator マルチオミクス / システム生物学 / 代謝アダプテーション / ２型糖尿病 / 2型糖尿病 / トランスオミクス Less

Development of an integrative method for inferring intercellular and intracellular networks based on cell–cell communicationsPrincipal Investigator
- Principal Investigator
  
  土屋貴穂
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  University of Tsukuba
Development of a method for estimating integrated intra- and inter-cellular networks using single-cell spatial transcriptomicsPrincipal Investigator
- Principal Investigator
  
  Tsuchiya Takaho
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  University of Tsukuba
Establishment of gRNA design method for gene therapy by avoiding mutations based on population genome dataPrincipal Investigator
- Principal Investigator
  
  Tsuchiya Takaho
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  1002:Human informatics, applied informatics and related fields
- Research Institution
  University of Tsukuba
Metabolic adaptation of type 2 diabetes
- Principal Investigator
  
  Kuroda Shinya
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] The RNA-binding protein Msi2 regulates autophagy during myogenic differentiation2024
- Author(s)
  Wang R, Kato F, Watson RY, Beedle AM, Call JA, Tsunoda Y, Noda T, Tsuchiya T, Kashima M, Hattori A, Ito T.
- Journal Title
  
  Life Sci Alliance .
  
  Volume: 7 Issue: 5 Pages: e202302016-e202302016
- DOI
  10.26508/lsa.202302016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19431, KAKENHI-PROJECT-20K19915
[Journal Article] Transcription factor-binding k-mer analysis clarifies the cell type dependency of binding specificities and cis-regulatory SNPs in humans2023
- Author(s)
  Tahara Saeko、Tsuchiya Takaho、Matsumoto Hirotaka、Ozaki Haruka
- Journal Title
  
  BMC Genomics
  
  Volume: 24 Issue: 1
- DOI
  10.1186/s12864-023-09692-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K17992, KAKENHI-PROJECT-20K19915
[Journal Article] DNA hypomethylation characterizes genes encoding tissue-dominant functional proteins in liver and skeletal muscle2023
- Author(s)
  Maehara H.、Kokaji T.、Hatano A.、Suzuki Y.、Matsumoto M.、Nakayama K. I.、Egami R.、Tsuchiya T.、Ozaki H.、Morita K.、Shirai M.、Li D.、Terakawa A.、Uematsu S.、Hironaka K.、Ohno S.、Kubota H.、Araki H.、Miura F.、Ito T.、Kuroda S.
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 19118-19118
- DOI
  10.1038/s41598-023-46393-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K17992, KAKENHI-PROJECT-20K19915, KAKENHI-PROJECT-21K16349, KAKENHI-PROJECT-21H04759, KAKENHI-PROJECT-23K23870
[Journal Article] CCPLS reveals cell-type-specific spatial dependence of transcriptomes in single cells2022
- Author(s)
  Tsuchiya Takaho、Hori Hiroki、Ozaki Haruka
- Journal Title
  
  Bioinformatics
  
  Volume: 38 Issue: 21 Pages: 4868-4877
- DOI
  10.1093/bioinformatics/btac599
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K19915, KAKENHI-PROJECT-19K20394
[Journal Article] In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states.2022
- Author(s)
  Kokaji T, Eto M, Hatano A, Yugi K, Morita K, Ohno S, Fujii M, Hironaka KI, Ito Y, Egami R, Uematsu S, Terakawa A, Pan Y, Maehara H, Li D, Bai Y, Tsuchiya T, Ozaki H, Inoue H, Kubota H, Suzuki Y, Hirayama A, Soga T, Kuroda S.
- Journal Title
  
  Sci Rep
  
  Volume: 12 Issue: 1 Pages: 13719-13719
- DOI
  10.1038/s41598-022-17964-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19545, KAKENHI-PROJECT-20K19915, KAKENHI-PROJECT-21K14467, KAKENHI-PROJECT-21K16349, KAKENHI-PROJECT-20H03237, KAKENHI-PROJECT-20H04102, KAKENHI-PROJECT-19K20382, KAKENHI-PROJECT-19K20394, KAKENHI-PROJECT-18H03979, KAKENHI-PLANNED-18H05431, KAKENHI-ORGANIZER-17H06299, KAKENHI-PLANNED-17H06300
[Journal Article] Identifying potential regulators of JAGGED1 expression in portal mesenchymal cells2022
- Author(s)
  Nishino Teppei、Yoshihara Masaharu、Nakayama Takahiro、Tsuchiya Takaho、Tahara Saeko、Ozaki Haruka、Takahashi Satoru
- Journal Title
  
  BMC Research Notes
  
  Volume: 15 Issue: 1
- DOI
  10.1186/s13104-022-06058-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K19915
[Journal Article] ゲノム編集技術と大規模ゲノムデータに基づく遺伝子治療2021
- Author(s)
  土屋貴穂
- Journal Title
  
  BIO Clinica
  
  Volume: Vol.36(5) Pages: 448-452
- Data Source
  KAKENHI-PROJECT-19K24361
[Journal Article] Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle2021
- Author(s)
  Egami Riku、Kokaji Toshiya、Hatano Atsushi、et al.
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 3 Pages: 102217-102217
- DOI
  10.1016/j.isci.2021.102217
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21386, KAKENHI-PROJECT-19K20382, KAKENHI-PROJECT-19K20394, KAKENHI-PROJECT-20K19915, KAKENHI-PLANNED-17H06300, KAKENHI-PROJECT-18H05215, KAKENHI-PUBLICLY-20H04943, KAKENHI-PROJECT-20H04102, KAKENHI-PROJECT-19J10234, KAKENHI-PROJECT-19J22134, KAKENHI-PROJECT-19K24361, KAKENHI-ORGANIZER-17H06299, KAKENHI-PROJECT-18H03979, KAKENHI-PLANNED-16H06577, KAKENHI-PLANNED-20H05930, KAKENHI-PROJECT-18KT0020, KAKENHI-PLANNED-18H05431, KAKENHI-PROJECT-20H03237
[Journal Article] ゲノム編集技術と大規模ゲノムデータに基づいた遺伝子治療の展望2021
- Author(s)
  土屋貴穂
- Journal Title
  
  Precision Medicine
  
  Volume: Vol.4(2) Pages: 167-171
- Data Source
  KAKENHI-PROJECT-19K24361
[Journal Article] ゲノム編集技術と大規模ゲノムデータに基づく遺伝子治療2021
- Author(s)
  土屋貴穂
- Journal Title
  
  BIO Clinica
  
  Volume: Vol.36(5) Pages: 448-452
- Data Source
  KAKENHI-PROJECT-20K19915
[Journal Article] Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity2020
- Author(s)
  Kokaji Toshiya、Hatano Atsushi、Ito Yuki、et al.
- Journal Title
  
  Science Signaling
  
  Volume: 13 Issue: 660 Pages: 1236-1236
- DOI
  10.1126/scisignal.aaz1236
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21386, KAKENHI-PROJECT-19K20382, KAKENHI-PROJECT-19K20394, KAKENHI-PROJECT-20K19915, KAKENHI-PLANNED-17H06300, KAKENHI-PROJECT-18H05215, KAKENHI-PUBLICLY-19H04969, KAKENHI-PUBLICLY-19H05243, KAKENHI-PUBLICLY-20H04847, KAKENHI-PUBLICLY-20H04943, KAKENHI-PROJECT-18H02431, KAKENHI-PROJECT-20H04102, KAKENHI-PROJECT-19K24361, KAKENHI-ORGANIZER-17H06299, KAKENHI-PROJECT-18H03979, KAKENHI-PLANNED-16H06577, KAKENHI-PLANNED-18H05431, KAKENHI-PLANNED-20H05930, KAKENHI-PROJECT-18KT0020, KAKENHI-PROJECT-20H03237
[Journal Article] 集団ゲノムデータから展望する遺伝子治療とプレシジョンメディシンの動向2020
- Author(s)
  土屋貴穂
- Journal Title
  
  Precision Medicine
  
  Volume: Vol.3(10) Pages: 630-634
- Data Source
  KAKENHI-PROJECT-19K24361
[Journal Article] Stability of RNA sequences derived from the coronavirus genome in human cells2020
- Author(s)
  Wakida Hiroyasu、Kawata Kentaro、Yamaji Yuta、Hattori Emi、Tsuchiya Takaho、Wada Youichiro、Ozaki Haruka、Akimitsu Nobuyoshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 527 Issue: 4 Pages: 993-999
- DOI
  10.1016/j.bbrc.2020.05.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16635, KAKENHI-PROJECT-19K20394, KAKENHI-PROJECT-20K19915, KAKENHI-PROJECT-19K22679, KAKENHI-PROJECT-19K24361
[Journal Article] 遺伝子治療のためのゲノム編集技術と集団ゲノムデータ2020
- Author(s)
  土屋貴穂
- Journal Title
  
  Medical Science Digest
  
  Volume: Vol.46(12) Pages: 766-770
- Data Source
  KAKENHI-PROJECT-19K24361
[Journal Article] 集団ゲノムデータに基づくことによる遺伝子治療の展望2020
- Author(s)
  土屋貴穂
- Journal Title
  
  Precision Medicine
  
  Volume: Vol.3(6) Pages: 581-585
- Data Source
  KAKENHI-PROJECT-19K24361
[Journal Article] ゲノム編集技術を用いた遺伝子治療の開発動向2019
- Author(s)
  内田恵理子, 平松直人, 犬飼直人, 岩井謙一, 渡辺武志, 川崎秀吉, 田村幸太朗, 土屋貴穂, 吉見英治, 高橋則彦, 伊原辰哉, 藤本和則, 山下晃人, 小野貴士, 高木観, 小野竜一, 内藤雄樹, 井上貴雄
- Journal Title
  
  医薬品医療機器レギュラトリーサイエンス
  
  Volume: Vol.50(8)
- NAID
  40021992942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K24361
[Presentation] Predicting SNPs' effects on transcriptional factor binding and cell-type specificity using a crowd of ChIP-seq data2022
- Author(s)
  田原沙絵子, 土屋貴穂, 松本拡高, 尾崎遼
- Organizer
  日本人類遺伝学会第67回大会
- Data Source
  KAKENHI-PROJECT-20K19915
[Presentation] MOCCS-DB: ヒト転写因子認識配列の多様性データベース2022
- Author(s)
  田原沙絵子,土屋貴穂,松澤亮輔,尾崎遼
- Organizer
  トーゴーの日シンポジウム2022
- Data Source
  KAKENHI-PROJECT-20K19915
[Presentation] MOCCSプロファイルで明らかにする、転写因子認識配列の細胞型特異性とヒト一塩基多型が転写因子結合へ与える影響2022
- Author(s)
  Saeko Tahara, Takaho Tsuchiya, Hirotaka Matsumoto and Haruka Ozaki
- Organizer
  2022年日本バイオインフォマティクス学会年会・第11回生命医薬情報学連合大会(IIBMP2022)
- Data Source
  KAKENHI-PROJECT-20K19915
[Presentation] k-mer profile analysis clarifies cell-type specific TF binding landscape in human2021
- Author(s)
  Saeko Tahara, Takaho Tsuchiya and Haruka Ozaki
- Organizer
  日本バイオインフォマティクス学会 2021年年会第10回生命医薬情報学連合大会（IBMP2021）
- Data Source
  KAKENHI-PROJECT-20K19915
[Presentation] CCPLS reveals cell-type specific spatial dependence of transcriptome in single cells2021
- Author(s)
  Takaho Tsuchiya and Haruka Ozaki
- Organizer
  CREST BioDX Symposium 2021
- Data Source
  KAKENHI-PROJECT-20K19915
[Presentation] Cell-Cell PLS regression analysis reveals cell-type specific spatial dependency of transcriptome in single cells2021
- Author(s)
  Takaho Tsuchiya and Haruka Ozaki
- Organizer
  日本バイオインフォマティクス学会 2021年年会第10回生命医薬情報学連合大会（IBMP2021）
- Data Source
  KAKENHI-PROJECT-20K19915
[Presentation] CellCellTopic：cell-cell interaction analysis by Dirichlet multinomial regression topic modeling2020
- Author(s)
  Takaho Tsuchiya and Haruka Ozaki
- Organizer
  日本バイオインフォマティクス学会 2020年年会第9回生命医薬情報学連合大会（IBMP2020）
- Data Source
  KAKENHI-PROJECT-20K19915
[Presentation] ChIP-Atlasの二次解析による多彩な転写因子認識配列の解明および更なるデータベース化2020
- Author(s)
  田原沙絵子、土屋貴穂、尾崎遼
- Organizer
  トーゴーの日シンポジウム
- Data Source
  KAKENHI-PROJECT-19K24361
[Presentation] ChIP-seqデータベースの大規模解析で解明する細胞型ごとに多彩な転写因子認識配列2020
- Author(s)
  田原沙絵子、土屋貴穂、尾崎遼
- Organizer
  日本バイオインフォマティクス学会 2020年年会第9回生命医薬情報学連合大会（IBMP2020）
- Data Source
  KAKENHI-PROJECT-19K24361
[Presentation] System Identification of Signaling Dependent Gene Expression with Different Time-Scale Data2020
- Author(s)
  土屋貴穂
- Organizer
  Institute for Frontier Life and Medical Sciences, Kyoto University, Seminar Series of Cell Fate Dynamics & Therapeutics
- Invited
- Data Source
  KAKENHI-PROJECT-19K24361
[Presentation] シングルセル空間トランスクリプトームデータを用いた遺伝子制御ネットワークの空間分布解析2019
- Author(s)
  Tsuchiya, T. and Ozaki, H.
- Organizer
  第8回生命医薬情報学連合大会（IIBMP2019）
- Data Source
  KAKENHI-PROJECT-19K24361

1. Kuroda Shinya (50273850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 稲葉有香 (20571970)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 小林大樹 (20448517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 幡野敦 (30755533)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 尾崎遼 (10743346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 川田健太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 井上啓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 野田岳志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tsuchiya Takaho 土屋 貴穂

Research Projects

Research Products

Co-Researchers

Development of an integrative method for inferring intercellular and intracellular networks based on cell&#8211;cell communicationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a method for estimating integrated intra- and inter-cellular networks using single-cell spatial transcriptomicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of gRNA design method for gene therapy by avoiding mutations based on population genome dataPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Metabolic adaptation of type 2 diabetes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] The RNA-binding protein Msi2 regulates autophagy during myogenic differentiation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcription factor-binding k-mer analysis clarifies the cell type dependency of binding specificities and cis-regulatory SNPs in humans2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNA hypomethylation characterizes genes encoding tissue-dominant functional proteins in liver and skeletal muscle2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CCPLS reveals cell-type-specific spatial dependence of transcriptomes in single cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identifying potential regulators of JAGGED1 expression in portal mesenchymal cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ゲノム編集技術と大規模ゲノムデータに基づく遺伝子治療2021

Author(s)

Journal Title

Data Source

[Journal Article] Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ゲノム編集技術と大規模ゲノムデータに基づいた遺伝子治療の展望2021

Author(s)

Journal Title

Data Source

[Journal Article] ゲノム編集技術と大規模ゲノムデータに基づく遺伝子治療2021

Author(s)

Journal Title

Data Source

[Journal Article] Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity2020

Author(s)

Journal Title

DOI

Data Source

Tsuchiya Takaho 土屋貴穂

Development of an integrative method for inferring intercellular and intracellular networks based on cell–cell communicationsPrincipal Investigator

[Presentation] MOCCSプロファイルで明らかにする、転写因子認識配列の細胞型特異性とヒト一塩基多型が転写因子結合へ与える影響2022